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Medically Reviewed Content
Updated: May 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,711 treatment centers offering naltrexone (vivitrol) across the United States.

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Cenikor Foundation
Amarillo, TX

Situated in Amarillo, TX, the Cenikor Foundation provides extensive treatment for substance use disorders, along with specialized support for individuals facing concurrent substance use and significant mental health challenges in adults, as well as severe emotional issues in children. The center offers various treatment modalities such as intensive outpatient programs, outpatient services, and daytime treatment options. Emphasizing approaches like 12-step facilitation, anger management, and brief interventions, this facility serves both adult men and women, including active duty military members. Committed to offering tailored, effective care, Cenikor Foundation aims to foster long-term recovery for adults and young adults of all genders.

Cenikor Foundation
Amarillo, TX

Situated in Amarillo, TX, the Cenikor Foundation specializes in a wide array of addiction recovery services. This center offers detox services, treatment for substance abuse, transitional housing, halfway house accommodations, and sober living arrangements. With options for inpatient detoxification and various treatment models, the facility employs methods like 12-step facilitation, anger management, and brief interventions. Additionally, there are specialized programs designed for active duty military members as well as programs for adult men and women. The center is dedicated to providing quality care for both adults and young adults, ensuring effective support for those seeking recovery.

Cen Clear Child Services Inc

Situated in Philipsburg, PA, Cen Clear Child Services Inc offers an all-encompassing approach to substance abuse treatment for adults dealing with serious mental health issues and for children facing significant emotional challenges. The center provides various treatment options, including intensive outpatient programs, outpatient services, and medication-assisted therapies using methadone, buprenorphine, or naltrexone. Their methodologies incorporate anger management, cognitive behavioral therapy, and the Matrix Model. Programs are customized for adult men and women, with particular attention to the needs of both younger and older adults. Committed to delivering high-quality care rooted in evidence-based practices, this center remains focused on aiding individuals in their recovery journey.

Cenikor Foundation
Farmington, NM

Situated in Farmington, NM, the Cenikor Foundation delivers a wide array of services geared towards treating addiction for both adults and young adults. This facility features residential detox programs, round-the-clock residential support, and short-term stay options designed for those aiming to overcome substance use disorders along with associated mental health issues. By employing proven methods such as the 12-step approach, anger management techniques, and cognitive behavioral therapy, the center customizes its treatment plans to meet the specific needs of each person. Emphasizing personalized care, the center provides tailored programs to tackle the distinct challenges encountered by men and women. Experience top-notch care and assistance at the Cenikor Foundation.

Cenikor Foundation

Based in Austin, TX, the Cenikor Foundation delivers a variety of in-depth rehabilitation services. Focused on detoxification and substance use disorder treatment, this center offers residential detox services, round-the-clock residential options, and short-term residential programs. Their treatment approach incorporates 12-step guidance, anger management techniques, and cognitive behavioral therapy. Cenikor Foundation also features specific programs for active military personnel, men, and women, serving both adult and young adult clients. Renowned for its high-quality care and a wide array of treatment alternatives, this facility stands out for individuals pursuing personalized and effective addiction recovery solutions.

Cen Clear Child Services Inc

Cen Clear Child Services Inc, situated in Saint Marys, PA, delivers exceptional substance abuse recovery services and expert support for individuals facing dual diagnoses of substance use disorders and significant mental health conditions in adults, or emotional challenges in youth. This establishment features robust intensive outpatient and standard outpatient options, encompassing medication-assisted treatments such as methadone/buprenorphine or naltrexone. Emphasizing therapeutic approaches like anger management, cognitive behavioral therapy, and the Matrix Model, the center is equipped to assist adult men and women, and older adults. Care is adapted to suit the distinct needs of each gender, promoting a thorough path to wellness for everyone who seeks their help.

Cen Clear Child Services Inc

Cen Clear Child Services Inc, situated in Clarion, PA, provides dedicated substance use recovery programs for adults and older adults. Their services encompass intensive outpatient, outpatient, and medication-assisted treatment options using methadone, buprenorphine, or naltrexone. The center employs evidence-based therapies such as anger management, cognitive behavioral therapy, and the Matrix Model. They offer distinct programs designed for adult men and women, facilitating personalized care. Cen Clear Child Services Inc is committed to delivering high-quality rehabilitation to all clients, adapting services to individual requirements. For those in need of thorough addiction support and a nurturing atmosphere, Cen Clear Child Services Inc strives to guide individuals toward sustained sobriety.

Cen Clear Child Services Inc

Cen Clear Child Services Inc, situated in Roaring Spring, PA, provides targeted substance abuse rehabilitation for adults with significant mental health conditions and for children experiencing emotional distress. Their extensive offerings encompass intensive outpatient, standard outpatient, and medication-assisted treatments like methadone, buprenorphine, or naltrexone. Employing proven therapeutic strategies, including anger management, cognitive behavioral therapy, and the Matrix Model, the center addresses both addiction and mental wellness. Tailored services for adult men and women, catering to adults and older adults of all genders, ensure personalized care and support for sustainable recovery.

Cen Clear Child Services Inc

Cen Clear Child Services Inc, situated in Yeagertown, PA, offers targeted care for adults facing co-occurring substance use and severe mental health challenges, as well as children with significant emotional disturbances. The facility's offerings encompass intensive outpatient services, general outpatient support, and medication-assisted treatment for opioid use disorders (methadone/buprenorphine or naltrexone). Employing therapeutic strategies like anger management, cognitive behavioral therapy, and the Matrix Model, Cen Clear Child Services Inc provides individualized treatment plans for adult men and women. Open to adults and seniors of any gender, this center is dedicated to providing effective, research-backed interventions to aid individuals in their recovery journey.

Centennial Mental Health Center Inc

Centennial Mental Health Center Inc in Fort Morgan, CO, specializes in providing outpatient services for individuals dealing with substance use issues, co-occurring disorders, and significant mental health challenges in both adults and children. The center administers outpatient treatments that include methadone, buprenorphine, and naltrexone, emphasizing evidence-based methods like cognitive behavioral therapy, anger management, and motivational incentives. It offers customized programs designed for adolescents, women, and victims of sexual abuse, guaranteeing personalized support for adults and seniors of all genders. Renowned for its high-quality services and extensive assistance, Centennial Mental Health Center Inc is a reliable choice for those in need of effective and empathetic rehabilitation solutions.

Cen Clear Child Services Inc

Situated in Huntingdon, PA, Cen Clear Child Services Inc provides extensive treatment options for substance abuse while addressing co-occurring disorders. The facility offers a range of services, including intensive outpatient programs, outpatient care, and treatments with methadone, buprenorphine, or naltrexone. Utilizing proven strategies such as cognitive behavioral therapy, anger management, and the Matrix Model, the center serves both adult men and women, as well as senior clients. With an emphasis on specialized care for both adults and children, gender-specific programs, and a strong dedication to high-quality treatment, individuals in search of effective rehabilitation can find the necessary support and recovery opportunities at this center.

Cen Clear Child Services Inc

Cen Clear Child Services Inc, situated in Clearfield, PA, delivers excellent rehabilitative care for those facing addiction and intertwined mental health challenges. The center offers various treatment levels, including intensive outpatient, outpatient, and standard outpatient programs. These services incorporate proven therapeutic methods like anger management, cognitive behavioral therapy, and the Matrix Model. Catering to adult men and women, this establishment serves adults and older adults irrespective of gender. Cen Clear Child Services Inc emphasizes personalized support and a collaborative treatment strategy to provide superior recovery assistance.

Centennial Mental Health Center Inc

Centennial Mental Health Center Inc. in Sterling, CO, provides targeted outpatient services for individuals of all ages struggling with substance abuse and co-occurring mental health conditions. Their therapeutic approach incorporates anger management, cognitive behavioral therapy, and motivational incentives to create personalized treatment plans. The center distinguishes itself with specialized programs for adolescents, adult women, and survivors of sexual trauma, fostering a holistic recovery journey. Catering to adults and seniors across all gender identities, Centennial Mental Health Center Inc. utilizes research-backed therapies and a committed team to deliver exceptional support for those aiming to conquer addiction and enhance their psychological health.

Cen Clear Child Services Inc

Cen Clear Child Services Inc, located in Punxsutawney, PA, provides comprehensive, research-backed therapeutic interventions for individuals grappling with addiction and co-occurring psychological conditions. Their offerings cater to both young individuals and adults, encompassing intensive outpatient, standard outpatient, and continuing outpatient care levels. Employing therapeutic modalities like dialectical behavior therapy, dialectical behavior therapy, and integrated dual diagnosis treatment, the center customizes recovery plans to each person's unique requirements. Distinct programs designed for adult men and women offer targeted, gender-affirming assistance. Catering to adults and older adults, Cen Clear Child Services Inc is dedicated to delivering high-quality care with empathy, establishing itself as a significant provider of effective recovery solutions.

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Cen Clear Child Services Inc, situated in Coalport, PA, provides an extensive selection of substance use treatment options for both adults and seniors. The center focuses on addressing co-occurring substance use issues along with significant mental health challenges and emotional problems in children. It offers various treatment formats, including intensive outpatient, outpatient, and standard outpatient programs, ensuring personalized care through evidence-based methods like cognitive behavioral therapy, anger management, and the Matrix Model. Special programs designed specifically for men and women deliver effective, gender-focused support. Cen Clear Child Services Inc is dedicated to offering top-notch care that aids individuals in their journey towards enduring recovery.

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Centennial Mental Health Center Inc, located in Akron, CO, provides outpatient treatment for substance use disorders, catering to both adults and children facing overlapping mental health challenges. The facility features dedicated programs for adolescents, adult females, and individuals with dual diagnoses. Emphasizing approaches such as cognitive behavioral therapy, anger management, and motivational incentives, the center creates personalized treatment plans designed to address specific needs. Offering outpatient alternatives like methadone/buprenorphine and naltrexone, Centennial Mental Health Center Inc serves individuals of all genders, ensuring comprehensive care that promotes recovery and mental well-being.

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Centennial Mental Health Center Inc, located in Elizabeth, CO, delivers extensive outpatient care for adults facing substance use challenges alongside serious mental health disorders, as well as for children dealing with significant emotional issues. The center is adept in anger management, cognitive behavioral therapy, and motivational incentives, offering customized support for adolescents, women, and individuals who have experienced sexual trauma. Catering to adults and seniors of all identities, the center provides outpatient treatment options including methadone, buprenorphine, or naltrexone, alongside standard outpatient services. With an emphasis on personalized, evidence-informed strategies, Centennial Mental Health Center Inc guarantees high-quality support for those in pursuit of recovery.

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Centennial Mental Health Center Inc, located in Wray, CO, specializes in offering outpatient care for adults dealing with substance use issues and significant mental health disorders, as well as addressing severe emotional challenges in children. The center utilizes a variety of evidence-based treatment methods, including cognitive behavioral therapy, anger management, and motivational incentives. Custom programs cater to specific groups such as adolescents, women, and individuals who have faced sexual abuse. This facility is dedicated to providing personalized support for adults and seniors of all genders, ensuring that each client's distinct requirements are met. For those in need of compassionate and effective addiction recovery solutions, Centennial Mental Health Center Inc is recognized as a reliable source of quality rehabilitation services.

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Centennial Mental Health Center Inc located in Yuma, CO specializes in outpatient services for adults dealing with substance abuse and serious mental health disorders, as well as children facing significant emotional challenges. The center emphasizes personalized treatment plans, offering services such as anger management, cognitive behavioral therapy, and motivational techniques. Programs specifically designed for adolescents, women, and survivors of sexual abuse provide extensive care options. This facility caters to both adult men and women, featuring a variety of treatment approaches, including outpatient methadone, buprenorphine, or naltrexone therapies. Centennial Mental Health Center Inc is committed to delivering exceptional care to assist individuals in their recovery journey.

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Centennial Mental Health Center Inc, located in Burlington, CO, delivers targeted outpatient services for individuals dealing with substance abuse and dual diagnosis issues, catering to both adults and children. Their offerings encompass anger management programs, cognitive behavioral therapy, and motivational incentives. The center places a strong emphasis on addressing the needs of specific groups, including adolescents, adult women, and survivors of sexual trauma, ensuring that care is customized for a diverse range of clients, including adults and seniors of varying genders. Whether individuals are in need of routine outpatient care or specific treatments such as methadone or buprenorphine, they can anticipate personalized assistance and scientifically-based strategies aimed at achieving sustained recovery. The center's dedication to high-quality rehabilitation makes it a reputable option for those in pursuit of comprehensive mental health services.

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Centennial Mental Health Center Inc, located in Limon, CO, delivers outpatient services for adults managing substance dependency alongside significant mental health challenges. The center is equipped to provide targeted support for those facing both addiction and emotional difficulties. Their therapeutic methods encompass anger control, cognitive behavioral strategies, and motivational reinforcement. Distinct programs are available for young people, adult women, and survivors of sexual trauma. The center assists adult and senior individuals of all genders. Prioritizing excellent care and personalized recovery paths, Centennial Mental Health Center Inc is committed to fostering enduring sobriety and enhanced psychological health for its clients.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated May 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)