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Medically Reviewed Content
Updated: May 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,711 treatment centers offering naltrexone (vivitrol) across the United States.

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Cielo Treatment Center

Situated in Portland, OR, Cielo Treatment Center specializes in rehabilitation for adults and young adults facing challenges with substance use disorders, alongside mental health concerns and emotional issues. The center offers various treatment options such as intensive outpatient programs, outpatient services, and day treatment. Emphasizing 12-step facilitation, anger management, and short-term interventions, Cielo Treatment Center is committed to serving LGBTQ individuals and young adults. Their customized approach for both male and female clients guarantees personalized attention and assistance. If you are in search of empathetic and efficient addiction recovery solutions, this center is focused on supporting you through your healing journey.

Cincinnati VA Medical Center

Situated in Cincinnati, Ohio, the Cincinnati VA Medical Center delivers extensive addiction recovery services aimed at both adults and young adults. This center features hospital-based detoxification and addresses substance use disorders alongside related mental health challenges. With a focus on veteran care, it tailors its programs to meet the needs of both men and women. Utilizing methods like 12-step facilitation and anger management, the center emphasizes the provision of high-quality, evidence-backed treatment. Whether individuals are in need of detoxification or continuous recovery support, they can take advantage of the specialized programs and individualized attention offered at this esteemed facility.

Cirque Lodge
Provo, UT

Situated in Provo, Utah, Cirque Lodge specializes in extensive treatment for adults and young adults dealing with substance use issues. The center emphasizes support for co-occurring disorders, offering a range of programs that include long-term, short-term, and residential care customized to meet individual requirements. Cirque Lodge employs a variety of therapeutic techniques such as 12-step assistance, anger management, and brief interventions to aid in the recovery process. Specialized programs cater to adult men, women, and those with concurrent mental health challenges. The facility is committed to providing exemplary care for all clients, establishing itself as an excellent option for effective and tailored rehabilitation services.

Cirque Lodge Studio

Cirque Lodge Studio in Orem, UT, provides extensive long-term residential care for individuals battling addiction and dual diagnoses. The center specializes in treating substance use disorders and accompanying mental health challenges for adults and young adults. Employing strategies such as 12-step integration, anger control techniques, and brief intervention methods, the facility delivers targeted support for adult men and women, particularly those with concurrent conditions. Cirque Lodge Studio features residential detox services and round-the-clock support, fostering a secure setting for healing. The availability of distinct programs for male and female clients highlights the center's dedication to personalized, high-quality recovery and mental well-being journeys.

Citizen Advocates
Ogdensburg, NY

Citizen Advocates, situated in Ogdensburg, NY, provides an extensive variety of outpatient services aimed at tackling substance use disorders alongside associated mental health issues impacting both adults and youth. The center is adept in detoxification, substance abuse treatment, and addressing the needs of those suffering from significant mental health challenges or emotional issues. Emphasizing evidence-based methods such as cognitive behavioral therapy, anger management, and brief interventions, Citizen Advocates offers personalized support for male and female clients. The facility is particularly focused on outpatient detox programs, as well as treatments involving methadone/buprenorphine and naltrexone, while also catering to individuals with simultaneous disorders, ensuring they receive the high-quality care necessary for their recovery journey.

Circle Health Services

Circle Health Services, located in Cleveland, OH, specializes in complete substance abuse rehabilitation for adults and older individuals. Their treatment options include intensive outpatient care, standard outpatient services, and partial hospitalization programs. Employing methods like 12-step support, emotional regulation training, and brief counseling techniques, the facility customizes recovery plans. They also offer distinct support for expectant and new mothers. Circle Health Services provides a welcoming space for all genders, fostering an environment of encouragement. Committed to high-quality services and individualized treatment strategies, the center aims to guide individuals toward conquering addiction and maintaining long-term sobriety.

CLARE Matrix
Santa Monica, CA

Situated in Santa Monica, CA, CLARE Matrix stands out as a leading rehabilitation facility dedicated to detoxification and substance use recovery for adult males. The center provides various options including long-term residential stays, detoxification services, and around-the-clock residential treatment aimed at those who have faced intimate partner violence, domestic abuse, and sexual trauma. Emphasizing 12-step methods, anger management, and brief intervention strategies, CLARE Matrix delivers effective support for adults, seniors, and younger individuals on their path to recovery. With its focused programs and committed team, the center fosters a nurturing space for healing and personal development.

CLARE Matrix
Santa Monica, CA

CLARE Matrix, situated in Santa Monica, California, provides a wide range of addiction treatment options. The center focuses on detox services and substance abuse recovery, emphasizing long-term residential care. With an emphasis on 12-step support, anger management, and brief intervention techniques, CLARE Matrix serves adult men and women, including those affected by domestic violence or intimate partner abuse. This facility caters to both adults and young adults, offering customized care for both genders. CLARE Matrix is recognized for its high-quality treatment and individualized programs, making it a reliable option for individuals in need of rehabilitation.

CLARE Matrix
Santa Monica, CA

The CLARE Matrix facility in Santa Monica, California, delivers exceptional substance abuse recovery programs specifically designed for adult women. They excel in providing detox and ongoing treatment, with a structured long-term residential model. Their approach integrates 12-step principles, anger management techniques, and brief intervention strategies. CLARE Matrix is particularly attuned to the needs of women who have faced domestic violence, intimate partner abuse, or sexual trauma. Offering targeted care for adults, older adults, and young adults, the center is dedicated to providing thorough rehabilitation in a secure and supportive setting for its female clientele.

Circle Park Behavioral Health Services

Circle Park Behavioral Health Services, located in Florence, SC, provides a wide range of treatment options for substance use disorders, incorporating methods like anger management, brief interventions, and cognitive behavioral therapy. The center features tailored programs for various groups, including active military members, men, women, and services specifically designed for children and adolescents, ensuring personalized treatment for every individual. Circle Park offers intensive outpatient programs, general outpatient services, and targeted outpatient treatments with methadone, buprenorphine, or naltrexone. Committed to high-quality care, this facility employs evidence-based strategies coupled with a caring approach, making it a reliable choice for those in need of effective addiction recovery solutions.

CKF Addiction Treatment Inc

CKF Addiction Treatment Inc, situated in Salina, KS, offers a wide array of services designed for those in need of assistance with substance use issues. The facility specializes in detoxification and intensive outpatient care, incorporating methods like 12-step principles and cognitive behavioral techniques. Unique programs are available for adult women as well as clients involved with the criminal justice system. CKF Addiction Treatment Inc accommodates both adults and youth, featuring gender-specific programs for males and females. The center provides various treatment formats, including outpatient options and medication-assisted therapies with methadone, buprenorphine, or naltrexone, focusing on high-quality care and research-backed practices to aid individuals on their recovery journey.

Ciganek LLC
Centreville, MD

Ciganek LLC in Centreville, MD, provides outpatient services for adults and young adults, specializing in detoxification and substance use disorder treatment. Their approach emphasizes preventing relapse through telemedicine and telehealth therapies. They offer distinct programs for active-duty military personnel, adult men, and adult women, ensuring individualized care for all clients. Ciganek LLC is dedicated to delivering high-quality, personalized treatment plans designed to foster successful recovery. By integrating scientifically supported methods with specialized interventions, they address the specific requirements of each individual seeking to overcome substance use challenges.

Citywide Health Corporation

Citywide Health Corporation, located in Pikesville, MD, provides extensive addiction treatment services designed for adults and young adults. The center focuses on dual diagnosis treatment for adults with co-occurring mental health and substance use conditions, and for children experiencing significant emotional challenges. Offering both intensive outpatient and outpatient care, including medication-assisted treatment with methadone, buprenorphine, or naltrexone, the facility fosters a nurturing setting for those pursuing sobriety. Employing evidence-based practices such as cognitive behavioral therapy, relapse prevention techniques, and specialized counseling for substance use disorders, this institution is committed to offering excellent care to all genders dealing with combined mental health and addiction issues.

CKF Addiction Treatment Inc

CKF Addiction Treatment Inc located in Abilene, KS, provides a wide range of substance use services for both adults and children/adolescents. The center features intensive outpatient programs, general outpatient services, and options for outpatient methadone, buprenorphine, or naltrexone treatment. Emphasizing methods such as 12-step facilitation, brief intervention, and cognitive behavioral therapy, CKF Addiction Treatment Inc customizes treatment strategies to meet the unique needs of each patient. With expertise in working with criminal justice and forensic populations, this facility caters to both male and female clients. Renowned for its high-quality care and reliance on evidence-based practices, CKF Addiction Treatment Inc is committed to assisting individuals in overcoming addiction and attaining sustained recovery.

CKF Addiction Treatment Inc

CKF Addiction Treatment Inc, located in McPherson, KS, provides a thorough program for individuals battling substance use disorders. Their services encompass intensive outpatient, standard outpatient, and medication-assisted treatment with methadone, buprenorphine, or naltrexone. The center is equipped to assist clients across all age groups, including adults and minors, and serves both men and women. Employing proven therapeutic methods like 12-step facilitation, motivational interviewing, and cognitive behavioral therapy, CKF Addiction Treatment Inc delivers personalized care. A significant area of expertise lies in their dedicated support for individuals involved with the criminal justice system. CKF Addiction Treatment Inc is committed to delivering high-quality, compassionate care in a recovery-focused setting.

Clackamas Health Centers

Clackamas Health Centers, situated in Sandy, OR, delivers outpatient services for individuals of all ages grappling with substance use and co-occurring mental health challenges. Their approach integrates brief interventions, cognitive behavioral therapy, and the Matrix Model to support adults, adolescents, and seniors. This facility is dedicated to providing individualized care through specialized programs designed for distinct age and gender groups, including adult men and women. Clackamas Health Centers prioritizes evidence-based practices and high-quality treatment, offering thorough rehabilitation to guide clients toward lasting recovery.

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Situated in San Francisco, California, the City and County of San Francisco rehabilitation center provides extensive outpatient care for addiction and co-occurring mental health issues in individuals of all ages. Employing evidence-based methods like motivational interviewing, cognitive behavioral therapy, and reinforcement strategies, the center delivers personalized treatment plans. Their specialized outpatient detoxification services, including medication-assisted treatment with methadone, buprenorphine, or naltrexone, highlight a distinct commitment to addressing substance use disorders concurrently with significant mental health challenges. This facility ensures high-quality, gender-inclusive recovery support for everyone.

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Waterbury, CT

CJR Waterbury, situated in Waterbury, CT, delivers extensive outpatient care for individuals facing substance use challenges and related mental health disorders, serving both adults and children. This facility features tailored programs specifically designed for adolescents and young adults, as well as for those with mental health concerns. Treatment modalities offered encompass anger management, cognitive behavioral therapy, and various brief intervention techniques. CJR Waterbury serves a diverse clientele, including men, women, seniors, and adults. Prioritizing personalized care and high-quality treatment, this center provides outpatient options involving methadone, buprenorphine, or naltrexone, in conjunction with standard outpatient services. If you or someone you know is looking for reliable rehabilitation options, CJR Waterbury stands out as a reputable option.

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Santa Monica, CA

Situated in Santa Monica, CA, CLARE Matrix is a leading rehabilitation facility that delivers a variety of specialized services aimed at individuals aiming to overcome substance use challenges. The center features all-encompassing long-term residential treatments, including detoxification and round-the-clock support. Emphasizing 12-step methods, anger management strategies, and concise intervention techniques, CLARE Matrix is dedicated to serving adults and young adults of any gender. What distinguishes this center are its unique programs designed for individuals who have faced trauma, intimate partner violence, domestic abuse, and sexual assault. With a strong dedication to high-quality care, CLARE Matrix shines as a symbol of hope for those embarking on their recovery journey.

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Los Angeles, CA

CLARE Matrix in Los Angeles, CA, provides comprehensive outpatient services for adults grappling with substance use disorders. Their programs are designed for both men and women, offering specialized support for individuals who have faced domestic abuse. CLARE Matrix excels in incorporating 12-step principles, anger management techniques, and brief intervention strategies into their treatment plans. They are committed to delivering high-quality, personalized care for adults and young adults on their path to recovery. Recognizing the varied needs of those seeking sobriety, CLARE Matrix offers outpatient options such as methadone, buprenorphine, or naltrexone. For those in search of empathetic and thorough treatment within a nurturing atmosphere, CLARE Matrix is a distinguished choice for embarking on your recovery.

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Pittsfield, IL

Clarity Healthcare, situated in Pittsfield, IL, presents an extensive array of outpatient services aimed at addressing substance use disorders alongside co-occurring mental health issues for both adults and children. This facility features targeted programs tailored for adolescents, men, and women, accommodating a wide range of ages and gender identities. The treatment methodologies utilized encompass 12-step facilitation, brief intervention techniques, and cognitive behavioral therapy, all aimed at providing a customized and research-informed care approach. Prioritizing quality and individualized assistance, Clarity Healthcare offers outpatient options for methadone, buprenorphine, or naltrexone treatment, along with standard outpatient services, all within a nurturing environment that promotes recovery.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated May 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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