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Medically Reviewed Content
Updated: May 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,711 treatment centers offering naltrexone (vivitrol) across the United States.

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Cliffside Malibu 2

Cliffside Malibu 2, situated in Malibu, CA, delivers thorough recovery programs for individuals and adolescents facing addiction and co-occurring psychological challenges. This establishment provides round-the-clock hospital-based inpatient detoxification and care. The curriculum incorporates 12-step guidance, emotional regulation strategies, and brief counseling. Targeted programs are available for adult men and women, alongside individuals affected by domestic or intimate partner abuse. Dedicated to superior support, this center delivers tailored therapy for diverse age demographics and genders, fostering individualized and successful healing.

Clifton Springs Hosp Clinic
Clifton Springs, NY

Situated in Clifton Springs, NY, Clifton Springs Hosp Clinic delivers extensive outpatient treatment for substance use and targeted support for adults facing concurrent mental health challenges or emotional issues in children. The facility offers outpatient options such as methadone/buprenorphine and naltrexone therapies, along with standard outpatient services. Emphasizing methods like 12-step facilitation, anger management, and brief interventions, this center serves both male and female clients, including young adults. Renowned for its proficiency in addressing co-occurring disorders, Clifton Springs Hosp Clinic is distinguished by its high-quality care and individualized programs aimed at promoting long-term recovery.

Clinica Ambulatoria Aibonito

Located in Aibonito, PR, Clinica Ambulatoria Aibonito specializes in outpatient care for individuals struggling with substance use issues, including adults and children facing concurrent mental health challenges. The center's programs include focused therapies such as anger management, brief interventions, and cognitive behavioral approaches. Catering to different demographics, the facility creates customized treatment plans for adolescents, adult men, and women. With an emphasis on outpatient options for methadone, buprenorphine, or naltrexone, this center provides extensive support for those on their path to recovery. Serving both genders, Clinica Ambulatoria Aibonito is dedicated to offering personalized, high-quality care that fosters healing and supports sustainable sobriety.

Clinica Monsenor Oscar A Romero

Clinica Monsenor Oscar A Romero, located in Los Angeles, CA, delivers a wide array of treatment options for substance use disorders for both adults and children/adolescents who are also dealing with serious mental health challenges or emotional issues. The facility offers intensive outpatient programs, outpatient services, and treatments involving methadone, buprenorphine, or naltrexone. Emphasizing 12-step support, anger management techniques, and short-term interventions, the center serves a diverse clientele, including active military members, adolescents, and men. The services are available to both men and women, ensuring individualized care that meets various needs. With its high standard of care and specialized programs, it stands out as a top choice for those in search of effective rehabilitation solutions in the Los Angeles region.

CMS Dearborn Heights
Dearborn Heights, MI

CMS Dearborn Heights, situated in Dearborn Heights, MI, is a dedicated facility providing tailored substance use disorder therapy for adults and adolescents. This center delivers outpatient care, incorporating medication-assisted treatment with methadone, buprenorphine, or naltrexone. Employing proven therapeutic methods like cognitive behavioral therapy, contingency management, and motivational interviewing, the program aids individuals on their path to recovery. A notable aspect of their approach is a specific focus on the needs of pregnant and new mothers. Serving both men and women, CMS Dearborn Heights offers comprehensive addiction treatment within a supportive outpatient environment.

CMS Sterling Heights
Sterling Heights, MI

Situated in Sterling Heights, MI, CMS Sterling Heights stands out as a premier rehabilitation center dedicated to addressing substance use issues among adults and young adults. This center provides a range of outpatient services, featuring treatments such as methadone/buprenorphine or naltrexone therapies. Utilizing evidence-based methods like cognitive behavioral therapy, motivational interviewing, and contingency management, CMS Sterling Heights tailors its care to meet the unique needs of each individual. The center also has specialized programs for pregnant and postpartum women. Committed to delivering high-quality and gender-specific treatment for both men and women, this facility is focused on empowering individuals in their recovery journey.

Clinica Ambulatoria Orocovis

Situated in Orocovis, PR, Clinica Ambulatoria Orocovis delivers extensive outpatient rehabilitation options for those facing challenges related to substance abuse and concurrent mental health issues. This center focuses on outpatient treatments using methadone, buprenorphine, or naltrexone, and integrates techniques like anger management, brief interventions, and cognitive behavioral therapy to facilitate healing. The facility has specialized programs designed for adolescents, adult males, and adult females, addressing a wide variety of needs. By offering care to both adults and younger individuals, Clinica Ambulatoria Orocovis ensures that each patient receives customized treatment plans aimed at their specific circumstances, fostering a nurturing and effective journey towards sustained recovery.

Clinical Del Alma

Clinical Del Alma in Tucson, Arizona, provides comprehensive outpatient substance use disorder services tailored for adults managing co-occurring serious mental health conditions. Their evidence-based curriculum incorporates vital components such as anger management, brief intervention strategies, and cognitive behavioral therapy. This esteemed institution offers tailored support for active duty military members, adolescents, and adult males. Services extend to adult and senior individuals across all genders. Clinical Del Alma is committed to delivering superior treatment outcomes, empowering individuals to successfully navigate the complexities of addiction and mental health issues. Through a diverse array of specialized offerings and scientifically validated methodologies, the center champions individuals in their pursuit of lasting recovery.

Clinic 5 LLC
Columbus, OH

Clinic 5 LLC, located in Columbus, OH, provides extensive addiction recovery care within a welcoming and expert setting. This center delivers detox and drug/alcohol use disorder treatment through its outpatient, day treatment, and partial hospitalization programs. Clinic 5 LLC employs proven methods such as 12-step encouragement, quick intervention strategies, and cognitive behavioral techniques to customize recovery paths for each person. Featuring dedicated services for active military personnel, young people, and adult men, Clinic 5 LLC assists adults and older adults of any gender. Patients will receive excellent care and individualized assistance as they work toward sobriety at this location.

Clinica Monsenor Oscar A Romero

Clinica Monsenor Oscar A Romero, located in Los Angeles, CA, stands as a complete rehabilitation resource. They focus on providing expert care for individuals, both young and adult, grappling with addiction and concurrent mental health challenges. Their offerings include robust outpatient services, methadone and buprenorphine treatment, and proven therapeutic methods such as 12-step facilitation and anger management. The clinic demonstrates a commitment to inclusivity with targeted programs for active military personnel, teenagers, and adult men. Serving both genders and age groups, Clinica Monsenor Oscar A Romero emphasizes a person-centered recovery journey marked by tailored plans and excellent support.

Clinical Consultants LLC

Clinical Consultants LLC, located in West Jordan, UT, specializes in providing treatment for adults dealing with substance use issues alongside severe mental health conditions, as well as addressing emotional challenges in children. Their programs, which include both outpatient and intensive outpatient options, are grounded in evidence-based practices such as 12-step facilitation, anger management techniques, and brief intervention strategies. The center primarily focuses on supporting adult men and women, particularly those who have faced intimate partner violence, ensuring that care is customized for individual recovery needs. Supporting a diverse clientele of all genders, Clinical Consultants LLC is dedicated to offering a comprehensive and empathetic rehabilitation experience aimed at fostering enduring wellness and recovery for those who seek help.

Clinica Ambulatoria CIMA Caguas

Clinica Ambulatoria CIMA Caguas, located in Caguas, PR, delivers outpatient substance abuse services for individuals of all ages experiencing co-occurring mental health challenges. Their expertise includes anger management, brief intervention strategies, and cognitive behavioral therapy, ensuring personalized treatment plans. The center caters to diverse groups through specialized programs for adolescents, adult males, and females, fostering a nurturing atmosphere. They offer both regular outpatient services and medication-assisted treatment options such as methadone, buprenorphine, and naltrexone. Clinica Ambulatoria CIMA Caguas is committed to providing high-quality, effective rehabilitation for both substance use and mental health concerns.

Clinical and Support Options Inc

Situated in Springfield, MA, Clinical and Support Options Inc delivers extensive outpatient services aimed at those needing detox and treatment for substance abuse. This center is adept at addressing co-occurring disorders, providing services such as outpatient detox, methadone and buprenorphine treatments, along with therapeutic interventions including anger management and cognitive-behavioral therapy. Customized programs cater to both adult men and women, including those who have faced intimate partner violence. Catering to adults and seniors, the facility includes gender-specific treatment to enhance personalized care. With a commitment to quality and tailored assistance, Clinical and Support Options Inc strives to empower clients toward sustainable recovery.

CMCSB Russell Co
Lebanon, VA

CMCSB Russell Co, situated in Lebanon, VA, delivers a wide range of outpatient services for individuals grappling with substance use issues and co-occurring mental health conditions, covering both adults and children. This center focuses on tailored therapeutic approaches, serving individuals from diverse backgrounds. By implementing well-established treatment methods like cognitive behavioral therapy, the Matrix Model, and motivational interviewing, CMCSB Russell Co fosters a nurturing atmosphere conducive to healing. The facility offers various outpatient options, including methadone/buprenorphine or naltrexone therapies, in addition to standard outpatient care, ensuring that each person receives high-quality, customized treatment plans to address their unique challenges with addiction and mental health.

Clinical Outcomes Group Inc

Clinical Outcomes Group Inc, situated in Pottsville, PA, delivers extensive treatment for adults facing substance use issues alongside severe mental health disorders, as well as for children dealing with emotional challenges. The facility offers various treatment modalities, including intensive outpatient programs, outpatient services, and options for methadone, buprenorphine, or naltrexone therapy. Tailored programs are available for active duty military personnel, adolescents, and adult men, addressing a wide range of needs. By employing techniques such as 12-step support, anger management, and brief intervention, the center focuses on personalized treatment plans. Catering to both men and women, as well as children and teenagers, Clinical Outcomes Group Inc emphasizes high-quality care and effective rehabilitation methods.

Clinton Cnty Community Services Board

Clinton Cnty Community Services Board in Plattsburgh, NY, delivers extensive support for individuals, both young and adult, grappling with substance use and co-occurring mental health issues. Their outpatient services encompass medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside therapeutic approaches like cognitive behavioral therapy, anger management, and brief intervention strategies. Prioritizing high-quality care, the center accommodates adult men, women, and those with dual diagnoses. Catering to a broad age range including seniors, Clinton Cnty Community Services Board is distinguished by its personalized recovery plans designed to meet the specific requirements of each person facing addiction and mental health concerns.

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Situated in Malibu, CA, Cliffside Malibu 3 delivers extensive addiction treatment options for both adults and young adults. This facility specializes in inpatient detox services and addresses issues related to substance use disorders, including accompanying mental health challenges. The treatment program incorporates proven methods such as 12-step support, anger management, and brief interventions. Catering to both men and women, as well as those who have encountered intimate partner or domestic abuse, Cliffside Malibu 3 emphasizes high-quality care and personalized treatment strategies aimed at fostering long-term recovery.

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Clinical and Support Options Inc., located in Athol, MA, provides outpatient care for adults struggling with substance use disorders and co-occurring severe mental health challenges. They also serve children and adolescents experiencing serious emotional disturbances. The facility employs scientifically validated treatment methods including anger management, cognitive behavioral therapy, and motivational interviewing. Their approach emphasizes personalized attention, accommodating adults and young people across all genders. Clinical and Support Options Inc. demonstrates its dedication to high-quality services through custom-designed treatment paths and specific therapeutic offerings. Individuals searching for a nurturing and successful recovery setting will discover a full spectrum of assistance at this location.

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Clinical Consultants LLC, located in Ogden, UT, delivers targeted care for adults struggling with addiction and co-occurring severe mental health conditions, as well as for children facing emotional difficulties. Their services encompass intensive outpatient, standard outpatient, and medication-assisted treatment using methadone, buprenorphine, or naltrexone. The center emphasizes evidence-based practices such as 12-step facilitation, anger management, and brief intervention strategies. Serving a diverse clientele including adult men and women, older adults, and survivors of domestic abuse, Clinical Consultants LLC provides personalized treatment plans designed for optimal recovery in a nurturing setting.

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Clinical Consultants LLC, located in Tooele, UT, specializes in providing targeted treatment for substance use disorders and co-occurring mental health conditions for both adults and children. The center offers a range of services including intensive outpatient programs, outpatient services, and medication-assisted treatments with methadone, buprenorphine, or naltrexone. Emphasizing methods such as 12-step support, anger management techniques, and brief intervention strategies, it serves both adult men and women, as well as individuals who have faced intimate partner violence. Catering to adults and seniors of diverse backgrounds, Clinical Consultants LLC is dedicated to delivering personalized care, making it an essential option for those in need of all-encompassing rehabilitation services in the Tooele region.

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Cedar Bluff, VA

Situated in Cedar Bluff, VA, CMCSB delivers extensive outpatient treatment for substance use issues among both adults and young adults. The center excels in addressing co-occurring substance use disorders alongside significant mental health challenges or emotional difficulties, offering customized care through proven methodologies like cognitive behavioral therapy and motivational interviewing. Programs are designed to meet the distinct requirements of each individual, including options for outpatient treatment with methadone, buprenorphine, or naltrexone. CMCSB is committed to providing high-quality support for all clients, regardless of gender. If you are looking for effective, tailored treatment in a nurturing setting, this center is focused on guiding you toward sustainable recovery.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated May 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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