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Medically Reviewed Content
Updated: October 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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CleanSlate Centers

CleanSlate Centers in Altoona, PA, provides outpatient services for individuals struggling with addiction. Their treatment options include medication-assisted treatment with methadone, buprenorphine, or naltrexone. They employ evidence-based therapies such as motivational interviewing, relapse prevention strategies, and counseling for substance use disorders. The center is dedicated to offering personalized care for adult men and women, fostering a recovery journey built on individual needs and quality support within a welcoming atmosphere.

CleanSlate Centers

CleanSlate Centers in Warsaw, IN, specializes in outpatient care for addiction, prioritizing personalized support. They offer medication-assisted treatment with methadone, buprenorphine, or naltrexone for adults and young adults, regardless of gender. Their program incorporates techniques like motivational interviewing, relapse prevention, and counseling to foster successful recovery. CleanSlate Centers is committed to providing excellent care adapted to the specific requirements of each person overcoming substance use challenges.

CleanSlate Medical Group of Kentucky

CleanSlate Medical Group of Kentucky, located in Bowling Green, provides outpatient treatment services for substance use disorders, featuring methadone/buprenorphine or naltrexone therapies. The center employs techniques such as motivational interviewing, relapse prevention, and personalized counseling for individuals facing addiction. Its approach is designed to cater to both adults and young adults, regardless of gender, ensuring a individualized care plan. CleanSlate Medical Group of Kentucky is recognized for its dedication to assisting individuals in conquering addiction in a safe and nurturing environment. Whether individuals are looking for help for themselves or someone they care about, this facility is committed to supporting their recovery journey.

Clear Conscience Counseling LLC

Clear Conscience Counseling LLC, located in South Plainfield, NJ, offers comprehensive treatment for substance use disorders along with mental health services for both adults and children. The center features intensive outpatient programs, such as methadone and buprenorphine treatments, and employs a variety of therapeutic methods including 12-step support, anger management, and short-term interventions. With programs specifically designed for active duty military members, as well as tailored options for adult men and women, this facility meets the varied needs of its clientele. Clear Conscience Counseling LLC is committed to delivering high-quality care and utilizing evidence-based practices to assist individuals on their recovery journeys.

Clear Detox Center
Costa Mesa, CA

Nestled in Costa Mesa, CA, Clear Detox Center delivers thorough detox and addiction recovery services for individuals and adolescents. This institution features hospital-based inpatient detox, treatment, and round-the-clock hospital inpatient support. Emphasizing personalized attention, the center employs strategies including 12-step facilitation, anger management, and brief intervention. Clear Detox Center distinguishes itself through its customized treatment blueprints designed to meet each individual's specific requirements. The center accommodates both male and female patients, fostering a welcoming and inclusive atmosphere for everyone pursuing excellent addiction treatment.

Clear Recovery of Cache Valley

Clear Recovery of Cache Valley, located in Providence, UT, offers comprehensive outpatient care for individuals struggling with substance abuse and concurrent mental health issues in both adults and children. The facility provides various programs, including outpatient services and partial hospitalization, and is particularly focused on anger management, cognitive behavioral therapy, and motivational incentives. They have tailored initiatives for those who have faced issues related to intimate partner or domestic violence. Clear Recovery is dedicated to serving individuals of all gender identities and emphasizes high-quality, evidence-based practices to aid clients in their recovery process.

Clear Shores Inc
Hollywood, FL

Clear Shores Inc, located in Hollywood, FL, is dedicated to providing extensive support for individuals battling substance use disorders and offering transitional living accommodations. They are particularly adept at addressing complex cases involving co-occurring substance use and significant mental health challenges in adults, as well as emotional difficulties in children. The center's treatment offerings include intensive outpatient, standard outpatient, and partial hospitalization programs. Their therapeutic approach emphasizes 12-step facilitation, anger management techniques, and brief intervention strategies. Clear Shores Inc welcomes active duty military personnel, adult men, and women, and also provides services for young adults of any gender, all committed to delivering high-quality care and fostering recovery.

Clearbrook Treatment Center MA LLC

Clearbrook Treatment Center MA LLC, located in Baldwinville, MA, provides extensive care for adults and young adults struggling with addiction. They offer various levels of care, including extended residential stays, outpatient services, and inpatient detox, all customized to each person's specific requirements. Utilizing methodologies such as 12-step program support, techniques for managing anger, and brief intervention strategies, Clearbrook prioritizes creating a unique treatment path for everyone. The facility is particularly adept at addressing dual diagnoses of substance abuse and mental health conditions, guaranteeing high-standard treatment through its distinct focus on personalized plans. Catering to both men and women, Clearbrook Treatment Center MA LLC is committed to guiding individuals toward sustained sobriety.

Clearfield Comp Treatment Ctr

Clearfield Comp Treatment Ctr, situated in Clearfield, PA, delivers tailored programs for individuals and adolescents struggling with substance use disorders. The center provides intensive outpatient care, general outpatient services, and medication-assisted treatment options including methadone, buprenorphine, or naltrexone. Employing strategies like 12-step facilitation, anger management, and brief interventions, they serve adult men and women, including those affected by intimate partner or domestic violence. Clearfield Comp Treatment Ctr is dedicated to offering personalized support for all clients, male and female, establishing itself as a thorough resource for addiction recovery in the region.

ClearVision Health and Wellness LLC

ClearVision Health and Wellness LLC, located in Hazleton, PA, provides a wide range of detox and substance use treatment options. The center features hospital-based inpatient detox services, round-the-clock care, and residential detox programs. It employs a diverse array of methods, such as 12-step programs, anger management strategies, and short intervention techniques. Additionally, there are specialized offerings for active duty military members, as well as tailored programs for adult men and women. With a commitment to serving adults and seniors of all backgrounds, ClearVision Health and Wellness LLC prioritizes personalized, high-quality treatment. This facility represents a supportive refuge for those on their journey toward overcoming addiction.

CleanSlate Centers
Alexandria, IN

CleanSlate Centers in Alexandria, IN, provides accessible outpatient care for adults and young adults grappling with substance use disorders. Their approach centers on personalized treatment plans, incorporating medication-assisted treatment options like methadone, buprenorphine, or naltrexone. Evidence-based therapeutic techniques, including motivational interviewing, relapse prevention strategies, and individual counseling, are employed to foster lasting recovery. This facility is committed to offering a supportive and gender-inclusive space for all individuals embarking on their path to sobriety and a healthier future.

Cleanse Clinic
Lexington, KY

The Cleanse Clinic located in Lexington, KY, provides both intensive outpatient and outpatient treatment options for individuals dealing with substance use and concurrent mental health conditions, catering to both adults and children. The clinic emphasizes personalized care through methods like cognitive behavioral therapy and motivational incentives. With a specialization in customized treatment strategies, Cleanse Clinic serves adults and young adults of all gender identities. Committed to delivering high-quality care, the center offers outpatient solutions involving methadone, buprenorphine, or naltrexone treatments. Whether individuals need short-term intervention or a more detailed program, this facility is dedicated to offering customized support for their recovery paths.

CleanSlate Centers
Owensboro, KY

CleanSlate Centers in Owensboro, KY, delivers outpatient care for substance use disorders, prioritizing personalized approaches. They offer outpatient medication-assisted treatment (methadone, buprenorphine, or naltrexone) for adults and young adults, serving all genders. Through techniques like motivational interviewing, relapse prevention planning, and counseling, this location customizes services to fit individual client requirements. Dedicated to high-quality support, CleanSlate Centers strives to assist individuals in their recovery process with thorough and empathetic addiction treatment.

Clear Skye Treatment Center

Clear Skye Treatment Center, situated in Gaffney, SC, specializes in outpatient addiction recovery services, emphasizing strategies for preventing relapse and providing counseling for substance use disorders. They cater to specific groups, including active military personnel, adult men, and adult women. This facility provides care for adults and young adults of all genders, offering medication-assisted treatment options like methadone, buprenorphine, or naltrexone, as well as general outpatient care and remote therapy services through telemedicine. Clear Skye Treatment Center is dedicated to offering effective and supportive care for those striving to conquer addiction, ensuring a broad spectrum of services to address various recovery requirements.

CleanSlate Centers
Lafayette, IN

CleanSlate Centers in Lafayette, IN, provides outpatient care for individuals battling substance use. Their program includes medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside specialized therapies like motivational interviewing, relapse prevention strategies, and counseling for substance use disorders. This facility offers a customized treatment experience for adults and young adults, ensuring that each person receives the attention needed to address their addiction. CleanSlate Centers in Lafayette, IN, is committed to aiding recovery through personalized, evidence-based support.

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Rochester, PA

Situated in Rochester, PA, Clear Choices delivers an extensive array of addiction recovery services aimed at both adults and young adults. The facility offers detox and substance use treatment options, including intensive outpatient, outpatient, and outpatient detox programs. Utilizing proven methods like cognitive behavioral therapy, motivational interviewing, and strategies for preventing relapse, Clear Choices assists individuals in their recovery process. What distinguishes this center is its customized treatment plans designed to cater to the specific needs of every client. Committed to providing exceptional care, Clear Choices is open to both men and women in need of effective and tailored addiction recovery support.

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Clear Day Treatment of Westmoreland, situated in Greensburg, PA, provides comprehensive long-term residential and detoxification services for adults and young adults addressing substance use and co-occurring mental health challenges. Employing proven methods such as cognitive behavioral therapy and 12-step facilitation, the center offers targeted support for those who have experienced intimate partner violence. Distinct programs designed for adult men and women foster a secure and encouraging atmosphere. Committed to delivering excellent care and personalized treatment strategies, this establishment aims to guide clients toward sustained sobriety and improved mental well-being.

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Clear Minds Behavioral Health in Baton Rouge, LA, provides distinct programs for adults facing dual diagnoses of substance use disorders and severe mental health conditions, alongside services for children with significant emotional challenges. Their treatment options encompass intensive outpatient care, day treatment, and partial hospitalization, integrating methodologies like 12-step facilitation, anger management techniques, and brief intervention strategies. The center caters to a diverse clientele, including adolescents, adult men, and women, as well as senior adults of all genders. Clear Minds Behavioral Health is dedicated to delivering high-quality, individualized support for those pursuing thorough recovery within a supportive setting.

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Canoga Park, CA

Clear View Canyon Inc, located in Canoga Park, CA, delivers complete addiction recovery services for adults and adolescents struggling with dependency and co-occurring psychological conditions. The center features hospital-based inpatient detoxification and treatment, offering specialized assistance for active military personnel, adult men, and women. Employing proven methods such as cognitive behavioral therapy and 12-step facilitation, Clear View Canyon Inc guarantees excellent care adapted to individual requirements. Whether in need of detox, addiction treatment, or dual diagnosis care, individuals will find customized support in a nurturing setting. This center caters to both male and female individuals, representing a crucial avenue for those pursuing sobriety.

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Prairie City, IA

Clearview Recovery Inc, located in Prairie City, IA, specializes in holistic treatment for substance use disorders and offers targeted support for individuals facing concurrent mental health challenges. The center features various treatment options such as intensive outpatient services, long-term residential care, and traditional outpatient programs. Emphasizing 12-step approaches, anger management techniques, and brief therapeutic interventions, Clearview Recovery Inc customizes its programs to suit the unique needs of each individual. Additionally, it provides specialized services for adult women and those who have experienced intimate partner violence, domestic abuse, or sexual trauma. As a women-only facility, it provides a nurturing and secure space for adults and older individuals in their recovery journey.

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Clearview Recovery Inc, located in Newton, IA, provides extensive care for individuals struggling with addiction and offers transitional housing specifically for adult women. The center excels in addressing dual diagnoses involving substance abuse and significant mental health conditions in adults, alongside severe emotional issues in children. Emphasizing both long-term residential stays and outpatient services, Clearview Recovery Inc features tailored programs for those impacted by domestic violence, intimate partner abuse, and sexual trauma. Their treatment methodologies incorporate 12-step support, techniques for managing anger, and brief intervention techniques. Clearview Recovery Inc is dedicated to delivering individualized and successful treatment for older adults and other adults who prefer a women-only setting.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated October 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)