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Updated: May 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,711 treatment centers offering naltrexone (vivitrol) across the United States.

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Colorado West Regional Mental Hlth Ctr

Colorado West Regional Mental Health Center in Rangely, CO, provides extensive support for individuals of all ages battling substance misuse, particularly when accompanied by significant mental health challenges. Utilizing evidence-based approaches such as cognitive behavioral therapy, the Matrix Model, and motivational interviewing, the center delivers various levels of care, including intensive outpatient, outpatient, and standard outpatient programs. Targeted services are available for adolescents, adult men, and adult women, alongside specialized support for seniors. The center is dedicated to offering personalized and excellent care, fostering lasting recovery and overall wellness for every client.

Colorado West Regional Mental Hlth Ctr

Colorado West Regional Mental Health Center in Steamboat Springs, CO, delivers a complete spectrum of care for mental well-being and substance dependencies. The facility specializes in treating addiction and dual diagnosis conditions in younger and older individuals via structured intensive outpatient, outpatient, and standard outpatient therapeutic formats. Employing proven methodologies such as cognitive behavioral therapy, the Matrix Model, and motivational interviewing, the center serves teenagers, adult men, and women. Dedicated to assisting adults and older adults across all gender identities, this establishment guarantees tailored assistance and encouragement for individuals pursuing healing and improved mental health.

Colorado West Regional Mental Hlth Ctr

The Granby, Colorado facility, Colorado West Regional Mental Health Center, provides thorough support for individuals struggling with substance abuse and those managing dual diagnoses of addiction and severe mental health challenges. Their treatment options include intensive outpatient, standard outpatient, and flexible outpatient services, all rooted in proven methods like cognitive behavioral therapy, the Matrix Model, and motivational interviewing. Tailored services are available for young people, adult men, and women, while welcoming adults and seniors of any gender. Committed to fostering lasting recovery and mental well-being, this center prioritizes delivering exceptional care within a nurturing atmosphere.

Colton Comprehensive Treatment Center

Colton Comprehensive Treatment Center, situated in Colton, CA, delivers comprehensive outpatient care focused on overcoming addiction. Their services include outpatient detox and medication-assisted treatment utilizing methadone, buprenorphine, or naltrexone. Employing evidence-based therapies such as 12-step facilitation, anger management, and brief intervention, the center supports adults, seniors, and young adults. Specialized programs are offered for active duty military personnel, adult men, and adult women. Serving a diverse clientele, Colton Comprehensive Treatment Center is dedicated to personalized recovery pathways and high-quality support for individuals battling substance use disorders.

Columbia River Mental Health Services

Columbia River Mental Health Services, located in Vancouver, WA, delivers a wide array of treatment options for individuals struggling with addiction and related mental health challenges. Their services include intensive outpatient programs, general outpatient care, and specific medication-assisted treatment programs utilizing methadone, buprenorphine, or naltrexone. Employing proven therapeutic methods like brief intervention, cognitive behavioral therapy, and the Matrix Model, the center provides personalized care to adult men and women, along with young adults experiencing co-occurring conditions. Prioritizing high-quality and customized support, Columbia River Mental Health Services is dedicated to meeting the distinct requirements of every person they serve.

Columbia Saint Marys Hospital

Columbia Saint Marys Hospital in Mequon, WI, delivers extensive addiction recovery programs for adults and young adults. Their services include hospital-based inpatient detox, round-the-clock inpatient hospital care, and structured intensive outpatient therapy. Employing approaches like 12-step facilitation, brief intervention, and cognitive behavioral therapy, they support individuals managing co-occurring mental health and substance use issues, including trauma survivors. Columbia Saint Marys Hospital provides distinct programs for men and women, delivering excellent care to those pursuing healing from addiction and mental health concerns.

Columbus Public Health

Columbus, OH is home to Columbus Public Health, a facility delivering thorough programs for substance use recovery. They provide specialized care including intensive outpatient, standard outpatient, and medication-assisted treatment options like methadone, buprenorphine, or naltrexone. Their expertise lies in areas such as anger management, brief intervention strategies, and cognitive behavioral therapy. Columbus Public Health uniquely supports adult men, adult women, and individuals affected by intimate partner or domestic violence. With a commitment to personalized, evidence-based approaches, they serve adults and young adults of all genders, guiding them toward lasting recovery.

Columbus Springs Dublin

Columbus Springs Dublin, situated in Dublin, OH, delivers thorough addiction rehabilitation for adults and young adults. This establishment provides inpatient hospital detoxification and care for substance use disorders, alongside co-occurring mental health challenges. Their treatment methods encompass 12-step facilitation, anger management, and brief intervention strategies. Columbus Springs Dublin excels in attending to individuals with concurrent mental health and substance use disorders, offering customized treatment plans. Recognizing distinct needs, they operate separate programs for male and female patients, prioritizing effective, evidence-backed therapies for enduring recovery.

Columbus Springs East

Situated in Columbus, OH, Columbus Springs East delivers extensive rehabilitation programs for adults and young adults facing challenges with substance abuse and related mental health issues. This center features inpatient detox services, ongoing treatment, and round-the-clock care, employing methods such as 12-step guidance and anger management techniques. Focused on those with dual diagnoses, the facility provides customized programs for both men and women. Committed to high-quality care and evidence-supported strategies like brief intervention, Columbus Springs East is devoted to aiding individuals in their recovery process.

CommonHealth Recovery

CommonHealth Recovery, located in Frankfort, KY, provides extensive treatment for substance use disorders and dedicated services for those facing co-occurring mental health and substance use challenges. The facility features intensive outpatient programs, standard outpatient care, and medication-assisted treatment options including methadone, buprenorphine, or naltrexone. Their approach emphasizes anger management, brief intervention strategies, and cognitive behavioral therapy, serving adult men and women, as well as survivors of intimate partner violence. CommonHealth Recovery offers personalized, high-standard care for adults and young adults of any gender, promoting lasting recovery and overall wellness.

Columbus Regional Health

Columbus Regional Health in Columbus, IN, delivers complete addiction recovery programs designed for individuals of all ages. Their offerings include intensive outpatient therapy, outpatient detox, and general outpatient care, all employing proven methods like 12-step integration, cognitive behavioral therapy, and the Matrix Model. They have particular expertise in assisting individuals with dual diagnoses (mental health and substance use issues) and those involved with the legal system. Prioritizing personalized support, Columbus Regional Health provides distinct treatment paths for men and women. This institution is dedicated to delivering excellent care and assistance to everyone on their journey to sobriety.

Columbia Saint Marys Hospital

Nestled in Milwaukee, WI, Columbia Saint Marys Hospital provides extensive addiction recovery services for adults and adolescents. This facility excels in addressing dual diagnoses, integrating treatment for substance dependence with significant mental health conditions or emotional challenges. Offering a variety of care settings, including intensive outpatient, outpatient, and standard outpatient options, the center delivers personalized support adapted to each individual's unique requirements. Their therapeutic interventions utilize proven methods like anger management, brief counseling, and cognitive behavioral therapy. Additionally, Columbia Saint Marys Hospital features targeted programs designed for adult men, adult women, and survivors of intimate partner or domestic abuse. Emphasizing high-quality care and a nurturing atmosphere, the hospital is committed to guiding people toward lasting wellness.

Columbia Wellness
Longview, WA

Columbia Wellness, situated in Longview, WA, delivers extensive recovery support for adults and young adults facing addiction and co-occurring mental health conditions. The facility features intensive outpatient programs, standard outpatient services, and targeted treatments for detox and medication-assisted recovery. Employing proven therapeutic methods such as cognitive behavioral therapy and motivational interviewing, the center prioritizes personalized treatment plans and strategies to prevent relapse. Columbia Wellness offers dedicated care to individuals of all genders pursuing healing from substance abuse and mental health issues.

Commitment House LLC
Elizabethtown, KY

Commitment House LLC, located in Elizabethtown, KY, delivers expert care for adult women facing addiction and concurrent serious mental health challenges. The program features intensive outpatient, outpatient, and day treatment modalities, employing proven methods such as 12-step facilitation, brief intervention, and cognitive behavioral therapy. Designed specifically for adult women of all ages, including older adults, seniors, and younger adults, the center is dedicated to high-quality, individualized recovery plans, making it a prime option for those pursuing thorough and personalized rehabilitation.

Commonwealth Counseling Centers

At Commonwealth Counseling Centers in Prestonsburg, KY, we provide a full spectrum of care for adults and young adults struggling with addiction. Our expertise extends to treating co-occurring substance use disorders and severe mental health conditions in adults, alongside emotional challenges in children. We offer robust intensive outpatient and standard outpatient services, incorporating medications like methadone, buprenorphine, and naltrexone. Our therapeutic framework includes 12-step facilitation, anger management, and brief intervention strategies. We proudly serve active duty military, adult men, and women, ensuring that both genders receive tailored, high-quality support for addiction and dual diagnoses.

Columbiana County MH Center

Situated in Salem, OH, the Columbiana County MH Center provides targeted substance abuse treatment for adults facing concurrent mental health issues. This center offers a range of services including intensive outpatient programs, methadone/buprenorphine treatment, and different therapeutic modalities like cognitive behavioral therapy and anger management strategies. There are also specialized programs designed for individuals in the criminal justice system and those dealing with dual diagnoses. Committed to delivering high-quality care, the facility caters to adults and seniors of all gender identities who are in need of extensive rehabilitation support to tackle both substance use and mental health concerns.

Columbiana County MH Center
East Liverpool, OH

Located in East Liverpool, OH, the Columbiana County MH Center delivers targeted care for individuals grappling with substance use and concurrent mental health issues, catering to both adults and children. The center's diverse range of programs encompasses intensive outpatient services, outpatient support, and treatment options involving methadone, buprenorphine, or naltrexone. Utilizing proven techniques such as anger management, cognitive behavioral therapy, and community reinforcement alongside vouchers, the facility aims to offer personalized treatment plans. With a strong emphasis on individuals with co-occurring disorders and those involved with the justice system, the Columbiana County MH Center is dedicated to supporting adults and seniors of all backgrounds with understanding and professionalism.

COMCARE of Sedgwick County

COMCARE of Sedgwick County in Wichita, KS, is a facility dedicated to aiding individuals facing challenges with addiction and accompanying mental health issues. They offer structured outpatient programs, general outpatient services, and medication-supported therapies including methadone, buprenorphine, or naltrexone. The center employs proven therapeutic methods, such as cognitive behavioral therapy and contingency management, to assist patients in their journey toward wellness. COMCARE delivers thorough support for adults and young adults, with distinct programs designed for adult men, adult women, and those with dual diagnoses. Discover effective and individualized support at this premier recovery establishment.

Comm Mental Health Consultants Inc

Comm Mental Health Consultants Inc, located in Harrisonville, MO, provides a wide range of rehabilitation services aimed at adults and seniors facing challenges related to substance abuse and concurrent mental health disorders. The center offers various levels of care including intensive outpatient programs, day treatment options, and partial hospitalization, all grounded in research-backed methods such as cognitive behavioral therapy and anger management techniques. Tailored programs are available for adolescents, as well as adult men and women, focusing on the unique needs of each demographic. Committed to delivering high-quality, personalized care, this center strives to support clients in their journey toward sustainable recovery and improved mental health.

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Situated in Lisbon, OH, Columbiana County MH Center delivers extensive treatment for substance use and offers specialized services for individuals facing concurrent mental health issues. The center features both intensive outpatient and outpatient programs, including treatment alternatives such as methadone/buprenorphine and naltrexone. Prioritizing evidence-based methods, the facility employs cognitive behavioral therapy as well as community reinforcement strategies with vouchers, accommodating adults and seniors of various genders. There are also dedicated programs for those dealing with co-occurring disorders and those who are part of the criminal justice system. Columbiana County MH Center is recognized for its exceptional care and personalized treatment strategies aimed at helping individuals in their recovery journey.

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Comm Mental Health Consultants Inc in Nevada, MO is dedicated to providing extensive, research-supported therapies for those struggling with addiction and concurrent mental health challenges. Their programs include intensive outpatient, day treatment, and partial hospitalization options, all customized for adults and young individuals. Employing methods like cognitive behavioral therapy and anger management, the center also features specific services for military personnel, teenagers, and adult men. This establishment serves individuals of all ages, including seniors, and all genders, ensuring high-quality support throughout the recovery process.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated May 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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