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Medically Reviewed Content
Updated: October 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Columbus Public Health

Columbus, OH is home to Columbus Public Health, a facility delivering thorough programs for substance use recovery. They provide specialized care including intensive outpatient, standard outpatient, and medication-assisted treatment options like methadone, buprenorphine, or naltrexone. Their expertise lies in areas such as anger management, brief intervention strategies, and cognitive behavioral therapy. Columbus Public Health uniquely supports adult men, adult women, and individuals affected by intimate partner or domestic violence. With a commitment to personalized, evidence-based approaches, they serve adults and young adults of all genders, guiding them toward lasting recovery.

Columbus Springs Dublin

Columbus Springs Dublin, situated in Dublin, OH, delivers thorough addiction rehabilitation for adults and young adults. This establishment provides inpatient hospital detoxification and care for substance use disorders, alongside co-occurring mental health challenges. Their treatment methods encompass 12-step facilitation, anger management, and brief intervention strategies. Columbus Springs Dublin excels in attending to individuals with concurrent mental health and substance use disorders, offering customized treatment plans. Recognizing distinct needs, they operate separate programs for male and female patients, prioritizing effective, evidence-backed therapies for enduring recovery.

Columbus Springs East

Situated in Columbus, OH, Columbus Springs East delivers extensive rehabilitation programs for adults and young adults facing challenges with substance abuse and related mental health issues. This center features inpatient detox services, ongoing treatment, and round-the-clock care, employing methods such as 12-step guidance and anger management techniques. Focused on those with dual diagnoses, the facility provides customized programs for both men and women. Committed to high-quality care and evidence-supported strategies like brief intervention, Columbus Springs East is devoted to aiding individuals in their recovery process.

CommonHealth Recovery

CommonHealth Recovery, located in Frankfort, KY, provides extensive treatment for substance use disorders and dedicated services for those facing co-occurring mental health and substance use challenges. The facility features intensive outpatient programs, standard outpatient care, and medication-assisted treatment options including methadone, buprenorphine, or naltrexone. Their approach emphasizes anger management, brief intervention strategies, and cognitive behavioral therapy, serving adult men and women, as well as survivors of intimate partner violence. CommonHealth Recovery offers personalized, high-standard care for adults and young adults of any gender, promoting lasting recovery and overall wellness.

ComWell
Chester, IL

Situated in Chester, IL, ComWell delivers an extensive array of rehabilitation services. This center focuses on treating substance use disorders and serves adults facing serious mental health challenges or children dealing with significant emotional issues. Available treatment modalities include intensive outpatient programs, standard outpatient care, and options for methadone or buprenorphine/naltrexone outpatient therapy. ComWell utilizes various methods such as 12-step facilitation, anger management, and short-term interventions. Their specialized programs are designed for trauma survivors and those experiencing both mental health and substance use challenges. ComWell is committed to providing personalized care for individuals of all ages and genders, facilitating their journey toward recovery.

ComWell
Red Bud, IL

Situated in Red Bud, IL, ComWell provides extensive outpatient rehabilitation services for both adults and younger individuals facing substance abuse and concurrent mental health challenges. The center features targeted programs for current military members, those who have experienced trauma, and patients with dual diagnoses. Various treatment methods are employed, including 12-step support, anger management strategies, and brief interventions. ComWell emphasizes high-quality care by customizing treatment plans to fit the specific requirements of each client. The center also offers outpatient options for methadone/buprenorphine and naltrexone treatments along with standard outpatient services designed for both men and women.

ComWell
Okawville, IL

Situated in Okawville, IL, ComWell stands out as a prominent rehabilitation facility. It specializes in outpatient treatment for adults struggling with substance use issues and also addresses the needs of both adults and children facing concurrent substance use and serious mental health challenges. The center has dedicated programs for individuals who have undergone trauma, those with dual diagnoses, and clients entangled in the criminal justice system. ComWell offers outpatient options such as methadone/buprenorphine and naltrexone therapy, alongside general outpatient services. Treatment methods include 12-step programs, anger management strategies, and brief intervention techniques. With customized programs catering to different genders and age groups, ComWell is committed to delivering exceptional and holistic care to aid individuals in their recovery process.

ComWell
Sparta, IL

Situated in Sparta, IL, ComWell stands out as a premier rehabilitation center that provides outpatient services for individuals grappling with substance addiction and associated mental health challenges, catering to both adults and children. The center features targeted programs designed specifically for trauma survivors and those facing dual diagnoses. Treatment methods at ComWell include 12-step guidance, anger management techniques, and brief intervention strategies. Offering services designed for both men and women, the facility provides outpatient treatments that encompass methadone/buprenorphine or naltrexone options alongside standard outpatient care. ComWell is committed to delivering top-notch, all-encompassing care while supporting individuals on their recovery journeys.

Columbus Regional Health

Columbus Regional Health in Columbus, IN, delivers complete addiction recovery programs designed for individuals of all ages. Their offerings include intensive outpatient therapy, outpatient detox, and general outpatient care, all employing proven methods like 12-step integration, cognitive behavioral therapy, and the Matrix Model. They have particular expertise in assisting individuals with dual diagnoses (mental health and substance use issues) and those involved with the legal system. Prioritizing personalized support, Columbus Regional Health provides distinct treatment paths for men and women. This institution is dedicated to delivering excellent care and assistance to everyone on their journey to sobriety.

Commitment House LLC
Elizabethtown, KY

Commitment House LLC, located in Elizabethtown, KY, delivers expert care for adult women facing addiction and concurrent serious mental health challenges. The program features intensive outpatient, outpatient, and day treatment modalities, employing proven methods such as 12-step facilitation, brief intervention, and cognitive behavioral therapy. Designed specifically for adult women of all ages, including older adults, seniors, and younger adults, the center is dedicated to high-quality, individualized recovery plans, making it a prime option for those pursuing thorough and personalized rehabilitation.

Commonwealth Counseling Centers

At Commonwealth Counseling Centers in Prestonsburg, KY, we provide a full spectrum of care for adults and young adults struggling with addiction. Our expertise extends to treating co-occurring substance use disorders and severe mental health conditions in adults, alongside emotional challenges in children. We offer robust intensive outpatient and standard outpatient services, incorporating medications like methadone, buprenorphine, and naltrexone. Our therapeutic framework includes 12-step facilitation, anger management, and brief intervention strategies. We proudly serve active duty military, adult men, and women, ensuring that both genders receive tailored, high-quality support for addiction and dual diagnoses.

Comm Mental Health Consultants Inc

Comm Mental Health Consultants Inc, located in Harrisonville, MO, provides a wide range of rehabilitation services aimed at adults and seniors facing challenges related to substance abuse and concurrent mental health disorders. The center offers various levels of care including intensive outpatient programs, day treatment options, and partial hospitalization, all grounded in research-backed methods such as cognitive behavioral therapy and anger management techniques. Tailored programs are available for adolescents, as well as adult men and women, focusing on the unique needs of each demographic. Committed to delivering high-quality, personalized care, this center strives to support clients in their journey toward sustainable recovery and improved mental health.

CommQuest Services Inc

CommQuest Services Inc, located in Canton, OH, provides extensive addiction recovery programs for individuals of all ages. Their expertise encompasses withdrawal management, comprehensive substance abuse care, and dual diagnosis treatment. They offer structured intensive outpatient, standard outpatient, and outpatient detoxification options. Through therapeutic approaches such as anger management, cognitive behavioral techniques, and motivational interviewing, patients receive individualized support. The center is notably equipped to serve specific populations including those involved with the justice system, military households, and veterans. CommQuest Services Inc is dedicated to delivering effective, research-supported treatment for both addiction and co-occurring mental health conditions for all genders.

Communicare
Sardis, MS

Situated in Sardis, MS, Communicare is a fully-equipped rehabilitation facility that delivers targeted treatment options for substance abuse and concurrent mental health issues affecting both adults and children. The center offers a variety of services, including intensive outpatient programs, standard outpatient care, and treatments with methadone, buprenorphine, or naltrexone. Emphasizing techniques such as 12-step guidance, anger management, and short-term intervention strategies, Communicare addresses the needs of teenagers and individuals dealing with trauma, intimate partner abuse, and domestic violence. With a commitment to high-quality care, the center formulates personalized treatment strategies for adults and seniors across all gender identities to foster sustainable recovery.

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Situated in Lisbon, OH, Columbiana County MH Center delivers extensive treatment for substance use and offers specialized services for individuals facing concurrent mental health issues. The center features both intensive outpatient and outpatient programs, including treatment alternatives such as methadone/buprenorphine and naltrexone. Prioritizing evidence-based methods, the facility employs cognitive behavioral therapy as well as community reinforcement strategies with vouchers, accommodating adults and seniors of various genders. There are also dedicated programs for those dealing with co-occurring disorders and those who are part of the criminal justice system. Columbiana County MH Center is recognized for its exceptional care and personalized treatment strategies aimed at helping individuals in their recovery journey.

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Comm Mental Health Consultants Inc in Nevada, MO is dedicated to providing extensive, research-supported therapies for those struggling with addiction and concurrent mental health challenges. Their programs include intensive outpatient, day treatment, and partial hospitalization options, all customized for adults and young individuals. Employing methods like cognitive behavioral therapy and anger management, the center also features specific services for military personnel, teenagers, and adult men. This establishment serves individuals of all ages, including seniors, and all genders, ensuring high-quality support throughout the recovery process.

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Senatobia, MS

Situated in Senatobia, MS, Communicare specializes in outpatient care for adults facing substance misuse and co-occurring mental health issues, as well as for children experiencing significant emotional difficulties. The center offers a variety of services, including outpatient treatment options like methadone or buprenorphine and naltrexone therapies, 12-step programs, anger management, and short-term intervention strategies. With an emphasis on distinct groups such as teens, those who have encountered trauma or domestic violence, and individuals impacted by intimate partner violence, Communicare provides customized support for each person. Catering to adults and seniors of all genders, this establishment is dedicated to offering exceptional, personalized care aimed at fostering enduring recovery.

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Oxford, MS

Communicare, situated in Oxford, MS, is a multifaceted rehabilitation facility that specializes in addressing substance use issues along with accompanying mental health challenges in both adults and children. The center offers a variety of treatment options, such as intensive outpatient programs, standard outpatient services, and medication-assisted therapies like methadone, buprenorphine, and naltrexone. Employing research-backed methodologies, Communicare provides support through 12-step programs, anger management courses, and brief interventions. The center features distinctive programs aimed at adolescents, those affected by intimate partner or domestic violence, and individuals who have experienced trauma. With dedicated services designed for adults and seniors of diverse backgrounds, Communicare is committed to delivering personalized care and support for every individual.

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Oxford, MS

Situated in Oxford, MS, Communicare provides an array of specialized treatment options designed for both adults and young adults facing challenges related to substance use and concurrent mental health conditions. The center offers a variety of services, including hospital inpatient detoxification and around-the-clock hospital inpatient care, delivering thorough support for those on their journey to recovery. By employing strategies such as 12-step facilitation and anger management, Communicare customizes its treatment plans to align with the specific needs of each client. Additionally, the center features distinct programs for active duty military personnel, as well as for adult men and women, ensuring a tailored approach to care. With an emphasis on high-quality and individualized treatment, Communicare is committed to assisting individuals in achieving enduring sobriety and overall wellness.

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Pittsboro, MS

Situated in Pittsboro, MS, Communicare specializes in providing outpatient care for individuals dealing with substance abuse and co-occurring mental health issues, serving both adults and children. The center focuses on customized treatment plans for those who have faced trauma or domestic violence, fostering a nurturing atmosphere for recovery. Employing methods like 12-step support and anger management techniques, Communicare prioritizes personalized attention for each client. Their offerings include outpatient treatments with methadone/buprenorphine and specific interventions for older adults. Moreover, they feature tailored programs for teenagers, accommodating a broad spectrum of needs. The facility also implements gender-specific services for men and women to ensure a more tailored therapeutic journey.

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Holly Springs, MS

Communicare, located in Holly Springs, MS, provides a variety of outpatient treatment options that address issues related to substance use, co-occurring disorders, and traumatic experiences. The center is particularly adept at dealing with intimate partner violence, domestic abuse, and trauma recovery, and it serves adults and seniors of all genders. The treatment methodologies implemented include 12-step programs, anger management, and short-term interventions. With a special emphasis on adolescents and those facing serious mental health challenges, Communicare ensures effective care through outpatient services, including methadone/buprenorphine or naltrexone therapies. This facility is committed to guiding clients through their recovery process with tailored and thorough support.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated October 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)