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Medically Reviewed Content
Updated: October 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Community and Family Resources

Situated in Tipton, IA, Community and Family Resources provides a full range of substance abuse treatment services for adults, children, and teenagers. Their outpatient programs feature options such as methadone/buprenorphine or naltrexone treatment, employing evidence-based methods like cognitive behavioral therapy and motivational interviewing. With a commitment to personalized care, this center fosters a welcoming environment for all clients, regardless of gender. The facility's distinct focus on brief interventions guarantees that treatment is both targeted and efficient. For those in need of high-quality outpatient addiction support tailored to individual needs, this center is committed to guiding clients towards recovery.

Compass Behavioral Health

Situated in Garden City, KS, Compass Behavioral Health provides outpatient treatment for substance use disorders affecting both adults and children who also face mental health challenges. This center focuses on various therapeutic methods, including cognitive behavioral therapy, motivational interviewing, and techniques aimed at preventing relapse. Customized treatment plans are offered for teenagers, adult males, and adult females. Catering to men and women of all ages, this facility is committed to delivering empathetic care and evidence-supported treatment modalities. Whether individuals are pursuing aid for themselves or someone close to them, Compass Behavioral Health is devoted to offering exceptional, personalized care to foster recovery and enhance overall wellness.

Compass Health
Raymore, MO

Compass Health, situated in Raymore, MO, is an esteemed rehabilitation facility providing a wide range of treatment options. This center focuses on addressing substance abuse as well as co-occurring disorders for both adults and children. Emphasizing various treatment modalities, including intensive outpatient, outpatient, and standard outpatient care, Compass Health delivers personalized support through methods such as anger management, brief intervention, and cognitive behavioral therapy. A distinctive feature of this center is its dedicated program for those grappling with concurrent mental health and substance abuse issues. Catering to clients of all genders and ages, Compass Health prioritizes high-quality, customized treatment to foster enduring recovery.

CompDrug
Columbus, OH

CompDrug, situated in Columbus, OH, provides targeted care for individuals struggling with substance use, including those with co-occurring mental health conditions in adults or emotional challenges in youth. This center delivers intensive outpatient, outpatient, and medication-assisted treatment options, all grounded in proven therapeutic approaches. CompDrug's services encompass anger management, brief intervention, and cognitive behavioral therapy, serving adult men, women, expectant and new mothers, and young adults. The facility champions gender-specific programming for both men and women, offering personalized assistance. Clients can expect exceptional support and thorough treatment at CompDrug.

Compass Health
Wentzville, MO

Compass Health, situated in Wentzville, MO, provides a wide array of treatment services for adults and older adults dealing with substance use issues. The center focuses on addressing co-occurring substance use disorders and significant mental health challenges in adults, as well as serious emotional issues in children. They offer various treatment modalities, including intensive outpatient, outpatient, and traditional outpatient programs. Emphasizing personalized care, Compass Health utilizes evidence-supported methods such as anger management, brief intervention techniques, and cognitive behavioral therapy. Their specialized treatment plans are crafted to support both male and female clients, fostering enduring recovery and enhanced well-being.

Community and Family Resources

Community and Family Resources in Iowa City, IA, delivers dedicated detox programs for adults and young adults within a residential environment. This center prioritizes personalized attention, offering continuous assistance adjusted to every individual's requirements. Employing methods like brief intervention, motivational interviewing, and counseling for substance use disorders, the facility guarantees a thorough recovery journey. Featuring distinct services for both male and female individuals, Community and Family Resources serves a broad spectrum of people aiming for sobriety. Anyone looking for a nurturing and successful recovery program will discover excellent treatment and individualized support at this location.

Compass Health
Lebanon, MO

Situated in Lebanon, MO, Compass Health provides focused treatment for adults and seniors dealing with substance use issues. Their outpatient program offers consistent therapy employing proven methods such as brief interventions, cognitive behavioral therapy, and motivational interviewing. This center effectively support individuals facing both mental health challenges and substance use disorders, promising an all-encompassing care approach. Emphasizing customized treatment strategies, Compass Health extends its services to both men and women with dedication and skill. For those in need of high-quality addiction rehabilitation in an encouraging setting, Compass Health is a strong choice for personalized recovery solutions.

Compass Health
Boonville, MO

Compass Health, located in Boonville, MO, delivers various outpatient treatment options for both substance use issues and concurrent mental health conditions in individuals of all ages. The center focuses on specialties such as anger management, cognitive behavioral therapy, and trauma-informed care, addressing a wide array of client needs. Offering outpatient treatments with medications like methadone, buprenorphine, and naltrexone, the facility aids those struggling with pain alongside addiction. With programs designed for adults and children alike, and welcoming both males and females, Compass Health emphasizes personalized care and evidence-supported methods to foster enduring recovery and enhanced well-being.

Compass Health
Linn Creek, MO

Situated in Linn Creek, MO, Compass Health provides an extensive array of substance abuse treatment options for both adults and young adults. The center excels in addressing simultaneous substance use and significant mental health challenges, along with emotional issues in children. It offers a variety of treatment modalities including intensive outpatient, outpatient, and traditional outpatient programs. With an emphasis on anger management, brief interventions, and cognitive behavioral therapy, Compass Health serves both men and women. The center’s targeted programs for individuals dealing with dual diagnoses ensure comprehensive care and assistance for those on the path to recovery.

Compass Health
Osceola, MO

Situated in Osceola, MO, Compass Health provides outpatient treatment for substance use alongside specialized support for adults facing co-occurring mental health challenges and children with emotional issues. The center employs regular outpatient care through proven methodologies like anger management, brief interventions, and cognitive behavioral therapy. Compass Health is particularly noted for its dedication to assisting trauma survivors and those managing both mental health and substance use disorders, as well as individuals dealing with pain in addition to substance use concerns. With programs designed for both adults and children and services available for all genders, this facility guarantees thorough and high-quality support for those on their journey to recovery and wellness.

Compass Health
El Dorado Springs, MO

Situated in El Dorado Springs, MO, Compass Health delivers extensive treatment for substance use issues impacting both adults and children alongside mental health challenges. The center features intensive outpatient services, general outpatient care, and targeted treatment options including methadone, buprenorphine, or naltrexone. Employing techniques like anger management, cognitive behavioral therapy, and brief interventions, this facility addresses the needs of individuals with overlapping pain and substance abuse problems. Compass Health is open to adults and seniors from all backgrounds, providing personalized care and guidance throughout the recovery process.

Compass Health
Warsaw, MO

Situated in Warsaw, MO, Compass Health delivers extensive treatment solutions for substance use disorders, particularly for those facing concurrent mental health issues. The center offers various formats of care, including intensive outpatient, outpatient, and standard outpatient programs, customized to meet the specific needs of adults and seniors. Employing methodologies such as anger management, brief intervention, and cognitive behavioral therapy, Compass Health emphasizes a holistic approach to recovery. Specialized programs are available for individuals with both mental health and substance use challenges. This facility serves both men and women, committed to offering exceptional care and assistance for individuals striving to overcome addiction and enhance their mental health.

Compass Health
Harrisonville, MO

Situated in Harrisonville, MO, Compass Health stands out as a leading rehabilitation facility focusing on outpatient care for both substance use issues and accompanying mental health disorders in individuals of all ages. The center features targeted programs designed for those who have endured trauma, along with support for individuals dealing with simultaneous pain and substance use challenges. Compass Health employs proven methods, including cognitive behavioral therapy and motivational interviewing, to provide clients with exceptional care. Emphasizing short-term interventions and personalized treatment strategies, this center serves both men and women looking for thorough and impactful rehabilitation options.

Compass Health
Warrensburg, MO

Situated in Warrensburg, MO, Compass Health delivers extensive rehabilitation services aimed at adults and young adults facing challenges related to substance use and concurrent mental health disorders. The center features both residential and short-term residential treatment options, employing proven methods like cognitive behavioral therapy and motivational interviewing. Compass Health is particularly adept at supporting clients who have undergone trauma, those dealing with simultaneous mental health and substance use issues, as well as individuals experiencing co-occurring pain and substance use challenges. With an emphasis on personalized care, this facility welcomes both male and female clients, fostering an encouraging and inclusive atmosphere for everyone on their path to recovery.

Compass Health
Sullivan, MO

Situated in Sullivan, MO, Compass Health stands out as a prominent rehabilitation center that provides outpatient care for both substance use disorders and concurrent mental health issues affecting adults and children. The facility is dedicated to techniques such as brief interventions, cognitive behavioral therapy, and motivational interviewing, offering personalized treatment for those who have endured trauma or face challenges with pain and substance use. With programs crafted for individuals of all ages and genders, Compass Health is committed to delivering top-notch, evidence-backed therapies to aid clients in their recovery journey. If you or someone you know is in need of thorough and empathetic addiction support, Compass Health is ready to assist.

Compass Health
Columbia, MO

Compass Health, situated in Columbia, MO, provides a variety of outpatient treatment options focused on substance use issues and co-existing mental health challenges for both adults and children. The center ensures personalized support by employing methods like cognitive behavioral therapy, anger management, and brief intervention strategies. Designed with specific programs for active duty service members as well as male and female adults, Compass Health addresses the unique requirements of its clients. By accommodating both adults and younger individuals, the facility guarantees thorough care for all demographics. Highlighting its commitment to high-quality, tailored treatment, Compass Health remains a reliable choice for individuals seeking effective rehabilitation for addiction.

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In Washington, IA, Community and Family Resources provides extensive support for individuals battling substance use disorders via its outpatient services. The center offers targeted treatment options including outpatient care with methadone/buprenorphine or naltrexone, standard outpatient services, and brief intervention strategies. Employing proven methods such as cognitive behavioral therapy and contingency management/motivational incentives, the facility crafts personalized care plans for a diverse clientele, encompassing adults and young people of any gender. Community and Family Resources is distinguished by its dedication to customized recovery journeys and high-quality, individualized attention.

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Community and Family Resources, situated in Clive, IA, delivers outpatient care for adults struggling with substance use disorders. They also provide tailored interventions for individuals experiencing co-occurring substance use and mental health challenges, encompassing serious mental illness in adults and significant emotional disturbances in children. Their treatment modalities include 12-step facilitation, brief intervention strategies, and cognitive behavioral therapy. The center is equipped to serve a broad spectrum of individuals with specific programs for active duty military personnel, adolescents, and adult men. Catering to adults and seniors of all genders, Community and Family Resources ensures comprehensive support through outpatient medication-assisted treatment (methadone/buprenorphine or naltrexone) and general outpatient services.

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Columbia, MO

Situated in Columbia, MO, Compass Health stands out as a leading rehabilitation center dedicated to addressing substance abuse and co-occurring disorders in both adults and children. The facility features a range of treatment options, including intensive outpatient, outpatient, and standard outpatient programs, employing proven methods like cognitive behavioral therapy and motivational interviewing. Compass Health offers targeted programs for adult women, individuals who have experienced trauma, and those facing dual mental health challenges. Designed for adults, seniors, and young adults, this women-centered facility commits to delivering exceptional care for individuals in need of thorough and effective rehabilitation services.

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Columbia, MO

Situated in Columbia, MO, Compass Health provides a variety of research-supported treatment options for substance abuse and concurrent mental health challenges in both adults and children. Individuals can participate in intensive outpatient care, day outpatient programs, and partial hospitalization. The facility excels in offering services such as anger management, brief interventions, and cognitive behavioral therapy. Tailored programs are available specifically for teenagers, those facing dual diagnoses, and individuals dealing with both pain and substance dependence. Compass Health is dedicated to serving adults and older adults of all genders, emphasizing quality care and customized treatment strategies to meet each client's unique requirements.

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Owensville, MO

Situated in Owensville, MO, Compass Health delivers a wide variety of outpatient services aimed at helping individuals recover from substance use disorders and related mental health challenges. This center focuses on detoxification, treatment for substance use issues, and assists those dealing with concurrent pain and addiction. Emphasizing brief interventions, cognitive behavioral therapy, and motivational interviewing, Compass Health customizes treatment strategies to address the specific needs of each individual. The facility offers specialized programs for those who have faced trauma and for individuals with co-occurring mental health difficulties. Catering to both adults and youth, the center provides outpatient detox services and treatments using methadone/buprenorphine or naltrexone, welcoming clients from all genders.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated October 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)