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Medically Reviewed Content
Updated: October 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Complete Hlthcare Addiction/Gynecology

Complete Hlthcare Addiction/Gynecology located in Pickerington, OH, offers a wide range of addiction treatment options for both adults and seniors. This center specializes in detoxification, substance use disorder therapies, and offers targeted support for individuals dealing with dual diagnoses of substance abuse and significant mental health issues, as well as emotional challenges in children. With an emphasis on methods such as 12-step programs, anger management, and brief intervention strategies, the center serves a diverse population, including military personnel, teenagers, and adult males. Whether offering intensive outpatient programs or structured outpatient services, the facility is dedicated to providing personalized care that meets the unique needs of each individual.

Complete Hlthcare Addiction/Gynecology

Situated in Columbus, OH, Complete Hlthcare Addiction/Gynecology delivers an extensive array of services for addiction and mental health issues. The facility specializes in detox services, treatment for substance use disorders, and focused care for patients facing both substance use challenges and significant mental health conditions. It offers various treatment formats such as intensive outpatient, outpatient, and daytime programs. Emphasizing methods like 12-step support, anger control, and brief intervention strategies, this center serves a diverse clientele, including active military personnel, teenagers, adult men and women, as well as seniors. With customized treatment plans for both genders, the center is committed to providing exceptional, personalized care for those on the path to recovery and improved well-being.

Complete Hlthcare Addiction/Gynecology

Based in Columbus, OH, Complete Hlthcare Addiction/Gynecology is a multifaceted rehabilitation facility that provides a variety of treatment alternatives. The center addresses detoxification, substance abuse issues, and co-occurring mental health disorders for both adults and children. They offer a range of programs including intensive outpatient, outpatient, and day treatment to meet diverse needs. Employing methods such as the 12-step program, anger management sessions, and brief intervention strategies, the center prioritizes personalized care. Additionally, specialized services are available for active military personnel, adolescents, and adult males. Catering to adults and seniors of all genders, this facility delivers high-quality care with an emphasis on customized treatment plans to aid individuals in their recovery processes.

Comprehensive Behavioral Health Center

Situated in Denver, Colorado, the Comprehensive Behavioral Health Center delivers outpatient services for adults dealing with substance abuse and concurrent severe mental health challenges, as well as for children facing serious emotional difficulties. The center focuses on anger management, brief therapeutic interventions, and cognitive behavioral therapy, providing customized care for both adult men and women, including those with a history of trauma. With programs available for adults and young adults of all genders, this facility adopts a holistic approach to recovery. Whether in need of outpatient methadone/buprenorphine or naltrexone therapy, or general outpatient services, clients can anticipate exceptional, personalized support at this center.

Comprehensive Behavioral Health Center

Situated in Denver, CO, the Comprehensive Behavioral Health Center provides various outpatient treatment options aimed at tackling substance abuse and concurrent mental health challenges in both adults and children. The center employs techniques like anger management, cognitive behavioral therapy, and brief therapeutic interventions, delivering customized care for adult men, women, and individuals with trauma histories. With an emphasis on high-quality, personalized treatment, the facility serves a diverse clientele, including adults and young adults across all genders. Whether individuals are in need of standard outpatient services or specialized treatment involving methadone, buprenorphine, or naltrexone, they can discover personalized assistance at this center.

Comprehensive Wellness Centers

Comprehensive Wellness Centers, located in Lake Worth, FL, provides a variety of top-notch rehabilitation services designed for both adults and young adults. The center specializes in intensive outpatient care, long-term residential treatment, and customized outpatient programs that align with individual requirements. Emphasizing 12-step approaches, anger management, and short intervention methods, this facility focuses on addressing substance abuse issues as well as concurrent mental health disorders. It features specialized programs for active duty military individuals, men, and women. With additional offerings such as transitional housing and sober living arrangements, the center fosters a nurturing environment for recovery. Committed to delivering effective and compassionate support, Comprehensive Wellness Centers is a reliable option for those pursuing meaningful rehabilitation results.

Comprehensive Behavior Health Center

Situated in East Saint Louis, IL, the Comprehensive Behavior Health Center delivers an array of targeted therapies. Their offerings include programs for substance use disorders, transitional living arrangements, and treatment for those dealing with both substance use and severe mental health issues. The center features options for long-term residential support, outpatient care, as well as outpatient treatment utilizing methadone, buprenorphine, or naltrexone. Utilizing techniques like 12-step facilitation, brief interventions, and cognitive behavioral therapy, the center serves adults, teenagers, and active military members. Customized programs are designed for men, women, and various age demographics. Committed to providing effective care for those on the path to recovery, this facility is recognized for its thorough and personalized treatment services.

Comprehensive Addiction Programs Inc

Situated in Fresno, CA, Comprehensive Addiction Programs Inc delivers an extensive array of specialized services aimed at assisting individuals facing addiction challenges. The facility offers hospital-based inpatient detoxification and treatment for adults dealing with substance use disorders along with coexisting severe mental health issues, and it also addresses significant emotional disturbances in children. Emphasizing personalized care, the program integrates various methods, including 12-step support, anger management techniques, and cognitive behavioral therapy. Catering to adults and young adults of all genders, this center is committed to delivering exceptional, custom treatment that aids individuals in their recovery journey.

Comprehensive and Psych Associates LLC

Comprehensive and Psych Associates LLC, situated in Laurel, MD, provides targeted outpatient care for adults dealing with substance use and co-occurring mental health issues, as well as emotional challenges in children. Emphasizing personalized treatment, the center offers outpatient options including methadone, buprenorphine, and naltrexone along with standard outpatient services. It features distinctive programs such as 12-step support, anger management, and brief interventions, catering to both adults and young clients. With gender-specific services available, this center commits to delivering a thorough and customized treatment journey for everyone in pursuit of effective recovery solutions.

Comprehensive Healthcare

Situated in Pasco, WA, Comprehensive Healthcare provides a variety of focused treatment options for those dealing with substance use and mental health challenges. The center offers intensive outpatient, outpatient, and standard outpatient programs designed to meet the unique needs of both adults and children/adolescents. Employing proven methodologies such as cognitive behavioral therapy and motivational interviewing, this facility serves individuals of all genders and includes specialized programs for younger clients as well as those facing dual diagnoses. With an emphasis on high-quality care and personalized treatment plans, the center is an important asset for individuals looking for thorough rehabilitation support.

Comprehensive Life Resources

Comprehensive Life Resources in Tacoma, WA, provides varied outpatient programs for adults, youth, and older adults dealing with substance use challenges. They are particularly skilled in addressing dual diagnoses of mental health and addiction, employing proven methods like CBT, MI, and CM. A unique aspect of this center is their specialized support for individuals with a history of sexual abuse or trauma. Comprehensive Life Resources emphasizes personalized care for all genders, aiming to offer effective treatment within a nurturing setting. They are committed to helping clients achieve sustained recovery through both general outpatient care and specific interventions.

Comprehensive Life Resources

Comprehensive Life Resources, situated in Tacoma, WA, specializes in providing extensive outpatient services for individuals of all ages struggling with substance use and co-occurring mental health conditions. The center employs proven therapeutic methods, including cognitive behavioral therapy and motivational interviewing, to deliver tailored support. They have a particular focus on assisting clients who have experienced trauma or sexual abuse. Comprehensive Life Resources is committed to delivering high-quality, personalized treatment plans designed to guide both adult and young adult men and women toward lasting recovery from intertwined mental health and substance use challenges.

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Flemingsburg, KY

Situated in Flemingsburg, KY, Comprehend Inc delivers targeted rehabilitation solutions for adults and seniors facing challenges related to substance use and concurrent mental health disorders. The center features both intensive outpatient and outpatient treatment options, incorporating methadone and buprenorphine therapies. With an emphasis on 12-step support, anger management techniques, and concise intervention strategies, Comprehend Inc customizes its approach to meet the unique needs of each individual. The facility is particularly noted for its specialized programs catering to clients involved in the criminal justice system. Comprehend Inc serves a diverse clientele, providing high-quality care and assistance to those in search of thorough and effective rehabilitation support.

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Maysville, KY

Comprehend Inc located in Maysville, KY, delivers a variety of focused rehabilitation services. The center specializes in intensive outpatient treatment, outpatient support, and medication-assisted therapy using methadone/buprenorphine or naltrexone for those struggling with substance use disorders. Their personalized treatment options feature 12-step programs, anger management sessions, and brief therapeutic interventions. Comprehend Inc serves a diverse client base, including adults, seniors, and both male and female individuals, with specific initiatives for adolescents, adult men, and those involved in the criminal justice system. The center's dedication to addressing both substance use and mental health challenges in a holistic manner distinguishes it, providing thorough support for those on their path to recovery.

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Vanceburg, KY

In Vanceburg, KY, Comprehend Inc delivers a full spectrum of recovery support for adults and older adults facing addiction and dual diagnoses. Services include intensive outpatient, outpatient, and specific medication-assisted treatment options like methadone, buprenorphine, or naltrexone. Their approach emphasizes 12-step principles, emotional regulation techniques, and short-term counseling strategies, serving all genders. A key offering is their tailored program for individuals involved with the legal system. Comprehend Inc is committed to offering excellent, personalized support throughout the recovery process.

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Comprehensive Community Services, located in Kingsport, TN, provides a variety of scientifically proven therapeutic approaches for adults and young adults facing challenges with substance abuse and accompanying mental health disorders. Their services encompass intensive outpatient programs, standard outpatient care, and specific treatments involving methadone, buprenorphine, or naltrexone. Utilizing methods like 12-step program encouragement, anger management strategies, and brief intervention techniques, this institution offers customized assistance to active military members, adult men, and women. The facility's gender-segregated programs are designed to foster a secure and encouraging atmosphere for everyone. Dedicated to high standards of care, Comprehensive Community Services strives to guide individuals toward sustained sobriety and well-being.

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Comprehensive Community Services located in Johnson City, TN, delivers a variety of tailored treatment programs designed for individuals facing substance use issues, as well as co-occurring mental health challenges and emotional disorders, catering to both adults and children. The center offers a range of services, including intensive outpatient therapy, standard outpatient support, and treatment options involving methadone, buprenorphine, or naltrexone. Emphasizing approaches such as 12-step programs, anger management, and brief therapeutic interventions, the facility customizes its offerings to suit each person's unique situation. Additionally, specialized programs are available for active military members, adult males, and females. This center is committed to delivering exceptional, all-encompassing care to aid individuals of all genders in their recovery journeys.

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Comprehensive Community Services in Kingsport, TN, presents a variety of evidence-supported treatment options for substance abuse and co-occurring mental health issues in both adults and children. The center offers intensive outpatient programs, outpatient care, and targeted treatment with methadone, buprenorphine, or naltrexone. With an emphasis on 12-step support, anger management tactics, and short intervention methods, this facility serves adult males, females, and active military members. By providing tailored care for adults and young adults of all genders, Comprehensive Community Services stands out as an essential provider for those in need of effective and customized addiction recovery.

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Comprehensive Community Services in Kingsport, TN, delivers a variety of targeted treatments for individuals dealing with substance use issues and concurrent mental health disorders, catering to both adults and children. The center features diverse programs, including intensive outpatient care, long-term residential options, and traditional outpatient services. Treatments are personalized and include methods such as 12-step support, anger management, and short-term interventions. Additionally, there are specialized programs designed for active military personnel, as well as distinct offerings for adult men and women, reflecting the center's commitment to inclusivity. Dedicated to supporting recovery and overall wellness, Comprehensive Community Services in Kingsport aims to provide superior, individualized care for all genders.

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Comprehensive Connections, situated in Mount Vernon, IL, delivers a variety of scientifically-backed treatment plans designed for each person. This location provides detox services, addiction treatment, temporary housing, and sober living for young people and adults. Offering intensive outpatient, extended residential, and outpatient programs, the facility employs methods like 12-step support, emotional regulation techniques, and short-term counseling. They focus on specialized programs for current military personnel, adult males, and teenagers. Comprehensive Connections, open to both genders, is committed to delivering excellent support throughout the recovery process.

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Comprehensive Healthcare, situated in Yakima, WA, delivers extensive addiction treatment options for both adults and young adults facing challenges with substance use and concurrent mental health issues. The center features various programs including hospital inpatient, long-term residential care, and round-the-clock residential support, employing effective methods such as 12-step facilitation, cognitive behavioral therapy, and brief interventions. With tailored programs designed for adult men, adult women, and individuals who have experienced intimate partner violence, this center addresses a wide range of needs. Providing exceptional care for all clients, this facility is recognized as a reliable source of comprehensive rehabilitation services within the Yakima community.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated October 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)