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Medically Reviewed Content
Updated: May 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,711 treatment centers offering naltrexone (vivitrol) across the United States.

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Crossroads
Mesa, AZ

Crossroads, situated in Mesa, Arizona, provides thorough substance abuse treatment tailored for adult women battling addiction. This center offers various levels of care, including intensive outpatient, extended residential stays, and standard outpatient services. Their therapeutic approaches encompass 12-step facilitation, anger management techniques, and cognitive behavioral therapy. Specialized programs are available for active duty military members, adult women, and survivors of intimate partner violence. Crossroads serves adults across all age groups, with a particular emphasis on female clients. Their dedication to high-quality care establishes a nurturing setting for individuals pursuing freedom from substance use disorders, delivering personalized treatment strategies and empathetic assistance at every stage of recovery.

Crossroads
Phoenix, AZ

Crossroads in Phoenix, AZ, provides focused substance abuse care via intensive outpatient, outpatient, and medication-assisted treatment (MAT) options including methadone, buprenorphine, and naltrexone. Their therapeutic framework incorporates 12-step facilitation, anger management, and cognitive behavioral therapy. Recognizing varied needs, they offer distinct programs for active military personnel, adult men, and adult women. This center is equipped to assist adults and young adults of all genders, delivering personalized support. Crossroads is committed to offering excellent care within a nurturing setting, emphasizing successful recovery pathways. For those in Phoenix looking for thorough addiction treatment, Crossroads is prepared to assist in your journey to sobriety.

Crossroads
Mesa, AZ

Crossroads, situated in Mesa, AZ, stands as a leading facility dedicated to aiding adults and young adults in overcoming substance dependency. This center provides a multifaceted recovery journey through its outpatient services, including methadone/buprenorphine treatment and standard outpatient programs. The therapeutic framework at Crossroads encompasses 12-step facilitation, anger management techniques, and cognitive behavioral therapy to cater to diverse client requirements. Distinctive offerings for active military members, adult men, and adult women highlight the center's specialized approach. Crossroads is committed to delivering personalized support and care to all individuals, regardless of gender, as they work towards breaking free from addiction and rebuilding their futures.

Crossroads Center
Cincinnati, OH

Crossroads Center in Cincinnati, OH, delivers a complete spectrum of care for individuals grappling with addiction and co-occurring psychological challenges, serving both younger and adult populations. This establishment features intensive outpatient, extended residential stays, and standard outpatient services, all grounded in proven therapeutic methods like cognitive behavioral therapy and strategies for managing anger. Distinct treatment paths are offered for teenagers, adult men, and adult women. Emphasizing personalized attention, Crossroads Center is equipped to support male and female patients of varying ages, offering customized assistance to address each person's specific circumstances. Discover exceptional treatment and achieve sustainable healing at this reputable center, committed to fostering long-term wellness.

Crossroads Treatment Centers

Crossroads Treatment Centers in Knoxville, TN, delivers accessible outpatient substance abuse recovery programs. Their approach centers on preventing setbacks and providing expert guidance for addiction. Services include medication-assisted treatment (methadone, buprenorphine, naltrexone), with the added convenience of remote counseling sessions. The center is particularly dedicated to supporting expectant and new mothers, serving adults and young adults across all gender identities. Crossroads Treatment Centers is dedicated to fostering a nurturing space for those on their journey to sobriety, with personalized care designed for individual circumstances.

Crossroads Treatment Centers

Crossroads Treatment Centers, situated in Hermitage, TN, provides outpatient programs for substance use disorders, offering treatments that include methadone, buprenorphine, and naltrexone. This center emphasizes strategies for relapse prevention and offers counseling focused on addiction, along with access to telehealth services. With a particular emphasis on supporting pregnant and postpartum women, it serves both adults and young adults across genders. Crossroads Treatment Centers is dedicated to delivering a holistic and compassionate pathway to recovery, guaranteeing personalized care and tailored treatment plans. If you or someone you care about is looking for specialized support in a nurturing setting, this center might be an ideal option for your recovery journey.

Crossroads Treatment Centers

Crossroads Treatment Centers located in Murfreesboro, TN, focuses on outpatient treatment for adults and young adults dealing with substance use issues. The center provides outpatient services including methadone, buprenorphine, and naltrexone treatments, with an emphasis on preventing relapse and offering counseling for substance use disorders. They have a distinctive program designed specifically for pregnant and postpartum women, ensuring a holistic approach to care. Additionally, the center incorporates telemedicine and telehealth options to improve accessibility for its clients. Crossroads Treatment Centers in Murfreesboro is dedicated to delivering high-quality care through an array of targeted services and evidence-based methods for both men and women.

Crossroads Treatment Centers

Crossroads Treatment Centers, located in Danville, VA, specializes in outpatient treatment for substance use for both adults and young adults. The center features tailored programs specifically designed for pregnant and postpartum women, serving clients of all genders. Among the services offered are counseling for substance use disorders and telehealth options. Crossroads Treatment Centers also presents outpatient options including methadone, buprenorphine, and naltrexone treatments. Committed to delivering high-quality care and personalized assistance, this center is focused on supporting individuals in their journey to overcome addiction. For those seeking thorough treatment in a supportive atmosphere, Crossroads Treatment Centers is dedicated to guiding clients towards recovery with empathy and professionalism.

Crossroads Turning Points Inc

Crossroads Turning Points Inc. in Alamosa, CO, delivers extensive addiction recovery programs for adults and older individuals. They offer detox services, substance use disorder therapy, and tailored support for adults dealing with co-occurring substance use and severe mental health conditions, along with children experiencing emotional difficulties. Services include intensive outpatient and outpatient treatment, as well as medication-assisted treatment options like methadone, buprenorphine, or naltrexone. The center employs therapeutic methods such as 12-step facilitation, anger management, and brief intervention to provide personalized recovery plans. Dedicated programs are provided for teenagers, adult men, and adult women, serving a broad spectrum of individuals. Crossroads Turning Points Inc. is recognized for its commitment to high-quality care and customized treatment paths, making it a significant resource for individuals pursuing successful addiction recovery.

Crossroads Counseling Services Inc

"Crossroads Counseling Services Inc located in Saint Clairsville, OH, specializes in providing tailored treatment programs for substance use in a supportive setting. The facility offers a variety of options, including intensive outpatient programs, outpatient services, and day treatment for individuals of all ages, from adults to children and adolescents. Emphasizing 12-step programs, anger management, and short-term interventions, the center customizes its approach to fit the unique requirements of each client. Additionally, there are specialized offerings for those who have faced trauma and individuals entangled in the criminal justice system. Dedicated to delivering high-quality care, the center accommodates both male and female clients in their pursuit of effective and empathetic rehabilitation solutions."

Crossroads Treatment Center

Crossroads Treatment Center, located in Lagrange, GA, specializes in providing outpatient treatment for substance use challenges among adults and young adults. The center offers methadone, buprenorphine, or naltrexone as part of their outpatient services, in addition to counseling for substance use disorders and options for telehealth therapy. With a dedicated focus on the needs of pregnant and postpartum women, the center ensures that this population receives appropriate support. Both male and female clients benefit from personalized care plans designed to meet their unique needs. Crossroads Treatment Center prioritizes high-quality care to effectively assist individuals in their journey toward overcoming substance use disorders.

Crossroads Treatment Centers

Crossroads Treatment Centers in Memphis, TN, delivers comprehensive outpatient care for substance use disorders, utilizing medication-assisted treatments such as methadone, buprenorphine, and naltrexone. They equip clients with relapse prevention techniques, offer individual and group counseling for addiction, and provide telehealth options for greater accessibility. This center is particularly dedicated to serving pregnant and postpartum women, while also extending support to adult and young adult individuals across all genders. Crossroads Treatment Centers in Memphis is committed to delivering personalized treatment plans within a nurturing atmosphere, positioning it as a premier destination for those pursuing successful and empathetic recovery from addiction.

Crossroads Counseling Inc

Crossroads Counseling Inc, located in Williamsport, PA, provides targeted substance abuse care for adults facing concurrent severe mental health disorders. This establishment offers robust intensive outpatient, standard outpatient, and outpatient medication-assisted treatments (methadone/buprenorphine or naltrexone). Employing techniques such as anger management, brief intervention, and cognitive behavioral therapy, the center serves young people, adult men, and adult women. Its specialized care extends to adult and senior populations, ensuring personalized support for both male and female individuals. Crossroads Counseling Inc distinguishes itself through its extensive treatment modalities, personalized care strategies, and dedication to superior support for individuals on their journey to overcome addiction and mental health struggles.

Crossroads Counseling Inc

Crossroads Counseling Inc, located in Lock Haven, PA, provides a variety of specialized rehabilitation options. The center features intensive outpatient programs, standard outpatient services, and treatments involving methadone, buprenorphine, or naltrexone. With an emphasis on addressing substance use disorders alongside significant mental health challenges, participants can access methods like anger management, brief interventions, and cognitive behavioral therapy. Distinct programs are available for adolescents as well as adult men and women. Catering to adults and seniors of all genders, the center is committed to delivering personalized assistance for individuals striving to recover from addiction and mental health issues. The combination of high-quality care and customized programs establishes Crossroads Counseling Inc as an essential support for those embarking on their recovery journey.

Crossroads Turning Points Inc

Crossroads Turning Points Inc in Lamar, CO, specializes in treating substance use disorders and co-occurring mental health issues for both adults and children. The center offers various treatment programs, including intensive outpatient care, outpatient services, and options for methadone, buprenorphine, or naltrexone. By emphasizing methods such as 12-step programs, anger management, and brief interventions, the facility serves a diverse population that includes adolescents, adult men, and women. Catering to individuals across different gender identities, this center provides personalized care designed to address specific needs. The high standard of care and unique services available at this facility make it an essential option for those in need of thorough addiction rehabilitation and mental health assistance.

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Crossroads Center of Frederick in Frederick, MD delivers thorough addiction recovery services for adults and older adults. Their offerings include intensive outpatient, outpatient, and standard outpatient care. Employing proven methods like 12-step integration, motivational interviewing, and CBT, the center customizes recovery plans. Specialized services cater to younger individuals. Committed to excellent support, Crossroads Center of Frederick welcomes both men and women, fostering a nurturing atmosphere for those pursuing sobriety.

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Bloomsburg, PA

Crossroads Counseling in Bloomsburg, PA, provides comprehensive outpatient substance abuse rehabilitation for adults and young individuals facing concurrent mental health challenges. Their tailored services extend to those with a history of trauma and dual diagnosis, offering specialized interventions. The center employs strategies such as anger management, brief intervention techniques, and cognitive behavioral therapy for both male and female clients. They offer medication-assisted treatment options, including methadone, buprenorphine, or naltrexone, alongside standard outpatient services. Catering to a broad age range, from adults to seniors, Crossroads Counseling is dedicated to delivering individualized and gender-sensitive care to aid in the recovery journey.

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State College, PA

Crossroads Counseling Inc, located in State College, PA, provides a wide array of treatment options for substance use, as well as transitional housing and support for individuals with co-occurring disorders, suitable for both adults and children. Their range of outpatient services features intensive care along with methadone and buprenorphine therapies. Emphasizing techniques such as anger management, brief intervention, and cognitive behavioral therapy, the center offers targeted assistance for adolescents, women, and those who have faced traumatic experiences. Catering to both men and women of all ages, Crossroads Counseling Inc is dedicated to delivering personalized, high-quality care to facilitate the healing and recovery process. If you or someone close to you is in need of reliable rehabilitation services, this center provides a variety of programs designed to address specific challenges.

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Crossroads Counseling Inc. in Wellsboro, PA delivers multifaceted substance abuse recovery programs for individuals of all ages, addressing concurrent mental health challenges. Their offerings include structured intensive outpatient, standard outpatient, and medication-assisted outpatient treatment options. Utilizing therapeutic strategies such as anger management, brief intervention, and cognitive behavioral techniques, Crossroads Counseling Inc. is equipped to support adolescents, those with trauma histories, and individuals managing dual diagnoses. Open to adults and seniors across the gender spectrum, the center is committed to providing excellent care within a nurturing setting.

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Crossroads Counseling Inc, located in Sunbury, PA, provides comprehensive outpatient services for individuals grappling with addiction and concurrent mental health challenges. Their specialized programs address a variety of needs, including anger management, cognitive behavioral therapy, and trauma-informed care, for both adults and younger individuals. Recognizing the complexity of co-occurring disorders, Crossroads Counseling Inc develops individualized treatment strategies. The center is dedicated to offering thorough and supportive care to adults and older adults, irrespective of gender. Their proficiency in outpatient pharmacotherapy, including methadone, buprenorphine, and naltrexone, distinguishes them as a leading provider of customized and impactful recovery solutions.

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Crossroads to Recovery, located in Brooklyn, NY, provides comprehensive outpatient and intensive outpatient treatment for substance use issues, targeting both adults and young adults. The center is particularly adept at addressing co-occurring substance use and serious mental health disorders in adults, as well as significant emotional challenges in children. Emphasizing methods such as anger management, short-term interventions, and cognitive behavioral therapy, the facility delivers personalized treatment plans designed for each individual. Additionally, distinct programs are available for individuals who have faced intimate partner violence, domestic violence, and those involved in the criminal justice system. Crossroads to Recovery welcomes clients of all genders, promoting an inclusive approach to the rehabilitation process for everyone.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated May 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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