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Medically Reviewed Content
Updated: October 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Cumberland Recovery Response Center

Cumberland Recovery Response Center, located in Fayetteville, NC, specializes in a wide range of rehabilitation services designed for adults and young adults facing challenges with substance use disorders and co-occurring mental health issues. This center features dedicated inpatient detoxification and treatment options that cater specifically to the unique requirements of each individual. Emphasizing proven strategies such as 12-step facilitation and contingency management, the center guarantees high-quality support for all clients, regardless of gender. Programs tailored for adult women, those who have experienced intimate partner violence, and individuals with a background of sexual abuse highlight the center's distinct offerings. If you or someone you care about is looking for passionate and effective addiction recovery solutions, this center is committed to guiding you on your journey to wellness.

CuraSouth
Largo, FL

CuraSouth in Largo, FL, is a premier facility providing high-quality alcohol and drug detox, alongside comprehensive substance abuse treatment. Emphasizing immersive residential care and round-the-clock assistance, this center delivers tailored programs for adult men and women, as well as survivors of domestic abuse. Employing proven methods such as 12-step encouragement, emotional regulation techniques, and prompt support strategies, CuraSouth serves adults and adolescents of any gender. Distinguished by its thorough and empathetic approach, CuraSouth represents an excellent option for individuals in search of effective recovery services within a nurturing setting.

CuraWest
Denver, CO

CuraWest, situated in Denver, CO, delivers an extensive range of addiction treatment options, including detox and substance abuse rehabilitation. This center features residential detox services along with round-the-clock and short-term residential care designed for both adults and young adults. Emphasizing methods like 12-step facilitation, anger management, and short interventions, CuraWest serves adult men and women, including those who have been affected by domestic or intimate partner violence. By providing tailored care that considers various age groups and genders, they ensure that each client receives a personalized treatment plan, prioritizing high-quality care and ongoing support throughout their journey to recovery.

Cypress Lakes Lodge
Woodville, TX

Cypress Lakes Lodge, situated in Woodville, TX, provides a wide range of rehabilitation services aimed at adults and young adults facing substance abuse and related mental health issues. The center features inpatient detox services and a variety of treatment methodologies, including 12-step programs, anger management, and quick intervention strategies. Designed to serve specific groups such as active duty military personnel, as well as adult men and women, Cypress Lakes Lodge is equipped to meet the needs of various individuals. Their commitment to high-quality care and personalized treatment strategies positions them as a premier option for those in search of effective and customized addiction recovery solutions.

Cumberland River Behavioral Health

Cumberland River Behavioral Health in London, KY, provides dedicated rehabilitation programs for adult men facing challenges with substance misuse and concurrent severe mental health concerns. Their offerings include extended, brief, and round-the-clock residential care, utilizing proven methods like 12-step integration, emotional regulation techniques, and cognitive restructuring. Catering specifically to adult and older male individuals, this center distinguishes itself through its all-encompassing treatment plans and customized support for those requiring transitional living or sober living environments. Cumberland River Behavioral Health is committed to delivering excellent care and assistance to individuals pursuing sobriety and a renewed life.

Cummins BH Systems Inc

Cummins BH Systems Inc, located in Lebanon, IN, specializes in comprehensive outpatient and intensive outpatient services for adults managing substance use disorders alongside co-occurring mental health challenges, as well as for children experiencing significant emotional disturbances. The facility features tailored treatment tracks designed for adolescents, adult men, and adult women. Its therapeutic modalities encompass anger management techniques, brief intervention strategies, and cognitive behavioral therapy. Emphasizing personalized care plans, Cummins BH Systems Inc serves both male and female individuals, offering outpatient medication-assisted treatment options including methadone, buprenorphine, and naltrexone. For those seeking recovery support for themselves or a family member, Cummins BH Systems Inc delivers expert care for adults and young people requiring specialized addiction intervention.

DREAM Provider Care Services

DREAM Provider Care Services, located in Plymouth, NC, provides an extensive range of outpatient services aimed at addressing substance use issues along with co-occurring mental health challenges. This center specializes in supporting both adults dealing with severe mental health disorders and children struggling with emotional issues. They offer a variety of therapies, including 12-step programs, anger management classes, and cognitive behavioral therapy. Customized programs are available for active military members, teenagers, and adult men, ensuring specific needs are met. The center prioritizes quality care for adults and seniors of all genders, with distinct programs designed for both men and women. Whether you're looking for outpatient options, treatment with methadone/buprenorphine/naltrexone, or standard outpatient care, this facility creates individualized treatment strategies to assist each person on their recovery journey.

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Cumberland River Behavioral Health, located in Barbourville, KY, provides a variety of treatments for substance use and unique programs aimed at children and adults facing dual diagnosis of mental health disorders. The center offers different levels of outpatient care, including intensive outpatient and standard outpatient services, employing methods like anger management, brief interventions, and cognitive behavioral therapy. With specialized programs designed for teenagers as well as adult men and women, the facility meets the needs of various age and gender demographics. Cumberland River Behavioral Health is committed to delivering high-quality care and support to those in pursuit of effective rehabilitation within a nurturing and professional setting.

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Cumberland River Behavioral Health, situated in Mount Vernon, KY, provides outstanding outpatient services for individuals dealing with substance use issues. This center is adept at addressing co-occurring substance use disorders along with significant mental health challenges in adults, as well as serious emotional issues in children. The therapeutic methods utilized encompass anger management, brief intervention, and cognitive behavioral therapy. The facility offers tailored programs for teenagers, adult men, and women, ensuring it meets the unique needs of various age groups and genders. Dedicated to delivering high-quality care for adults and the elderly, Cumberland River Behavioral Health serves as a reliable option for those in need of effective rehabilitation solutions.

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Cumberland River Behavioral Health, located in Middlesboro, KY, provides outpatient treatment for adults dealing with substance use issues alongside serious mental health disorders. The center's offerings encompass anger management, brief interventions, and cognitive behavioral therapy. They cater to specific populations, including adolescents and both adult men and women. With a commitment to serving all adults and seniors regardless of gender, this facility emphasizes personalized care that meets the unique needs of each individual. Through a diverse range of treatment methods and focused programs, Cumberland River Behavioral Health aims to assist individuals in their recovery process.

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Cumberland River Behavioral Health in Manchester, KY, provides outpatient care for individuals struggling with substance use and co-occurring mental health conditions. They support adults with severe mental health challenges and children experiencing emotional disturbances. Their therapeutic offerings encompass anger management, brief intervention, and cognitive behavioral therapy. The center features distinct programs designed for adolescents, adult men, and adult women, accommodating diverse gender needs. Emphasizing a client-centered approach for adults and seniors, Cumberland River Behavioral Health delivers effective, individualized treatment strategies.

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Cumberland River Behavioral Health, situated in McKee, KY, delivers comprehensive outpatient care for individuals of all ages struggling with substance use and co-occurring mental health conditions. Their approach incorporates scientifically-backed methods such as anger management, brief intervention, and cognitive behavioral therapy. Dedicated tracks are available for adolescents, adult men, and adult women. The center is committed to offering personalized, high-quality treatment for adults and seniors across all genders, emphasizing a holistic recovery process. Cumberland River Behavioral Health is recognized for its specialized programs and steadfast dedication to supporting effective rehabilitation.

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At Cumberland River Behavioral Health in Harlan, KY, adults and seniors facing challenges with substance abuse and concurrent mental health conditions can find a wide array of recovery support. The facility presents various levels of care, including intensive outpatient, standard outpatient, and less intensive outpatient treatment plans, all customized to each person's specific requirements. Emphasizing techniques such as anger management, brief intervention, and cognitive behavioral therapy, this establishment also delivers targeted programs for young people, adult men, and adult women. By serving both male and female individuals, Cumberland River Behavioral Health cultivates an encouraging and welcoming atmosphere for anyone pursuing effective addiction recovery and mental wellness services.

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Cumberland River Behavioral Health in Corbin, KY, provides outpatient services for individuals of all ages struggling with addiction, with a particular focus on those also experiencing significant mental health conditions. Their standard outpatient offerings utilize proven therapeutic methods, including anger management techniques, brief intervention strategies, and cognitive behavioral therapy. The center caters to specific demographic needs with specialized care for adult men, adult women, and dedicated programs for seniors. Emphasizing personalized recovery plans, Cumberland River Behavioral Health is committed to delivering effective support for both men and women navigating substance use disorders and co-occurring mental health concerns.

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Cumberland River Behavioral Health in Williamsburg, KY, delivers outpatient services for individuals facing substance use and co-occurring mental health challenges. They serve adults with significant mental health conditions, as well as children with serious emotional disruptions. Dedicated programs are available for teenagers, adult men, and adult women. Therapeutic methods employed include anger management techniques, brief intervention strategies, and cognitive behavioral therapy. This center accommodates adult men and women, along with seniors, prioritizing customized, quality care. Through a variety of focused initiatives and scientifically supported therapies, Cumberland River Behavioral Health commits to assisting individuals in achieving lasting recovery.

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Cumberland River Behavioral Health, situated in Pittsburg, KY, provides dedicated support for adults battling substance use disorders, particularly those with concurrent severe mental health conditions. The facility offers a spectrum of care, encompassing intensive outpatient, outpatient, and standard outpatient treatment modalities. They employ proven therapeutic methods like anger management, brief intervention strategies, and cognitive behavioral therapy. Catering to various demographics, Cumberland River Behavioral Health features distinct programs for adolescents, adult men, and adult women. Their services extend to adults and seniors across all genders, guaranteeing tailored recovery journeys for everyone who seeks assistance.

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Cumberland River Behavioral Health in Pineville, KY, delivers a complete spectrum of addiction treatment services, featuring tailored support for those facing concurrent serious mental health challenges. Their offerings include intensive, standard, and traditional outpatient care. Employing proven methods such as cognitive behavioral therapy and anger management, this establishment serves adults and seniors, with dedicated programs for young people, adult men, and adult women. Dedicated to high standards of care, Cumberland River Behavioral Health fosters a nurturing setting for individuals pursuing recovery and well-being.

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Indianapolis, IN

Cummins BH Systems Inc in Indianapolis, IN, offers comprehensive substance use treatment with a focus on co-occurring serious mental health issues in adults and emotional disturbances in children. Their outpatient programs feature intensive care and specialized methadone/buprenorphine treatments. The center adopts evidence-based approaches including anger management, brief interventions, and cognitive behavioral therapy. With tailored programs for adolescents, adult men, and women, Cummins BH Systems Inc caters to diverse needs. Serving adults and children, this facility provides gender-specific care for both males and females. Clients can expect high-quality, individualized treatment to support their journey towards recovery.

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Greencastle, IN

Situated in Greencastle, IN, Cummins BH Systems Inc delivers extensive treatment for substance abuse alongside specialized support for individuals facing severe mental health challenges. The center features a range of treatment options, including intensive outpatient programs and outpatient care using methadone and buprenorphine. Emphasizing techniques like cognitive behavioral therapy, anger management, and brief interventions, this facility customizes its offerings to address the unique requirements of each client. It also provides dedicated programs aimed at adolescents and adult men and women, catering to a diverse demographic. With a strong dedication to providing superior care, Cummins BH Systems Inc is a reliable option for individuals seeking impactful rehabilitation aid.

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Crawfordsville, IN

Cummins BH Systems Inc, located in Crawfordsville, IN, is dedicated to providing extensive support for individuals facing substance use challenges, particularly those also managing serious mental health conditions. The facility offers a range of therapeutic options, including intensive outpatient, standard outpatient, and medication-assisted treatment with methadone, buprenorphine, or naltrexone. Their approach incorporates specialized therapies such as anger management, brief intervention, and cognitive behavioral therapy, all customized to meet the unique requirements of each person. Cummins BH Systems Inc also features distinct programs for adolescents, adult men, and adult women, ensuring that care is tailored to specific age groups and genders. They serve both adults and younger individuals, offering gender-affirming care. Cummins BH Systems Inc is committed to delivering high-standard care within a nurturing atmosphere, guiding clients toward sustained well-being and recovery.

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Cummins BH Systems Inc, located in Avon, IN, provides comprehensive, science-backed therapies for addiction and related mental health challenges. Their offerings encompass intensive outpatient services, standard outpatient care, and specific medication-assisted treatments like methadone, buprenorphine, or naltrexone. Utilizing methodologies such as anger management, brief intervention, and cognitive behavioral therapy, the center serves adults and young people. They feature distinct programs for adult males, adult females, and adolescents, all designed to foster healing and well-being in a nurturing setting for all clients.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated October 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)