Buprenorphine Treatment Centers in South Carolina
Medically reviewed by Sarah Mitchell, LCSWLast reviewed: April 2026
Our directory lists 65 buprenorphine providers across South Carolina, with the largest concentrations in Greenville (7), Florence (5) and Columbia (3).
Buprenorphine (Suboxone, Subutex, Sublocade, Zubsolv) is a partial opioid agonist that reduces cravings and withdrawal symptoms for opioid use disorder. It can be prescribed in outpatient settings by qualified clinicians.
Treatment landscape in South Carolina:
- SC Medicaid covers substance abuse treatment
- Coastal and inland treatment options
- Faith-based and traditional programs
- Growing specialty treatment centers
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Buprenorphine providers in South Carolina
Greenville · 7 centers

Life Line Services LLC
Greenville, SC
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Crossroads Treatment Centers
Greenville, SC
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Phoenix Center
Greenville, SC
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Florence · 5 centers

Starting Point of Florence PC
Florence, SC
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Circle Park Behavioral Health Services
Florence, SC
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Charleston · 3 centers

Lantana Recovery
Charleston, SC
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Ralph H Johnson VA Medical Center
Charleston, SC
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Columbia · 3 centers

Crossroads Treatment Centers
Columbia, SC
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LRADAC
Columbia, SC
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Myrtle Beach · 3 centers

Myrtle Beach Treatment Specialists
Myrtle Beach, SC
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Center of HOPE of Myrtle Beach LLC
Myrtle Beach, SC
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South Strand Internists
Myrtle Beach, SC
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North Charleston · 3 centers

Transcendence Treatment Center LLC
North Charleston, SC
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Center for Behavioral Health
North Charleston, SC
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Charleston Center of Charleston County
North Charleston, SC
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Conway · 2 centers

Lighthouse Behavioral Health Hospital
Conway, SC
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Greenwood · 2 centers

Cornerstone
Greenwood, SC
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Lancaster · 2 centers
Orangeburg · 2 centers

Tri County Commission on
Orangeburg, SC
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William J McCord
Orangeburg, SC
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Rock Hill · 2 centers

Keystone Substance Abuse Services
Rock Hill, SC
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Spartanburg · 2 centers

Mel Med LLC
Spartanburg, SC
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Sumter · 2 centers

Tandem Health
Sumter, SC
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Abbeville · 1 center

Cornerstone
Abbeville, SC
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Aiken · 1 center
Anderson · 1 center
Barnwell · 1 center

Axis I Center of Barnwell
Barnwell, SC
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Beaufort · 1 center
Clinton · 1 center
Dillon · 1 center
Duncan · 1 center
Easley · 1 center

Recovery Concepts of Carolina Upstate
Easley, SC
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Edgefield · 1 center

Cornerstone
Edgefield, SC
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Fort Mill · 1 center
Gaffney · 1 center
Georgetown · 1 center
Greer · 1 center

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Hartsville · 1 center
Lexington · 1 center

LRADAC
Lexington, SC
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Mc Cormick · 1 center

Cornerstone
Mc Cormick, SC
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Moncks Corner · 1 center
Mullins · 1 center
Newberry · 1 center

Westview Behavioral Health Services
Newberry, SC
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Pickens · 1 center
Saluda · 1 center

Westview Behavioral Health Services
Saluda, SC
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Seneca · 1 center

Crossroads Treatment Centers
Seneca, SC
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Simpsonville · 1 center

Ascent Recovery Solutions
Simpsonville, SC
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Summerville · 1 center

Dorchester County Commission on
Summerville, SC
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West Columbia · 1 center

Lexington Treatment Specialists
West Columbia, SC
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Winnsboro · 1 center

Fairfield Behavioral Health Services
Winnsboro, SC
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Healthy Connections
Healthy Connections covers buprenorphine and naltrexone; methadone coverage is available at licensed OTPs across the state.
State regulations
South Carolina Department of Alcohol and Other Drug Abuse Services (DAODAS) licenses OTPs and funds 17 county alcohol and drug authorities.
- Cash or self-payment64
- Medicaid58
- Private health insurance57
- Federal, or any government funding for substance use treatment programs47
- SAMHSA funding/block grants45
- State-financed health insurance plan other than Medicaid36
- Outpatient63
- Outpatient methadone/buprenorphine or naltrexone treatment54
- Regular outpatient treatment52
- Intensive outpatient treatment27
- Outpatient detoxification13
Frequently Asked Questions About Buprenorphine in South Carolina
Do I have to be in active withdrawal to begin buprenorphine?
For buprenorphine, patients typically need to be in mild withdrawal before the first dose to avoid precipitated withdrawal. Methadone can be started without withdrawal, and naltrexone requires 7–14 opioid-free days. Your South Carolina provider will explain the induction protocol that applies to your medication.
Is buprenorphine cheaper in Greenville than in rural South Carolina?
Costs can vary modestly by location — Greenville has more buprenorphine providers competing on price, and several FQHCs offering sliding-scale fees. Rural South Carolina has fewer options, and patients may incur travel costs, but per-visit fees are often comparable.
Does Healthy Connections cover telehealth MAT visits in South Carolina?
Yes. Healthy Connections reimburses telehealth buprenorphine visits at parity with in-person visits in South Carolina; methadone induction still generally requires an in-person visit due to federal OTP rules. Follow-up methadone counseling can be telehealth.
Does insurance cover the counseling portion of buprenorphine the same as the medication?
Yes. Parity law requires equal coverage for the medication and counseling components of MAT. Counseling copays often match mental-health visit copays (typically $20–$50 for commercial plans in South Carolina). Providers bill counseling and medication separately.
Does South Carolina allow emergency-department MAT induction?
Yes. South Carolina hospitals routinely start buprenorphine in the ED and bridge patients to outpatient MAT. The state’s opioid-response plan funds ED warm-handoff coordinators who connect patients to buprenorphine providers in their home zip code before discharge.
Can I take buprenorphine while travelling outside South Carolina?
Yes. Buprenorphine and naltrexone prescriptions travel with you. For methadone, your clinic coordinates with an out-of-state guest-dosing OTP; plan at least 2 weeks ahead for domestic travel, longer for international. Ask the clinic about guest-dosing letters.
How long does the first buprenorphine appointment take?
The first appointment typically runs 90–180 minutes: medical history, physical exam, intake paperwork, counseling assessment, lab tests, and the first dose or prescription. Plan for 2–3 hours and arrange transportation in case of post-dose drowsiness.
Will I get medication on the first day of buprenorphine?
Usually yes. South Carolina programs following low-barrier protocols provide the first buprenorphine dose or naltrexone prescription on day one. Methadone first doses are administered in-clinic and require SAMHSA-certified protocols that are typically completed during the intake visit.
What are the common side effects of buprenorphine?
Common side effects are usually mild and transient: nausea, constipation, headache, drowsiness, sweating, and insomnia. Most resolve within 1–2 weeks of dose stabilization. Persistent side effects are addressed by dose adjustment or switching medications at your South Carolina clinic.
Can I start buprenorphine while already pregnant?
Yes. Starting MAT during pregnancy is strongly recommended for patients with OUD. South Carolina perinatal-addiction programs offer priority same-day access; OB-MAT coordinated care improves maternal and infant outcomes dramatically compared to untreated OUD.
What happens in buprenorphine counseling sessions?
Sessions cover craving management, relapse-prevention skills, coping strategies, relationship issues, trauma processing if relevant, and goal setting for recovery. The counselor and client collaborate on a written treatment plan that is updated every 30–90 days in South Carolina.
Can I be fired for taking buprenorphine in South Carolina?
Under the ADA, you cannot be fired solely because you are enrolled in buprenorphine. Current illegal drug use is not protected, but lawful MAT enrollment is. Safety-sensitive roles (CDL, aviation) have additional rules — an employment attorney can review your specific situation.
Other Treatment Options in South Carolina
Buprenorphine Treatment in Other States
Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)

















