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Medically Reviewed Content
Updated: April 2026
Sources: SAMHSA, NIDA

Buprenorphine Treatment Centers in South Carolina

Medically reviewed by Sarah Mitchell, LCSWLast reviewed: April 2026

Our directory lists 65 buprenorphine providers across South Carolina, with the largest concentrations in Greenville (7), Florence (5) and Columbia (3).

Buprenorphine (Suboxone, Subutex, Sublocade, Zubsolv) is a partial opioid agonist that reduces cravings and withdrawal symptoms for opioid use disorder. It can be prescribed in outpatient settings by qualified clinicians.

Treatment landscape in South Carolina:

  • SC Medicaid covers substance abuse treatment
  • Coastal and inland treatment options
  • Faith-based and traditional programs
  • Growing specialty treatment centers

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Buprenorphine providers in South Carolina

Filters:

Greenville · 7 centers

Life Line Services LLC - Facility Image
$$

Services:

DetoxificationSubstance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Crossroads Treatment Centers - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment
Greenville Metro Treatment Center - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Florence · 5 centers

HopeHealth Inc - Facility Image

HopeHealth Inc

Florence, SC

Insurance Accepted$$

Services:

Substance use treatment
Starting Point of Florence PC - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment
Circle Park Behavioral Health Services - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Charleston · 3 centers

Lantana Recovery - Facility Image

Lantana Recovery

Charleston, SC

Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Ralph H Johnson VA Medical Center - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Crossroads Treatment Centers - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Columbia · 3 centers

Crossroads Treatment Centers - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment
LRADAC - Facility Image

LRADAC

Columbia, SC

Insurance Accepted$$

Services:

DetoxificationSubstance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Prisma Health - Facility Image

Prisma Health

Columbia, SC

Insurance Accepted$$

Services:

DetoxificationSubstance use treatment

Myrtle Beach · 3 centers

Myrtle Beach Treatment Specialists - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment
Center of HOPE of Myrtle Beach LLC - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment
South Strand Internists - Facility Image

South Strand Internists

Myrtle Beach, SC

Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

North Charleston · 3 centers

Transcendence Treatment Center LLC - Facility Image
Insurance Accepted$$

Services:

Substance use treatment
Center for Behavioral Health - Facility Image

Center for Behavioral Health

North Charleston, SC

Insurance Accepted$$

Services:

DetoxificationSubstance use treatment
Charleston Center of Charleston County - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment

Conway · 2 centers

Shoreline Behavioral Health Services - Facility Image
Insurance Accepted$$

Services:

Substance use treatment
Lighthouse Behavioral Health Hospital - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Greenwood · 2 centers

Cornerstone - Facility Image

Cornerstone

Greenwood, SC

Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Greenwood Treatment Specialists - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Lancaster · 2 centers

Counseling Services of Lancaster - Facility Image
Insurance Accepted$$

Services:

Substance use treatment
Lancaster Treatment Specialists - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Orangeburg · 2 centers

Tri County Commission on - Facility Image
Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
William J McCord - Facility Image

William J McCord

Orangeburg, SC

Insurance Accepted$$

Services:

DetoxificationSubstance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Rock Hill · 2 centers

Keystone Substance Abuse Services - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment
Rock Hill Treatment Specialists - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Spartanburg · 2 centers

Mel Med LLC - Facility Image

Mel Med LLC

Spartanburg, SC

$$

Services:

DetoxificationSubstance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
BHG Spartanburg Treatment Center - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Sumter · 2 centers

Tandem Health - Facility Image

Tandem Health

Sumter, SC

Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Sumter Treatment Specialists - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Abbeville · 1 center

Cornerstone - Facility Image

Cornerstone

Abbeville, SC

Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Aiken · 1 center

BHG Aiken Treatment Center - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Anderson · 1 center

Southwest Carolina Trt Ctr LLC - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Barnwell · 1 center

Placeholder image
Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Beaufort · 1 center

Placeholder image

Beaufort County

Beaufort, SC

Insurance Accepted$$

Services:

Substance use treatment

Clinton · 1 center

Clear Skye Treatment Center - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Dillon · 1 center

Trinity Behavioral Care - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Duncan · 1 center

Placeholder image
Insurance Accepted$$

Services:

Substance use treatment

Easley · 1 center

Recovery Concepts of Carolina Upstate - Facility Image
Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Edgefield · 1 center

Placeholder image

Cornerstone

Edgefield, SC

Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Fort Mill · 1 center

York County Treatment Center - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Gaffney · 1 center

Clear Skye Treatment Center - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Georgetown · 1 center

Placeholder image

Georgetown County

Georgetown, SC

Insurance Accepted$$

Services:

Substance use treatment

Greer · 1 center

Carolina Center for Behavioral Health - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Hartsville · 1 center

Starting Point of Darlington - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Lexington · 1 center

LRADAC - Facility Image

LRADAC

Lexington, SC

Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Mc Cormick · 1 center

Cornerstone - Facility Image

Cornerstone

Mc Cormick, SC

Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Moncks Corner · 1 center

Placeholder image

Ernest E Kennedy Center

Moncks Corner, SC

Insurance Accepted$$

Services:

Substance use treatment

Mullins · 1 center

Trinity Behavioral Care - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Newberry · 1 center

Westview Behavioral Health Services - Facility Image
Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Pickens · 1 center

Placeholder image
Insurance Accepted$$

Services:

Substance use treatment

Saluda · 1 center

Placeholder image
Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Seneca · 1 center

Crossroads Treatment Centers - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment

Simpsonville · 1 center

Ascent Recovery Solutions - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment

Summerville · 1 center

Dorchester County Commission on - Facility Image
Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

West Columbia · 1 center

Lexington Treatment Specialists - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Winnsboro · 1 center

Fairfield Behavioral Health Services - Facility Image
Insurance Accepted$$

Services:

Substance use treatment
Coverage & Regulations in South Carolina

Healthy Connections

Healthy Connections covers buprenorphine and naltrexone; methadone coverage is available at licensed OTPs across the state.

State regulations

South Carolina Department of Alcohol and Other Drug Abuse Services (DAODAS) licenses OTPs and funds 17 county alcohol and drug authorities.

SAMHSA National Helpline: 1-800-662-4357Crisis: 988
Commonly Accepted Insurance
  • Cash or self-payment64
  • Medicaid58
  • Private health insurance57
  • Federal, or any government funding for substance use treatment programs47
  • SAMHSA funding/block grants45
  • State-financed health insurance plan other than Medicaid36
Available Settings
  • Outpatient63
  • Outpatient methadone/buprenorphine or naltrexone treatment54
  • Regular outpatient treatment52
  • Intensive outpatient treatment27
  • Outpatient detoxification13

Frequently Asked Questions About Buprenorphine in South Carolina

Do I have to be in active withdrawal to begin buprenorphine?

For buprenorphine, patients typically need to be in mild withdrawal before the first dose to avoid precipitated withdrawal. Methadone can be started without withdrawal, and naltrexone requires 7–14 opioid-free days. Your South Carolina provider will explain the induction protocol that applies to your medication.

Is buprenorphine cheaper in Greenville than in rural South Carolina?

Costs can vary modestly by location — Greenville has more buprenorphine providers competing on price, and several FQHCs offering sliding-scale fees. Rural South Carolina has fewer options, and patients may incur travel costs, but per-visit fees are often comparable.

Does Healthy Connections cover telehealth MAT visits in South Carolina?

Yes. Healthy Connections reimburses telehealth buprenorphine visits at parity with in-person visits in South Carolina; methadone induction still generally requires an in-person visit due to federal OTP rules. Follow-up methadone counseling can be telehealth.

Does insurance cover the counseling portion of buprenorphine the same as the medication?

Yes. Parity law requires equal coverage for the medication and counseling components of MAT. Counseling copays often match mental-health visit copays (typically $20–$50 for commercial plans in South Carolina). Providers bill counseling and medication separately.

Does South Carolina allow emergency-department MAT induction?

Yes. South Carolina hospitals routinely start buprenorphine in the ED and bridge patients to outpatient MAT. The state’s opioid-response plan funds ED warm-handoff coordinators who connect patients to buprenorphine providers in their home zip code before discharge.

Can I take buprenorphine while travelling outside South Carolina?

Yes. Buprenorphine and naltrexone prescriptions travel with you. For methadone, your clinic coordinates with an out-of-state guest-dosing OTP; plan at least 2 weeks ahead for domestic travel, longer for international. Ask the clinic about guest-dosing letters.

How long does the first buprenorphine appointment take?

The first appointment typically runs 90–180 minutes: medical history, physical exam, intake paperwork, counseling assessment, lab tests, and the first dose or prescription. Plan for 2–3 hours and arrange transportation in case of post-dose drowsiness.

Will I get medication on the first day of buprenorphine?

Usually yes. South Carolina programs following low-barrier protocols provide the first buprenorphine dose or naltrexone prescription on day one. Methadone first doses are administered in-clinic and require SAMHSA-certified protocols that are typically completed during the intake visit.

What are the common side effects of buprenorphine?

Common side effects are usually mild and transient: nausea, constipation, headache, drowsiness, sweating, and insomnia. Most resolve within 1–2 weeks of dose stabilization. Persistent side effects are addressed by dose adjustment or switching medications at your South Carolina clinic.

Can I start buprenorphine while already pregnant?

Yes. Starting MAT during pregnancy is strongly recommended for patients with OUD. South Carolina perinatal-addiction programs offer priority same-day access; OB-MAT coordinated care improves maternal and infant outcomes dramatically compared to untreated OUD.

What happens in buprenorphine counseling sessions?

Sessions cover craving management, relapse-prevention skills, coping strategies, relationship issues, trauma processing if relevant, and goal setting for recovery. The counselor and client collaborate on a written treatment plan that is updated every 30–90 days in South Carolina.

Can I be fired for taking buprenorphine in South Carolina?

Under the ADA, you cannot be fired solely because you are enrolled in buprenorphine. Current illegal drug use is not protected, but lawful MAT enrollment is. Safety-sensitive roles (CDL, aviation) have additional rules — an employment attorney can review your specific situation.

Other Treatment Options in South Carolina

Buprenorphine Treatment in Other States

Medically ReviewedUpdated: April 2026
Sources:SAMHSANIDACDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)