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Medically Reviewed Content
Updated: April 2026
Sources: SAMHSA, NIDA

Naltrexone Treatment Centers in South Carolina

Medically reviewed by Sarah Mitchell, LCSWLast reviewed: April 2026

Our directory lists 43 naltrexone providers across South Carolina, with the largest concentrations in Greenville (5), Florence (4) and North Charleston (3).

Naltrexone (Vivitrol, Revia) is an opioid antagonist used to treat both alcohol use disorder and opioid dependence. Available as a daily oral tablet or monthly extended-release injection, it blocks opioid receptors to reduce cravings and prevent relapse.

Treatment landscape in South Carolina:

  • SC Medicaid covers substance abuse treatment
  • Coastal and inland treatment options
  • Faith-based and traditional programs
  • Growing specialty treatment centers

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Naltrexone providers in South Carolina

Filters:

Greenville · 5 centers

Life Line Services LLC - Facility Image
$$

Services:

DetoxificationSubstance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Phoenix Center - Facility Image

Phoenix Center

Greenville, SC

Insurance Accepted$$

Services:

DetoxificationSubstance use treatment
Placeholder image

Pavillon

Greenville, SC

Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Florence · 4 centers

HopeHealth Inc - Facility Image

HopeHealth Inc

Florence, SC

Insurance Accepted$$

Services:

Substance use treatment
Circle Park Behavioral Health Services - Facility Image
Insurance Accepted$$

Services:

Substance use treatment
Florence Treatment Specialists - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

North Charleston · 3 centers

Transcendence Treatment Center LLC - Facility Image
Insurance Accepted$$

Services:

Substance use treatment
Center for Behavioral Health - Facility Image

Center for Behavioral Health

North Charleston, SC

Insurance Accepted$$

Services:

DetoxificationSubstance use treatment
Charleston Center of Charleston County - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment

Charleston · 2 centers

Lantana Recovery - Facility Image

Lantana Recovery

Charleston, SC

Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Ralph H Johnson VA Medical Center - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Columbia · 2 centers

LRADAC - Facility Image

LRADAC

Columbia, SC

Insurance Accepted$$

Services:

DetoxificationSubstance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Prisma Health - Facility Image

Prisma Health

Columbia, SC

Insurance Accepted$$

Services:

DetoxificationSubstance use treatment

Gaffney · 2 centers

Clear Skye Treatment Center - Facility Image
Insurance Accepted$$

Services:

Substance use treatment
Placeholder image
Insurance Accepted$$

Services:

Substance use treatment

Myrtle Beach · 2 centers

Myrtle Beach Treatment Specialists - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment
South Strand Internists - Facility Image

South Strand Internists

Myrtle Beach, SC

Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Orangeburg · 2 centers

Tri County Commission on - Facility Image
Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
William J McCord - Facility Image

William J McCord

Orangeburg, SC

Insurance Accepted$$

Services:

DetoxificationSubstance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Anderson · 1 center

Placeholder image

Anderson/Oconee

Anderson, SC

Insurance Accepted$$

Services:

Substance use treatment

Barnwell · 1 center

Placeholder image
Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Bishopville · 1 center

Placeholder image

Lee Center

Bishopville, SC

Insurance Accepted$$

Services:

Substance use treatment

Camden · 1 center

ALPHA Behavioral Health Center - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Chesterfield · 1 center

ALPHA Behavioral Health Center - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Conway · 1 center

Shoreline Behavioral Health Services - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Dillon · 1 center

Trinity Behavioral Care - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Georgetown · 1 center

Placeholder image

Georgetown County

Georgetown, SC

Insurance Accepted$$

Services:

Substance use treatment

Greer · 1 center

Carolina Center for Behavioral Health - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Lancaster · 1 center

Counseling Services of Lancaster - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Lexington · 1 center

LRADAC - Facility Image

LRADAC

Lexington, SC

Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Moncks Corner · 1 center

Placeholder image

Ernest E Kennedy Center

Moncks Corner, SC

Insurance Accepted$$

Services:

Substance use treatment

Mullins · 1 center

Trinity Behavioral Care - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Newberry · 1 center

Westview Behavioral Health Services - Facility Image
Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Pickens · 1 center

Placeholder image
Insurance Accepted$$

Services:

Substance use treatment

Rock Hill · 1 center

Keystone Substance Abuse Services - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment

Saluda · 1 center

Placeholder image
Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Seneca · 1 center

Anderson/Oconee - Facility Image

Anderson/Oconee

Seneca, SC

Insurance Accepted$$

Services:

Substance use treatment

Spartanburg · 1 center

Mel Med LLC - Facility Image

Mel Med LLC

Spartanburg, SC

$$

Services:

DetoxificationSubstance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Sumter · 1 center

Tandem Health - Facility Image

Tandem Health

Sumter, SC

Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Winnsboro · 1 center

Fairfield Behavioral Health Services - Facility Image
Insurance Accepted$$

Services:

Substance use treatment
Coverage & Regulations in South Carolina

Healthy Connections

Healthy Connections covers buprenorphine and naltrexone; methadone coverage is available at licensed OTPs across the state.

State regulations

South Carolina Department of Alcohol and Other Drug Abuse Services (DAODAS) licenses OTPs and funds 17 county alcohol and drug authorities.

SAMHSA National Helpline: 1-800-662-4357Crisis: 988
Commonly Accepted Insurance
  • Cash or self-payment42
  • Private health insurance41
  • Medicaid35
  • Federal, or any government funding for substance use treatment programs33
  • SAMHSA funding/block grants32
  • State-financed health insurance plan other than Medicaid23
Available Settings
  • Outpatient41
  • Regular outpatient treatment38
  • Outpatient methadone/buprenorphine or naltrexone treatment32
  • Intensive outpatient treatment24
  • Outpatient detoxification7

Frequently Asked Questions About Naltrexone in South Carolina

Can adolescents start naltrexone in South Carolina?

Patients 16 and older can generally be admitted to MAT including naltrexone with parental consent; some South Carolina providers specialize in youth MAT and follow American Academy of Pediatrics guidance. For patients under 18, two documented failed detox attempts are typically required before methadone, per federal rule.

What is the cheapest way to get naltrexone in South Carolina?

For most South Carolina residents, Healthy Connections is the lowest-cost option — co-pays are usually $0–$3. Without Medicaid, federally qualified health centers with sliding-scale fees are next cheapest, followed by State Opioid Response–funded clinics.

Does Healthy Connections cover long-acting buprenorphine (Sublocade) or naltrexone (Vivitrol)?

Yes. Healthy Connections covers Sublocade and Vivitrol as part of the MAT benefit; most plans require prior authorization documenting prior MAT adherence. Billing is handled by the South Carolina provider as a medical (not pharmacy) benefit.

Does insurance cover the counseling portion of naltrexone the same as the medication?

Yes. Parity law requires equal coverage for the medication and counseling components of MAT. Counseling copays often match mental-health visit copays (typically $20–$50 for commercial plans in South Carolina). Providers bill counseling and medication separately.

How often are naltrexone providers in South Carolina inspected?

SAMHSA surveys OTPs in South Carolina at least every 3 years; the state licensing agency conducts annual inspections. The DEA also audits controlled-substance handling. Accreditation bodies (CARF, Joint Commission) conduct separate 3-year cycles for many naltrexone providers.

Is there a maximum length of time I can stay on naltrexone in South Carolina?

No. There is no legal or clinical cap on how long you can remain on naltrexone in South Carolina. Insurance must continue to cover MAT as long as the prescribing clinician documents medical necessity.

Can I start naltrexone while I’m still using opioids?

For methadone and buprenorphine, continued opioid use at entry is expected — the medication is designed to stop use safely. For naltrexone, 7–14 opioid-free days are required first. Your South Carolina clinician will confirm the correct induction strategy at intake.

What happens if my drug screen is positive at the first visit?

A positive urine drug screen is expected for most patients entering MAT — it confirms the diagnosis. Positive screens are not used to deny admission at any South Carolina SAMHSA-certified OTP. Your clinician interprets results and builds an individualized plan from there.

What should I do if I miss a dose of naltrexone?

For sublingual buprenorphine or oral methadone, take the next dose at the scheduled time — do not double up. For monthly Sublocade or Vivitrol, contact your South Carolina clinic immediately if you miss the injection window to schedule a catch-up visit and prevent withdrawal or overdose relapse risk.

Should I stop naltrexone when I find out I’m pregnant?

No — abrupt discontinuation is dangerous for the pregnancy. Call your South Carolina MAT clinic right away; the team will coordinate with obstetrics to continue medication safely and arrange any dose adjustments needed as the pregnancy progresses.

What is peer-recovery support and is it available in South Carolina?

Peer-recovery support workers are trained individuals with lived recovery experience who provide mentoring, accompaniment to appointments, and navigation of resources. South Carolina Medicaid reimburses peer-support services; most mid-sized naltrexone providers employ certified peer specialists.

Can I keep my naltrexone treatment private from my health-insurance company?

If you use insurance, the insurer sees billed services (including MAT). They cannot share that with your employer or family. If you strongly value privacy from insurance, self-pay is the only fully insulated option.

Other Treatment Options in South Carolina

Naltrexone Treatment in Other States

Medically ReviewedUpdated: April 2026
Sources:SAMHSANIDACDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)