Naltrexone Treatment Centers in South Carolina
Medically reviewed by Sarah Mitchell, LCSWLast reviewed: April 2026
Our directory lists 43 naltrexone providers across South Carolina, with the largest concentrations in Greenville (5), Florence (4) and North Charleston (3).
Naltrexone (Vivitrol, Revia) is an opioid antagonist used to treat both alcohol use disorder and opioid dependence. Available as a daily oral tablet or monthly extended-release injection, it blocks opioid receptors to reduce cravings and prevent relapse.
Treatment landscape in South Carolina:
- SC Medicaid covers substance abuse treatment
- Coastal and inland treatment options
- Faith-based and traditional programs
- Growing specialty treatment centers
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Naltrexone providers in South Carolina
Greenville · 5 centers

Life Line Services LLC
Greenville, SC
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Pavillon
Greenville, SC
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Phoenix Center
Greenville, SC
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Florence · 4 centers

Circle Park Behavioral Health Services
Florence, SC
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North Charleston · 3 centers

Transcendence Treatment Center LLC
North Charleston, SC
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Center for Behavioral Health
North Charleston, SC
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Charleston Center of Charleston County
North Charleston, SC
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Charleston · 2 centers

Lantana Recovery
Charleston, SC
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Ralph H Johnson VA Medical Center
Charleston, SC
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Columbia · 2 centers

LRADAC
Columbia, SC
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Gaffney · 2 centers
Myrtle Beach · 2 centers

Myrtle Beach Treatment Specialists
Myrtle Beach, SC
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South Strand Internists
Myrtle Beach, SC
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Orangeburg · 2 centers

Tri County Commission on
Orangeburg, SC
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William J McCord
Orangeburg, SC
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Anderson · 1 center
Barnwell · 1 center

Axis I Center of Barnwell
Barnwell, SC
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Bishopville · 1 center
Camden · 1 center
Chesterfield · 1 center
Conway · 1 center
Dillon · 1 center
Georgetown · 1 center
Greer · 1 center

Services:
Lancaster · 1 center
Lexington · 1 center

LRADAC
Lexington, SC
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Moncks Corner · 1 center
Mullins · 1 center
Newberry · 1 center

Westview Behavioral Health Services
Newberry, SC
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Pickens · 1 center
Rock Hill · 1 center

Keystone Substance Abuse Services
Rock Hill, SC
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Saluda · 1 center

Westview Behavioral Health Services
Saluda, SC
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Seneca · 1 center
Spartanburg · 1 center

Mel Med LLC
Spartanburg, SC
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Sumter · 1 center

Tandem Health
Sumter, SC
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Winnsboro · 1 center

Fairfield Behavioral Health Services
Winnsboro, SC
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Healthy Connections
Healthy Connections covers buprenorphine and naltrexone; methadone coverage is available at licensed OTPs across the state.
State regulations
South Carolina Department of Alcohol and Other Drug Abuse Services (DAODAS) licenses OTPs and funds 17 county alcohol and drug authorities.
- Cash or self-payment42
- Private health insurance41
- Medicaid35
- Federal, or any government funding for substance use treatment programs33
- SAMHSA funding/block grants32
- State-financed health insurance plan other than Medicaid23
- Outpatient41
- Regular outpatient treatment38
- Outpatient methadone/buprenorphine or naltrexone treatment32
- Intensive outpatient treatment24
- Outpatient detoxification7
Frequently Asked Questions About Naltrexone in South Carolina
Can adolescents start naltrexone in South Carolina?
Patients 16 and older can generally be admitted to MAT including naltrexone with parental consent; some South Carolina providers specialize in youth MAT and follow American Academy of Pediatrics guidance. For patients under 18, two documented failed detox attempts are typically required before methadone, per federal rule.
What is the cheapest way to get naltrexone in South Carolina?
For most South Carolina residents, Healthy Connections is the lowest-cost option — co-pays are usually $0–$3. Without Medicaid, federally qualified health centers with sliding-scale fees are next cheapest, followed by State Opioid Response–funded clinics.
Does Healthy Connections cover long-acting buprenorphine (Sublocade) or naltrexone (Vivitrol)?
Yes. Healthy Connections covers Sublocade and Vivitrol as part of the MAT benefit; most plans require prior authorization documenting prior MAT adherence. Billing is handled by the South Carolina provider as a medical (not pharmacy) benefit.
Does insurance cover the counseling portion of naltrexone the same as the medication?
Yes. Parity law requires equal coverage for the medication and counseling components of MAT. Counseling copays often match mental-health visit copays (typically $20–$50 for commercial plans in South Carolina). Providers bill counseling and medication separately.
How often are naltrexone providers in South Carolina inspected?
SAMHSA surveys OTPs in South Carolina at least every 3 years; the state licensing agency conducts annual inspections. The DEA also audits controlled-substance handling. Accreditation bodies (CARF, Joint Commission) conduct separate 3-year cycles for many naltrexone providers.
Is there a maximum length of time I can stay on naltrexone in South Carolina?
No. There is no legal or clinical cap on how long you can remain on naltrexone in South Carolina. Insurance must continue to cover MAT as long as the prescribing clinician documents medical necessity.
Can I start naltrexone while I’m still using opioids?
For methadone and buprenorphine, continued opioid use at entry is expected — the medication is designed to stop use safely. For naltrexone, 7–14 opioid-free days are required first. Your South Carolina clinician will confirm the correct induction strategy at intake.
What happens if my drug screen is positive at the first visit?
A positive urine drug screen is expected for most patients entering MAT — it confirms the diagnosis. Positive screens are not used to deny admission at any South Carolina SAMHSA-certified OTP. Your clinician interprets results and builds an individualized plan from there.
What should I do if I miss a dose of naltrexone?
For sublingual buprenorphine or oral methadone, take the next dose at the scheduled time — do not double up. For monthly Sublocade or Vivitrol, contact your South Carolina clinic immediately if you miss the injection window to schedule a catch-up visit and prevent withdrawal or overdose relapse risk.
Should I stop naltrexone when I find out I’m pregnant?
No — abrupt discontinuation is dangerous for the pregnancy. Call your South Carolina MAT clinic right away; the team will coordinate with obstetrics to continue medication safely and arrange any dose adjustments needed as the pregnancy progresses.
What is peer-recovery support and is it available in South Carolina?
Peer-recovery support workers are trained individuals with lived recovery experience who provide mentoring, accompaniment to appointments, and navigation of resources. South Carolina Medicaid reimburses peer-support services; most mid-sized naltrexone providers employ certified peer specialists.
Can I keep my naltrexone treatment private from my health-insurance company?
If you use insurance, the insurer sees billed services (including MAT). They cannot share that with your employer or family. If you strongly value privacy from insurance, self-pay is the only fully insulated option.
Other Treatment Options in South Carolina
Naltrexone Treatment in Other States
Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)









