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Medically Reviewed Content
Updated: April 2026
Sources: SAMHSA, NIDA

Methadone Treatment Centers in South Carolina

Medically reviewed by Sarah Mitchell, LCSWLast reviewed: April 2026

Our directory lists 24 methadone clinics across South Carolina, with the largest concentrations in Greenville (2), Florence (2) and North Charleston (2).

Methadone is a long-acting opioid medication used to treat opioid use disorder by eliminating withdrawal symptoms and cravings without producing a high. It is dispensed through federally certified Opioid Treatment Programs (OTPs) under strict SAMHSA and state regulations.

Treatment landscape in South Carolina:

  • SC Medicaid covers substance abuse treatment
  • Coastal and inland treatment options
  • Faith-based and traditional programs
  • Growing specialty treatment centers

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Methadone clinics in South Carolina

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Florence · 2 centers

Starting Point of Florence PC - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment
Florence Treatment Specialists - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Greenville · 2 centers

Crossroads Treatment Centers - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment
Greenville Metro Treatment Center - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Myrtle Beach · 2 centers

Myrtle Beach Treatment Specialists - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment
Center of HOPE of Myrtle Beach LLC - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment

North Charleston · 2 centers

Center for Behavioral Health - Facility Image

Center for Behavioral Health

North Charleston, SC

Insurance Accepted$$

Services:

DetoxificationSubstance use treatment
Charleston Center of Charleston County - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment

Aiken · 1 center

BHG Aiken Treatment Center - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Anderson · 1 center

Southwest Carolina Trt Ctr LLC - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Charleston · 1 center

Crossroads Treatment Centers - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Clinton · 1 center

Clear Skye Treatment Center - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Columbia · 1 center

Crossroads Treatment Centers - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment

Duncan · 1 center

Placeholder image
Insurance Accepted$$

Services:

Substance use treatment

Easley · 1 center

Recovery Concepts of Carolina Upstate - Facility Image
Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Fort Mill · 1 center

York County Treatment Center - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Greenwood · 1 center

Greenwood Treatment Specialists - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Hartsville · 1 center

Starting Point of Darlington - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Lancaster · 1 center

Lancaster Treatment Specialists - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Rock Hill · 1 center

Rock Hill Treatment Specialists - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Seneca · 1 center

Crossroads Treatment Centers - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment

Simpsonville · 1 center

Ascent Recovery Solutions - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment

Sumter · 1 center

Sumter Treatment Specialists - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

West Columbia · 1 center

Lexington Treatment Specialists - Facility Image
Insurance Accepted$$

Services:

Substance use treatment
Coverage & Regulations in South Carolina

Healthy Connections

Healthy Connections covers buprenorphine and naltrexone; methadone coverage is available at licensed OTPs across the state.

State regulations

South Carolina Department of Alcohol and Other Drug Abuse Services (DAODAS) licenses OTPs and funds 17 county alcohol and drug authorities.

SAMHSA National Helpline: 1-800-662-4357Crisis: 988
Commonly Accepted Insurance
  • Cash or self-payment24
  • Medicaid24
  • Medicare23
  • Private health insurance18
  • Federal, or any government funding for substance use treatment programs17
  • SAMHSA funding/block grants15
Available Settings
  • Outpatient24
  • Outpatient methadone/buprenorphine or naltrexone treatment24
  • Regular outpatient treatment17
  • Outpatient detoxification9
  • Intensive outpatient treatment1

Frequently Asked Questions About Methadone in South Carolina

Do I need insurance to enroll in methadone treatment?

No. You can pay out of pocket, use Healthy Connections if eligible, or qualify for sliding-scale rates at many South Carolina federally qualified health centers. Uninsured patients should still call methadone clinics to ask about grant-funded slots and state-funded treatment vouchers.

How much does methadone treatment cost in South Carolina?

Self-pay monthly cost for methadone in South Carolina typically ranges from $150 to $700, depending on medication, counseling intensity, and whether lab work is included. Long-acting injectables (Sublocade, Vivitrol) billed without insurance can exceed $1,500 per dose. Most patients pay far less through insurance or Healthy Connections.

What’s the difference between Healthy Connections managed-care plans for MAT?

Healthy Connections managed-care organizations (MCOs) in South Carolina all cover MAT, but formulary details, prior-authorization rules, and in-network provider lists vary. Choose the MCO whose network includes your preferred methadone clinics; you can usually switch plans once a year.

Does Medicare cover methadone in South Carolina?

Yes. Medicare Part B covers methadone through enrolled Opioid Treatment Programs and Part D covers buprenorphine and naltrexone prescriptions. Medicare Advantage plans in South Carolina include the same MAT benefits under the integrated plan structure.

Does South Carolina allow telehealth induction for MAT?

Yes. DEA rules were permanently expanded in 2024 to allow audio-video telehealth for initial buprenorphine prescribing, and South Carolina law mirrors federal policy. Methadone induction still requires an in-person visit at an OTP for the first dose, though subsequent counseling can be delivered via telehealth. Naltrexone can be prescribed via telehealth with labs done in South Carolina.

What are the most common reasons patients stop methadone?

Common reasons include lifestyle stabilization (patient and clinician agree to taper), cost barriers, side effects, travel or employment disruption, and desire to try naltrexone after tapering. Many patients resume treatment later — clinics welcome return visits without judgment.

What should I avoid before my first methadone visit?

Avoid benzodiazepines, alcohol, and long-acting opioids for 6–12 hours before induction to reduce sedation risk. For buprenorphine, let the clinician know your last opioid use time so they can time the first dose to avoid precipitated withdrawal.

How soon after the first visit do I come back?

Follow-up within 3–7 days is standard after the first methadone visit to confirm response and titrate the dose. South Carolina clinics may see stable patients weekly for the first month, then space visits out as stability is achieved.

Are there allergic reactions to methadone?

True allergic reactions to methadone, buprenorphine, or naltrexone are rare. Rash, swelling, or difficulty breathing after a dose should be treated as an emergency — call 911 or go to a South Carolina emergency department. The MAT team can switch medications after stabilization.

Will my baby go through withdrawal if I take methadone?

Neonatal Opioid Withdrawal Syndrome (NOWS) can occur in infants exposed to methadone or buprenorphine prenatally and is routinely monitored at South Carolina delivery hospitals. NOWS is manageable with skilled nursing care; most infants go home within days to weeks with normal outcomes.

Is telehealth counseling available with methadone in South Carolina?

Yes. South Carolina MAT programs routinely deliver individual counseling and group therapy by video. Telehealth counseling is reimbursed at parity by Healthy Connections and most commercial insurers under current state and federal parity rules.

Do my pharmacy records show that I’m on methadone in South Carolina?

Buprenorphine and naltrexone prescriptions appear on pharmacy records like other prescriptions and are visible to dispensing pharmacies and authorized users of the PDMP. Methadone dispensed at an OTP is not reported to retail pharmacy systems.

Other Treatment Options in South Carolina

Methadone Treatment in Other States

Medically ReviewedUpdated: April 2026
Sources:SAMHSANIDACDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)