Methadone Treatment Centers in South Carolina
Medically reviewed by Sarah Mitchell, LCSWLast reviewed: April 2026
Our directory lists 24 methadone clinics across South Carolina, with the largest concentrations in Greenville (2), Florence (2) and North Charleston (2).
Methadone is a long-acting opioid medication used to treat opioid use disorder by eliminating withdrawal symptoms and cravings without producing a high. It is dispensed through federally certified Opioid Treatment Programs (OTPs) under strict SAMHSA and state regulations.
Treatment landscape in South Carolina:
- SC Medicaid covers substance abuse treatment
- Coastal and inland treatment options
- Faith-based and traditional programs
- Growing specialty treatment centers
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Methadone clinics in South Carolina
Florence · 2 centers

Starting Point of Florence PC
Florence, SC
Services:
Greenville · 2 centers

Crossroads Treatment Centers
Greenville, SC
Services:
Myrtle Beach · 2 centers

Myrtle Beach Treatment Specialists
Myrtle Beach, SC
Services:

Center of HOPE of Myrtle Beach LLC
Myrtle Beach, SC
Services:
North Charleston · 2 centers

Center for Behavioral Health
North Charleston, SC
Services:

Charleston Center of Charleston County
North Charleston, SC
Services:
Aiken · 1 center
Anderson · 1 center
Charleston · 1 center
Clinton · 1 center
Columbia · 1 center

Crossroads Treatment Centers
Columbia, SC
Services:
Duncan · 1 center
Easley · 1 center

Recovery Concepts of Carolina Upstate
Easley, SC
Services:
Fort Mill · 1 center
Greenwood · 1 center
Hartsville · 1 center
Lancaster · 1 center
Rock Hill · 1 center
Seneca · 1 center

Crossroads Treatment Centers
Seneca, SC
Services:
Simpsonville · 1 center

Ascent Recovery Solutions
Simpsonville, SC
Services:
Sumter · 1 center
West Columbia · 1 center

Lexington Treatment Specialists
West Columbia, SC
Services:
Healthy Connections
Healthy Connections covers buprenorphine and naltrexone; methadone coverage is available at licensed OTPs across the state.
State regulations
South Carolina Department of Alcohol and Other Drug Abuse Services (DAODAS) licenses OTPs and funds 17 county alcohol and drug authorities.
- Cash or self-payment24
- Medicaid24
- Medicare23
- Private health insurance18
- Federal, or any government funding for substance use treatment programs17
- SAMHSA funding/block grants15
- Outpatient24
- Outpatient methadone/buprenorphine or naltrexone treatment24
- Regular outpatient treatment17
- Outpatient detoxification9
- Intensive outpatient treatment1
Frequently Asked Questions About Methadone in South Carolina
Do I need insurance to enroll in methadone treatment?
No. You can pay out of pocket, use Healthy Connections if eligible, or qualify for sliding-scale rates at many South Carolina federally qualified health centers. Uninsured patients should still call methadone clinics to ask about grant-funded slots and state-funded treatment vouchers.
How much does methadone treatment cost in South Carolina?
Self-pay monthly cost for methadone in South Carolina typically ranges from $150 to $700, depending on medication, counseling intensity, and whether lab work is included. Long-acting injectables (Sublocade, Vivitrol) billed without insurance can exceed $1,500 per dose. Most patients pay far less through insurance or Healthy Connections.
What’s the difference between Healthy Connections managed-care plans for MAT?
Healthy Connections managed-care organizations (MCOs) in South Carolina all cover MAT, but formulary details, prior-authorization rules, and in-network provider lists vary. Choose the MCO whose network includes your preferred methadone clinics; you can usually switch plans once a year.
Does Medicare cover methadone in South Carolina?
Yes. Medicare Part B covers methadone through enrolled Opioid Treatment Programs and Part D covers buprenorphine and naltrexone prescriptions. Medicare Advantage plans in South Carolina include the same MAT benefits under the integrated plan structure.
Does South Carolina allow telehealth induction for MAT?
Yes. DEA rules were permanently expanded in 2024 to allow audio-video telehealth for initial buprenorphine prescribing, and South Carolina law mirrors federal policy. Methadone induction still requires an in-person visit at an OTP for the first dose, though subsequent counseling can be delivered via telehealth. Naltrexone can be prescribed via telehealth with labs done in South Carolina.
What are the most common reasons patients stop methadone?
Common reasons include lifestyle stabilization (patient and clinician agree to taper), cost barriers, side effects, travel or employment disruption, and desire to try naltrexone after tapering. Many patients resume treatment later — clinics welcome return visits without judgment.
What should I avoid before my first methadone visit?
Avoid benzodiazepines, alcohol, and long-acting opioids for 6–12 hours before induction to reduce sedation risk. For buprenorphine, let the clinician know your last opioid use time so they can time the first dose to avoid precipitated withdrawal.
How soon after the first visit do I come back?
Follow-up within 3–7 days is standard after the first methadone visit to confirm response and titrate the dose. South Carolina clinics may see stable patients weekly for the first month, then space visits out as stability is achieved.
Are there allergic reactions to methadone?
True allergic reactions to methadone, buprenorphine, or naltrexone are rare. Rash, swelling, or difficulty breathing after a dose should be treated as an emergency — call 911 or go to a South Carolina emergency department. The MAT team can switch medications after stabilization.
Will my baby go through withdrawal if I take methadone?
Neonatal Opioid Withdrawal Syndrome (NOWS) can occur in infants exposed to methadone or buprenorphine prenatally and is routinely monitored at South Carolina delivery hospitals. NOWS is manageable with skilled nursing care; most infants go home within days to weeks with normal outcomes.
Is telehealth counseling available with methadone in South Carolina?
Yes. South Carolina MAT programs routinely deliver individual counseling and group therapy by video. Telehealth counseling is reimbursed at parity by Healthy Connections and most commercial insurers under current state and federal parity rules.
Do my pharmacy records show that I’m on methadone in South Carolina?
Buprenorphine and naltrexone prescriptions appear on pharmacy records like other prescriptions and are visible to dispensing pharmacies and authorized users of the PDMP. Methadone dispensed at an OTP is not reported to retail pharmacy systems.
Other Treatment Options in South Carolina
Methadone Treatment in Other States
Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)











