Medication-Assisted Treatment (MAT) Centers in South Carolina
Medically reviewed by Sarah Mitchell, LCSWLast reviewed: April 2026
Our directory lists 75 MAT programs across South Carolina, with the largest concentrations in Greenville (8), Florence (5) and Myrtle Beach (4).
Medication-Assisted Treatment (MAT) combines FDA-approved medications — methadone, buprenorphine, and naltrexone — with counseling and behavioral therapies for comprehensive addiction care. MAT is the evidence-based gold standard for opioid and alcohol use disorders.
Treatment landscape in South Carolina:
- SC Medicaid covers substance abuse treatment
- Coastal and inland treatment options
- Faith-based and traditional programs
- Growing specialty treatment centers
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MAT programs in South Carolina
Greenville · 8 centers

Life Line Services LLC
Greenville, SC
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Crossroads Treatment Centers
Greenville, SC
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Pavillon
Greenville, SC
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Phoenix Center
Greenville, SC
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Florence · 5 centers

Starting Point of Florence PC
Florence, SC
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Circle Park Behavioral Health Services
Florence, SC
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Myrtle Beach · 4 centers

Myrtle Beach Treatment Specialists
Myrtle Beach, SC
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Center of HOPE of Myrtle Beach LLC
Myrtle Beach, SC
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Coastal Recovery and Wellness
Myrtle Beach, SC
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South Strand Internists
Myrtle Beach, SC
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Charleston · 3 centers

Lantana Recovery
Charleston, SC
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Ralph H Johnson VA Medical Center
Charleston, SC
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Columbia · 3 centers

Crossroads Treatment Centers
Columbia, SC
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LRADAC
Columbia, SC
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North Charleston · 3 centers

Transcendence Treatment Center LLC
North Charleston, SC
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Center for Behavioral Health
North Charleston, SC
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Charleston Center of Charleston County
North Charleston, SC
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Anderson · 2 centers
Clinton · 2 centers
Conway · 2 centers

Lighthouse Behavioral Health Hospital
Conway, SC
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Gaffney · 2 centers
Greenwood · 2 centers

Cornerstone
Greenwood, SC
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Lancaster · 2 centers
Orangeburg · 2 centers

Tri County Commission on
Orangeburg, SC
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William J McCord
Orangeburg, SC
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Rock Hill · 2 centers

Keystone Substance Abuse Services
Rock Hill, SC
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Seneca · 2 centers

Crossroads Treatment Centers
Seneca, SC
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Spartanburg · 2 centers

Mel Med LLC
Spartanburg, SC
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Sumter · 2 centers

Tandem Health
Sumter, SC
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Abbeville · 1 center

Cornerstone
Abbeville, SC
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Aiken · 1 center
Bamberg · 1 center

Michael C Watson Treatment Facility
Bamberg, SC
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Barnwell · 1 center

Axis I Center of Barnwell
Barnwell, SC
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Beaufort · 1 center
Bishopville · 1 center
Camden · 1 center
Chesterfield · 1 center
Dillon · 1 center
Duncan · 1 center
Easley · 1 center

Recovery Concepts of Carolina Upstate
Easley, SC
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Edgefield · 1 center

Cornerstone
Edgefield, SC
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Fort Mill · 1 center
Georgetown · 1 center
Greer · 1 center

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Hartsville · 1 center
Lexington · 1 center

LRADAC
Lexington, SC
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Mc Cormick · 1 center

Cornerstone
Mc Cormick, SC
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Moncks Corner · 1 center
Mullins · 1 center
Newberry · 1 center

Westview Behavioral Health Services
Newberry, SC
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Pickens · 1 center
Saluda · 1 center

Westview Behavioral Health Services
Saluda, SC
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Simpsonville · 1 center

Ascent Recovery Solutions
Simpsonville, SC
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Summerville · 1 center

Dorchester County Commission on
Summerville, SC
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West Columbia · 1 center

Lexington Treatment Specialists
West Columbia, SC
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Winnsboro · 1 center

Fairfield Behavioral Health Services
Winnsboro, SC
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Healthy Connections
Healthy Connections covers buprenorphine and naltrexone; methadone coverage is available at licensed OTPs across the state.
State regulations
South Carolina Department of Alcohol and Other Drug Abuse Services (DAODAS) licenses OTPs and funds 17 county alcohol and drug authorities.
- Cash or self-payment74
- Medicaid66
- Private health insurance66
- Federal, or any government funding for substance use treatment programs55
- SAMHSA funding/block grants52
- State-financed health insurance plan other than Medicaid39
- Outpatient73
- Regular outpatient treatment61
- Outpatient methadone/buprenorphine or naltrexone treatment58
- Intensive outpatient treatment32
- Outpatient detoxification14
Frequently Asked Questions About MAT in South Carolina
Do I have to stop using opioids before starting mat?
For methadone and buprenorphine, continued opioid use during induction is common and expected; the medication itself helps stop use. For naltrexone, however, you must complete a 7–14 day opioid-free period first. Your South Carolina clinician will tailor the induction based on your medication.
Are there any hidden fees at MAT programs in South Carolina?
Common extra charges include urine drug-screen add-ons ($10–$50), missed-appointment fees, and pharmacy dispensing fees for take-home methadone doses. Always ask for a written fee schedule before your first visit at any South Carolina provider.
Does Healthy Connections cover a full month’s supply of mat?
Yes. For methadone, Healthy Connections reimburses Opioid Treatment Programs (OTPs) for in-clinic and take-home dosing as a bundled rate — SAMHSA clinical rules, not insurance, govern take-home eligibility. For buprenorphine, Healthy Connections pays for the 30-day pharmacy fill. For long-acting naltrexone, the monthly injection is covered under the medical benefit.
Will UnitedHealthcare or Aetna cover mat?
Yes. Both UnitedHealthcare and Aetna cover the MAT benefit in South Carolina, including mat. Verify in-network providers and whether long-acting injectables require prior authorization; patient-advocate lines can confirm network status before you schedule.
Was the DEA X-waiver requirement for buprenorphine removed in South Carolina?
Yes — federal Congress eliminated the X-waiver in December 2022, so any South Carolina clinician with a DEA registration can now prescribe buprenorphine for OUD. Continuing-education requirements apply; training is free through Providers Clinical Support System (PCSS) and SAMHSA.
How often will I need to visit MAT programs in South Carolina?
Early in treatment, visits are weekly — sometimes daily for methadone induction. After stabilization, buprenorphine patients typically visit monthly, and methadone patients may qualify for take-home doses reducing visits to bi-weekly or monthly. Naltrexone injections are monthly.
Can I bring someone to my first mat visit in South Carolina?
Yes. Most South Carolina MAT programs allow a support person at intake and can include family in counseling with your permission. Having a trusted person to drive you, help with paperwork, and understand the plan is highly encouraged.
How long does the first mat appointment last?
Expect 2–3 hours for intake, medical exam, counseling assessment, and first dose or prescription. Some South Carolina clinics break intake over two visits if labs or records need to be obtained first. Plan accordingly and arrange transportation home.
Is constipation on mat a serious problem?
Constipation is one of the most common and persistent mat side effects. Daily fluids, fiber, stool softeners, and an over-the-counter laxative like polyethylene glycol are first-line. If severe, your South Carolina clinician may prescribe a peripherally acting opioid-receptor antagonist.
Can I deliver at any South Carolina hospital if I’m on mat?
Yes. All South Carolina birthing hospitals are equipped to care for MAT patients. Choosing a hospital with a dedicated perinatal-addiction protocol — often larger urban hospitals — can improve experience. Discuss delivery location with your OB and MAT team well before the due date.
Is counseling required when I start mat in South Carolina?
Federal rules require all SAMHSA-certified OTPs to offer counseling alongside methadone. Buprenorphine and naltrexone prescribing does not mandate counseling, but South Carolina providers strongly recommend it. Most insurance plans and Healthy Connections cover integrated counseling as part of the MAT benefit.
Can law enforcement see my mat records?
No — not without a narrowly tailored court order (not a standard subpoena). South Carolina MAT clinics train staff to reject improper requests. If a warrant is presented, the clinic attorney reviews its scope before any release.
Other Treatment Options in South Carolina
Medication-Assisted Treatment in Other States
Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)




















