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Medically Reviewed Content
Updated: April 2026
Sources: SAMHSA, NIDA

Medication-Assisted Treatment (MAT) Centers in South Carolina

Medically reviewed by Sarah Mitchell, LCSWLast reviewed: April 2026

Our directory lists 75 MAT programs across South Carolina, with the largest concentrations in Greenville (8), Florence (5) and Myrtle Beach (4).

Medication-Assisted Treatment (MAT) combines FDA-approved medications — methadone, buprenorphine, and naltrexone — with counseling and behavioral therapies for comprehensive addiction care. MAT is the evidence-based gold standard for opioid and alcohol use disorders.

Treatment landscape in South Carolina:

  • SC Medicaid covers substance abuse treatment
  • Coastal and inland treatment options
  • Faith-based and traditional programs
  • Growing specialty treatment centers

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MAT programs in South Carolina

Filters:

Greenville · 8 centers

Life Line Services LLC - Facility Image
$$

Services:

DetoxificationSubstance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Crossroads Treatment Centers - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment
Greenville Metro Treatment Center - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Florence · 5 centers

HopeHealth Inc - Facility Image

HopeHealth Inc

Florence, SC

Insurance Accepted$$

Services:

Substance use treatment
Starting Point of Florence PC - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment
Circle Park Behavioral Health Services - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Myrtle Beach · 4 centers

Myrtle Beach Treatment Specialists - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment
Center of HOPE of Myrtle Beach LLC - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment
Coastal Recovery and Wellness - Facility Image
$$

Services:

DetoxificationSubstance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Charleston · 3 centers

Lantana Recovery - Facility Image

Lantana Recovery

Charleston, SC

Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Ralph H Johnson VA Medical Center - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Crossroads Treatment Centers - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Columbia · 3 centers

Crossroads Treatment Centers - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment
LRADAC - Facility Image

LRADAC

Columbia, SC

Insurance Accepted$$

Services:

DetoxificationSubstance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Prisma Health - Facility Image

Prisma Health

Columbia, SC

Insurance Accepted$$

Services:

DetoxificationSubstance use treatment

North Charleston · 3 centers

Transcendence Treatment Center LLC - Facility Image
Insurance Accepted$$

Services:

Substance use treatment
Center for Behavioral Health - Facility Image

Center for Behavioral Health

North Charleston, SC

Insurance Accepted$$

Services:

DetoxificationSubstance use treatment
Charleston Center of Charleston County - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment

Anderson · 2 centers

Southwest Carolina Trt Ctr LLC - Facility Image
Insurance Accepted$$

Services:

Substance use treatment
Placeholder image

Anderson/Oconee

Anderson, SC

Insurance Accepted$$

Services:

Substance use treatment

Clinton · 2 centers

Clear Skye Treatment Center - Facility Image
Insurance Accepted$$

Services:

Substance use treatment
Gate Way Counseling Center - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Conway · 2 centers

Shoreline Behavioral Health Services - Facility Image
Insurance Accepted$$

Services:

Substance use treatment
Lighthouse Behavioral Health Hospital - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Gaffney · 2 centers

Clear Skye Treatment Center - Facility Image
Insurance Accepted$$

Services:

Substance use treatment
Placeholder image
Insurance Accepted$$

Services:

Substance use treatment

Greenwood · 2 centers

Cornerstone - Facility Image

Cornerstone

Greenwood, SC

Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Greenwood Treatment Specialists - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Lancaster · 2 centers

Counseling Services of Lancaster - Facility Image
Insurance Accepted$$

Services:

Substance use treatment
Lancaster Treatment Specialists - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Orangeburg · 2 centers

Tri County Commission on - Facility Image
Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
William J McCord - Facility Image

William J McCord

Orangeburg, SC

Insurance Accepted$$

Services:

DetoxificationSubstance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Rock Hill · 2 centers

Keystone Substance Abuse Services - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment
Rock Hill Treatment Specialists - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Seneca · 2 centers

Crossroads Treatment Centers - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment
Anderson/Oconee - Facility Image

Anderson/Oconee

Seneca, SC

Insurance Accepted$$

Services:

Substance use treatment

Spartanburg · 2 centers

Mel Med LLC - Facility Image

Mel Med LLC

Spartanburg, SC

$$

Services:

DetoxificationSubstance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
BHG Spartanburg Treatment Center - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Sumter · 2 centers

Tandem Health - Facility Image

Tandem Health

Sumter, SC

Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children
Sumter Treatment Specialists - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Abbeville · 1 center

Cornerstone - Facility Image

Cornerstone

Abbeville, SC

Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Aiken · 1 center

BHG Aiken Treatment Center - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Bamberg · 1 center

Placeholder image
Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Barnwell · 1 center

Placeholder image
Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Beaufort · 1 center

Placeholder image

Beaufort County

Beaufort, SC

Insurance Accepted$$

Services:

Substance use treatment

Bishopville · 1 center

Placeholder image

Lee Center

Bishopville, SC

Insurance Accepted$$

Services:

Substance use treatment

Camden · 1 center

ALPHA Behavioral Health Center - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Chesterfield · 1 center

ALPHA Behavioral Health Center - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Dillon · 1 center

Trinity Behavioral Care - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Duncan · 1 center

Placeholder image
Insurance Accepted$$

Services:

Substance use treatment

Easley · 1 center

Recovery Concepts of Carolina Upstate - Facility Image
Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Edgefield · 1 center

Placeholder image

Cornerstone

Edgefield, SC

Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Fort Mill · 1 center

York County Treatment Center - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Georgetown · 1 center

Placeholder image

Georgetown County

Georgetown, SC

Insurance Accepted$$

Services:

Substance use treatment

Greer · 1 center

Carolina Center for Behavioral Health - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Hartsville · 1 center

Starting Point of Darlington - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Lexington · 1 center

LRADAC - Facility Image

LRADAC

Lexington, SC

Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Mc Cormick · 1 center

Cornerstone - Facility Image

Cornerstone

Mc Cormick, SC

Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Moncks Corner · 1 center

Placeholder image

Ernest E Kennedy Center

Moncks Corner, SC

Insurance Accepted$$

Services:

Substance use treatment

Mullins · 1 center

Trinity Behavioral Care - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Newberry · 1 center

Westview Behavioral Health Services - Facility Image
Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Pickens · 1 center

Placeholder image
Insurance Accepted$$

Services:

Substance use treatment

Saluda · 1 center

Placeholder image
Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

Simpsonville · 1 center

Ascent Recovery Solutions - Facility Image
Insurance Accepted$$

Services:

DetoxificationSubstance use treatment

Summerville · 1 center

Dorchester County Commission on - Facility Image
Insurance Accepted$$

Services:

Substance use treatmentTreatment for co-occurring substance use plus either serious mental health illness in adults/serious emotional disturbance in children

West Columbia · 1 center

Lexington Treatment Specialists - Facility Image
Insurance Accepted$$

Services:

Substance use treatment

Winnsboro · 1 center

Fairfield Behavioral Health Services - Facility Image
Insurance Accepted$$

Services:

Substance use treatment
Coverage & Regulations in South Carolina

Healthy Connections

Healthy Connections covers buprenorphine and naltrexone; methadone coverage is available at licensed OTPs across the state.

State regulations

South Carolina Department of Alcohol and Other Drug Abuse Services (DAODAS) licenses OTPs and funds 17 county alcohol and drug authorities.

SAMHSA National Helpline: 1-800-662-4357Crisis: 988
Commonly Accepted Insurance
  • Cash or self-payment74
  • Medicaid66
  • Private health insurance66
  • Federal, or any government funding for substance use treatment programs55
  • SAMHSA funding/block grants52
  • State-financed health insurance plan other than Medicaid39
Available Settings
  • Outpatient73
  • Regular outpatient treatment61
  • Outpatient methadone/buprenorphine or naltrexone treatment58
  • Intensive outpatient treatment32
  • Outpatient detoxification14

Frequently Asked Questions About MAT in South Carolina

Do I have to stop using opioids before starting mat?

For methadone and buprenorphine, continued opioid use during induction is common and expected; the medication itself helps stop use. For naltrexone, however, you must complete a 7–14 day opioid-free period first. Your South Carolina clinician will tailor the induction based on your medication.

Are there any hidden fees at MAT programs in South Carolina?

Common extra charges include urine drug-screen add-ons ($10–$50), missed-appointment fees, and pharmacy dispensing fees for take-home methadone doses. Always ask for a written fee schedule before your first visit at any South Carolina provider.

Does Healthy Connections cover a full month’s supply of mat?

Yes. For methadone, Healthy Connections reimburses Opioid Treatment Programs (OTPs) for in-clinic and take-home dosing as a bundled rate — SAMHSA clinical rules, not insurance, govern take-home eligibility. For buprenorphine, Healthy Connections pays for the 30-day pharmacy fill. For long-acting naltrexone, the monthly injection is covered under the medical benefit.

Will UnitedHealthcare or Aetna cover mat?

Yes. Both UnitedHealthcare and Aetna cover the MAT benefit in South Carolina, including mat. Verify in-network providers and whether long-acting injectables require prior authorization; patient-advocate lines can confirm network status before you schedule.

Was the DEA X-waiver requirement for buprenorphine removed in South Carolina?

Yes — federal Congress eliminated the X-waiver in December 2022, so any South Carolina clinician with a DEA registration can now prescribe buprenorphine for OUD. Continuing-education requirements apply; training is free through Providers Clinical Support System (PCSS) and SAMHSA.

How often will I need to visit MAT programs in South Carolina?

Early in treatment, visits are weekly — sometimes daily for methadone induction. After stabilization, buprenorphine patients typically visit monthly, and methadone patients may qualify for take-home doses reducing visits to bi-weekly or monthly. Naltrexone injections are monthly.

Can I bring someone to my first mat visit in South Carolina?

Yes. Most South Carolina MAT programs allow a support person at intake and can include family in counseling with your permission. Having a trusted person to drive you, help with paperwork, and understand the plan is highly encouraged.

How long does the first mat appointment last?

Expect 2–3 hours for intake, medical exam, counseling assessment, and first dose or prescription. Some South Carolina clinics break intake over two visits if labs or records need to be obtained first. Plan accordingly and arrange transportation home.

Is constipation on mat a serious problem?

Constipation is one of the most common and persistent mat side effects. Daily fluids, fiber, stool softeners, and an over-the-counter laxative like polyethylene glycol are first-line. If severe, your South Carolina clinician may prescribe a peripherally acting opioid-receptor antagonist.

Can I deliver at any South Carolina hospital if I’m on mat?

Yes. All South Carolina birthing hospitals are equipped to care for MAT patients. Choosing a hospital with a dedicated perinatal-addiction protocol — often larger urban hospitals — can improve experience. Discuss delivery location with your OB and MAT team well before the due date.

Is counseling required when I start mat in South Carolina?

Federal rules require all SAMHSA-certified OTPs to offer counseling alongside methadone. Buprenorphine and naltrexone prescribing does not mandate counseling, but South Carolina providers strongly recommend it. Most insurance plans and Healthy Connections cover integrated counseling as part of the MAT benefit.

Can law enforcement see my mat records?

No — not without a narrowly tailored court order (not a standard subpoena). South Carolina MAT clinics train staff to reject improper requests. If a warrant is presented, the clinic attorney reviews its scope before any release.

Other Treatment Options in South Carolina

Medication-Assisted Treatment in Other States

Medically ReviewedUpdated: April 2026
Sources:SAMHSANIDACDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)