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Medically Reviewed Content
Updated: October 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Greenbriar Treatment Center

Greenbriar Treatment Center, situated in Pittsburgh, PA, provides a wide array of addiction recovery services for adults. Their offerings include intensive outpatient, standard outpatient, and day treatment programs designed for adults and young adults. Tailored to meet the distinct needs of men and women, Greenbriar Treatment Center utilizes proven methods like 12-step facilitation, anger management, and cognitive behavioral therapy for personalized care. Their dedication to high-quality treatment and ongoing support establishes them as a dependable resource for individuals striving for sobriety.

Greenhouse Outpatient Center

The Greenhouse Outpatient Center, located in Arlington, TX, provides an extensive variety of treatment options for individuals facing substance use disorders, concurrent mental health challenges, and trauma-related issues. The center is designed to cater to both adults and young adults, offering intensive outpatient programs, transitional housing, and day treatment services. Employing evidence-based methodologies such as 12-step facilitation and anger management, the center serves a diverse clientele, including both men and women. A distinctive aspect of this center is its emphasis on supporting those who have experienced sexual abuse or trauma, fostering a nurturing atmosphere for recovery. The Greenhouse Outpatient Center is committed to delivering exceptional care to aid individuals in their recovery journey.

Greenhouse Treatment Center

Situated in Grand Prairie, Texas, the Greenhouse Treatment Center delivers an extensive array of services for both adults and young adults looking to overcome substance use issues alongside concurrent mental health challenges. This establishment features hospital-based detoxification and treatment options, with particular attention to active military members, those impacted by intimate partner violence, domestic abuse, and sexual trauma. Emphasizing 12-step methods, anger management strategies, and short-term intervention techniques, the center supports clients of all genders. Discover personalized care and assistance designed to meet your unique requirements at the Greenhouse Treatment Center.

Guardian Intensive Outpatient Program

Guardian Intensive Outpatient Program, located in Hoboken, NJ, provides comprehensive treatment for substance use disorders, utilizing strategies like 12-step facilitation, anger management, and brief intervention. This center offers targeted care for adult men, adult women, and individuals who have faced intimate partner or domestic violence. Serving adults and young adults of all genders, Guardian Intensive Outpatient Program delivers customized support for those pursuing successful addiction recovery. Dedicated to high-quality care and individual recovery paths, this facility is a vital resource for individuals on their journey to lasting sobriety.

Guardian Intensive Outpatient Program

Guardian Intensive Outpatient Program in New Brunswick, NJ, provides comprehensive care for adults of all genders battling substance use disorders. Their services include intensive outpatient, outpatient, and standard outpatient treatment options. The program excels in specialized therapies such as 12-step facilitation, anger management, and brief intervention strategies. Notably, they offer distinct programs designed for individuals who have endured intimate partner or domestic violence. Guardian Intensive Outpatient Program is committed to delivering high-quality, individualized support to guide clients toward lasting recovery.

Greenbriar Treatment Center

Greenbriar Treatment Center, located in Waynesburg, PA, provides a wide range of substance abuse treatment services in a nurturing setting. The center offers various options, including long-term, short-term, and 24-hour residential care for adults and young adults. Employing methods such as 12-step support, anger management techniques, and cognitive-behavioral therapy, this facility specifically addresses the needs of individuals dealing with both mental health and substance use disorders. Committed to personalized treatment, Greenbriar Treatment Center strives to support clients in their journey toward sustainable recovery.

Guidance Center
Southgate, MI

The Guidance Center, situated in Southgate, MI, delivers exceptional recovery programs. Its expertise lies in helping adults and young adults overcome substance dependence through intensive and standard outpatient services. Employing therapeutic methods like anger management, cognitive behavioral therapy, and the Matrix Model, this institution supports individuals facing combined mental health and substance use challenges. Each client receives personalized attention, with treatment plans designed to address their specific requirements. Open to all genders, the center provides thorough and impactful care within a nurturing atmosphere.

Greenbriar Treatment Center

Greenbriar Treatment Center, situated in Washington, PA, delivers thorough addiction care for adults and young adults. The facility offers several levels of care, including intensive outpatient, outpatient, and partial hospitalization programs. Emphasizing 12-step facilitation, anger management, and cognitive behavioral therapy, Greenbriar Treatment Center customizes its therapeutic strategies to address each person's unique recovery journey. The center also boasts distinct programs designed specifically for adult men and women, providing focused support. Their commitment is to delivering excellent addiction treatment services to both male and female individuals within a nurturing setting.

Guest House Counseling Clinic

Guest House Counseling Clinic, situated in Milwaukee, WI, delivers outpatient drug and alcohol rehabilitation for adults. They also offer dedicated services for those managing mental health conditions alongside substance use disorders. Their standard outpatient services employ proven methods such as anger management, brief interventions, and cognitive behavioral therapy. Primarily serving adult men and individuals with dual diagnoses, the clinic is equipped to address unique requirements. Accepting adult and young adult patients of all genders, Guest House Counseling Clinic provides effective support and comprehensive recovery care in a comfortable setting.

Greenleaf Woods Med Assisted Recovery

Greenleaf Woods Med Assisted Recovery, located in Greenland, NH, specializes in outpatient treatment for substance use issues, focusing on adults with co-occurring serious mental health disorders and children with emotional challenges. The center offers outpatient options for methadone, buprenorphine, and naltrexone, employing techniques such as motivational interviewing, relapse prevention strategies, and counseling specifically for substance use disorders. With programs customized for adolescents, adult men, and women, the facility serves a diverse clientele of all genders, including seniors. Greenleaf Woods Med Assisted Recovery is dedicated to providing personalized, high-quality care to facilitate successful recovery pathways.

Guidance Care Center Inc

Guidance Care Center Inc, situated in Key West, FL, delivers a full range of addiction treatment options for both adults and seniors. The center offers intensive outpatient programs, outpatient services, and detoxification support. It employs cognitive behavioral therapy, motivational interviewing, and techniques for preventing relapse, focusing on the treatment of individuals with dual diagnoses of substance use and significant mental health conditions. The center features specialized programs for those with trauma, HIV or AIDS, and co-occurring disorders. Prioritizing personalized care, Guidance Care Center Inc accommodates clients of all genders looking for sincere and effective rehabilitation.

Guidance Center
Leavenworth, KS

Situated in Leavenworth, KS, the Guidance Center provides extensive outpatient services for adults struggling with substance abuse and concurrent serious mental health disorders. Employing various methods such as 12-step facilitation, anger management techniques, and brief intervention strategies, this center offers targeted programs for adult men and women, including those who have faced intimate partner violence. Catering to adults and seniors of all genders, the center ensures top-notch care customized to meet each person's unique needs. Committed to evidence-based approaches and individualized support, the Guidance Center is focused on assisting clients in achieving lasting recovery and enhanced mental health.

Greenwich House Inc

Greenwich House Inc, located in New York, NY, provides outpatient services focused on substance use disorders for adults facing co-occurring severe mental health conditions, as well as emotional challenges in children. The center is known for its outpatient treatment options including methadone, buprenorphine, and naltrexone, and applies therapeutic techniques such as anger management, brief interventions, and cognitive behavioral therapy. It offers specialized programs designed for adult men and women, as well as those who have experienced intimate partner and domestic violence. Serving a diverse population of adults and young adults, Greenwich House Inc commits to delivering personalized care that meets the specific needs of individuals, making it a top option for those in search of comprehensive and specialized addiction recovery services in the New York region.

Griswold Behavioral Health Center

Griswold Behavioral Health Center, situated in Palmer, MA, focuses on comprehensive outpatient services to address substance abuse and co-existing severe mental health challenges in adults, as well as significant emotional issues in children. The center employs various methods such as 12-step programs, anger management, and succinct intervention strategies. Committed to tailored care, it serves individuals of all genders, including both adults and seniors. The offerings feature outpatient treatments involving methadone/buprenorphine or naltrexone alongside standard outpatient services. For those looking for dedicated and personalized rehabilitation support, Griswold Behavioral Health Center is a worthy option.

Guidance Center
Oskaloosa, KS

Situated in Oskaloosa, KS, the Guidance Center provides targeted outpatient services for individuals struggling with substance abuse and concurrent mental health issues, catering to both adults and children. Their programs, grounded in evidence-based practices, encompass 12-step facilitation, anger management, and brief intervention techniques. This center offers customized care for adult men and women, along with resources for clients who have experienced domestic violence. Emphasizing care for adult and senior populations, the center ensures that all clients, regardless of gender, benefit from compassionate and efficient treatment. The Guidance Center’s dedication to high-quality care and personalized support makes it an essential option for those in need of comprehensive rehabilitation services.

Guidance Center
Atchison, KS

The Guidance Center, situated in Atchison, KS, provides extensive outpatient services for individuals of all ages dealing with substance use and related mental health challenges. Employing methods like 12-step facilitation, anger management techniques, and brief intervention strategies, the center delivers personalized treatment plans. Dedicated programs are available for adult men, women, and survivors of domestic violence. The facility's focus extends to adult and senior individuals, with specific programs designed for both men and women in these age groups. The Guidance Center is committed to delivering high-quality, evidence-based care to aid clients in their recovery process.

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Greenbriar Treatment Center in Pittsburgh, PA, provides extensive addiction recovery services for adults and young adults. Their offerings include intensive outpatient, standard outpatient, and partial hospitalization programs. Utilizing approaches such as 12-step facilitation, anger management, and cognitive behavioral therapy, Greenbriar Treatment Center customizes care plans to suit each person's unique requirements. The center also features specialized tracks for adult men and women. Committed to high-quality support and a nurturing atmosphere, this establishment serves both male and female individuals looking for successful recovery within a professional setting.

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Greenhope Services for Women Inc in New York, NY, is a dedicated facility providing extensive residential and round-the-clock care for adult women facing substance use challenges. The center delivers customized treatment plans, incorporating strategies like 12-step support, emotional regulation, and short-term counseling. It is equipped to assist women who have endured intimate partner abuse, domestic violence, and sexual trauma. Serving adult, senior, and younger adult women, the center fosters a secure and nurturing space for healing. Greenhope Services for Women Inc is recognized for its holistic approach and unwavering dedication to enabling women to achieve lasting sobriety.

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Guidance Care Center Inc, situated in Key Largo, Florida, delivers a wide range of outpatient services designed for detoxification, treatment of substance use disorders, and addressing co-occurring conditions in both adults and children. The center employs strategies such as cognitive behavioral therapy, motivational interviewing, and techniques for relapse prevention to offer targeted support for trauma survivors, those with dual diagnoses, and clients within the criminal justice system. Customized programs are provided for adult men and women, as well as seniors, which include outpatient detox and treatments using methadone, buprenorphine, or naltrexone. With a commitment to high-quality care and methodologies backed by research, this center is focused on assisting individuals in their recovery journey.

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Guidance Care Center Inc, situated in Marathon, FL, provides extensive outpatient care for adults and children dealing with detoxification, substance abuse, and co-occurring mental health issues. Their approach emphasizes cognitive behavioral therapy, motivational interviewing, and relapse prevention, offering tailored programs for trauma survivors, those with dual diagnoses, and individuals involved in the criminal justice system. Guidance Care Center Inc supports adults and seniors of all genders with outpatient detox, methadone/buprenorphine treatment, and naltrexone therapy, ensuring personalized and impactful support.

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Bradford, PA

The Guidance Center, situated in Bradford, PA, provides outpatient services for individuals battling substance use disorders. They also offer specialized treatment for co-occurring conditions, addressing both substance use issues and severe mental health challenges in adults, as well as serious emotional disturbances in children. Their therapeutic approaches include anger management, brief intervention, and cognitive behavioral therapy, all incorporated into customized programs. The center serves adults and seniors, welcoming individuals of all genders and prioritizing personalized care through individualized treatment plans. For those in need of extensive rehabilitation, the Guidance Center is committed to delivering effective and individually crafted support.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated October 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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