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Medically Reviewed Content
Updated: October 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Hoboken University Medical Center

Hoboken University Medical Center, located in Hoboken, NJ, specializes in extensive treatment for adults facing substance use challenges alongside mental health disorders, as well as for children grappling with significant emotional issues. The facility provides various services, including outpatient therapy, day programs, and partial hospitalization, all designed to meet the unique needs of each individual. Techniques such as 12-step facilitation, anger management, and brief interventions are integrated into the therapeutic process. The center also offers specialized programs aimed at adolescents and distinct support for adult men and women. By focusing on gender-specific strategies, Hoboken University Medical Center ensures that both adult and younger clients receive the customized assistance they require. The center is committed to delivering high-quality care and individualized treatment plans, empowering individuals to achieve sustainable recovery.

Holland Pathways
Wichita, KS

Located in Wichita, KS, Holland Pathways provides an extensive array of treatment services for those looking to address substance use disorders alongside co-existing mental health issues. This center emphasizes specialized inpatient detoxification and treatment options, incorporating methods such as 12-step facilitation, anger management, and brief interventions. It also features dedicated programs for active duty service members and distinct offerings for adult men and women, ensuring a wide range of support. Holland Pathways is designed to assist both adults and young adults, regardless of gender, and is committed to delivering personalized care that fosters enduring recovery and overall well-being.

Holyoke Medical Center Inc

Holyoke Medical Center Inc, located in Holyoke, MA, is dedicated to providing comprehensive rehabilitation programs. They offer various levels of care, including intensive outpatient services, standard outpatient therapy, and partial hospitalization programs. The center's therapeutic modalities emphasize 12-step facilitation, anger management techniques, and brief intervention strategies. Holyoke Medical Center Inc extends specialized support to active military personnel, adult men, and women, addressing a wide spectrum of patient needs. Their services encompass treatment for substance use disorders, as well as co-occurring mental health conditions in adults and serious emotional disturbances in children. Serving a broad demographic of adults and young adults, the facility is committed to delivering high-quality care and recovery assistance.

Hope Harbor Wellness

Hope Harbor Wellness, located in Hiram, GA, provides extensive treatment for adults and young adults facing substance use challenges alongside significant mental health conditions. The center features tailored programs for individuals who have gone through intimate partner violence and offers a range of services including intensive outpatient, outpatient, and day treatment. By incorporating techniques such as 12-step facilitation, anger management, and brief intervention strategies, the facility serves both men and women. With a commitment to personalized care and scientifically backed methods, Hope Harbor Wellness aims to offer effective support for individuals pursuing recovery in a nurturing setting.

Hofunity Behavioral Health LLC

Hofunity Behavioral Health LLC, situated in Phoenix, AZ, provides a full spectrum of addiction recovery care. Their offerings include detox, treatment for substance use disorders, and supportive housing. The center operates as a hospital inpatient facility, available around the clock. Treatment methodologies employed encompass 12-step facilitation and anger management. Targeted programs are available for adult women and those who have experienced intimate partner violence or sexual abuse. Hofunity Behavioral Health LLC serves adults and young adults of all genders, delivering expert and empathetic rehabilitation for lasting sobriety.

Holdfast Recovery
Prescott, AZ

Holdfast Recovery, located in Prescott, AZ, delivers a wide array of rehabilitation options aimed at adults and young adults facing challenges related to substance use and concurrent mental health conditions. The center features various treatment formats, including intensive outpatient care, outpatient day programs, and partial hospitalization options. Holdfast Recovery excels in methods such as 12-step support, anger management, and brief intervention strategies. This center serves a diverse clientele, encompassing active duty military members, adult males, and those who have gone through experiences of intimate partner violence. By offering targeted programs for both men and women, Holdfast Recovery prioritizes personalized care and assistance for individuals determined to conquer addiction and attain sustainable recovery.

Hope Center
Lexington, KY

Situated in Lexington, KY, Hope Center provides an extensive array of long-term residential and detox programs specifically designed for adult males facing substance use challenges. This center emphasizes 12-step support, cognitive behavioral techniques, and anger management therapies to foster enduring recovery. Specialized programs address the needs of adult men who have experienced intimate partner violence, domestic assaults, and sexual trauma. Catering to seniors, young adults, and adult men, Hope Center fosters a nurturing atmosphere for individuals working to conquer addiction. Its dedication to high-quality care and personalized treatment approaches distinguishes it as a reliable choice for rehabilitation.

Hope Center
Lexington, KY

Situated in Lexington, KY, Hope Center provides an extensive array of addiction recovery services designed specifically for adult males. This center focuses on long-term residential treatment, detoxification in a residential setting, and around-the-clock care programs. By incorporating techniques like 12-step methodologies, anger management, and cognitive behavioral therapy, the facility ensures personalized support for those affected by intimate partner violence, domestic abuse, and sexual trauma. Emphasizing support for adults, seniors, and young adults alike, Hope Center is committed to offering effective, gender-sensitive care that fosters long-term recovery and overall wellness.

Hockanum Valley Community Council Inc

Hockanum Valley Community Council Inc, situated in Vernon Rockville, CT, provides outpatient services for individuals struggling with substance use. Their specialized care extends to adults managing co-occurring serious mental health conditions, as well as children facing emotional disturbances. The facility offers distinct programs designed for adult men and women, including those affected by domestic or intimate partner violence. Treatment methodologies encompass anger management, brief intervention strategies, and cognitive behavioral therapy. Beyond general outpatient care, Hockanum Valley Community Council Inc also offers outpatient medication-assisted treatment using methadone, buprenorphine, or naltrexone, serving both adult and pediatric populations. Their all-encompassing services are structured to address the unique needs of male and female clients, aiming to deliver effective rehabilitation.

Hope Grief Loss and Substance Abuse

Nestled in Alamosa, CO, "Hope Grief Loss and Substance Abuse" delivers targeted interventions for individuals grappling with addiction and co-occurring psychological challenges. They also address emotional difficulties in younger populations. Their diverse array of outpatient services, including intensive options, features customized therapeutic modalities like anger management, brief intervention, and cognitive behavioral therapy. Special programs are available for adult men, women, and survivors of domestic violence. The center's dedication extends to providing personalized support for both adult and child clients, aiming for holistic healing and recovery.

Hollywood Medical Rehabilitation Care

Hollywood Medical Rehabilitation Care, located in Los Angeles, CA, focuses on outpatient services that are geared towards detoxification and treatment for substance use disorders. The facility offers outpatient detox, as well as treatment options including methadone, buprenorphine, or naltrexone. Various therapeutic methods such as 12-step facilitation, anger management, and brief interventions are incorporated into the treatment plans. Specialized programs are available for active military personnel, adolescents, and adult males, ensuring comprehensive care for individuals of all genders, including children and teens. Hollywood Medical Rehabilitation Care is dedicated to providing high-quality treatment to support individuals in their recovery journey, making it a preferred option for those in need of effective addiction solutions.

Homeward Bound Inc

Homeward Bound Inc, located in Dallas, TX, delivers a wide array of rehabilitation services aimed at adults and young adults facing challenges related to substance use disorders alongside mental health issues. The facility features residential detox programs, round-the-clock care, and short-term residential options customized to meet each person's unique requirements. Employing evidence-based methods such as cognitive behavioral therapy and the Matrix Model, Homeward Bound Inc is dedicated to 12-step facilitation and trauma-informed practices. The center offers tailored programs for adult men, adult women, and individuals who have faced trauma, ensuring that treatment is specifically designed for each client. With a focus on high-quality care and gender-responsive services, Homeward Bound Inc is recognized as a reliable option for those on the path to recovery and wellness.

Hollow Creek Treatment Center LLC

Hollow Creek Treatment Center LLC, situated in Bismarck, AR, specializes in tailored programs for substance use rehabilitation. The center features hospital inpatient care, round-the-clock hospital services, and intensive outpatient programs, serving both adults and young adults across all genders. Emphasizing 12-step facilitation, anger management strategies, and brief intervention techniques, it supports adult clients, including those who have faced intimate partner or domestic violence. Hollow Creek Treatment Center LLC is committed to delivering personalized, high-quality treatment to assist clients in their recovery journeys.

Hope Alive Center

Hope Alive Center, located in Madison, TN, delivers extensive addiction rehabilitation services for both adults and children. This facility focuses on detoxification, treatment for substance misuse, and provides targeted support for individuals facing both substance use challenges and significant mental health issues. The center features long-term residential options, outpatient services, and outpatient detox programs to meet varying client needs. By employing methods such as 12-step facilitation, anger management techniques, and brief intervention strategies, Hope Alive Center guarantees personalized treatment. Additionally, the center offers distinct programs designed for adult men and women, as well as those who have experienced intimate partner violence and domestic abuse, distinguishing it in the field. It serves a diverse clientele, ensuring high-quality care throughout the recovery process.

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Hogar Santisima Trinidad is situated in Toa Alta, PR, and specializes in providing inpatient detoxification and treatment services specifically for adult men facing substance use challenges. The center emphasizes a holistic approach to care, incorporating methods such as 12-step programs, anger management, and short-term interventions. There are tailored programs for adult men who have gone through experiences of intimate partner violence, domestic violence, and trauma. With an emphasis on delivering personalized and effective rehabilitation for adult, senior, and young adult males, this facility is dedicated to supporting individuals on their journey towards recovery from substance addiction.

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Phoenixville, PA

Holcomb Associates, located in Phoenixville, PA, delivers a wide array of outpatient services aimed at addressing substance use issues. The center focuses on individuals facing both substance use disorders and significant mental health challenges, offering specialized care for emotional difficulties in children as well. Their intensive outpatient programs are customized to meet the specific requirements of each patient. Treatment methods utilized here include 12-step programs, cognitive behavioral therapy, and anger management strategies. Holcomb Associates also offers distinct programs for active duty military personnel, teenagers, and adult males. The facility serves adults and seniors of all genders, providing essential support and high-quality care for those on their journey to recovery from addiction and mental health struggles.

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Kennett Square, PA

Holcomb Associates Inc, located in Kennett Square, PA, provides a wide array of treatment options for individuals dealing with substance use issues and concurrent mental health disorders, catering to both adults and children. The center specializes in various levels of care including intensive outpatient programs, outpatient treatment, and targeted therapies involving methadone or buprenorphine, as well as naltrexone. Utilizing proven methodologies such as 12-step programs, cognitive behavioral therapy, and anger management techniques, Holcomb Associates Inc addresses the specific requirements of active-duty service members, teenagers, and adult males. The center's programs are tailored for adults and seniors across genders, ensuring a supportive environment for those striving for recovery from addiction and mental health difficulties.

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In Phoenix, AZ, Homes of Personal Enrichment provides all-encompassing care for adult men struggling with substance use within a secure and encouraging setting. This facility is particularly adept at addressing dual diagnoses of substance use disorders and significant mental health conditions. They offer tailored treatment for individuals who have endured intimate partner violence, domestic abuse, and sexual trauma. The center features extended and shorter residential programs, operating 24/7, and employs strategies such as 12-step integration, emotional regulation techniques, and concise therapeutic interventions. Catering to adults, older adults, and young adults, Homes of Personal Enrichment is committed to delivering excellent care to support each person's journey toward healing.

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Homeward Bound Inc in Dallas, TX, is dedicated to providing expert care for individuals grappling with addiction and dual diagnoses affecting adults and young people. The facility features robust intensive outpatient and standard outpatient services, alongside medication-assisted treatment options such as methadone and buprenorphine. Emphasizing principles like the 12-step model, emotional regulation strategies, and short-term counseling techniques, Homeward Bound Inc serves adult women, emerging adults, and those involved with the legal system. Their personalized strategies are designed to meet the distinct requirements of every client, ensuring thorough support and recovery. For those needing assistance with substance abuse or concurrent mental health challenges, this center offers high-quality, empathetic treatment.

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San Diego, CA

Hope Canyon, located in San Diego, California, delivers extensive addiction recovery services for both adults and young adults. This center offers long-term residential treatment, detox programs within a residential setting, and round-the-clock support. Emphasizing practices such as 12-step facilitation and anger management, it specifically addresses the needs of individuals facing co-occurring mental health and substance use issues. Additionally, the facility provides specialized support for trauma survivors and various gender-specific programs. With its commitment to high-quality care and tailored treatment strategies, Hope Canyon stands out as an excellent option for those in pursuit of compassionate rehabilitation in the San Diego region.

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Bayboro, NC

Hope Clinic, situated in Bayboro, North Carolina, delivers outpatient care for substance use disorders, emphasizing strategies to prevent recurrence. This establishment features tailored services for adult men and women, addressing the needs of both older adults and younger individuals. Employing diverse treatment modalities such as outpatient medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside standard outpatient services, the clinic guarantees personalized support for every client's specific circumstances. Catering to both male and female individuals, Hope Clinic is dedicated to providing high-quality, evidence-supported interventions to aid those seeking to overcome addiction.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated October 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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