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Medically Reviewed Content
Updated: October 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Intervention911
Palm Springs, CA

Intervention911 in Palm Springs, CA provides targeted substance abuse care for adults facing combined significant mental health challenges or emotional distress in youth. The facility offers robust outpatient services, including intensive and day treatment, utilizing approaches like 12-step support, anger control techniques, and short-term therapeutic strategies. They have developed specific programs for active military members, adult men, and adult women. Catering to adults and young adults across the gender spectrum, Intervention911 delivers exceptional treatment and assistance for those pursuing thorough recovery services within the Palm Springs community.

Into Action Recovery Centers

Situated in Houston, TX, Into Action Recovery Centers delivers a wide range of addiction treatment options, including detox and substance use rehabilitation. Emphasizing long-term residential care, the facility offers residential detox services and around-the-clock support. The center employs proven strategies such as 12-step methods, anger management, and cognitive behavioral therapy. Specialized programs are available for active duty military members, as well as distinct services for adult men and women, including young adults of all genders. Into Action Recovery Centers creates a nurturing atmosphere for those pursuing customized addiction recovery paths, guaranteeing high-quality care and individualized programs to meet each person's specific requirements.

Into Action Recovery Centers

Into Action Recovery Centers, situated in Houston, TX, provides tailored substance abuse rehabilitation for adults and young adults. They emphasize intensive outpatient, outpatient, and day treatment models, integrating interventions like 12-step support, anger management, and cognitive behavioral techniques. Specific programs are offered for active military, adult men, and adult women, serving both genders in a welcoming setting. Into Action Recovery Centers is committed to offering superior, research-backed treatment for those pursuing lasting sobriety and recovery.

Iowa Specialty Hospital and Clinic

Iowa Specialty Hospital and Clinic, situated in Belmond, IA, provides expert rehabilitation for addiction and co-occurring mental health issues for all age groups. They offer outpatient services, including medication-assisted treatment with methadone, buprenorphine, or naltrexone. Their therapeutic approach incorporates cognitive behavioral therapy, the Matrix Model, and motivational interviewing. Specialized programs are designed for active military, men, and women, and they welcome adults and seniors of any gender. This center is dedicated to delivering exceptional, holistic addiction care. Iowa Specialty Hospital and Clinic is a reliable choice for those pursuing effective and individualized recovery.

Iris Healing Center
Woodland Hills, CA

Iris Healing Center, situated in Woodland Hills, CA, delivers an extensive array of rehabilitation services aimed at assisting adults and young adults dealing with substance abuse and concurrent mental health conditions. The center features intensive outpatient care, outpatient day programs, and partial hospitalization, utilizing methods like 12-step support, anger management strategies, and brief intervention techniques. With dedicated programs for active military members, as well as adult men and women, Iris Healing Center addresses a variety of client backgrounds. This facility prioritizes personalized treatment and evidence-based methodologies, distinguishing itself through high-quality therapeutic options that are customized to meet the specific needs of each individual.

Iris Healing Retreat
Woodland Hills, CA

Iris Healing Retreat, based in Woodland Hills, CA, specializes in extensive treatment for detoxification, substance use disorders, and associated mental health issues for both adults and young people. The center features hospital inpatient care and round-the-clock support, offering 12-step programs, anger management sessions, and short intervention methods. Unique programs are available for active military members as well as distinct services for adult men and women. This facility is committed to providing customized care that addresses the specific needs of all clients. Prioritizing high-quality, individualized treatment, Iris Healing Retreat is recognized as a reliable choice for individuals seeking effective rehabilitation options.

Iris Wellness Group
Chattanooga, TN

Iris Wellness Group in Chattanooga, TN provides extensive substance abuse treatment for both adults and young individuals. They are particularly adept at addressing dual diagnoses involving substance use and significant mental health conditions in adults, alongside severe emotional challenges in children. Their treatment modalities encompass intensive outpatient programs, day treatment, and partial hospitalization, ensuring a flexible approach to client needs. Employing strategies like 12-step support, anger management, and concise intervention techniques, Iris Wellness Group delivers personalized, high-quality care. Targeted programs are offered for teenagers, adult men, and adult women, serving clients of all genders and ages.

Iroquois Mental Health Center

Situated in Watseka, IL, the Iroquois Mental Health Center provides extensive treatment options for substance use and individualized care for those dealing with concurrent mental health issues. Emphasizing intensive outpatient services, outpatient therapy, and standard outpatient care, this facility incorporates 12-step programs, anger management strategies, and short intervention techniques. Specialized initiatives are designed for youth, men, and women, accommodating adults and seniors of all identities. The center’s customized strategy guarantees exceptional support for individuals pursuing rehabilitation and assistance with substance abuse and mental wellness challenges.

Isaiah House
Danville, KY

Isaiah House, situated in Danville, KY, delivers an extensive variety of services aimed at treating addiction. This center focuses on detox and managing substance abuse, offering programs such as intensive outpatient care, outpatient services, and treatments involving methadone/buprenorphine or naltrexone. Emphasizing approaches like 12-step support, brief interventions, and cognitive behavioral therapy, Isaiah House caters to both active-duty military members as well as adult men and women. The facility provides customized care for adults and young adults of all genders, highlighting its dedication to individualized rehabilitation. Isaiah House distinguishes itself through its high-quality programs and unwavering commitment to assisting individuals in overcoming addiction.

Isaiah House
Willisburg, KY

Situated in Willisburg, KY, Isaiah House specializes in providing extensive addiction treatment services designed exclusively for adult males. The center offers long-term residential treatment, detoxification in a residential setting, and around-the-clock support. Emphasizing 12-step programs, anger management, and targeted interventions, Isaiah House customizes its approaches to address the specific challenges faced by clients who have encountered intimate partner violence. Catering to active military members, adult men, and elderly individuals, this facility fosters a nurturing atmosphere for those on their recovery journey. Isaiah House is recognized for its exceptional care and dedication to helping individuals reclaim their lives from substance use disorders with dignity and compassion.

Isaiah House
Willisburg, KY

Isaiah House, situated in Willisburg, KY, provides an extensive array of rehabilitation services tailored for adult males aiming to overcome substance abuse issues. Emphasizing long-term residential care, the center offers programs that include detoxification and transitional housing with around-the-clock support. Specialized services are available for active duty military members, adult men, and individuals who have faced intimate partner violence. Utilizing research-backed methods such as 12-step facilitation and anger management, the center assists clients in their pursuit of recovery. Isaiah House is dedicated to serving a diverse clientele, including adults and seniors, in a caring atmosphere exclusively for men, ensuring customized treatment and high-quality care.

Isaiah House
Chaplin, KY

Located in Chaplin, KY, Isaiah House stands out as a prominent rehabilitation center focused on providing long-term residential support for adult men facing challenges related to substance use disorders. The center offers a well-rounded range of services, including detoxification, transitional housing, and round-the-clock residential care. Emphasizing 12-step facilitation, anger management, and brief interventions, Isaiah House creates customized programs specifically for individuals affected by intimate partner violence and those in active military service. Catering to adults, seniors, and young adults, this facility ensures high-quality, gender-specific treatment aimed at fostering enduring recovery. If you or someone you care about is looking for a structured and nurturing setting to overcome addiction, Isaiah House presents a specialized program tailored to address your individual needs.

Iowa Specialty Hospital and Clinic

Iowa Specialty Hospital and Clinic, situated in Garner, IA, offers an extensive range of treatment options for substance use disorders and co-occurring mental health issues, targeting both adults and children. The center features outpatient services, including methadone and buprenorphine therapy, and employs proven methods like cognitive behavioral therapy and motivational interviewing. Tailored programs are available for active military personnel as well as adult men and women, ensuring the facility meets the diverse needs of its clients. Committed to delivering high-quality, personalized care, Iowa Specialty Hospital and Clinic focuses on effective and empathetic rehabilitation solutions to assist individuals on their recovery journey.

Intervention Specialists

Intervention Specialists in Elizabeth, NJ, delivers tailored substance abuse therapy for adults and young adults facing co-occurring severe mental health conditions or emotional challenges. Their treatment options include intensive outpatient, standard outpatient, and day programs. These programs integrate methodologies such as 12-step facilitation, anger management, and cognitive behavioral therapy. Recognizing unique needs, they offer specific care plans for adult men, women, and individuals affected by domestic or intimate partner violence. Intervention Specialists is dedicated to providing high-quality care to foster recovery and comprehensive well-being for all clients.

Intervention911
Palm Springs, CA

Intervention911, located in Palm Springs, CA, specializes in extensive rehabilitation solutions for both adults and young adults facing challenges related to substance abuse and concurrent mental health issues. The center features long-term residential therapy, detox services on-site, and around-the-clock supervision. It employs various methods, including 12-step programs, strategies for managing anger, and short-term interventions. Intervention911 has dedicated programs for active duty military personnel, as well as specific offerings for men and women, addressing the needs of a broad range of individuals. This facility is committed to providing personalized care for both genders, ensuring that each client receives focused support and guidance. Discover effective treatment in a nurturing atmosphere at Intervention911.

Inwood Community Services Inc

Inwood Community Services Inc, located in New York, NY, provides targeted outpatient programs for substance abuse that are designed to address the unique requirements of its clientele. Emphasizing methods such as 12-step support, anger management, and brief intervention techniques, this center delivers thorough care for both adults and seniors. They also have specialized programs for teenagers, as well as separate tracks for adult men and women, ensuring that treatment plans are personalized. Inwood Community Services Inc is recognized for its dedication to high-quality care, offering outpatient options for methadone/buprenorphine or naltrexone in addition to standard outpatient services. With a focus on gender-specific treatment for male and female participants, this center remains committed to fostering inclusivity and efficacy in the recovery journey.

Iron Recovery and Wellness Center

Iron Recovery and Wellness Center located in Toms River, NJ, specializes in providing treatment for adults dealing with substance use issues alongside significant mental health disorders, as well as offering support for children with emotional challenges. Emphasizing intensive outpatient and outpatient programs, the center presents customized treatment options such as anger management, cognitive behavioral therapy, and short-term interventions. It also features exclusive programs for active military members, as well as dedicated services for adult men and women. Catering to both adult and young adult populations, this facility is committed to delivering high-quality care through individualized treatment strategies and evidence-based methodologies. Iron Recovery and Wellness Center is distinguished by its all-encompassing services and dedication to aiding individuals in their recovery process.

Iron Recovery and Wellness Center

The Iron Recovery and Wellness Center, located in Brick, NJ, specializes in extensive treatment for substance use disorders affecting both adults and children who also face significant mental health challenges. The center offers a range of services including intensive outpatient programs, outpatient care, and treatment with methadone or buprenorphine. Employing techniques like anger management, cognitive behavioral therapy, and brief intervention, the center customizes its services to meet the unique needs of each individual. Additionally, it features specialized programs designed for active duty military personnel, adolescents, and adult males. Catering to clients of all genders, Iron Recovery and Wellness Center is committed to providing high-quality support for those on their path to recovery from addiction in a compassionate and professional setting.

Iron Recovery and Wellness Center

At Iron Recovery and Wellness Center, situated in Trenton, NJ, we focus on tailored substance use interventions for adults facing concurrent serious mental health challenges. We also support children with emotional disturbances. Our offerings include robust intensive outpatient and standard outpatient services, incorporating medication-assisted treatment options such as methadone, buprenorphine, or naltrexone. Our therapeutic framework integrates techniques like anger management, brief counseling, and cognitive behavioral therapy. The center is proud to offer distinct programs for active military personnel, adult men, and adult women, demonstrating our commitment to diverse populations. We welcome adults and young adults of all genders, emphasizing individualized care plans and scientifically-proven therapeutic methods.

Iroquois Mental Health Center

Situated in Kankakee, Illinois, the Iroquois Mental Health Center provides outpatient treatment for substance abuse, targeting both adults and children facing significant mental health difficulties. Employing methods such as 12-step support and anger management, this facility offers consistent outpatient services and short-term interventions. With tailored programs designed for teenagers, adult males, and females, the center supports a variety of individuals. Aimed at assisting adults and older adults regardless of gender, the center is dedicated to offering high-quality care to enable clients to tackle their challenges and realize sustainable recovery.

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Situated in Manteno, IL, Iroquois Mental Health Center delivers a wide array of treatment services designed for both adults and children facing challenges related to substance use and co-occurring mental health issues. The center features various treatment modalities, including intensive outpatient, outpatient, and standard outpatient programs, customized to meet the unique requirements of each individual. Implementing methodologies like 12-step support, anger management techniques, and brief intervention, the center offers distinct programs catering to adolescents, as well as adult men and women. With an emphasis on care for adults and seniors of all genders, Iroquois Mental Health Center is committed to providing exceptional, personalized support to aid individuals in their recovery journey.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated October 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)