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Medically Reviewed Content
Updated: October 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Isaiah House
Versailles, KY

Isaiah House, situated in Versailles, KY, is dedicated to delivering an extensive array of addiction recovery services customized for adults and seniors. This center excels in offering residential detox services, round-the-clock supervision, and short-term residential programs. With strengths in 12-step support, anger management, and brief intervention strategies, Isaiah House focuses on tailored assistance for adult women, particularly those affected by intimate partner violence. Emphasizing compassion and high-quality care, this facility specifically addresses the needs of female clients struggling with substance use disorders. Whether you or someone close to you requires specialized assistance in a safe and caring setting, Isaiah House stands ready to provide support.

Isaiah House
Harrodsburg, KY

Isaiah House, located in Harrodsburg, KY, specializes in addiction recovery with a primary emphasis on extended residential services. This center caters to adult women, seniors, and young adults affected by intimate partner abuse. Isaiah House prioritizes a supportive atmosphere with a strong focus on 12-step principles and anger management techniques for women pursuing healing. The facility provides around-the-clock assistance through its residential detox and transitional housing, ensuring comprehensive support for all residents. Additionally, the program employs targeted intervention methods to effectively meet individual requirements. Isaiah House is distinguished by its commitment to delivering personalized care that addresses the specific challenges faced by its clients.

Jackson Comprehensive Treatment Center

In Jackson, Mississippi, the Jackson Comprehensive Treatment Center is dedicated to assisting individuals on their journey to overcome substance use disorders. The center offers comprehensive care, including detox services, structured outpatient programs, and flexible outpatient detox options. They employ evidence-based therapeutic strategies such as 12-step integration, emotional regulation techniques, and short-term counseling. The Jackson Comprehensive Treatment Center provides specialized support for active military personnel, adult men, and adult women, ensuring a personalized approach. Catering to adults and young adults across the gender spectrum, they are equipped to address both substance use challenges and co-occurring mental health conditions with a focus on effective, compassionate treatment.

Jade Wellness Center
Monroeville, PA

Situated in Monroeville, PA, Jade Wellness Center provides a range of addiction recovery services for both adults and teenagers. The center includes detox services and various treatment options such as intensive outpatient programs, outpatient care, and day treatment sessions. It utilizes specific methodologies, including 12-step support, anger management, and brief intervention strategies, to address the individual needs of men, women, and young people. Jade Wellness Center prioritizes personalized care in a nurturing atmosphere to foster recovery. If you are looking for help for yourself or someone close to you, this facility is committed to supporting clients in their journey towards sustained sobriety.

Jade Wellness Center
Pittsburgh, PA

Situated in Pittsburgh, PA, Jade Wellness Center delivers an extensive array of services for addiction recovery. The facility specializes in detoxification and substance use treatment via both intensive outpatient and outpatient programs, which also include outpatient detox. Emphasizing techniques such as 12-step facilitation, anger management, and brief interventions, Jade Wellness Center serves adults, teenagers, and those who have faced trauma. There are specialized programs designed for adult women and adolescents. This center supports both male and female clients, fostering a welcoming and supportive atmosphere for everyone. With a strong dedication to providing high-quality care, Jade Wellness Center stands out as a reliable option for individuals in need of effective and tailored addiction recovery solutions.

Jade Wellness Center

Situated in Wexford, PA, Jade Wellness Center specializes in a broad range of addiction recovery services designed for both adults and teenagers. The facility offers detox and substance abuse treatment through various outpatient options, including intensive outpatient care and detoxification programs. Emphasizing 12-step methodologies, anger management, and brief interventions, Jade Wellness Center serves a diverse clientele of males and females. Additionally, it features specialized programs for adult men, adult women, and adolescents. By providing customized treatment plans, the center ensures individuals receive high-quality support on their journey toward recovery, establishing itself as a reliable option for effective rehabilitation services.

James A Haley Veterans Hospital

Situated in Tampa, Florida, James A Haley Veterans Hospital delivers an extensive array of rehabilitation services aimed at both adults and young adults. The facility emphasizes detoxification, treatment for substance use disorders, and addressing co-occurring conditions involving serious mental health issues in adults or significant emotional challenges in children. It offers a variety of care options, including intensive outpatient programs, general outpatient services, and outpatient detoxification. By focusing on techniques such as anger management, brief interventions, and cognitive behavioral therapy, this center serves clients of all genders, including adult women and those who have faced trauma or domestic violence. You can expect exceptional care and tailored programs that are committed to aiding individuals in their recovery process.

James H Quillen VAMC
Mountain Home, TN

Situated in Mountain Home, TN, the James H Quillen VAMC delivers a wide range of addiction rehabilitation services for both adults and adolescents. The center offers inpatient detoxification and treatment for those struggling with substance use disorders, alongside support for co-occurring severe mental health issues. It features customized programs specifically designed for adult men, adult women, and individuals affected by intimate partner violence, ensuring that each client receives personalized care. Utilizing methods such as 12-step facilitation, anger management techniques, and brief therapeutic interventions, the center emphasizes a holistic approach to recovery. The James H Quillen VAMC is firmly committed to providing high-quality care and assisting individuals throughout their recovery journey.

Jamestown Healing Clinic

Jamestown Healing Clinic, situated in Sequim, WA, provides extensive care for adults and youth struggling with significant mental health conditions and substance use disorders. Their robust outpatient services utilize proven methods such as cognitive behavioral therapy and community reinforcement to foster enduring recovery. The clinic is particularly adept at addressing co-occurring disorders and offers outpatient methadone/buprenorphine services. Tailored to serve individuals involved with the criminal justice system and forensic clients, Jamestown Healing Clinic welcomes adults and seniors of all genders. Their dedication to high-quality, personalized treatment plans establishes them as a premier destination for effective rehabilitation.

JFK University Medical Center

JFK University Medical Center, situated in Edison, NJ, provides a wide range of rehabilitation services aimed at helping both adults and children who are facing challenges related to substance use and concurrent mental health conditions. Their offerings encompass intensive outpatient programs, standard outpatient services, and targeted treatments with methadone, buprenorphine, or naltrexone. The center employs various therapeutic methods, such as anger management therapies, brief interventions, and cognitive behavioral techniques. Committed to delivering high-quality care, they serve a diverse clientele, including individuals from the criminal justice sector. JFK University Medical Center is dedicated to customizing rehabilitation programs to address the specific needs of each person, fostering a compassionate and effective pathway to recovery.

JWalker Intensive Outpatient

Situated in Orem, Utah, JWalker Intensive Outpatient is dedicated to providing extensive care for individuals grappling with substance misuse and those in need of supportive housing. The center focuses on dual diagnosis cases, addressing both addiction and significant mental health conditions in adults, as well as serious emotional challenges in children. Through structured programs like intensive outpatient and day treatment, clients receive guidance in 12-step principles, anger management techniques, and effective brief interventions. Special provisions are made for active military members, adult men, and women. JWalker Intensive Outpatient offers a full spectrum of services for both genders, committed to delivering excellent treatment and encouragement for those on their path to recovery.

Isaiah House
Chaplin, KY

Nestled in Chaplin, KY, Isaiah House is dedicated to delivering superior rehabilitation programs for adult men battling addiction. This center provides a nurturing setting for extended residential care, transitional living options, and sober living environments. Emphasizing 12-step support and emotional regulation techniques, Isaiah House also expertly addresses co-occurring substance abuse and severe mental health conditions in men. Distinctive offerings include specialized support for those affected by intimate partner and domestic abuse. Catering also to active duty military members, this institution is distinguished by its holistic approach to successful addiction recovery for men within a secure and organized atmosphere.

Jackson VAMC GV Sonny Montgomery

Situated in Jackson, MS, the Jackson VAMC GV Sonny Montgomery center delivers extensive detoxification and treatment services for substance use disorders, catering to both adults and younger individuals. With a strong emphasis on addressing co-occurring substance use issues alongside severe mental health conditions in adults and significant emotional disturbances in children, this facility offers inpatient care supported around the clock. The treatment methods include 12-step facilitation, anger management, and brief interventions, designed for both male and female patients, with specialized programs available for active duty military personnel, as well as adult men and women. Committed to providing high-quality, tailored care, this center stands as a source of hope for individuals striving for recovery.

Janus South County
Watsonville, CA

Janus South County, situated in Watsonville, CA, is a well-regarded facility that focuses on rehabilitation for adults and young adults dealing with substance use issues. The center provides outpatient services that include treatment with methadone, buprenorphine, or naltrexone. Committed to delivering high-quality care, Janus South County employs a range of evidence-based practices, such as brief interventions, cognitive behavioral therapy, and motivational incentives combined with contingency management. The center also features specialized programs designed for clients who have undergone trauma as well as for pregnant or postpartum women. It fosters a welcoming environment for both male and female clients, ensuring that individuals looking for effective addiction rehabilitation receive the necessary support.

JFK Alcohol and Drug Abuse Trt Ctr

Situated in Black Mountain, NC, JFK Alcohol and Drug Abuse Trt Ctr delivers an extensive array of services for those facing challenges with substance use disorders. This center features inpatient hospital detoxification and treatment, with an emphasis on co-occurring mental health issues in adults and severe emotional disturbances in children. Utilizing evidence-based methods such as cognitive behavioral therapy and motivational interviewing, the center customizes its treatment plans to meet the unique needs of each individual. It also offers specialized programs for active duty military members, as well as for adult men and women. JFK Alcohol and Drug Abuse Trt Ctr is committed to providing exceptional care in a nurturing atmosphere for adults and young adults of all genders.

Jackson Community Mental Hlth Ctr

Situated in Opa Locka, Florida, Jackson Community Mental Hlth Ctr is a multifaceted rehabilitation center that provides detox services, treatment for substance abuse, and targeted assistance for individuals dealing with simultaneous substance use and severe mental health issues in adults, as well as significant emotional challenges in children. The center offers various treatment formats, including inpatient detox in a hospital setting, round-the-clock inpatient care, and outpatient programs. Utilizing evidence-based methods like cognitive behavioral therapy, motivational interviewing, and strategies to prevent relapse, the center also has specialized initiatives designed for adult men and women, as well as individuals who have faced trauma. Services are customized to meet the needs of both adult and young adult clients, ensuring quality care in a nurturing atmosphere for those on their path to recovery.

Janus Community Clinic

Janus Community Clinic in Santa Cruz, CA, provides comprehensive outpatient care for individuals facing substance use challenges. Their specialized offerings include methadone, buprenorphine, and naltrexone treatments. Employing strategies such as brief intervention, cognitive behavioral therapy, and motivational incentives, the clinic crafts personalized treatment plans. They also feature dedicated support for those with trauma histories and for pregnant or postpartum individuals. Janus Community Clinic welcomes adults and young adults of all genders, delivering effective care within a nurturing setting.

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Baltimore, MD

Issaiah House is situated in Baltimore, MD, and specializes in delivering extensive substance abuse treatment programs for both adult men and women. This facility offers various levels of care, including intensive outpatient programs, outpatient day treatment, and partial hospitalization. Employing methods such as 12-step facilitation, anger management, and brief intervention, Issaiah House effectively supports individuals dealing with co-occurring mental health and substance use disorders, as well as those entangled in the criminal justice system. The center serves both adults and young adults, providing customized care designed to address each person's specific needs. Dedicated to high-quality and individualized treatment, Issaiah House strives to assist clients throughout their recovery journey.

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The James E. Van Zandt VA Medical Center located in Altoona, PA, delivers a wide array of addiction recovery services for both adults and children. This facility excels in detoxification, treatment for substance use disorders, and addressing co-occurring mental health issues. It offers intensive outpatient programs, outpatient detox services, and ongoing therapy sessions. Emphasizing 12-step support, management of anger issues, and short-term interventions, the center serves active duty service members, women, and those affected by domestic violence. Catering to a diverse group that includes adults, seniors, and young adults, the center provides exceptional care through personalized, evidence-based treatment strategies.

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Laguna Niguel, CA

JBW Associates Inc, situated in Laguna Niguel, CA, delivers a thorough array of services aimed at assisting individuals in overcoming substance use disorders alongside co-occurring mental health issues. The facility offers inpatient detox and treatment options that incorporate proven methods, including 12-step programs, brief interventions, and cognitive behavioral therapy. It serves adult men and women, including those who have faced intimate partner or domestic violence. With tailored programs for both adults and younger individuals, JBW Associates Inc is committed to offering high-quality, personalized care to aid clients in their pursuit of enduring sobriety and enhanced mental health.

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JSAS Healthcare Inc, situated in Neptune, NJ, delivers a full spectrum of outpatient care for addiction, including detox, substance abuse recovery, and treatment for co-occurring mental health issues, serving both adults and adolescents. Their offerings include outpatient detox alongside medication-assisted treatment with methadone, buprenorphine, or naltrexone. The center employs strategies such as 12-step facilitation, anger management, and cognitive behavioral therapy, addressing the needs of adult men and women, as well as individuals with dual diagnoses. Their program is designed for adults and young adults, accommodating both genders. JSAS Healthcare Inc prioritizes high-quality, evidence-based treatment, making it a trusted option for those in need of individualized addiction recovery services.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated October 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)