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Medically Reviewed Content
Updated: September 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Northwestern Medicine
Orland Park, IL

Located in Orland Park, IL, Northwestern Medicine delivers targeted support for individuals battling substance use issues alongside mental health disorders, catering to both adults and children. The facility features several treatment options, including intensive outpatient, outpatient, and day treatment programs that integrate techniques such as anger management, brief intervention, and cognitive behavioral therapy. It also focuses on individuals with dual diagnoses and customizes its services for adults and young adults of all genders. With a commitment to high standards of care and a holistic approach to rehabilitation, Northwestern Medicine is a premier option for those in need of tailored treatment for addiction and mental health difficulties.

Northwestern Medicine Palos Hospital

Northwestern Medicine Palos Hospital, located in Palos Heights, IL, provides a wide range of addiction treatment solutions for both adults and young adults. This center features inpatient detoxification services and treatment for substance use disorders, accommodating those with co-occurring serious mental health conditions in adults and emotional issues in children. Offering specialized programs that emphasize personalized care, the facility employs methods like 12-step guidance, anger management, and short-term interventions. Catering to both men and women, Northwestern Medicine Palos Hospital is committed to delivering high-quality care and customized treatment strategies to assist individuals as they navigate their recovery process.

Novant Health Forsyth Medical Center

Novant Health Forsyth Medical Center located in Winston Salem, NC, delivers an extensive array of rehabilitation services designed for adults and young adults facing challenges related to substance use and concurrent mental health issues. The center features hospital-based detoxification and treatment programs, with particular attention to those experiencing severe emotional disturbances. Emphasizing personalized treatment strategies, including anger management, short-term interventions, and motivational rewards, this facility guarantees customized care for every individual. Clients of all genders benefit from high-quality, gender-sensitive treatment within a nurturing and therapeutic space that promotes enduring recovery.

Northwest Integrated Health

Northwest Integrated Health in Puyallup, WA, provides tailored substance use disorder services for adults with co-occurring mental health conditions and children experiencing significant emotional challenges. Their therapeutic approaches include cognitive behavioral therapy, the Matrix Model, and motivational interviewing, delivered through intensive outpatient and traditional outpatient programs utilizing methadone, buprenorphine, or naltrexone. The center uniquely addresses the needs of adult men and women, as well as survivors of intimate partner violence and domestic abuse. Catering to adults and young adults across the gender spectrum, Northwest Integrated Health is dedicated to delivering effective care through individualized strategies and specialized support for comprehensive recovery.

Northwest Integrated Health

Situated in Lakewood, WA, Northwest Integrated Health delivers a wide array of treatment options for substance use issues in both adults and young adults. The center is adept at managing co-occurring substance use disorders in conjunction with significant mental health challenges or emotional issues in children. Emphasizing strategies such as cognitive behavioral therapy, the Matrix Model, and motivational interviewing, this facility offers various treatment formats, including intensive outpatient, outpatient, and options for methadone/buprenorphine or naltrexone. Northwest Integrated Health serves adult men and women, as well as individuals who have faced intimate partner violence or domestic abuse. Their programs are designed to be gender-specific, ensuring personalized care for both females and males and providing high-quality, effective rehabilitation experiences.

Northwestern Community Services

Situated in Winchester, VA, Northwestern Community Services presents an extensive selection of treatment options for both adults and children. This facility focuses on detox support, treatment for substance use disorders, and addressing co-occurring conditions. It offers intensive outpatient, outpatient, and outpatient detox services. Emphasizing methodologies such as 12-step facilitation, anger management, and brief intervention, the center supports active duty military members, as well as adult men and women. Northwestern Community Services is dedicated to delivering personalized, high-quality care to assist individuals of all ages and genders in attaining long-term recovery.

Northwood Health Systems

Northwood Health Systems, located in Wheeling, WV, provides a wide range of addiction recovery services for adults and older adults facing substance use challenges alongside mental health concerns. This center offers various treatment options, including intensive outpatient programs, outpatient detox, and general outpatient services, employing methods like 12-step programs, anger management strategies, and brief interventions. There are specialized programs designed for individuals with dual diagnoses and those who are part of the criminal justice system. Prioritizing personalized care for both men and women, Northwood Health Systems is dedicated to offering effective support for those on the path to recovery.

Northwest Integrated Health

Northwest Integrated Health, situated in Tacoma, WA, provides a wide range of substance use recovery programs along with targeted assistance for individuals facing co-occurring substance use issues and severe mental health challenges in adults, as well as significant emotional disturbances in children. The facility offers various treatment options including intensive outpatient programs, general outpatient services, and specialized outpatient therapies such as methadone/buprenorphine or naltrexone treatments. Emphasizing approaches like cognitive behavioral therapy, the Matrix Model, and motivational interviewing, the center customizes its treatments to cater to the unique requirements of each individual. Specific services are designed for adult men, adult women, individuals impacted by intimate partner violence, and survivors of domestic violence. Northwest Integrated Health is dedicated to providing adults and young adults across all genders with high-quality, research-supported care.

Northwest Integrated Health

Northwest Integrated Health in Tacoma, WA, provides extensive addiction recovery services alongside expert support for those facing combined mental health challenges. Their services are designed for adults and young adults, featuring distinct programs for adult men and women. The center offers various levels of care, including intensive outpatient, outpatient, and medication-assisted treatments utilizing methadone, buprenorphine, or naltrexone. Employing proven methods such as cognitive behavioral therapy, the Matrix Model, and motivational interviewing, this establishment delivers personalized treatment for every individual. Northwest Integrated Health distinguishes itself through its dedication to superior care and customized recovery strategies for enduring sobriety.

Northwest Resources II Inc

Northwest Resources II Inc in Olympia, WA, delivers targeted substance use disorder therapies for adults and adolescents. Their services encompass intensive outpatient, standard outpatient, and medication-assisted treatment options like methadone, buprenorphine, or naltrexone. Employing approaches such as 12-step facilitation, brief intervention, and CBT, the center supports individuals facing co-occurring mental health and addiction challenges, particularly those with a history of trauma. Northwest Resources II Inc serves both men and women, offering personalized care to foster enduring sobriety.

Nova Behavioral Health Inc

Situated in Dayton, OH, Nova Behavioral Health Inc provides an array of addiction treatment services, including detoxification, comprehensive substance use therapy, transitional accommodations, and sober living environments. The center features various care options such as long-term residential stays, detoxification programs, and round-the-clock support. Nova emphasizes personalized treatment through methods like 12-step facilitation, cognitive behavioral therapy, and motivational interviewing. It also offers specialized programs for active duty military members as well as services tailored for adult men and women. With a commitment to quality care and customized treatment strategies, Nova Behavioral Health Inc is recognized as a leading provider of effective rehabilitation solutions for both adults and young adults.

Nova Behavioral Health Inc

Situated in Dayton, OH, Nova Behavioral Health Inc offers a wide array of services for those dealing with addiction, including detox services and various treatment options for substance use, as well as transitional living arrangements like sober homes and halfway houses. The facility provides intensive outpatient care, long-term residential programs, and standard outpatient services, employing evidence-based techniques such as cognitive behavioral therapy, motivational interviewing, and 12-step facilitation. Nova Behavioral Health features specialized programs designed for active duty military members, as well as distinct offerings for adult men and women, ensuring a comprehensive approach to treatment that accommodates a variety of individuals. The center is dedicated to delivering personalized, high-standard care for both adults and young adults, regardless of gender.

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Situated in Enid, OK, the Northwest Center for Behavioral Health provides dedicated outpatient services designed for the treatment of substance use issues and co-occurring conditions in both adults and children. This center employs a variety of therapeutic methods, including anger management, cognitive behavioral therapy, and brief intervention strategies. The personalized care model at this facility ensures that every client receives customized attention. Catering to individuals of all ages and genders, the Northwest Center for Behavioral Health prioritizes high-quality care and utilizes evidence-based techniques. Those in need of routine outpatient services or specific treatments such as methadone, buprenorphine, or naltrexone can access extensive support here.

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Located in Fairview, OK, the Northwest Center for Behavioral Health offers comprehensive outpatient services for substance use, co-occurring disorders in adults, and emotional disturbances in children. This facility specializes in anger management, brief interventions, and cognitive behavioral therapy, providing individualized treatment plans for each client. Serving adults and seniors of all genders, the center stands out for its tailored approach and high-quality care. With programs like outpatient methadone/buprenorphine treatment and regular outpatient services, the Northwest Center for Behavioral Health is a top choice for those seeking effective and personalized rehabilitation options.

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Northwest Center for Behavioral Health, situated in Guymon, OK, provides dedicated services for individuals of all ages facing addiction and accompanying mental health challenges. They employ various treatment modalities, including intensive outpatient, standard outpatient, and medication-assisted treatment options like methadone, buprenorphine, and naltrexone. Their approach incorporates proven techniques such as anger management, brief intervention, and cognitive behavioral therapy, ensuring personalized support. The center serves adults and seniors across all genders, committed to delivering effective, customized rehabilitation programs to guide clients toward lasting recovery.

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Situated in Alva, OK, Northwest Center for Behavioral Health delivers targeted outpatient care for individuals struggling with substance abuse and co-occurring mental health conditions across all age groups. The center employs a variety of scientifically supported methods, such as anger control techniques, cognitive behavioral therapy, and customized treatment plans. Emphasizing personalized care, the facility serves adults and older adults of any gender. Available services encompass outpatient medication-assisted treatment (methadone/buprenorphine or naltrexone), standard outpatient services, and short-term counseling. Northwest Center for Behavioral Health is committed to providing excellent support and treatment for those on their journey to recovery and wellness.

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Situated in Williston, ND, the Northwest Human Service Center delivers extensive substance abuse rehabilitation for both adults and minors facing concurrent mental health challenges. The center features both intensive outpatient and standard outpatient programs, which include methadone and buprenorphine therapies. Employing proven methods such as cognitive behavioral therapy and the Matrix Model, this facility serves clients of all genders and offers tailored programs for teenagers and individuals with dual diagnoses. Committed to exceptional care and personalized treatment strategies, the center aims to support clients in attaining sustainable recovery and enhanced psychological health.

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Northwest Resources II Inc, situated in Shelton, WA, delivers thorough addiction treatment for adults and adolescents facing concurrent severe mental health conditions. The facility offers various levels of care, including intensive outpatient, outpatient services, and medication-assisted treatment utilizing methadone, buprenorphine, or naltrexone. Their therapeutic approach incorporates 12-step facilitation, brief intervention strategies, and cognitive behavioral therapy, ensuring personalized treatment plans. Northwest Resources II Inc has a particular focus on adult males but also serves both male and female clients. Their commitment lies in delivering exceptional care to foster successful recovery journeys.

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New Martinsville, WV

Northwood Health Systems, located in New Martinsville, WV, provides a variety of research-backed treatment options for individuals dealing with substance abuse and mental health issues, applicable to both adults and children. The facility offers comprehensive outpatient programs, featuring specific therapies involving methadone/buprenorphine or naltrexone. By employing methodologies such as cognitive behavioral therapy and anger management techniques, Northwood Health Systems effectively serves clients with dual diagnoses and those with interactions in the criminal justice system. With customized treatment plans designed for adults and seniors of all genders, this center is dedicated to offering exceptional care to assist individuals in their recovery journey.

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Located in Moundsville, WV, Northwood Health Systems offers a wide range of substance use rehabilitation services, as well as targeted support for adults facing severe mental health challenges and children experiencing significant emotional issues. The center provides outpatient treatment options, which include therapies such as methadone/buprenorphine and naltrexone. Its evidence-based strategies feature techniques like anger management, brief interventions, and cognitive behavioral therapy. Focusing on personalized care, the facility serves adults and seniors of all genders, ensuring that each treatment plan is customized to meet the specific requirements of every individual. Northwood Health Systems is committed to delivering exceptional care and assistance to those on their journey to recovery and wellness.

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Nova Counseling Services Inc in Oshkosh, WI, delivers focused care for individuals struggling with substance use disorders within a secure and encouraging setting. The center provides various program lengths, including extended, brief, and round-the-clock residential stays, emphasizing 12-step principles, cognitive behavioral techniques, and motivational interviewing strategies. Nova Counseling Services Inc customizes treatment plans to meet the distinct needs of each adult and senior client. Notable offerings include transitional living accommodations and sober living residences, facilitating a well-defined journey toward lasting recovery. The facility's dedicated men's program creates a distinct environment for male participants pursuing successful addiction treatment.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated September 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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