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Medically Reviewed Content
Updated: September 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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River Source Treatment Center

Situated in Arizona City, AZ, River Source Treatment Center provides extensive rehabilitation programs for both adults and young adults facing challenges with substance abuse and concurrent mental health issues. The center features inpatient detoxification and treatment services that employ methods like 12-step support, anger management therapy, and brief interventions. With tailored programs designed for active military personnel, men, and women, River Source Treatment Center addresses the distinct needs of every client. Its commitment to outstanding care and gender-specific treatment options makes it a preferred destination for individuals looking for personalized and effective addiction recovery solutions.

River Hills Community Health Center

Situated in Ottumwa, IA, the River Hills Community Health Center provides targeted outpatient services for adults grappling with substance use disorders. The center employs a personalized methodology for treatment, particularly addressing the challenges of concurrent substance abuse and severe mental health issues or emotional challenges. Offering a variety of services such as counseling for substance use disorders and telehealth therapy options, this facility serves both men and women who are in search of effective treatment. Their offerings include outpatient services for methadone/buprenorphine or naltrexone, alongside standard outpatient care. If you or someone close to you needs customized and holistic support for addiction, this center is committed to offering expert care for adults.

River Valley Counseling Center

At River Valley Counseling Center in Chicopee, MA, adults and children experiencing significant emotional disturbances can access outpatient care for substance use. The center specializes in techniques such as anger management, cognitive behavioral therapy, and short-term interventions, catering to individuals facing the challenges of co-occurring pain and addiction. Specific programs are designed to support adolescents and young adults effectively. River Valley Counseling Center is equipped to serve both male and female clients, ensuring treatment is delivered with professionalism and compassion. This facility offers proven therapeutic methods and personalized attention for those in need of addiction recovery and mental health assistance.

River Valley Medical Wellness

River Valley Medical Wellness, situated in Russellville, AR, provides a full spectrum of addiction recovery support. Their expertise includes detox, substance abuse rehabilitation, and care for dual diagnoses in individuals of all ages. Emphasizing intensive outpatient, general outpatient, and outpatient detox programs, they integrate methods like 12-step support, anger management training, and brief therapeutic interventions. River Valley Medical Wellness supports teens, adult men and women, and older adults, welcoming individuals of any gender. Renowned for its high standards and tailored treatment plans, this center is a leading option for those pursuing effective, individualized recovery.

River Parishes Treatment Center

River Parishes Treatment Center in La Place, LA, provides comprehensive outpatient services for adults battling substance use disorders, particularly those experiencing co-occurring mental health challenges. They also support children with significant emotional difficulties. Their treatment options include medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside standard outpatient care. Therapeutic interventions such as anger management, brief intervention strategies, and cognitive behavioral therapy are integrated into treatment plans. The center has developed specialized programs tailored for adolescents, adult men, and adult women, emphasizing a personalized approach to recovery. Catering to adults and seniors across genders, River Parishes Treatment Center is dedicated to delivering high-quality, individualized support for long-term healing.

River Valley Counseling Center

River Valley Counseling Center, located in Westfield, MA, provides outpatient treatment for adults and children facing significant mental health challenges or emotional issues related to substance use. The center emphasizes services like anger management, brief therapeutic interventions, and cognitive behavioral therapy, ensuring consistent outpatient support for individuals dealing with concurrent pain and substance use disorders. River Valley Counseling Center also offers customized programs for teenagers and young adults, accommodating both males and females who are in search of exceptional rehabilitation services. Their holistic methodology and commitment to personalized care position this facility as a preferred option for those seeking meaningful and empathetic treatment.

River Valley Counseling Center

River Valley Counseling Center in Holyoke, MA, provides extensive outpatient services for individuals of all ages grappling with substance use and concurrent mental health challenges. This facility is particularly adept at addressing anger management, implementing brief interventions, and utilizing cognitive behavioral therapy. They offer specialized support for adolescents, those managing pain alongside substance use, and young adults. Prioritizing personalized treatment plans, River Valley Counseling Center welcomes both male and female clients across the lifespan, creating a nurturing setting for those pursuing proven rehabilitation strategies in the Holyoke region.

River Hills Community Health Center

River Hills Community Health Center, located in Oskaloosa, IA, specializes in providing outpatient treatment tailored for adults dealing with substance use issues and associated mental health disorders. This facility emphasizes personalized care, offering counseling for substance use disorders and access to telemedicine therapy. Catering to both men and women, River Hills focuses on a unique approach to recovery. Among its services are outpatient treatments using methadone, buprenorphine, or naltrexone. The center is recognized for its exceptional care and dedication to assisting individuals on the path to recovery and improved mental health.

River Valley Counseling Center

River Valley Counseling Center, situated in Easthampton, MA, offers extensive outpatient care for adult substance abuse. They also provide integrated treatment for individuals, both children and adults, experiencing both mental health conditions and substance use challenges. Their specialized services include programs targeting anger management, brief intervention, and cognitive behavioral therapy, with particular attention paid to adolescents, individuals managing co-occurring pain and substance use issues, and young adults. Serving a diverse clientele of all ages and genders, the center is committed to delivering excellent support through personalized treatment plans designed to address specific requirements.

RiverValley Behavioral Health

RiverValley Behavioral Health, located in Providence, KY, specializes in outpatient treatment for substance use and offers focused care for those facing both substance use issues and serious mental health challenges. Emphasizing methods such as 12-step programs, anger management, and concise intervention strategies, the center creates customized treatment plans for active military members, youths, and adult males. Catering to adults and seniors of all genders, this facility ensures top-notch care within a nurturing setting. Individuals looking for help with substance use or concurrent disorders can anticipate extensive services aimed at fostering long-term recovery and enhanced psychological health.

RiverValley Behavioral Health

RiverValley Behavioral Health located in Beaver Dam, KY, provides outpatient treatment for substance use issues along with specialized support for adults facing both substance use disorders and significant mental health challenges, as well as for children dealing with serious emotional disturbances. The treatment program incorporates 12-step facilitation, anger management techniques, and short-term interventions. It also offers targeted programs for active military personnel, adolescents, and adult males, accommodating individuals of all genders, including seniors. RiverValley Behavioral Health is dedicated to delivering personalized care, establishing itself as an essential option for those pursuing thorough and effective rehabilitation solutions in the Beaver Dam community.

RiverValley Behavioral Health

RiverValley Behavioral Health, situated in Owensboro, KY, provides targeted care for individuals struggling with substance use and co-occurring mental health issues, catering to both adults and children. Emphasizing inpatient and residential treatment options, the center employs various methodologies including 12-step programs, anger management techniques, and cognitive behavioral therapy. Special programs designed for adult women and those who are pregnant or postpartum address particular requirements. RiverValley Behavioral Health is dedicated to serving adults, seniors, and young adults, with a particular emphasis on female-focused services. Clients can anticipate receiving exceptional care and support in a nurturing and therapeutic setting.

RiverValley Behavioral Health

RiverValley Behavioral Health, located in Lewisport, KY, delivers effective outpatient substance use recovery services for adults experiencing significant mental health challenges, as well as emotional issues in children. The facility offers focused support for active duty military personnel, teenagers, and adult males. Their treatment methods incorporate 12-step programs, techniques for managing anger, and brief interventions. RiverValley Behavioral Health creates customized programs for both men and women, accommodating adults and older individuals in need of thorough and personalized rehabilitation options. Clients can expect compassionate support and treatments grounded in evidence-based practices at this center.

RiverValley Behavioral Health

RiverValley Behavioral Health in Owensboro, KY, offers specialized addiction recovery services for adult men, older adults, and young adults. Their treatment options include intensive outpatient, outpatient, and day treatment programs, incorporating 12-step facilitation, anger management techniques, and cognitive behavioral therapy. They provide distinct programs for adult men and individuals involved in the criminal justice system, addressing specific requirements. RiverValley Behavioral Health distinguishes itself by focusing on customized care for male patients, guaranteeing personalized treatment and assistance. Clients will find a full spectrum of services and proven therapeutic approaches, all delivered with a dedication to high standards of care and sustained sobriety.

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River City Professional Csl Servs LLC, located in Monroe, LA, specializes in complete care for individuals struggling with addiction and dual diagnoses of significant mental health challenges. The program includes robust intensive outpatient care, general outpatient services, and medication-assisted treatment options such as methadone, buprenorphine, or naltrexone. They utilize approaches like 12-step facilitation, anger management training, and brief intervention, serving a wide age range from children and adolescents to adults and young adults. The center also offers specialized support for teens, adult men, and adult women, providing individualized attention. Their dedication to high-quality treatment and varied therapeutic methods establishes River City Professional Csl Servs LLC as a key provider for effective recovery services.

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River City Rehabilitation Center Inc, located in New Braunfels, TX, provides targeted substance abuse treatment services for both adults and young adults. The center offers various outpatient options, such as methadone, buprenorphine, or naltrexone therapies along with standard outpatient care. Emphasizing tailored treatment plans, they employ proven methods including 12-step programs, brief interventions, and cognitive behavioral techniques. River City Rehabilitation Center is particularly attentive to the needs of adult men and women, offering gender-specific programs that foster a nurturing atmosphere for all clients. If you are seeking effective addiction recovery in a caring environment, this facility is an excellent choice for thorough and individualized support.

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River City Rehabilitation Center Inc. in San Antonio, TX, delivers targeted outpatient services for individuals battling substance use disorders. Their comprehensive approach encompasses various treatment modalities such as medication-assisted treatment with methadone, buprenorphine, or naltrexone, standard outpatient care, and support through 12-step facilitation. Employing strategies like brief intervention and cognitive behavioral therapy, the center supports adults, including young adults, and offers gender-specific programming. River City Rehabilitation Center is dedicated to providing effective and individualized care for adults pursuing recovery.

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River Valley Counseling Center in Springfield, MA, delivers outpatient services for substance abuse and targeted support for those experiencing both addiction and significant mental health challenges. The center employs proven therapeutic methods, including anger management, brief intervention, and cognitive behavioral therapy, within its regular outpatient framework. They offer individualized plans for teens, young adults, and individuals managing both pain and substance use disorders, catering to all ages and genders. River Valley Counseling Center is distinguished by its wide array of treatment choices and dedication to offering effective care to support clients' recovery journeys.

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River Valley Primary Care Services, located in Fort Smith, AR, provides focused outpatient care for adults dealing with substance use disorders alongside serious mental health conditions, as well as emotional challenges affecting children. The center administers outpatient treatments using methadone, buprenorphine, or naltrexone, complemented by ongoing outpatient services. Their specialized methodology encompasses brief interventions, motivational interviewing, and relapse prevention strategies. By emphasizing customized treatment programs, River Valley Primary Care Services effectively supports young males and adolescents, fostering a nurturing and considerate setting for individuals in need of high-quality addiction recovery services in the Fort Smith region.

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RiverValley Behavioral Health, located in Henderson, KY, delivers an extensive range of outpatient services designed for individuals dealing with substance use issues and concurrent mental health disorders, serving both adults and children. The center features tailored programs aimed at active duty military personnel, teenagers, and adult males. Employing strategies like 12-step facilitation, anger management, and brief interventions, this facility supports both male and female adults as well as older adults. Committed to providing high-quality care through evidence-based methodologies, RiverValley Behavioral Health strives to assist clients in attaining sustainable recovery and enhanced mental health.

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RiverValley Behavioral Health, located in Morganfield, KY, specializes in outpatient treatment for adults struggling with substance use issues, while also addressing accompanying serious mental health conditions. The center has programs tailored to address emotional challenges in children. With therapies that include 12-step support, anger management techniques, and brief intervention strategies, it offers targeted services for active military members, adolescents, and adult men. Catering to adults and seniors of all genders, this rehabilitation center provides high-quality care within a nurturing setting. For those in need of thorough addiction treatment that considers co-occurring disorders, RiverValley Behavioral Health could be an excellent choice.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated September 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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