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Medically Reviewed Content
Updated: May 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,711 treatment centers offering naltrexone (vivitrol) across the United States.

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RiverVista Behavioral Health Hospital

RiverVista Behavioral Health Hospital, located in Columbus, OH, delivers extensive recovery support for adults and young adults facing addiction and co-occurring severe mental health conditions. The center features inpatient detoxification and treatment programs, with dedicated services for active military members. Through personalized strategies such as 12-step facilitation and anger management techniques, RiverVista guarantees a custom recovery plan. Its gender-specific programs for adult men and women address varied requirements, and brief intervention methods aid in successful rehabilitation. Clients will receive exceptional, round-the-clock inpatient care within a nurturing setting designed to foster wellness and personal development.

Riverwalk Ranch
Mansfield, TX

Riverwalk Ranch, located in Mansfield, TX, delivers extensive treatment options for adults and young adults facing challenges related to substance use and concurrent mental health issues. The center features tailored programs for active duty military personnel, adult males, and adult females, offering hospital-based inpatient detox and treatment in a nurturing atmosphere. By employing techniques such as 12-step programs, anger management, and brief interventions, the facility aims to offer personalized, high-quality care. Whether individuals are in need of detoxification, assistance with substance use, or support for co-occurring disorders, Riverwalk Ranch ensures efficient and empathetic care for all clients.

Roaring Brook Recovery

Roaring Brook Recovery in Lexington, KY, delivers extensive addiction care for adults and adolescents facing dual diagnoses of mental health disorders. The center features intensive outpatient, day treatment, and partial hospitalization options. Employing 12-step integration, anger control techniques, and brief intervention strategies, Roaring Brook Recovery customizes healing plans. Distinct programs are available for active military members, as well as adult men and women. Committed to high standards, this establishment guides both male and female individuals toward lasting sobriety.

Rochester General Hospital

Rochester General Hospital, situated in Rochester, NY, delivers extensive treatment for substance use disorders affecting both adults and youth, particularly those facing significant mental health issues concurrently. The facility offers outpatient services that include individualized options such as methadone/buprenorphine or naltrexone therapies. Emphasizing personalized recovery, the center utilizes methodologies like cognitive behavioral therapy, motivational interviewing, and brief interventions. Specialized programs are available for adult men, adult women, and individuals with trauma histories. With a commitment to serving both genders, Rochester General Hospital strives to provide high-quality rehabilitation services that assist individuals in their path toward sobriety.

ROAD to a Better Life
Somersworth, NH

"ROAD to a Better Life" located in Somersworth, NH, provides outpatient services for adults and young adults dealing with substance use issues. This center focuses on preventing relapse and delivers personalized care aimed at achieving high standards. It offers various outpatient options including methadone/buprenorphine or naltrexone therapies, regular outpatient services, and telehealth sessions. Each program is customized to meet the specific needs of clients, whether they are male or female, who are on their path to recovery. If you’re in search of a detailed outpatient program that emphasizes individual care and relapse prevention strategies, "ROAD to a Better Life" may be an ideal fit for you.

Road to Recovery Treatment Services

Road to Recovery Treatment Services, situated in Fountain Valley, CA, delivers a thorough selection of addiction treatment options. This establishment focuses on detoxification and the management of substance use disorders, offering extended stay residential, immediate detox residential, and round-the-clock residential support. Employing methods including 12-step program assistance, emotional regulation skills training, and cognitive behavioral strategies, the center serves adult individuals and young adults, irrespective of gender. Emphasizing support for those with histories of sexual abuse, trauma, or co-occurring mental health and substance use challenges, Road to Recovery Treatment Services is committed to providing personalized and effective care for individuals striving for healing.

Rivyve Behavioral Health
Bullhead City, AZ

Rivyve Behavioral Health, located in Bullhead City, AZ, specializes in extended residential care for adults dealing with substance use disorders and co-occurring mental health challenges, alongside offering support for children with significant emotional issues. The center features targeted programs designed specifically for active duty service members, as well as programs for men and women. By employing methods such as 12-step facilitation, anger management training, and targeted interventions, Rivyve Behavioral Health delivers personalized care aimed at meeting each client's unique requirements. Serving adults and young individuals of every gender, the center is committed to providing top-notch, customized treatment that fosters long-term recovery and overall well-being.

ROAD to a Better Life

"ROAD to a Better Life" located in Merrimack, NH, delivers extensive treatment options for substance use disorders aimed at both adults and young adults. This center offers outpatient services that include methadone, buprenorphine, or naltrexone therapies, alongside strategies for relapse prevention and telehealth services. Committed to personalized care, "ROAD to a Better Life" serves both male and female clients, ensuring that each treatment plan is customized to meet individual needs. For those in search of compassionate and effective addiction recovery solutions, this facility is devoted to helping you pave your path to a brighter and healthier future.

Road to Recovery Lawrence LLC

Road to Recovery Lawrence LLC, located in Wichita, KS, delivers comprehensive outpatient care for individuals facing addiction and co-occurring mental health challenges. The center provides diverse treatment options, such as medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside evidence-based therapies like 12-step program integration, anger control, and short-term counseling. They are committed to personalized treatment plans, serving young people, adult males, and adult females. Road to Recovery Lawrence LLC is equipped to support clients of all genders, fostering a nurturing space for recovery. Their mission is to facilitate a successful transition to a sober life through effective, research-supported methodologies.

ROAD to a Better Life

Situated in Concord, NH, "ROAD to a Better Life" is a dedicated rehabilitation facility that specializes in outpatient treatment for substance use disorders. This center provides various treatment options, including outpatient services for methadone, buprenorphine, or naltrexone, regular outpatient therapy, as well as telemedicine and telehealth sessions. Emphasizing relapse prevention and tailored counseling for substance use issues, the center ensures customized care plans for both adults and adolescents. Committed to delivering high-quality support, "ROAD to a Better Life" welcomes male and female clients who are looking for an individualized journey towards recovery.

RiverValley Behavioral Health

RiverValley Behavioral Health, located in Providence, KY, specializes in outpatient treatment for substance use and offers focused care for those facing both substance use issues and serious mental health challenges. Emphasizing methods such as 12-step programs, anger management, and concise intervention strategies, the center creates customized treatment plans for active military members, youths, and adult males. Catering to adults and seniors of all genders, this facility ensures top-notch care within a nurturing setting. Individuals looking for help with substance use or concurrent disorders can anticipate extensive services aimed at fostering long-term recovery and enhanced psychological health.

RiverValley Behavioral Health

RiverValley Behavioral Health located in Beaver Dam, KY, provides outpatient treatment for substance use issues along with specialized support for adults facing both substance use disorders and significant mental health challenges, as well as for children dealing with serious emotional disturbances. The treatment program incorporates 12-step facilitation, anger management techniques, and short-term interventions. It also offers targeted programs for active military personnel, adolescents, and adult males, accommodating individuals of all genders, including seniors. RiverValley Behavioral Health is dedicated to delivering personalized care, establishing itself as an essential option for those pursuing thorough and effective rehabilitation solutions in the Beaver Dam community.

RiverValley Behavioral Health

RiverValley Behavioral Health, situated in Owensboro, KY, provides targeted care for individuals struggling with substance use and co-occurring mental health issues, catering to both adults and children. Emphasizing inpatient and residential treatment options, the center employs various methodologies including 12-step programs, anger management techniques, and cognitive behavioral therapy. Special programs designed for adult women and those who are pregnant or postpartum address particular requirements. RiverValley Behavioral Health is dedicated to serving adults, seniors, and young adults, with a particular emphasis on female-focused services. Clients can anticipate receiving exceptional care and support in a nurturing and therapeutic setting.

RiverValley Behavioral Health

RiverValley Behavioral Health, located in Lewisport, KY, delivers effective outpatient substance use recovery services for adults experiencing significant mental health challenges, as well as emotional issues in children. The facility offers focused support for active duty military personnel, teenagers, and adult males. Their treatment methods incorporate 12-step programs, techniques for managing anger, and brief interventions. RiverValley Behavioral Health creates customized programs for both men and women, accommodating adults and older individuals in need of thorough and personalized rehabilitation options. Clients can expect compassionate support and treatments grounded in evidence-based practices at this center.

RiverValley Behavioral Health

RiverValley Behavioral Health in Owensboro, KY, offers specialized addiction recovery services for adult men, older adults, and young adults. Their treatment options include intensive outpatient, outpatient, and day treatment programs, incorporating 12-step facilitation, anger management techniques, and cognitive behavioral therapy. They provide distinct programs for adult men and individuals involved in the criminal justice system, addressing specific requirements. RiverValley Behavioral Health distinguishes itself by focusing on customized care for male patients, guaranteeing personalized treatment and assistance. Clients will find a full spectrum of services and proven therapeutic approaches, all delivered with a dedication to high standards of care and sustained sobriety.

RiverValley Behavioral Health

RiverValley Behavioral Health in Owensboro, KY, provides extensive programs for addiction and dual diagnosis care, addressing co-occurring substance use disorders alongside significant mental health or emotional challenges. The center offers several levels of care including intensive outpatient, outpatient, and day treatment/partial hospitalization. Their approach incorporates 12-step facilitation, anger management, and brief intervention strategies. RiverValley Behavioral Health is equipped to serve active duty military, adolescents, adult men, and people of any gender. They also extend their personalized recovery support to adults and seniors, ensuring tailored treatment for each client.

Rock County Human Services Department

Situated in Janesville, WI, the Rock County Human Services Department delivers focused treatment for adults and young adults dealing with both substance use and significant mental health challenges. The facility offers both intensive outpatient and standard outpatient programs, featuring treatments such as methadone/buprenorphine and naltrexone. By employing techniques like cognitive behavioral therapy, community reinforcement, and contingency management, the center customizes its services to cater to the unique requirements of each client. Emphasizing personalized care, this center accommodates both male and female clients, providing a thorough and effective rehabilitation journey.

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Riverside University Health System, situated in Desert Hot Springs, CA, delivers extensive rehabilitation programs. Their expertise lies in addressing substance use disorders and co-occurring mental health conditions. They offer various levels of care, including intensive outpatient, standard outpatient, and day treatment. Employing proven therapeutic methods such as cognitive behavioral therapy and the Matrix Model, this center supports adults, young adults, and adolescents. Specific programs are available for active duty military personnel, adult men, and those with significant mental health challenges. Riverside University Health System is committed to high-quality, individualized treatment designed to foster sustained recovery.

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RiverValley Behavioral Health, located in Henderson, KY, delivers an extensive range of outpatient services designed for individuals dealing with substance use issues and concurrent mental health disorders, serving both adults and children. The center features tailored programs aimed at active duty military personnel, teenagers, and adult males. Employing strategies like 12-step facilitation, anger management, and brief interventions, this facility supports both male and female adults as well as older adults. Committed to providing high-quality care through evidence-based methodologies, RiverValley Behavioral Health strives to assist clients in attaining sustainable recovery and enhanced mental health.

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RiverValley Behavioral Health, located in Morganfield, KY, specializes in outpatient treatment for adults struggling with substance use issues, while also addressing accompanying serious mental health conditions. The center has programs tailored to address emotional challenges in children. With therapies that include 12-step support, anger management techniques, and brief intervention strategies, it offers targeted services for active military members, adolescents, and adult men. Catering to adults and seniors of all genders, this rehabilitation center provides high-quality care within a nurturing setting. For those in need of thorough addiction treatment that considers co-occurring disorders, RiverValley Behavioral Health could be an excellent choice.

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East Machias, ME

Situated in East Machias, ME, RMCL/HealthWays specializes in outpatient care for adults dealing with substance use issues alongside serious mental health disorders and offers support for children facing emotional challenges. The center offers a variety of services such as outpatient treatment with methadone, buprenorphine, or naltrexone, as well as anger management sessions, brief interventions, and cognitive behavioral therapy. RMCL/HealthWays designs specific programs for active duty military personnel, adolescents, and adult males, ensuring that it meets the needs of both adults and seniors across all genders. The facility is committed to providing top-notch care and personalized treatment strategies to foster recovery and well-being for every client.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated May 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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