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Medically Reviewed Content
Updated: May 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,711 treatment centers offering naltrexone (vivitrol) across the United States.

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UF Health Shands
Gainesville, FL

UF Health Shands, located in Gainesville, FL, delivers a complete range of addiction recovery options, emphasizing medically supervised detox and thorough substance use disorder therapy. The facility offers flexible care levels, including intensive outpatient, standard outpatient, and partial hospitalization programs. Utilizing evidence-based therapeutic techniques like 12-step integration, emotional regulation training, and motivational interviewing, UF Health Shands supports adult men and women, including those impacted by domestic violence. This center is dedicated to providing effective and compassionate care for adults and young adults of all genders on their journey to lasting sobriety.

UNC Health Pardee
Hendersonville, NC

UNC Health Pardee, located in Hendersonville, NC, provides an extensive range of rehabilitation services aimed at individuals facing challenges with substance use disorders alongside co-existing mental health issues. The center features inpatient detoxification and treatment options, with dedicated programs for adults dealing with significant emotional challenges and trauma survivors. Emphasizing 12-step programs, anger management techniques, and short-term interventions, this facility serves both adult men and women, as well as young adults. The customized approaches at UNC Health Pardee cater to various age groups and genders, ensuring that each person receives the specific support they need on their path to healing.

Under Angels Wings Recovery Center

At Under Angels Wings Recovery Center in Brooklyn, NY, we provide extensive outpatient services for addiction and dependency, including detoxification and medication-assisted treatment options such as methadone, buprenorphine, and naltrexone. Our approach incorporates evidence-based practices like 12-step facilitation, anger management, and brief intervention strategies. We are committed to serving a wide range of individuals, from active military members and adolescents to adult men and women, ensuring personalized care for patients of all ages and genders to guide them toward lasting wellness.

Unison Behavioral Health

Unison Behavioral Health, situated in Waycross, GA, delivers dedicated long-term residential care aimed at treating substance use disorders and co-occurring severe mental health issues in adults, as well as emotional disturbances in children. This facility offers round-the-clock support and personalized treatment strategies, including cognitive behavioral therapy, brief interventions, and anger management. Special programs are designed for adult women, particularly those who have experienced intimate partner violence, domestic violence, and sexual abuse. The center prioritizes the needs of female clients but also accommodates seniors and young adults. With a commitment to high-quality care and targeted programs, Unison Behavioral Health serves as a vital support system for individuals in need of tailored rehabilitation solutions.

United American Indian Involvement

United American Indian Involvement located in Los Angeles, CA, provides outpatient services for substance use disorders aimed at both adult men and women. This center is particularly skilled in supporting individuals who have faced intimate partner and domestic violence. Treatment methods include 12-step facilitation, brief intervention, and cognitive behavioral therapy. The program serves a diverse clientele of adults and young adults, ensuring a nurturing atmosphere for recovery. For those looking for effective treatment that respects cultural backgrounds, this center could be the perfect option for your path to recovery.

United Community Center

The United Community Center in Milwaukee, WI, provides extensive support for individuals battling addiction. This center excels in addressing dual diagnoses, meaning it treats both substance abuse and severe mental health conditions in adults, or significant emotional challenges in children. They offer various levels of care, including extended residential stays, outpatient programs, and intensive day treatment. Their therapeutic approaches include anger management, short-term counseling, and cognitive behavioral therapy. The United Community Center welcomes adult men and women, including survivors of domestic and intimate partner violence. Dedicated to all genders and age groups, the center ensures top-tier care within a nurturing setting.

United Community and Family Services

United Community and Family Services in Norwich, CT, delivers extensive outpatient care. They focus on addiction and dual diagnoses for all ages, offering specialized therapies like anger management, CBT, and short-term counseling. Programs are designed for service members, teens, and adult males. Treatment modalities include outpatient methadone, buprenorphine, or naltrexone. Serving a broad population including seniors and people of any gender, they are committed to effective, research-backed recovery support.

UHS of Dover LLC

UHS of Dover LLC, located in Dover, Delaware, provides extensive rehabilitation services aimed at both adults and children facing substance use disorders alongside mental health challenges. The center features tailored programs for men and women, offering inpatient detoxification and treatment in a secure and nurturing setting. Approaches such as 12-step facilitation, anger management, and brief interventions are employed to customize care according to each individual's needs. Committed to delivering high-quality support and a variety of services for all clients, UHS of Dover LLC is focused on facilitating the recovery journey for those they serve.

Ultimate Treatment Center

At Ashland, KY's Ultimate Treatment Center, we provide thorough addiction rehabilitation. Our services include detox and drug/alcohol treatment via intensive outpatient, standard outpatient, and outpatient detox options. We employ methods such as anger management, brief intervention, and cognitive behavioral therapy, serving adults and young adults of any gender. Specialized support is available for pregnant/postpartum individuals and veterans. Prioritizing personalized attention and proven techniques, our center is dedicated to aiding each person's path to lasting sobriety.

United Community and Family Services

Situated in Moosup, CT, United Community and Family Services provides extensive outpatient support for adults dealing with substance use and co-occurring serious mental health issues, as well as emotional challenges in children. The center has specific programs designed for active-duty military, teenagers, and adult males. By employing various therapeutic methods such as anger management, cognitive behavioral therapy, and short-term interventions, the facility ensures personalized care for adults and seniors across all genders. United Community and Family Services is committed to offering high-quality treatment that addresses the unique needs of each client, positioning itself as an important resource for individuals on their path to recovery.

Umass Harrington Healthcare at Webster

Umass Harrington Healthcare at Webster, situated in Webster, MA, provides targeted outpatient services for adults dealing with substance use issues and severe mental health disorders, as well as emotional challenges in children. The center delivers extensive support through programs such as anger management, cognitive behavioral therapy, and customized treatment plans designed for individual needs. Aiming to support both young adults and mature individuals, the facility serves clients of all genders. Offered services encompass outpatient treatments with methadone/buprenorphine or naltrexone, standard outpatient care, and brief intervention tactics. Committed to high-quality, personalized treatment, this center strives to assist individuals on their journey toward recovery.

United Community and Family Services

United Community and Family Services, situated in New London, CT, presents an extensive array of outpatient treatment options for substance use specifically tailored for both adults and children who also face mental health challenges. This center features targeted programs designed for active military members, youth, and adult males. Treatment methodologies encompass anger management, brief interventions, and cognitive behavioral therapy. Emphasizing high-quality care, the facility serves both men and women of all ages, including the elderly. Offered services include outpatient treatments utilizing methadone, buprenorphine, or naltrexone, along with consistent outpatient therapy sessions. United Community and Family Services is committed to guiding individuals through their recovery process.

United Community and Family Services

United Community and Family Services, located in Colchester, CT, provides outpatient services for adults dealing with substance use issues alongside serious mental health disorders. This center has designed specific programs aimed at active military personnel, teenagers, and adult males. Treatment methodologies incorporate strategies like anger management, cognitive behavioral therapy, and short-term interventions. Customized programs cater to the needs of both adult men and women, as well as seniors. Prioritizing high-quality care, this facility also offers outpatient treatments with methadone, buprenorphine, or naltrexone. Those in need of extensive rehabilitation services can access individualized support and effective treatment solutions at this esteemed center.

United Community and Family Services

Nestled in Jewett City, CT, United Community and Family Services delivers complete outpatient services for individuals grappling with substance use disorders, also supporting those with concurrent mental health challenges. They feature tailored programs for active military personnel, teens, and adult men. Treatment approaches encompass anger management, cognitive behavioral therapy, and brief intervention strategies. Emphasizing outpatient care, this facility provides medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside standard outpatient services. Catering to adults and seniors across all genders, United Community and Family Services ensures personalized, high-quality care.

Unison Health
Toledo, OH

Unison Health, situated in Toledo, OH, offers thorough support for individuals battling addiction and those dealing with combined mental health and substance use challenges. They provide robust outpatient programs, including medication-assisted treatment with methadone or buprenorphine, employing proven methods like 12-step integration and anger management techniques. Unison Health is dedicated to serving adults of all genders, including survivors of domestic abuse, and specifically addresses the needs of young adults as well. Discover supportive and successful recovery pathways at Unison Health.

UNC Horizons Program

UNC Horizons Program in Carrboro, NC, provides dedicated substance use recovery services for adult women, encompassing seniors and those who are pregnant or have recently given birth. Their therapeutic offerings include intensive outpatient, standard outpatient, and day treatment programs. This program emphasizes anger management techniques, brief intervention strategies, and cognitive behavioral therapy, customizing treatment plans for each individual. The center's distinction lies in its high standard of care and its specialized approach for adult women and new mothers. For women seeking external addiction treatment in a nurturing setting tailored to their specific needs, this center is a strong consideration.

Union Losson Recovery Center

Nestled in Buffalo, NY, Union Losson Recovery Center delivers outpatient care for adults grappling with substance use disorders and co-occurring serious mental health conditions. The center facilitates outpatient treatment using methadone, buprenorphine, and naltrexone, integrated with therapeutic modalities such as 12-step facilitation, anger management, and brief interventions. Tailored programs are available for active duty military, adolescents, and adult men, demonstrating the center's dedication to serving a varied client base. Union Losson Recovery Center provides support to adult men and women, as well as children and adolescents, aiming to offer effective, complete support for those pursuing lasting recovery.

Unison Health
Toledo, OH

Unison Health, situated in Toledo, OH, delivers an extensive variety of services for addiction recovery aimed at both adults and seniors. It features specialized programs catering to adolescents as well as separating options for adult men and women. The center offers detox services, treatment for substance use, transitional housing, and sober living environments. Employing techniques like cognitive behavioral therapy, anger management, and brief interventions, Unison Health provides multiple treatment formats, including intensive outpatient, long-term residential care, and outpatient support. Committed to high-quality care and individualized treatment plans, this rehabilitation center strives to aid individuals on their recovery paths while fostering a nurturing atmosphere for all clients.

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West Des Moines, IA

UCS Healthcare, located in West Des Moines, IA, provides dedicated addiction recovery programs for individuals seeking a path to lasting sobriety. The center features comprehensive offerings such as intensive outpatient care, general outpatient services, and medication-assisted treatment options including methadone, buprenorphine, or naltrexone. Employing evidence-based methods like anger management, brief intervention, and cognitive behavioral therapy, UCS Healthcare serves adult men and women, along with active duty military members. Specializing in care for adults and young adults, UCS Healthcare delivers personalized and effective support for overcoming substance use disorders.

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Unified Community Services, located in Dodgeville, WI, provides extensive treatment for substance use issues impacting both adults and children who also face significant mental health challenges. The center features various treatment methods, including intensive outpatient programs, outpatient services, and options for methadone, buprenorphine, or naltrexone. Emphasizing techniques such as anger management, brief interventions, and cognitive behavioral therapy, this facility is designed for individuals who have undergone trauma, including experiences of intimate partner or domestic violence. Unified Community Services is dedicated to delivering exceptional care to adults and seniors across all genders grappling with both mental health and substance use disorders.

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Unified Community Services, located in Lancaster, WI, delivers comprehensive outpatient services for individuals dealing with substance use issues alongside mental health challenges, catering to both adults and children. The center provides tailored treatment options that include anger management, cognitive behavioral therapy, and programs that address trauma. It specifically supports clients affected by intimate partner violence and those experiencing dual diagnoses. The facility serves adults and seniors of all genders, offering outpatient treatments such as methadone and buprenorphine. Committed to evidence-based practices, the center prioritizes delivering exceptional care for anyone pursuing assistance with addiction and mental health concerns.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated May 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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