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Medically Reviewed Content
Updated: September 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Unity Hospital of Rochester

Unity Hospital of Rochester, located in Rochester, NY, offers a wide range of treatment options for substance use disorders, including specialized support for those facing both substance use and significant mental health issues. The center provides outpatient services, featuring programs such as methadone and buprenorphine treatment, and employs proven strategies like cognitive behavioral therapy and motivational interviewing to aid in the recovery process. Catering to adult men and women, as well as individuals who have undergone trauma, the programs are designed to address the specific requirements of each client. Unity Hospital of Rochester is dedicated to providing high-quality care in a nurturing and empathetic atmosphere for adults and youth of all genders.

Unity Hospital of Rochester

Unity Hospital of Rochester, located in Rochester, NY, delivers outpatient services for individuals of all ages grappling with substance use and co-occurring mental health conditions. Their therapeutic methods encompass anger management, cognitive behavioral therapy, and brief intervention strategies. Tailored programs are available for adolescents, adult men, and adult women, with specialized gender-specific care designed to meet unique requirements. Emphasizing high standards and scientifically supported methods, Unity Hospital offers outpatient treatment using methadone, buprenorphine, or naltrexone, in addition to general outpatient services to foster lasting recovery and well-being.

University of Alabama at Birmingham

The University of Alabama at Birmingham, situated in Birmingham, AL, provides a wide range of rehabilitation services aimed at adults and seniors dealing with substance use issues and associated mental health challenges. This center offers intensive outpatient programs, as well as standard outpatient services, and features special initiatives designed for trauma survivors. Emphasizing techniques such as cognitive behavioral therapy, motivational interviewing, and contingency management, the facility serves a diverse clientele, including men, women, adolescents, and adult females. By utilizing evidence-based practices and personalized treatment plans, the center strives to deliver exceptional care to individuals embarking on their recovery paths.

University of Colorado Denver/ARTS

The University of Colorado Denver/ARTS, situated in Arvada, CO, provides targeted programs for substance use recovery aimed at adults and young adults. This center features intensive outpatient care, as well as outpatient services that include methadone, buprenorphine, or naltrexone treatments. Emphasizing anger management, concise intervention, and cognitive-behavioral therapy, the facility serves adult men and women along with individuals who have faced traumatic experiences. With customized programs for each gender, the University of Colorado Denver/ARTS is committed to delivering quality care and extensive support for those in need of effective and personalized addiction recovery solutions.

University of Iowa Healthcare

University of Iowa Healthcare in Iowa City, IA, provides extensive addiction recovery services for adults, youth, and older adults. This facility excels in managing withdrawal symptoms, treating substance use issues, and addressing dual diagnoses that include significant mental health challenges. Their program offerings feature approaches such as 12-step encouragement, cognitive behavioral therapy, and trauma-informed interventions, delivering customized assistance to individuals facing varied circumstances. A particular strength lies in their dedication to clients with co-occurring pain and addiction, guaranteeing comprehensive care. Regardless of gender, patients benefit from superior, scientifically-backed treatment within a hospital inpatient environment, fostering enduring recovery and enhanced health.

University of Maryland Medical Center

The University of Maryland Medical Center, situated in Baltimore, MD, delivers extensive addiction treatment designed for adults and young adults. Their expertise lies in outpatient detox, addressing substance use, and crafting unique care strategies. The center prioritizes preventing relapse and offers counseling for substance use disorders, ensuring high-quality support for all patients. Through telemedicine and telehealth, they provide accessible assistance regardless of location. The University of Maryland Medical Center is recognized for its dedication to customized treatment, establishing it as a premier destination for effective and caring addiction recovery.

University of New Mexico Hospital

Situated in Albuquerque, NM, the University of New Mexico Hospital provides an extensive array of outpatient services aimed at individuals requiring detoxification, addiction treatment, and support for simultaneous mental health issues. The center is proficient in areas such as anger management, short-term interventions, and cognitive behavioral therapy, offering customized programs for both adults and youth, all under a trauma-informed care framework. With a keen emphasis on clients encountering dual diagnoses, the facility provides outpatient detox, as well as treatments using methadone, buprenorphine, and naltrexone. Catering to both male and female clients, this center is committed to delivering high-quality care through evidence-based methods to aid individuals in their recovery journey.

Unlimited Bounds Human Services LLC

Situated in Curtis Bay, Maryland, Unlimited Bounds Human Services LLC delivers a complete suite of recovery support designed for people across the lifespan. They focus on detox, addiction care, and managing co-occurring mental health conditions, offering intensive outpatient, regular outpatient, and partial hospitalization options. Employing methods such as anger management, brief intervention, and cognitive behavioral therapy, the center customizes care to individual requirements. Key services include programs for young people, survivors of sexual abuse, and individuals facing combined mental health and substance use issues. Prioritizing excellent care and personalized support, Unlimited Bounds Human Services LLC is a reliable choice for healing.

UofL Health
Louisville, KY

Situated in Louisville, KY, UofL Health delivers a wide range of addiction treatment options for adults and older adults. This center features hospital-based inpatient detox services and addresses various substance use disorders, alongside related mental health issues. The treatment methods employed are grounded in evidence-based practices, including 12-step facilitation, cognitive-behavioral therapy, and brief intervention strategies. UofL Health has a particular emphasis on supporting adolescents, seniors, and those with dual diagnoses of mental health and substance use disorders. Committed to providing high-quality care and tailored treatment choices for both men and women, this center aims to empower individuals on their journey to sustained recovery.

Uprising Addiction Center

Uprising Addiction Center in Shreveport, LA, delivers a full spectrum of support for adults and young adults facing addiction. Their approach encompasses medically supervised detox, tailored substance abuse treatment, and dedicated support for co-occurring mental health concerns. Offering both intensive and standard outpatient services, they incorporate 12-step guidance, anger resolution techniques, and strategic brief interventions. Distinctive treatment tracks are available for individuals with trauma histories, those managing dual diagnoses, and clients dealing with pain alongside substance dependence. Uprising Addiction Center is committed to providing high-quality, gender-inclusive care for all individuals striving for recovery.

University Behavioral Center

University Behavioral Center, located in Orlando, FL, delivers an extensive range of services for detoxification and substance use disorders, with a focus on adults facing severe co-occurring mental health conditions and children dealing with emotional issues. The center features hospital inpatient care for detoxification and related treatments, providing around-the-clock support. Utilizing customized methods such as 12-step programs, anger management, and short intervention strategies, the facility supports active military personnel, men, and survivors of intimate partner violence. Catering to both adults and children/adolescents of any gender, University Behavioral Center is committed to offering top-notch care and individualized treatment plans to assist individuals in their recovery process.

University Hospital/Stony Brook ELIH

Situated in Riverhead, NY, University Hospital/Stony Brook ELIH delivers an extensive array of treatment solutions for individuals battling substance use disorders. It includes transitional living arrangements and addresses overlapping mental health issues for both adults and children. The center provides outpatient care, featuring methadone and buprenorphine therapy, alongside cognitive behavioral therapy. It emphasizes specialized programs in anger management, brief intervention, and tailored support for teens, adult women, and those with co-existing disorders, welcoming both male and female clients. Prioritizing quality and personalized care strategies, this facility stands out as a reliable option for individuals in need of effective rehabilitation services.

University of California San Francisco

University of California San Francisco, situated in San Francisco, California, delivers complete addiction recovery services for adults and adolescents. This institution is particularly adept at addressing dual diagnoses, managing substance use disorders concurrently with significant mental health conditions or developmental/emotional challenges in youth. Their offerings encompass outpatient treatment, including medication-assisted therapies with methadone, buprenorphine, or naltrexone, alongside standard outpatient support. Employing strategies such as brief intervention, cognitive behavioral therapy, and motivational interviewing, the center ensures personalized care plans. Distinct programs are available for adult men, adult women, and individuals with a history of trauma. The facility's commitment to high-quality, research-backed rehabilitation extends to specialized support for both genders.

University of Arkansas for

The University of Arkansas Rehabilitation Center, situated in Little Rock, AR, provides tailored outpatient programs for both adults and young adults grappling with substance use disorders and concurrent serious mental health issues. Emphasizing personalized treatment, this center offers a range of services, including 12-step initiatives, anger management classes, and brief intervention strategies. Distinctive programs are available for adult men and women, as well as individuals who have undergone sexual trauma. The center also provides outpatient treatment options using methadone/buprenorphine or naltrexone, ensuring that both male and female clients receive top-notch care. If you seek customized and efficient rehabilitation services, this facility is committed to aiding you on your path to recovery.

University of Michigan

Situated in Ann Arbor, MI, the University of Michigan provides a wide array of rehabilitation services tailored for adults and older adults. This center specializes in detoxification, treatment for substance use, and support for individuals with co-occurring conditions. Offering various options such as intensive outpatient programs, general outpatient services, and outpatient detox, it emphasizes the importance of 12-step methods, anger management, and brief interventions. The facility accommodates both males and females, alongside adolescents and trauma survivors. Renowned for its high-quality care and personalized treatment plans, the University of Michigan is recognized as an excellent choice for those in need of compassionate and effective addiction recovery services.

University of Vermont Medical Center

The University of Vermont Medical Center in Burlington, VT, delivers thorough substance use treatment for adults managing concurrent serious mental health issues, as well as for children with emotional disturbances. They offer intensive outpatient, standard outpatient, and day treatment services, employing proven methods such as 12-step facilitation and anger management. This center serves adult men and women, including those with a history of trauma. The facility also features tailored programs for adult men and women of all ages, guaranteeing personalized care and assistance for individuals on their journey to recovery from addiction and mental health struggles.

Unity Place of Monmouth County LLC

Unity Place of Monmouth County LLC, located in Oceanport, NJ, delivers thorough addiction recovery services and tailored support for adults facing concurrent serious mental health conditions, as well as for children with emotional challenges. The center offers robust outpatient programs, including intensive day treatment and partial hospitalization, employing methodologies like 12-step integration, emotional regulation techniques, and rapid intervention strategies. Committed to personalized recovery paths, the facility provides specialized tracks for adult men and women, alongside support for survivors of domestic or intimate partner abuse. Catering to adults and older adults of every gender, this establishment prioritizes excellent care within a nurturing setting.

University of Alabama at Birmingham

Nestled in Birmingham, AL, the University of Alabama at Birmingham provides extensive substance abuse recovery programs for adults and emerging adults. Their expertise lies in addressing co-occurring substance use disorders and severe mental health conditions. Services include intensive outpatient programs, standard outpatient care, and medication-assisted treatment with methadone, buprenorphine, or naltrexone. The center employs strategies like 12-step facilitation, anger management, and brief intervention, serving both men and women, including trauma survivors. Renowned for its excellent standards, this institution is a premier destination for those desiring tailored support within a nurturing setting.

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Cherry Hill, NJ

Situated in Cherry Hill, NJ, Unity Place provides an extensive array of rehabilitation services for individuals facing challenges related to substance use disorders alongside mental health issues. This center features intensive outpatient programs, day treatment options, and partial hospitalization tailored for both adults and young adults. Emphasizing 12-step support, anger management techniques, and brief intervention strategies, Unity Place is particularly attentive to the needs of adult women and individuals who have gone through trauma. By focusing on those with co-occurring mental health and substance use conditions, the center is dedicated to delivering high-quality care for all clients on their path to recovery.

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Situated in Hammonton, NJ, Unity Place of Atlantic County LLC provides focused rehabilitation services for both adults and young adults experiencing substance use issues alongside mental health challenges. The center features intensive outpatient programs, daytime outpatient treatment, and partial hospitalization, all grounded in evidence-based methods like 12-step facilitation, anger management, and cognitive behavioral therapy. Unity Place is dedicated to assisting individuals who have faced trauma, including intimate partner violence, domestic abuse, and sexual assault. Emphasizing high-quality care, this facility serves both male and female clients in pursuit of thorough and empathetic treatment.

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Situated in Baltimore, MD, the University of Maryland Medical Center delivers focused rehabilitation support for adults and young adults who are facing challenges related to substance use and concurrent mental health disorders. The center features a range of services, including intensive outpatient treatment, outpatient support, and options for methadone/buprenorphine and naltrexone therapies. Prioritizing methods such as cognitive behavioral therapy, motivational interviewing, and contingency management, this facility customizes its approach to meet the unique requirements of each individual. Specialized programs are offered for active duty military personnel, as well as tailored services for adult men and women. With a commitment to delivering high-caliber care and gender-sensitive treatment, it stands out as a leading option for individuals seeking thorough and effective rehabilitation assistance.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated September 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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