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Medically Reviewed Content
Updated: September 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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VA Northern Indiana Healthcare System

Situated in Marion, IN, the VA Northern Indiana Healthcare System delivers extensive addiction treatment options for both adults and young adults. The facility is adept in detoxification, managing substance use issues, and addressing co-occurring mental health conditions. It features hospital inpatient services that emphasize 12-step processes, anger management strategies, and brief intervention techniques. With dedicated programs for veterans and services catering to all genders, the center is committed to providing excellent care for those on the path to recovery from substance abuse. It creates a nurturing atmosphere aimed at facilitating healing and personal development, whether addressing addiction or mental health challenges.

VA Northern Indiana Healthcare System

The VA Northern Indiana Healthcare System in Fort Wayne, IN, provides dedicated rehabilitation programs for individuals, encompassing adults and young adults, who are navigating the complexities of substance use disorders alongside co-occurring mental health challenges. Their offerings include structured intensive outpatient treatment, services for outpatient detoxification, and general outpatient care. Therapeutic modalities employed include 12-step facilitation, anger management techniques, and brief intervention strategies. The center is committed to delivering high-quality, personalized care specifically designed for veterans, offering robust support for both male and female patients. For those in search of scientifically supported treatment within a nurturing setting, this establishment represents a strong option for successful recovery.

VA NY Harbor Healthcare System

The VA NY Harbor Healthcare System located in New York, NY offers a wide range of rehabilitation services aimed at supporting adults and young adults facing challenges from substance use disorders alongside mental health issues. The facility provides inpatient detoxification and treatment options, employing evidence-based methodologies such as 12-step support, anger management, and short counseling sessions. Specialized programs are available for adult men, adult women, and those who have faced sexual trauma. With an emphasis on personalized care, this center fosters a nurturing setting conducive to recovery. Programs designed specifically for men and women contribute to the success of individuals working to defeat addiction.

VA Pittsburgh Healthcare System

The VA Pittsburgh Healthcare System, situated in Pittsburgh, PA, offers an extensive array of outpatient services aimed at detoxification, treatment for substance use, and management of co-occurring disorders for both adults and children. This center is particularly dedicated to veterans, providing outpatient detox options as well as methadone and buprenorphine therapies. Emphasizing 12-step programs, anger management, and brief interventions, the facility serves both male and female adults, including young adults, who are looking for effective solutions for addiction and mental health issues. For veterans and civilians alike, this center may present an excellent opportunity for a supportive rehabilitation experience.

VA Portland Healthcare System

Located in Vancouver, WA, the VA Portland Healthcare System provides a wide array of services aimed at adults and seniors dealing with substance use issues alongside mental health challenges. The facility emphasizes intensive outpatient programs and detoxification services for those who need them. It specializes in care for adult women, trauma survivors, and individuals facing multiple disorders. The treatment methods utilized include 12-step facilitation, brief interventions, and cognitive behavioral therapy, all of which are designed to address the specific requirements of each client. The VA Portland Healthcare System is dedicated to delivering high-quality care, making it a reliable choice for people in search of addiction support and mental health assistance.

VA Puget Sound Healthcare System

The VA Puget Sound Healthcare System, situated in Tacoma, WA, delivers extensive recovery programs for adults and young adults struggling with addiction and related mental health challenges. Their offerings include intensive outpatient care, outpatient detox, and general outpatient services, all grounded in proven methods like cognitive behavioral therapy and contingency management. The center also features specialized tracks for adult men, adult women, and individuals with a history of trauma. Committed to high-quality, personalized treatment, this facility accommodates both male and female patients, fostering a nurturing atmosphere for those on their path to wellness.

VA Puget Sound Healthcare System

The VA Puget Sound Healthcare System, situated in Seattle, WA, delivers extensive substance abuse recovery programs for individuals of all ages. This institution offers tailored assistance for withdrawal management, addiction therapy, and concurrent mental health challenges. Services encompass inpatient hospital detox, structured outpatient programs, and round-the-clock hospital-based inpatient treatment. Employing research-backed methods like cognitive behavioral therapy and contingency management, the facility serves adult men and women, as well as survivors of sexual abuse. Its dedication to personalized care and high-standard rehabilitation makes it a premier destination for those pursuing successful recovery.

VA Roseburg Healthcare System

Situated in Roseburg, OR, the VA Roseburg Healthcare System delivers extensive programs for substance use recovery. This center features outpatient services such as methadone/buprenorphine or naltrexone therapy, standard outpatient sessions, and short-term interventions. The facility emphasizes cognitive behavioral therapy and motivational interviewing techniques. It also provides tailored programs for individuals who have faced trauma, including veterans. Adults and young adults of all genders can access high-quality care and specialized services offered here. If you or someone you know is in search of effective addiction treatment, the VA Roseburg Healthcare System is a commendable choice for customized, evidence-supported care.

VA Southern Nevada Healthcare System

At the VA Southern Nevada Healthcare System located in North Las Vegas, NV, individuals in need of intensive addiction recovery services can access focused treatment options. This center offers inpatient detoxification and care for those struggling with substance use disorders, including adults with co-occurring severe mental health issues and children facing significant emotional challenges. Emphasizing evidence-based methodologies such as cognitive behavioral therapy and anger management, the facility provides customized programs for adults and young adults across all gender identities. Specialized offerings are available for clients who have encountered trauma, domestic violence, intimate partner violence, or sexual abuse. Patients will receive premium, round-the-clock support in a nurturing setting at this esteemed institution.

Valiant Recovery
Punta Gorda, FL

Valiant Recovery, located in Punta Gorda, FL, provides a wide array of rehabilitation services for adults and young adults struggling with substance abuse and concurrent mental health challenges. The facility offers various treatment methods, including intensive outpatient, long-term residential, and outpatient programs, ensuring that it meets a broad spectrum of patient needs. Specialized programs are available for active duty military, as well as for adult men and women, allowing for customized care. Valiant Recovery employs methods like 12-step facilitation, anger management, and brief interventions to deliver effective, personalized support. With a commitment to serving individuals across different genders and age ranges, this center emphasizes holistic healing and bespoke treatment approaches.

VAMED Health Group LLC

Located in Winchester, VA, VAMED Health Group LLC offers specialized outpatient treatment for substance use and co-occurring serious mental health conditions in adults and emotional disturbances in children. The center provides comprehensive care through evidence-based approaches including 12-step facilitation, cognitive behavioral therapy, and motivational incentives. Tailored programs for pregnant/postpartum women and services for adults and young adults of both genders are available. With a focus on quality care and individualized treatment plans, this facility strives to support patients on their journey to recovery.

VOA Recovery
Louisville, KY

Situated in Louisville, KY, VOA Recovery delivers an all-encompassing treatment program for adult males dealing with substance use issues. This center is particularly adept at addressing co-occurring disorders alongside significant mental health challenges in adults, as well as critical emotional difficulties in younger individuals. Emphasizing both long-term and short-term residential options, VOA Recovery employs research-backed methods such as 12-step programs, cognitive behavioral therapy, and the Matrix Model. Special initiatives are designed for adult men, particularly those with experiences of intimate partner violence, domestic abuse, or sexual trauma. Catering to adults, seniors, and young adults alike, this facility ensures that care is customized to meet the unique requirements of its male clientele.

VOA Recovery
Louisville, KY

Located in Louisville, KY, VOA Recovery specializes in providing rehabilitation services for adult women facing challenges with substance use disorders and concurrent severe mental health issues. The center offers a range of treatment options, including long-term, short-term, and 24-hour residential programs, all based on proven methodologies such as 12-step facilitation, cognitive behavioral therapy, and the Matrix Model. VOA Recovery particularly emphasizes support for clients who have endured intimate partner violence, domestic abuse, and sexual trauma, customizing their programs to suit the distinct needs of every individual. Women of all ages, including seniors and young adults, can find a nurturing and secure space, benefiting from the exceptional care and tailored services provided at this facility.

VOA Addiction Recovery Services

VOA Addiction Recovery Services, located in Louisville, KY, delivers an extensive array of treatment options for substance use disorders, specifically designed for adult women, older adults, and young individuals grappling with severe mental health complications. The center offers a variety of programs, including intensive outpatient, long-term residential, and traditional outpatient services, employing strategies such as 12-step support, anger management techniques, and short intervention methods. Tailored programs are available for those who have faced intimate partner violence, domestic abuse, and sexual trauma. Committed to providing exceptional care, this center aims to assist individuals in overcoming addiction and mental health difficulties within a nurturing environment.

VA NY Harbor Healthcare System

The VA NY Harbor Healthcare System located in Brooklyn, NY, provides diverse treatment solutions for adults dealing with substance use issues and concurrent serious mental health disorders, as well as emotional challenges faced by children. The center features a variety of programs, including intensive outpatient services, long-term residential care, and traditional outpatient treatment, employing methodologies like 12-step programs, anger management techniques, and brief intervention strategies. It also offers specialized services for adult men, women, and individuals who have suffered from sexual abuse. This facility serves both adult and young adult populations, delivering personalized care with an emphasis on high-quality, evidence-based interventions.

VICTA
Providence, RI

Situated in Providence, RI, "VICTA" stands out as an exceptional rehabilitation facility that provides a wide array of services. It focuses on detoxification, treatment for substance use disorders, as well as addressing co-occurring conditions related to substance use and significant mental health challenges in adults, along with serious emotional issues in children. The center offers intensive outpatient programs, outpatient services, and options for partial hospitalization. Emphasizing 12-step encouragement, anger management strategies, and short-term interventions, "VICTA" is designed for adolescents, adult males, and adult females. This facility is dedicated to serving individuals of all ages and backgrounds, aiming to deliver personalized, high-quality support to foster effective recovery paths.

VIP Community Services

Situated in the Bronx, NY, VIP Community Services specializes in extensive substance use rehabilitation for adults, including individuals with significant mental health challenges. The facility offers various programs such as long-term residential, 24-hour care, and short-term stays, employing evidence-based methods like anger management, cognitive behavioral therapy, and brief interventions. Distinctive programs are designed for adult men and women, including those who have faced intimate partner or domestic violence. Committed to delivering high-quality care, VIP Community Services supports both men and women, ensuring services are customized to meet personal requirements.

VIP Community Services

VIP Community Services, situated in Bronx, NY, is a dedicated facility for adult men requiring extensive residential care due to substance use disorders and significant mental health challenges. The program utilizes proven therapeutic methods, including anger management techniques, cognitive behavioral therapy, and brief intervention strategies. Specializing in support for individuals who have encountered intimate partner violence, domestic abuse, or sexual assault, VIP Community Services serves a diverse age range of adult men, from young adults to seniors. This round-the-clock residential treatment offers continuous assistance within a secure and nurturing setting for men pursuing thorough, personalized recovery.

VERTEX LLC
Bronx, NY

VERTEX LLC, located in Bronx, NY, delivers a full spectrum of outpatient care, addressing detoxification, substance use concerns, and co-occurring mental health conditions for individuals of all ages. Their services include outpatient detox, medication-assisted treatment with methadone, buprenorphine, and naltrexone, and the application of proven therapeutic methods like anger management, brief intervention, and cognitive behavioral therapy. VERTEX LLC also features specialized tracks for adolescents, adult males, and adult females. This center offers customized support for both adults and young people, accommodating both genders. Committed to delivering high-quality, personalized treatment, VERTEX LLC is devoted to guiding individuals toward a healthier, sober life.

VOA Behavioral Health Services

VOA Behavioral Health Services, situated in Quincy, MA, delivers extensive outpatient care for individuals, including youth and adults, grappling with substance misuse and co-occurring mental health conditions. Their specialized offerings encompass anger management techniques, cognitive behavioral therapy, and concise intervention strategies. The center tailors its programs to specific demographics, featuring dedicated tracks for teenagers, adult men, and adult women. Catering to a broad age range from adolescents to seniors, VOA Behavioral Health Services distinguishes itself through its dedication to high-quality, evidence-backed treatment modalities. They provide various levels of care, including standard outpatient services and medication-assisted treatment options such as methadone, buprenorphine, and naltrexone, ensuring a supportive environment for all seeking recovery.

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VOA Behavioral Health Services in Taunton, MA, delivers outpatient support for adults managing both substance use disorders and significant mental health challenges. Their approach incorporates targeted therapies such as anger management, cognitive behavioral interventions, and brief counseling. They also provide distinct programs designed for young people, adult men, and women. The center features outpatient options for methadone and buprenorphine treatment, alongside standard outpatient care. Catering to a diverse clientele, including older adults, VOA Behavioral Health Services is dedicated to providing excellent care to aid individuals in their recovery process.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated September 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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