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Medically Reviewed Content
Updated: May 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,711 treatment centers offering naltrexone (vivitrol) across the United States.

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Youth Care of Utah

Situated in Draper, UT, Youth Care of Utah specializes in extensive treatment for substance use and offers targeted support for those facing severe mental health challenges or emotional issues. The center features a range of options, including long-term, short-term, and round-the-clock residential services. Employing proven methods like cognitive behavioral therapy, motivational interviewing, and anger management techniques, Youth Care of Utah is dedicated to assisting both young males and females. The facility prioritizes personalized care, focusing on adolescents and individuals with dual diagnoses, and is committed to providing quality, customized treatment plans to aid clients in their recovery journey.

Zenith Behavioral Health

Zenith Behavioral Health, located in Phoenix, AZ, provides an extensive range of addiction treatment services catering to both adults and children. This center focuses on detoxification, addressing substance use issues, and treating co-occurring mental health conditions. With inpatient hospital programs available and round-the-clock care, Zenith Behavioral Health fosters a nurturing atmosphere conducive to recovery. The facility employs proven methods, including 12-step facilitation, anger management strategies, and brief interventions. Specialized programs are available for teenagers and those affected by trauma, addressing distinct needs. Zenith Behavioral Health offers exceptional care for both male and female clients pursuing sustainable recovery.

Zinnia Exeter
Exeter, RI

Nestled in Exeter, RI, Zinnia Exeter stands as a leading recovery facility, delivering a spectrum of tailored programs for those pursuing freedom from addiction. The facility offers hospital-based inpatient detox, round-the-clock hospital inpatient support, and extended residential care. Emphasizing 12-step integration, emotional regulation strategies, and concise intervention methods, Zinnia Exeter welcomes adult individuals, including those impacted by domestic or intimate partner abuse. This establishment is committed to providing excellent, all-encompassing treatment to aid adults and young adults of any gender in their path to lasting abstinence.

Zucker Hillside Hospital Northwell

Situated in Glen Oaks, NY, Zucker Hillside Hospital Northwell provides dedicated rehabilitation services for adults dealing with substance use issues and serious co-occurring mental health disorders, as well as emotional challenges in children. The facility offers outpatient care options such as methadone/buprenorphine therapy and standard outpatient programs. With customized methods including 12-step programs, anger management, and brief therapeutic interventions, the center serves adult men and women, particularly those who have experienced intimate partner violence. Catering to individuals of all genders, this center emphasizes personalized care and utilizes evidence-based practices to foster sustainable recovery.

Zukoski Outpatient
Birmingham, AL

Situated in Birmingham, AL, Zukoski Outpatient delivers extensive treatment for substance use issues among both adults and young adults. This facility is dedicated to addressing co-occurring substance use disorders in conjunction with significant mental health conditions or emotional challenges. Emphasizing intensive outpatient programs and tailored support for trauma survivors, individuals with dual diagnoses, and those facing pain alongside substance use, the center adopts a customized strategy for rehabilitation. By implementing evidence-based practices like 12-step support, anger management, and brief intervention strategies, Zukoski Outpatient guarantees exceptional care for clients of all genders pursuing recovery.

Youth Emergency Services Inc

Youth Emergency Services Inc, situated in Gillette, WY, offers an extensive array of treatment solutions for those battling substance use challenges alongside mental health disorders. The center specializes in various approaches, including intensive outpatient care, long-term residential stays, and outpatient services. Among its distinctive offerings are anger management, cognitive behavioral therapy, and short-term interventions. Tailored programs exist for teenagers, adults coping with overlapping disorders, and those confronting both pain and substance dependence. Catering to males, females, and young adults, this center prioritizes high-quality care and personalized treatment plans to foster enduring recovery and improved well-being.

Zepf Center
Toledo, OH

Situated in Toledo, OH, Zepf Center delivers complete addiction recovery solutions for adults and young adults. This establishment offers detox and substance use treatment via intensive outpatient, outpatient, and day treatment options. Focusing on anger management, brief intervention, and cognitive behavioral therapy, Zepf Center serves both male and female individuals, including expectant/new mothers and those involved with the criminal justice system or forensic services. The center’s specific programs are designed to meet the distinct requirements of these groups. Individuals can anticipate high-standard care and customized recovery strategies to aid their healing process.

Zia Recovery Center
Las Cruces, NM

Situated in Las Cruces, NM, Zia Recovery Center delivers an array of all-inclusive addiction rehabilitation services. The facility encompasses detoxification, treatment for substance use disorders, transitional housing, and options for sober living, available in formats such as intensive outpatient care, long-term residential programs, and outpatient services. Zia Recovery Center employs methods including 12-step approaches, anger management techniques, and brief intervention strategies, serving adult men and women, as well as individuals who have faced domestic violence or intimate partner violence. With an emphasis on both adult and young adult populations, the center provides dedicated support specifically designed for males and females. Discover exceptional care and personalized assistance at Zia Recovery Center.

Youth Opportunities Upheld Inc

Youth Opportunities Upheld Inc, based in Worcester, MA, delivers outpatient services for substance use disorders along with specialized support for those facing dual challenges of substance use and significant mental health issues. The facility employs evidence-supported methodologies such as cognitive behavioral therapy and motivational interviewing to facilitate regular outpatient treatment. It serves a diverse clientele, offering targeted programs for adults as well as children and adolescents who have dealt with intimate partner violence, domestic violence, or sexual abuse. Committed to high-quality care, this center focuses on personalized interventions that empower individuals in their recovery journeys, catering to both male and female patients.

Youth and Shelter Services (YSS)

Youth and Shelter Services (YSS) in Webster City, IA, stands as a respected rehabilitation center. They offer outpatient services for individuals struggling with substance use, co-occurring mental health conditions, and emotional challenges in children. The center has tailored programs for active duty military personnel, teenagers, and adult men, serving both adult men and women, as well as seniors. Employing proven methods such as cognitive behavioral therapy and the Matrix Model, YSS delivers effective care through brief interventions. For those requiring medication-assisted treatment, they provide outpatient options including methadone/buprenorphine or naltrexone. YSS is dedicated to creating personalized recovery plans to assist each individual's healing process.

Youth Town of Tennessee Inc

Situated in Pinson, TN, Youth Town of Tennessee Inc delivers exceptional treatment for substance use disorders alongside specialized support for co-occurring mental health issues in adults and emotional challenges in youth. This facility offers a range of options, including hospital inpatient care, round-the-clock residential programs, and long-term rehabilitation services. It employs scientifically-supported methods, such as 12-step programs, cognitive-behavioral therapy, and motivational interviewing. Focusing on the needs of adolescents, this center serves both boys and girls. For those looking for a holistic and effective approach to recovery in a nurturing setting, Youth Town of Tennessee Inc is an outstanding option.

Ysleta Del Sur Pueblo

Situated in El Paso, TX, the Ysleta Del Sur Pueblo rehabilitation center provides outpatient services for those facing challenges related to substance abuse and concurrent mental health disorders. This establishment is dedicated to delivering focused support for adults experiencing emotional issues and for children with psychological conditions. Emphasizing techniques such as 12-step guidance, anger management strategies, and brief intervention, the center accommodates adult men, adult women, and teens. With programs customized for each gender, it ensures a well-rounded recovery experience. The center’s dedication to high-quality care and personalized treatment options makes it a leading choice for effective rehabilitation in the El Paso region.

YWCA of Fort Dodge
Fort Dodge, IA

The YWCA of Fort Dodge, situated in Fort Dodge, IA, delivers extensive support for individuals navigating substance use challenges. Their offerings encompass intensive outpatient care, extended residential stays, and flexible outpatient programs, specifically designed for adult women and those impacted by trauma. Employing strategies such as 12-step facilitation, anger management, and brief intervention, the YWCA of Fort Dodge excels in addressing co-occurring mental health and substance use conditions. Serving adults and young adults across genders, the center is committed to delivering high-quality, nurturing care, positioning it as a premier destination for individuals pursuing meaningful rehabilitation and lasting recovery.

ZION Integrated Behav Health Services

Situated in Atlantic, IA, ZION Integrated Behav Health Services presents a wide array of treatment solutions for those facing challenges with substance use and concurrent mental health issues. This facility features intensive outpatient, outpatient, and standard outpatient programs that integrate multiple methodologies, including anger management, brief interventions, and cognitive behavioral therapy. ZION Integrated Behav Health Services is equipped with specialized programs tailored for adolescents, adult men, and adult women, addressing a broad spectrum of needs. Serving both adults and seniors of all genders, the center prioritizes personalized care and guidance to assist clients in attaining enduring recovery and enhanced mental health.

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Situated in Ames, Iowa, Youth and Shelter Services (YSS) serves as a holistic rehabilitation facility that provides outpatient treatment for substance use issues alongside transitional housing options. This center focuses on addressing co-occurring substance use disorders and significant mental health challenges, utilizing personalized strategies like cognitive behavioral therapy and the Matrix Model. YSS serves a wide range of individuals, including active duty service members, youth, adult men, and older adults. With initiatives tailored for both genders, this facility promotes effective recovery and assistance within a nurturing and organized setting.

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Youth and Shelter Services (YSS) in Marshalltown, IA, provides effective recovery programs. The center focuses on addiction treatment, supportive housing, and dual diagnosis care for mental health and substance use disorders. Their outpatient options include methadone and buprenorphine services, utilizing proven methods such as CBT and the Matrix Model. YSS caters to specific groups including military members, teens, and adult males. They offer inclusive services for adults and older adults of any gender, ensuring personalized treatment plans.

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Situated in Mason City, IA, Youth and Shelter Services (YSS) delivers extensive treatment options for substance use for both adults and children facing simultaneous mental health challenges. The center provides outpatient services that feature regular treatment sessions emphasizing brief intervention, cognitive behavioral therapy, and the Matrix Model approach. YSS also focuses on particular demographics, including active military members, teenagers, and adult males. The facility offers customized care for adults and seniors across all genders, embracing evidence-based methods to ensure high-quality support. For those in search of dedicated addiction recovery services within a nurturing atmosphere, YSS in Mason City stands out as an excellent option.

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Zenith Hope Center LLC, located in Charlotte, NC, specializes in top-tier treatment for substance use disorders through its intensive outpatient, outpatient, and medication-assisted programs featuring methadone, buprenorphine, or naltrexone. Their therapeutic strategies encompass anger management, brief interventions, and cognitive behavioral therapy. The center specifically supports active duty military members and adult clients, including both men and women, with tailored programs to meet diverse needs. Zenith Hope Center LLC focuses on delivering holistic care for adults and young adults regardless of gender. With a strong emphasis on high-quality, evidence-based services within a nurturing atmosphere, this facility is an outstanding option for individuals seeking to overcome addiction.

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Situated in Zuni, NM, Zuni Recovery Center delivers exceptional treatment for substance use through its outpatient and regular outpatient services. This facility is dedicated to managing anger, offering brief interventions, and employing cognitive behavioral therapy to provide customized care for those on their recovery journey. It features specialized programs catering to active duty military personnel, teens, and adult men, addressing a wide range of needs. The center supports a diverse clientele, including adults, children, and seniors, ensuring that all age groups receive thorough assistance. With an emphasis on both male and female patients, Zuni Recovery Center adopts a holistic methodology in rehabilitation, fostering sustained recovery and overall wellness.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated May 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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