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Medically Reviewed Content
Updated: May 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,711 treatment centers offering naltrexone (vivitrol) across the United States.

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Centerstone of Illinois

Centerstone of Illinois in Alton, IL, provides dedicated care for individuals struggling with substance use disorders and co-occurring mental health challenges. They offer tailored treatment plans for adults and young people, encompassing intensive outpatient and standard outpatient services. Medication-assisted treatment options, including methadone, buprenorphine, and naltrexone, are available. The center emphasizes therapeutic modalities such as 12-step facilitation, anger management, and brief intervention strategies, with a particular understanding of trauma-informed care. Serving all genders across adult and child/adolescent populations, Centerstone of Illinois is committed to fostering an inclusive and supportive environment for those pursuing sustained sobriety.

Centerstone of Illinois

Centerstone of Illinois, located in Anna, IL, provides a wide range of addiction recovery services tailored for both adults and young adults. The center features specialized programs designed for active military personnel, as well as separate tracks for adult men and women, ensuring customized support for each group. Treatment modalities available include detox services, intensive outpatient programs, long-term residential care, and various outpatient options. Utilizing evidence-based methods such as 12-step support, anger management strategies, and brief intervention techniques, the facility effectively targets substance use issues. Committed to delivering high-quality care and personalized treatment plans, Centerstone of Illinois strives to facilitate clients' paths to recovery.

Centerstone of Illinois

Centerstone of Illinois in Carbondale, IL, delivers targeted therapies for individuals of all ages struggling with substance use and co-occurring mental health conditions. The program features intensive and standard outpatient care, encompassing medication-assisted treatment like methadone and buprenorphine. Utilizing methodologies such as 12-step facilitation, anger management techniques, and brief intervention strategies, the center customizes treatment plans to suit each person's unique requirements. They have particular expertise in supporting clients with trauma histories, serving adults, children, and adolescents across the gender spectrum. Centerstone of Illinois is dedicated to providing thorough, excellent rehabilitation services to aid individuals in their path to wellness.

Centerstone
Tullahoma, TN

Situated in Tullahoma, TN, Centerstone delivers extensive outpatient rehabilitation services aimed at addressing substance use disorders and co-occurring mental health issues. The center focuses on both adults and children/adolescents, offering customized programs that include anger management, cognitive behavioral therapy, and trauma-informed care. Prioritizing high-quality support, this facility features regular outpatient treatment options alongside specialized outpatient services like methadone/buprenorphine and naltrexone therapies. Centerstone is recognized for its proficiency in managing both mental health and substance use disorders, providing individualized rehabilitation strategies for male and female clients alike.

Centerstone of Illinois
West Frankfort, IL

Centerstone of Illinois, located in West Frankfort, IL, provides extensive treatment for adults facing substance use disorders, particularly those with significant mental health challenges, as well as for children dealing with severe emotional issues. The facility offers both intensive outpatient and outpatient programs that include options such as methadone, buprenorphine, or naltrexone therapies. Emphasizing strategies like 12-step support, anger management, and brief interventions, the center addresses the needs of individuals who have undergone trauma. Catering to a diverse population of adults and children/adolescents, Centerstone of Illinois ensures personalized care that meets the specific requirements of each person.

CenterPointe
Omaha, NE

CenterPointe of Omaha, NE, provides extensive residential treatment options, both long and short-term, for those facing challenges with substance abuse and accompanying mental health conditions. This facility is dedicated to employing proven therapeutic methods like cognitive behavioral therapy and contingency management to foster enduring recovery. CenterPointe serves a varied clientele with distinct programs for adult men, adult women, and individuals with trauma histories. They develop individualized treatment strategies for adults and young adults, irrespective of gender, ensuring customized support throughout the recovery process. Discover effective treatment and superior care at CenterPointe.

Centerstone
Madison, TN

Centerstone in Madison, TN offers outpatient substance use treatment and specialized care for individuals with co-occurring substance use and mental health disorders. Their programs cater to adults and children/adolescents, with a focus on brief intervention, cognitive behavioral therapy, and motivational interviewing. The facility provides outpatient methadone/buprenorphine or naltrexone treatment along with regular outpatient services. Centerstone's tailored approach to clients with co-occurring disorders ensures comprehensive and effective care. With services available for both male and female clients, this facility prioritizes quality care to support individuals on their path to recovery.

Centerstone
Lewisburg, TN

Centerstone, located in Lewisburg, TN, provides outpatient services for adults dealing with substance use issues. It also offers specialized treatment for children experiencing co-occurring substance use and significant mental health challenges. The center employs evidence-backed methodologies such as cognitive-behavioral therapy, motivational interviewing, and anger management. Emphasizing personalized treatment, Centerstone serves both adults and younger populations, offering gender-specific programs for males and females. Furthermore, the center includes outpatient treatment options with methadone, buprenorphine, or naltrexone. Patients receive attentive care customized to meet their individual requirements in a nurturing setting.

Centerstone of Indiana Inc

Centerstone of Indiana Inc, located in Seymour, IN, provides outpatient treatment for individuals dealing with substance use issues alongside significant mental health challenges or emotional difficulties. The center offers a range of tailored services, including outpatient treatments with methadone, buprenorphine, or naltrexone, as well as programs focused on anger management, brief interventions, and cognitive behavioral therapy. Catering to both adult men and women, the facility also supports clients who have faced domestic violence or intimate partner violence. With a commitment to high-quality, personalized care, Centerstone of Indiana Inc creates effective programs aimed at assisting adults and seniors in their journey toward recovery and overall well-being.

CenterPointe
Lincoln, NE

CenterPointe, located in Lincoln, NE, provides focused treatment for adults facing substance use issues alongside mental health challenges, as well as services for children dealing with significant emotional difficulties. Their treatments encompass intensive outpatient and outpatient programs that utilize proven methods, including cognitive behavioral therapy and anger management strategies. Additionally, the center offers outpatient treatment options for methadone and buprenorphine. What distinguishes CenterPointe is its commitment to personalized care, adapting its services to meet the unique needs of each individual. With an emphasis on high-quality, customized treatment, this center serves both adult men and women in need of thorough addiction recovery support.

CenterPointe
Lincoln, NE

CenterPointe in Lincoln, NE, provides dedicated long-term residential care for adults struggling with substance use disorders and complex mental health challenges. They also offer services for children facing significant emotional difficulties. Their approach involves customized treatment plans incorporating strategies like brief intervention, cognitive behavioral therapy, and motivational incentives. Notably, CenterPointe has developed specific programs for adult men, adult women, and individuals with a history of trauma. Committed to high standards of treatment, the center serves adults and young adults of all genders, fostering a complete and nurturing atmosphere for recovery and well-being.

Centerstone
Nashville, TN

Centerstone in Nashville, TN, provides targeted outpatient services for adults grappling with substance use disorders and co-occurring severe mental health conditions, alongside support for children experiencing emotional challenges. Their approach emphasizes personalized treatment strategies, incorporating techniques such as cognitive behavioral therapy and motivational interviewing. This center is committed to delivering individualized care that serves adults and youth of all genders. From standard outpatient programs to medication-assisted treatment options like methadone, buprenorphine, and naltrexone, Centerstone is equipped to guide individuals through a thorough and successful recovery process. For those in search of high-quality, personalized support, this establishment is devoted to fostering your journey toward improved well-being.

Centerstone
Chattanooga, TN

Centerstone located in Chattanooga, TN, delivers targeted outpatient services for adults dealing with substance abuse and concurrent mental health issues, as well as addressing emotional challenges in children. The center emphasizes personalized treatment, offering methods such as cognitive behavioral therapy, motivational interviewing, and teletherapy. Programs are customized for both adults and youth, with distinct pathways available for females and males. Their proficiency in managing outpatient treatments with methadone, buprenorphine, or naltrexone provides a holistic strategy towards recovery. Centerstone is dedicated to high-quality care and a variety of treatment modalities, making it an excellent option for individuals seeking rehabilitation support in the Chattanooga region.

Centerstone of Florida

Centerstone of Florida, located in Sarasota, FL, provides outpatient services for adults grappling with substance use issues alongside significant mental health challenges. The center's offerings encompass treatment using methadone, buprenorphine, or naltrexone, complemented by techniques such as 12-step facilitation, anger management, and targeted brief interventions. This facility is dedicated to serving active duty military members as well as adult males and females. With a commitment to addressing the unique requirements of both men and women, Centerstone of Florida emphasizes high-quality, personalized care, making it an essential option for individuals seeking thorough and effective addiction recovery solutions in the Sarasota region.

Centerstone of Illinois

Centerstone of Illinois, situated in Marion, IL, delivers targeted addiction recovery services for individuals and young people managing concurrent severe mental health challenges. The clinic offers robust outpatient programs, standard outpatient care, and medically supported recovery plans. Emphasizing strategies like 12-step encouragement, emotional regulation skills, and concise therapeutic methods, the center customizes its offerings to suit each person's unique requirements. With expertise in care designed to address past trauma, Centerstone of Illinois supports both male and female patients. The clinic's all-encompassing methodology and commitment to superior support establish it as a crucial provider for those in the Marion vicinity pursuing successful recovery solutions.

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San Rafael, CA

Center Point Inc, located in San Rafael, CA, provides extended residential and round-the-clock support for adult males pursuing detoxification and treatment for substance use issues. The center is adept in anger management, cognitive behavioral therapy, and employs the Matrix Model framework. Catering to adult men, seniors, and younger adults with concurrent mental health and substance use challenges, Center Point Inc also offers tailored services for individuals within the criminal justice system. Committed to evidence-based methodologies and personalized treatment strategies, this center aims to deliver exceptional care for individuals requiring thorough rehabilitation assistance.

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San Rafael, CA

Center Point Inc, located in San Rafael, CA, stands as a trusted institution dedicated to the detoxification and recovery of adult women facing challenges such as trauma, intimate partner abuse, or domestic violence. This center provides extended stays in a residential setting, emphasizing techniques like anger management, cognitive behavioral therapy, and the specialized Matrix Model. Catering to a range of age groups, including adults, seniors, and young adults, Center Point Inc is committed to delivering excellent care within a nurturing atmosphere. For those in need of thorough residential detox and therapeutic services in a secure and welcoming environment, this facility is prepared to guide individuals toward a healthier future.

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San Rafael, CA

Situated in San Rafael, California, CenterLink delivers extensive treatment for substance use disorders aimed at both adults and young adults. The center offers various programs, including intensive outpatient, outpatient, and standard outpatient options. It employs techniques such as anger management, cognitive behavioral therapy, and motivational incentives to create customized treatment plans that cater to the unique needs of each participant. With dedicated programs for adult men, women, and those who have faced trauma, CenterLink fosters a compassionate atmosphere for everyone. The center also provides gender-specific treatment for both females and males, reinforcing its commitment to high-quality care and individualized support, making it an excellent choice for individuals seeking effective rehabilitation.

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Estill Springs, TN

Centerstone, located in Estill Springs, TN, provides outpatient services for adults and young adults facing substance use issues alongside significant mental health conditions or emotional challenges. This center features targeted programs designed specifically for men, women, and individuals with co-occurring disorders. Treatment modalities encompass anger management, brief interventions, and cognitive behavioral therapy techniques. Emphasizing outpatient options, Centerstone presents standard outpatient therapies alongside choices for methadone/buprenorphine and naltrexone. Catering to both genders, the center is committed to delivering high-quality care and personalized treatment strategies for individuals pursuing recovery from addiction.

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Centerstone of Illinois in Carterville, IL, delivers targeted care for adults battling substance abuse alongside severe mental health challenges, and for children experiencing emotional difficulties. They offer structured day programs and less intensive therapy options, incorporating medication-assisted treatment like methadone, buprenorphine, or naltrexone. Key therapeutic approaches include guidance in 12-step programs, techniques for managing anger, and short-term counseling, with special attention given to individuals with trauma histories. This center supports adult and youth populations, welcoming both men and women. Centerstone of Illinois is committed to providing high-quality, personalized recovery plans for comprehensive rehabilitation.

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Centerstone of Indiana Inc, located in Connersville, IN, provides outpatient services for adults dealing with substance use disorders alongside significant mental health challenges, as well as emotional issues in children. Their program incorporates 12-step support, anger management strategies, and brief therapeutic interventions. This center focuses on assisting adult men and women, including those who have faced domestic violence. They offer outpatient treatment options with methadone, buprenorphine, or naltrexone, accommodating both adult and senior clients of all genders. Centerstone of Indiana Inc emphasizes high-quality care and personalized treatment plans, making it a reputable option for comprehensive rehabilitation in the Connersville area.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated May 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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