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Medically Reviewed Content
Updated: May 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,711 treatment centers offering naltrexone (vivitrol) across the United States.

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CentraCare/Saint Cloud Hospital

CentraCare/Saint Cloud Hospital, located in Saint Cloud, MN, delivers an extensive selection of rehabilitation services for adults and youth dealing with substance use issues. The center is adept at addressing co-occurring substance use disorders in conjunction with significant mental health conditions or emotional challenges in children. Treatment options include intensive outpatient programs and outpatient day treatment, with specialized approaches such as 12-step facilitation and anger management courses. A distinguishing aspect of the center is its tailored programs for seniors and older adults, ensuring that clients of all ages receive individualized care. With a commitment to high-quality, personalized support, this center is recognized as a reliable choice for individuals seeking effective options for addiction recovery.

CentraCare/Saint Cloud Hospital

CentraCare/Saint Cloud Hospital, located in Saint Cloud, MN, provides a broad spectrum of rehabilitation services designed to meet the needs of individuals of all ages and genders. The facility focuses on treating substance use issues and related mental health disorders in both adults and youth. They offer various treatment modalities such as intensive outpatient programs, outpatient care, and day treatment. Utilizing strategies like 12-step programs and anger management, the center ensures care is tailored to the unique needs of each patient. Additionally, specialized programs for teenagers and those dealing with concurrent mental health challenges further enrich the center’s service range. Individuals seeking rehabilitation services can rely on CentraCare/Saint Cloud Hospital for high-quality, personalized care.

Central Alabama VA Healthcare System

Situated in Tuskegee, Alabama, the Central Alabama VA Healthcare System provides an extensive array of treatment services for individuals dealing with substance use issues, transitional housing needs, and co-occurring mental health disorders, for both adults and children. The offerings include intensive outpatient programs, outpatient day services, and partial hospitalization. These treatments incorporate various methods, such as 12-step support, anger management therapy, and brief interventions tailored to individual needs. The center is dedicated to serving adult men and women, along with those who have faced intimate partner or domestic violence. Emphasizing high-quality care, the center is committed to creating a nurturing atmosphere for adults and young adults across all genders in their journey towards recovery.

Central City Integrated Health

Central City Integrated Health, situated in Detroit, MI, specializes in extensive addiction recovery for individuals of all ages who are concurrently facing mental health challenges. The center delivers outpatient care, including medication-assisted treatment options like methadone and buprenorphine. They also offer dedicated support for active military members, adult men, and women. Their approach incorporates proven methods such as 12-step support, anger management techniques, and short-term counseling, serving adults and young adults across the gender spectrum. Central City Integrated Health is committed to providing exceptional, customized treatment to meet each person's unique journey toward recovery.

Centerstone of Indiana Inc

Centerstone of Indiana Inc, located in Lexington, IN, offers a wide range of substance use treatment and transitional housing options within a long-term residential framework. This center is dedicated to addressing both substance use disorders and significant mental health challenges in adults, as well as emotional disturbances in younger populations. The treatment methods employed include 12-step programs, anger management techniques, and cognitive behavioral therapy. Special emphasis is placed on assisting adult women who have faced challenges such as intimate partner violence, domestic abuse, or sexual trauma. Catering to adults, seniors, and young women, this center prioritizes individualized care and support to facilitate each client's recovery journey.

Centerstone of Indiana Inc

Centerstone of Indiana Inc, located in Lexington, IN, provides extensive residential treatment for individuals facing substance use issues alongside co-occurring mental health challenges, catering to both adults and children. Their offerings include a range of evidence-based methods, such as 12-step programs, anger management techniques, and cognitive behavioral therapy. The center has a special focus on supporting adult women and individuals who have experienced intimate partner violence, domestic abuse, and sexual trauma. By prioritizing personalized care for adult, senior, and young adult females, Centerstone of Indiana Inc is dedicated to guiding clients through their recovery journey with high-quality support.

Centerstone of Indiana Inc

Centerstone of Indiana Inc in Columbus, IN, delivers thorough care for substance misuse and concurrent serious mental health disorders or emotional disruptions. This center features intensive outpatient, standard outpatient, and medication-assisted treatment programs, including methadone, buprenorphine, or naltrexone. Employing methods such as anger control, brief guidance, and cognitive-behavioral therapy, the facility customizes treatment plans. Specialized services are offered for young people, adult males, and adult females. Catering to adults and older adults of all genders, Centerstone of Indiana Inc is dedicated to providing excellent support for individuals navigating recovery from addiction and mental health issues.

Centerstone of Indiana Inc

Centerstone of Indiana Inc in Richmond, IN, delivers focused inpatient care for adult males contending with addiction and accompanying severe mental health issues or emotional difficulties. Employing methods such as 12-step support, emotional regulation techniques, and cognitive restructuring, the facility offers individualized support to those affected by past trauma, domestic abuse, or relationship violence. Serving adults, older adults, and younger adults, this male-exclusive residence provides both brief and round-the-clock accommodation. The center's all-encompassing strategies and distinct services position it as a prime option for individuals requiring effective treatment for multifaceted substance abuse and mental health concerns.

Centerstone of Indiana Inc

Centerstone of Indiana Inc in Scottsburg, IN provides extensive outpatient services for addiction and dual diagnoses. Their expert care encompasses medication-assisted treatment for opioid use disorder, anger management programs, short-term interventions, and cognitive behavioral therapy. This center serves adult men, adult women, and survivors of domestic or intimate partner abuse. Focusing on adults and seniors, Centerstone delivers individualized, evidence-based treatment in a nurturing setting, guided by skilled professionals.

Centerstone of Indiana Inc

Centerstone of Indiana Inc, located in Martinsville, IN, provides outpatient services for individuals dealing with substance use issues and those facing co-occurring mental health conditions in adults or emotional challenges in children. Their offerings include anger management, brief interventions, and cognitive behavioral therapy. The facility also delivers outpatient treatment options involving methadone, buprenorphine, or naltrexone. Catering to a diverse clientele, they have specialized programs for adolescents, adult men, and adult women, serving both male and female adults and seniors. Centerstone of Indiana Inc is dedicated to delivering personalized care and tailored treatment plans to foster recovery and enhance overall well-being.

Centerstone of Indiana Inc

Centerstone of Indiana Inc, located in Bedford, IN, delivers outpatient services focused on treating substance abuse and concurrent serious mental health disorders in adults, along with significant emotional issues in children. The center is proficient in anger management, short-term interventions, and cognitive behavioral therapy, offering personalized treatment for adult men and women, seniors, and those who have faced intimate partner or domestic violence. With offerings catered to both genders, this facility is committed to providing extensive assistance for a wide variety of individuals in need of effective rehabilitation support.

Centerstone of Indiana Inc

Centerstone of Indiana Inc located in Bloomington, IN provides extensive treatment options for adults dealing with substance use issues alongside mental health conditions, as well as support for children facing significant emotional challenges. Their specialized outpatient programs feature approaches such as 12-step support, anger management techniques, and short-term interventions. This center is committed to offering personalized care for adolescents and both men and women. It serves a diverse range of adults and seniors regardless of gender and includes outpatient options like methadone, buprenorphine, or naltrexone therapies. With an emphasis on high-quality care and customized treatment plans, Centerstone of Indiana Inc aims to assist clients in achieving sustainable recovery.

Centerstone of Indiana Inc

Centerstone of Indiana Inc in Greensburg, Indiana, delivers complete care for individuals struggling with addiction and co-occurring mental health conditions. They serve adults who have both substance use disorders and serious mental illnesses, as well as children facing significant emotional challenges. The center provides outpatient options, such as medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside cognitive behavioral therapy. Dedicated programs are available for adult men and women, and for those affected by domestic or intimate partner violence. Catering to adults and seniors across all gender identities, Centerstone of Indiana Inc emphasizes anger management, short-term support, and personalized treatment plans to foster enduring recovery. Their dedication to high standards and proven therapeutic approaches ensures they are a reliable resource for those seeking to regain their well-being.

Centerstone of Indiana Inc

Centerstone of Indiana Inc, located in Bloomington, IN, provides focused rehabilitation for adult men struggling with addiction and co-occurring severe mental health conditions. The center offers both residential and short-term residential care, utilizing proven methods such as 12-step facilitation, anger management techniques, and cognitive behavioral therapy. Distinctive programs are available for individuals who have faced trauma, intimate partner violence, or domestic abuse. Serving adult, senior, and young adult males, this establishment prioritizes high-quality support and tailored treatment strategies to foster recovery and overall well-being.

Centerstone of Indiana Inc

Centerstone of Indiana Inc, located in Madison, IN, provides extensive outpatient services for adults and youth addressing substance use concerns, alongside co-occurring mental health conditions. Their offerings encompass strategies for managing anger, cognitive behavioral techniques, and specific support for those impacted by domestic violence. The center offers outpatient medication-assisted treatment options like methadone, buprenorphine, or naltrexone, in addition to general outpatient therapy adapted for the distinct requirements of adult men and women. Emphasizing high-quality care and customized recovery paths, Centerstone of Indiana Inc supports individuals across all age groups, including seniors, who are navigating the complexities of addiction and mental wellness.

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Centerstone of Indiana Inc, located in Rushville, IN, specializes in outpatient care for substance use disorders and offers targeted support for adults dealing with concurrent substance use and serious mental health challenges, as well as children facing significant emotional difficulties. Their therapeutic methods encompass strategies such as anger management, brief interventions, and cognitive behavioral therapy. The center provides outpatient options including methadone, buprenorphine, or naltrexone treatments alongside standard outpatient care. With specific programs designed for adult men, women, and individuals who have faced domestic violence, Centerstone serves a diverse range of adults and seniors. Emphasizing customized care and research-backed methods, the center aims to deliver top-notch treatment for those on their path to recovery.

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Centerstone of Indiana Inc, located in Spencer, IN, provides a variety of outpatient programs aimed at addressing substance use disorders along with mental health challenges for both adults and youth. The center offers a range of services including 12-step programs, anger management courses, and short-term intervention strategies customized for each person. It also features specific programs designed for adult males, females, and those affected by domestic violence, ensuring a broad spectrum of support. Catering to adults and older individuals of all backgrounds, this facility emphasizes the delivery of excellent, individualized care to assist clients in their recovery journey.

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Central Behavioral Health in Norristown, PA, provides comprehensive outpatient care for adults struggling with substance use disorders. The center also addresses co-occurring mental health conditions in adults and emotional challenges in children. They offer tailored programs for active service members, teenagers, and adult men. Employing methods such as anger management, brief intervention, and cognitive behavioral therapy, Central Behavioral Health supports individuals of all ages and genders on their journey toward healing and lasting wellness.

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Central City Concern in Portland, Oregon, provides in-depth, long-term residential rehabilitation for individuals battling substance use disorders. This program is specifically designed to support adult women, seniors, and young adults who have endured intimate partner violence, domestic abuse, or sexual trauma. Through a combination of 12-step principles, anger management techniques, and cognitive behavioral therapy, the center offers a multifaceted approach to healing and recovery. Central City Concern prioritizes a nurturing atmosphere tailored to the unique challenges faced by its predominantly female clientele, establishing itself as a key provider of extended residential care in the Portland region.

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Central County Adult MH Services, located in Concord, California, provides a broad range of treatment options for adults dealing with substance use issues alongside severe mental health conditions. The center features various levels of care including intensive outpatient, outpatient, and standard outpatient programs that employ scientifically supported methods like 12-step facilitation, brief interventions, and cognitive behavioral therapy. The center offers specialized programs designed for individuals with dual diagnoses of mental health and substance use disorders, delivering customized support for both adults and young adults. With an emphasis on personalized treatment strategies and gender-sensitive care for both men and women, this center is dedicated to delivering high-quality rehabilitation services.

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Central Florida Behavioral Health, located in Tampa, FL, offers a wide range of addiction treatment services aimed at both adults and children grappling with co-occurring substance abuse and significant mental health issues. The center provides inpatient detox and treatment within a hospital setting, focusing on methods such as 12-step programs, anger management, and brief intervention techniques. Catering to various demographics, the facility features specialized plans for adolescents, as well as adult males and females, addressing the unique needs of different age groups and genders. Dedicated to delivering high-quality care, Central Florida Behavioral Health emphasizes personalized treatment approaches to foster recovery and overall wellness in a supportive rehabilitation atmosphere for adults and elderly individuals.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated May 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)