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Medically Reviewed Content
Updated: October 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Center for Great Expectations

Situated in Somerset, NJ, the Center for Great Expectations provides extensive residential care for adults dealing with substance use issues and serious co-occurring mental health challenges, along with addressing significant emotional difficulties in children. This center is dedicated to creating a secure and nurturing atmosphere, particularly for women who have faced intimate partner violence, domestic abuse, or sexual trauma. Emphasizing a 12-step approach, cognitive behavioral strategies, and motivational rewards, the center focuses on offering individualized and thorough support for its female clients. Catering to a diverse range of individuals, including adults, seniors, and young adults, the Center for Great Expectations is committed to delivering exceptional rehabilitation services customized to fit the specific needs of each person.

Center for Healthcare Services

Situated in San Antonio, TX, the Center for Healthcare Services specializes in addressing substance abuse alongside serious mental health issues in adults, as well as significant emotional challenges in children. This center provides various treatment options, including intensive outpatient, outpatient, and programs involving methadone/buprenorphine or naltrexone. Emphasizing techniques such as 12-step facilitation, anger management, and brief intervention strategies, the facility supports adult men and women, as well as individuals who have suffered from domestic or intimate partner violence. By offering personalized care for adults and young adults of all backgrounds, the Center for Healthcare Services emerges as an essential option for individuals in need of thorough rehabilitation support.

Center for Human Development Inc

Situated in La Grande, OR, the Center for Human Development Inc delivers an extensive variety of substance abuse treatment options for both adults and children dealing with concurrent mental health issues. Tailored programs are available for teens, as well as adult men and women, featuring both intensive outpatient and outpatient treatment alternatives, including options like methadone/buprenorphine and naltrexone. Utilizing evidence-based methods such as anger management, brief interventions, and cognitive behavioral therapy, the center guarantees personalized attention for every individual. Catering to adults and seniors across all genders, this facility is dedicated to providing top-notch care and assistance for those on the path to recovery from addiction and mental health challenges.

Center for Network Therapy

The Center for Network Therapy in Freehold, NJ, provides extensive care for those facing addiction and coinciding mental health challenges. They offer various levels of care, including intensive outpatient, general outpatient, and partial hospitalization programs. Their therapeutic methods, such as 12-step integration, motivational interviewing, and CBT, are adapted to meet the unique needs of each person. Catering to adult men and women, the Center for Network Therapy is recognized for its dedication to delivering effective, science-backed treatment within a compassionate setting.

Centerstone
Tullahoma, TN

Situated in Tullahoma, TN, Centerstone delivers extensive outpatient rehabilitation services aimed at addressing substance use disorders and co-occurring mental health issues. The center focuses on both adults and children/adolescents, offering customized programs that include anger management, cognitive behavioral therapy, and trauma-informed care. Prioritizing high-quality support, this facility features regular outpatient treatment options alongside specialized outpatient services like methadone/buprenorphine and naltrexone therapies. Centerstone is recognized for its proficiency in managing both mental health and substance use disorders, providing individualized rehabilitation strategies for male and female clients alike.

Center for Recovery

Situated in Newburgh, NY, the Center for Recovery specializes in providing tailored substance use treatment options for both adults and young adults. The center offers a range of services, including intensive outpatient programs, standard outpatient therapy, and medication-assisted treatments with methadone, buprenorphine, or naltrexone. Emphasizing 12-step programs, anger management techniques, and brief interventions, the center customizes its approach to meet the unique needs of each client. Catering to both men and women, the center employs a holistic and gender-sensitive methodology in its recovery process. Committed to delivering top-quality care and individualized treatment strategies, the Center for Recovery is dedicated to supporting individuals in achieving sustainable sobriety.

Center for Recovery

The Center for Recovery located in Newburgh, NY, specializes in outpatient programs for adults and young adults dealing with substance use issues. It offers treatment options such as methadone, buprenorphine, and naltrexone, with a strong focus on brief interventions, cognitive behavioral therapy, and motivational interviewing to assist clients throughout their recovery process. Prioritizing individualized treatment, the center serves both male and female clients, ensuring that each participant receives a customized approach that effectively meets their specific requirements. For those in search of comprehensive addiction treatment tailored to their needs, the Center for Recovery is committed to guiding you on your journey to wellness.

CenterPointe
Omaha, NE

CenterPointe of Omaha, NE, provides extensive residential treatment options, both long and short-term, for those facing challenges with substance abuse and accompanying mental health conditions. This facility is dedicated to employing proven therapeutic methods like cognitive behavioral therapy and contingency management to foster enduring recovery. CenterPointe serves a varied clientele with distinct programs for adult men, adult women, and individuals with trauma histories. They develop individualized treatment strategies for adults and young adults, irrespective of gender, ensuring customized support throughout the recovery process. Discover effective treatment and superior care at CenterPointe.

Centerstone
Madison, TN

Centerstone in Madison, TN offers outpatient substance use treatment and specialized care for individuals with co-occurring substance use and mental health disorders. Their programs cater to adults and children/adolescents, with a focus on brief intervention, cognitive behavioral therapy, and motivational interviewing. The facility provides outpatient methadone/buprenorphine or naltrexone treatment along with regular outpatient services. Centerstone's tailored approach to clients with co-occurring disorders ensures comprehensive and effective care. With services available for both male and female clients, this facility prioritizes quality care to support individuals on their path to recovery.

Centerstone
Lewisburg, TN

Centerstone, located in Lewisburg, TN, provides outpatient services for adults dealing with substance use issues. It also offers specialized treatment for children experiencing co-occurring substance use and significant mental health challenges. The center employs evidence-backed methodologies such as cognitive-behavioral therapy, motivational interviewing, and anger management. Emphasizing personalized treatment, Centerstone serves both adults and younger populations, offering gender-specific programs for males and females. Furthermore, the center includes outpatient treatment options with methadone, buprenorphine, or naltrexone. Patients receive attentive care customized to meet their individual requirements in a nurturing setting.

Center for Network Therapy

The Center for Network Therapy, situated in West Orange, NJ, delivers complete addiction recovery solutions for adults and adolescents. This establishment provides detox, drug and alcohol treatment, and specific support for individuals facing both addiction and significant mental health challenges in adults, or emotional disruptions in minors. Employing treatment levels from intensive outpatient to full-day outpatient, the center employs scientifically validated methods including 12-step facilitation, brief intervention, and cognitive behavioral therapy. Tailored recovery paths are crafted for male and female clients through customized treatment strategies. Discover superior support and individualized care at the Center for Network Therapy.

Center for Recovery
Queensbury, NY

Situated in Queensbury, NY, the Center for Recovery provides outpatient treatment for substance use issues in both adults and children dealing with serious mental health challenges or emotional difficulties. Their offerings include programs for anger management, short interventions, and cognitive behavioral therapy. catering to adolescents as well as adult men and women, this center delivers personalized care designed to meet the unique needs of every client. With a commitment to outpatient methadone/buprenorphine or naltrexone therapies, along with standard outpatient services, the center guarantees effective treatment for clients of all genders. If you or someone you care about is in need of addiction recovery services, the Center for Recovery is committed to offering thorough care and assistance.

Center of Excellence in

The Center of Excellence in Beaverton, Oregon, provides extensive outpatient care for individuals of all ages facing substance use challenges, including detoxification and co-occurring mental health issues. Their expertise extends to outpatient detox, medication-assisted treatment (MAT) with methadone, buprenorphine, or naltrexone, and virtual therapy options. The center offers distinct programs designed for teenagers, adult men, and adult women, emphasizing personalized treatment for adults and young adults across all gender identities.

CenterPointe
Lincoln, NE

CenterPointe, located in Lincoln, NE, provides focused treatment for adults facing substance use issues alongside mental health challenges, as well as services for children dealing with significant emotional difficulties. Their treatments encompass intensive outpatient and outpatient programs that utilize proven methods, including cognitive behavioral therapy and anger management strategies. Additionally, the center offers outpatient treatment options for methadone and buprenorphine. What distinguishes CenterPointe is its commitment to personalized care, adapting its services to meet the unique needs of each individual. With an emphasis on high-quality, customized treatment, this center serves both adult men and women in need of thorough addiction recovery support.

CenterPointe
Lincoln, NE

CenterPointe in Lincoln, NE, provides dedicated long-term residential care for adults struggling with substance use disorders and complex mental health challenges. They also offer services for children facing significant emotional difficulties. Their approach involves customized treatment plans incorporating strategies like brief intervention, cognitive behavioral therapy, and motivational incentives. Notably, CenterPointe has developed specific programs for adult men, adult women, and individuals with a history of trauma. Committed to high standards of treatment, the center serves adults and young adults of all genders, fostering a complete and nurturing atmosphere for recovery and well-being.

Centerstone
Nashville, TN

Centerstone in Nashville, TN, provides targeted outpatient services for adults grappling with substance use disorders and co-occurring severe mental health conditions, alongside support for children experiencing emotional challenges. Their approach emphasizes personalized treatment strategies, incorporating techniques such as cognitive behavioral therapy and motivational interviewing. This center is committed to delivering individualized care that serves adults and youth of all genders. From standard outpatient programs to medication-assisted treatment options like methadone, buprenorphine, and naltrexone, Centerstone is equipped to guide individuals through a thorough and successful recovery process. For those in search of high-quality, personalized support, this establishment is devoted to fostering your journey toward improved well-being.

Centerstone
Chattanooga, TN

Centerstone located in Chattanooga, TN, delivers targeted outpatient services for adults dealing with substance abuse and concurrent mental health issues, as well as addressing emotional challenges in children. The center emphasizes personalized treatment, offering methods such as cognitive behavioral therapy, motivational interviewing, and teletherapy. Programs are customized for both adults and youth, with distinct pathways available for females and males. Their proficiency in managing outpatient treatments with methadone, buprenorphine, or naltrexone provides a holistic strategy towards recovery. Centerstone is dedicated to high-quality care and a variety of treatment modalities, making it an excellent option for individuals seeking rehabilitation support in the Chattanooga region.

Centerstone of Florida

Centerstone of Florida, located in Sarasota, FL, provides outpatient services for adults grappling with substance use issues alongside significant mental health challenges. The center's offerings encompass treatment using methadone, buprenorphine, or naltrexone, complemented by techniques such as 12-step facilitation, anger management, and targeted brief interventions. This facility is dedicated to serving active duty military members as well as adult males and females. With a commitment to addressing the unique requirements of both men and women, Centerstone of Florida emphasizes high-quality, personalized care, making it an essential option for individuals seeking thorough and effective addiction recovery solutions in the Sarasota region.

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The Center for Wellness and Recovery of NE GA, situated in Toccoa, GA, offers extensive addiction recovery services for adults and young adults. Their offerings include detox, addiction counseling, and tailored support for those with co-occurring mental health and substance use disorders. They provide adaptable treatment plans such as intensive outpatient, standard outpatient, and outpatient detox. Employing methods like 12-step facilitation, anger management, and brief intervention, they aim for comprehensive well-being. Distinctive programs for men, women, and individuals with trauma history underscore their specialized approach. This center stands as a symbol of hope, dedicated to delivering exceptional care for those on the path to recovery.

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San Rafael, CA

Situated in San Rafael, California, CenterLink delivers extensive treatment for substance use disorders aimed at both adults and young adults. The center offers various programs, including intensive outpatient, outpatient, and standard outpatient options. It employs techniques such as anger management, cognitive behavioral therapy, and motivational incentives to create customized treatment plans that cater to the unique needs of each participant. With dedicated programs for adult men, women, and those who have faced trauma, CenterLink fosters a compassionate atmosphere for everyone. The center also provides gender-specific treatment for both females and males, reinforcing its commitment to high-quality care and individualized support, making it an excellent choice for individuals seeking effective rehabilitation.

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Estill Springs, TN

Centerstone, located in Estill Springs, TN, provides outpatient services for adults and young adults facing substance use issues alongside significant mental health conditions or emotional challenges. This center features targeted programs designed specifically for men, women, and individuals with co-occurring disorders. Treatment modalities encompass anger management, brief interventions, and cognitive behavioral therapy techniques. Emphasizing outpatient options, Centerstone presents standard outpatient therapies alongside choices for methadone/buprenorphine and naltrexone. Catering to both genders, the center is committed to delivering high-quality care and personalized treatment strategies for individuals pursuing recovery from addiction.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated October 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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