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Medically Reviewed Content
Updated: May 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,711 treatment centers offering naltrexone (vivitrol) across the United States.

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Cherokee Health Systems

Cherokee Health Systems in Knoxville, TN, provides all-encompassing addiction recovery services for individuals of all ages who are also dealing with mental health challenges. Their robust outpatient and intensive outpatient services feature tailored support for those needing methadone, buprenorphine, or naltrexone therapy. This center emphasizes approaches like cognitive behavioral therapy, anger management, and brief intervention techniques to deliver individualized assistance for those battling substance dependence. Cherokee Health Systems is recognized for its distinct offerings for individuals with co-occurring disorders, catering to men and women across the adult and senior age spectrums. Discover individualized treatment plans and scientifically validated therapies at this respected recovery facility.

Cherry Street Health Services

Cherry Street Health Services, located in Grand Rapids, MI, delivers a full spectrum of recovery support for individuals of all ages experiencing challenges with addiction and mental well-being. Their offerings include robust outpatient programs and targeted medication-assisted treatment options. The center emphasizes evidence-based therapeutic approaches such as 12-step support, strategies for managing anger, and concise counseling interventions, specifically designed to assist those with past trauma and co-occurring conditions. Cherry Street Health Services is committed to providing personalized, superior care for all individuals, regardless of gender, on their journey toward lasting recovery.

Cheyenne VA Healthcare System

Situated in Cheyenne, WY, the Cheyenne VA Healthcare System provides specialized rehabilitation programs aimed at adults and young adults facing challenges related to substance use and concurrent mental health disorders. Emphasizing 12-step methodologies, anger management techniques, and short-term interventions, this facility offers various types of care, including inpatient stays, intensive outpatient programs, and around-the-clock support. It features distinctive offerings for adult women and those impacted by intimate partner violence or sexual assault. Committed to delivering personalized treatment for both genders, the Cheyenne VA Healthcare System focuses on ensuring high standards of care to assist individuals in their recovery journey.

CHI Health Mercy Psychiatric Associate

CHI Health Mercy Psychiatric Associates, located in Council Bluffs, IA, provides targeted outpatient services for individuals of all ages grappling with addiction and co-occurring mental health conditions. Their therapeutic framework integrates techniques such as anger control strategies, cognitive behavioral therapy, and concise intervention methods to deliver personalized treatment plans. The center supports adults and older adults with various medication-assisted treatment options, including methadone, buprenorphine, and naltrexone. By prioritizing a unique care path for every patient, CHI Health Mercy Psychiatric Associates is dedicated to assisting those in need of support for substance abuse and psychological well-being.

Cherokee Health Systems

Cherokee Health Systems in Morristown, TN, provides outpatient support for adults and young adults managing substance use alongside mental health challenges. Their services include routine outpatient treatment, incorporating proven methods such as anger management, brief intervention, and cognitive behavioral therapy. They also offer tailored programs for individuals facing dual diagnoses of mental health and substance use disorders. This facility is committed to delivering high-quality care to both men and women, guiding them through a complete recovery process. Cherokee Health Systems is a resource for those seeking impactful rehabilitation in an encouraging setting, focused on supporting each person's journey toward wellness.

Chestnut Health Systems Inc

Chestnut Health Systems Inc in Granite City, IL, offers extensive support for adults battling addiction, especially those concurrently dealing with significant mental health challenges. Their services include robust outpatient programs and intensive outpatient care, featuring methadone/buprenorphine options. Utilizing proven methods like 12-step facilitation and anger management, Chestnut Health Systems Inc provides tailored support for men, women, and individuals with trauma histories. Their commitment extends to adult and senior clients of all genders, ensuring a compassionate setting for effective rehabilitation and lasting recovery.

CHI Health Psychiatric Associates

Located in Omaha, NE, CHI Health Psychiatric Associates provides outpatient services for substance use treatment and addresses co-occurring disorders along with severe mental health challenges in adults, as well as emotional issues in children. The center employs techniques such as brief intervention, cognitive behavioral therapy, and motivational incentives to create personalized treatment plans that cater to individual needs. With a commitment to serving all genders across both adult and child/adolescent populations, this center prioritizes high-quality care to facilitate recovery and enhance overall wellness. CHI Health Psychiatric Associates is devoted to guiding individuals on their journey toward lasting recovery from addiction.

Cherokee Health Systems

Cherokee Health Systems, located in Knoxville, TN, provides targeted outpatient services for individuals grappling with substance use disorders and co-occurring severe mental health challenges in adults, or emotional difficulties in young people. The center focuses on personalized treatment plans that include anger management, brief intervention strategies, and cognitive behavioral therapy. Their diverse programs are designed to serve adults and older adults across all gender identities. A key offering at Cherokee Health Systems is their outpatient medication-assisted treatment, utilizing methadone, buprenorphine, or naltrexone, to deliver high-quality and thorough addiction care. For those in search of effective, customized recovery support, this center is dedicated to guiding your path to wellness through established therapeutic methods and unwavering assistance.

Child and Family Center
Santa Clarita, CA

Situated in Santa Clarita, CA, the Child and Family Center provides tailored rehabilitation services for those dealing with substance abuse and accompanying mental health challenges. This center offers a range of services including intensive outpatient therapy, standard outpatient support, and treatments involving methadone, buprenorphine, or naltrexone. Emphasizing approaches such as anger management, brief interventions, and cognitive behavioral therapy, it serves both adults and youth who experience emotional difficulties. Specialized programs for teenagers and individuals with dual diagnoses are also offered. The center is inclusive, accepting clients of all genders to ensure comprehensive care and assistance for everyone on their path to recovery.

Cherokee Health Systems

Cherokee Health Systems in Blaine, TN, provides extensive outpatient care for substance use disorders affecting individuals of all ages, with a particular focus on those experiencing concurrent mental health challenges. Their approach centers on tailored treatment, offering options such as outpatient methadone, buprenorphine, or naltrexone services alongside consistent outpatient counseling. They employ proven therapeutic methods including anger management, brief intervention strategies, and cognitive behavioral therapy, serving adult men, women, and seniors. Cherokee Health Systems is committed to delivering high-quality, personalized recovery pathways.

Cherokee Health Systems

Cherokee Health Systems in Newport, TN, provides expert outpatient care for individuals of all ages grappling with substance use and co-occurring mental health challenges. Their therapeutic offerings encompass anger management, cognitive behavioral therapy, and brief intervention strategies, among others. This facility is particularly adept at serving clients with dual diagnoses, crafting individualized treatment plans to suit each person's unique requirements. Catering to adults and seniors irrespective of gender, Cherokee Health Systems distinguishes itself through its extensive outpatient methadone/buprenorphine services and dedication to superior patient outcomes. For those in search of impactful treatment within a nurturing setting, personalized assistance is readily available at this respected recovery center.

Cherry Street Health Center

Cherry Street Health Center, situated in Grand Rapids, MI, delivers a wide range of outpatient rehabilitation options for adults and children facing substance use issues alongside mental health challenges. This facility features targeted treatment initiatives for active military members, teens, and adult males. Their approach encompasses techniques such as anger management, brief interventions, and cognitive behavioral therapy. Emphasizing outpatient services, including methadone, buprenorphine, or naltrexone therapy, Cherry Street Health Center serves clients of all genders and ages. Discover personalized care and effective assistance at this center.

Chestnut Health Systems Inc

Chestnut Health Systems Inc in Bloomington, IL is a dedicated facility providing extensive support for those battling addiction and dual diagnoses. They offer various levels of care, including intensive outpatient, outpatient, and day treatment programs. Their therapeutic methods encompass anger management, cognitive behavioral therapy, and brief interventions. Specialized services are available for adult men, women, and survivors of domestic abuse. Chestnut Health Systems Inc is committed to delivering high-quality, evidence-based treatment for adults and seniors, fostering a journey toward lasting well-being.

Cherokee Health Systems

Cherokee Health Systems, located in Alcoa, TN, specializes in outpatient services for individuals dealing with substance use issues and concurrent mental health challenges, serving both adults and children. The center employs a variety of evidence-supported methodologies, such as cognitive behavioral therapy, anger management, and brief intervention techniques. Prioritizing high-quality care, Cherokee Health Systems focuses on individuals with dual diagnoses, offering outpatient treatments like methadone/buprenorphine and naltrexone. Their programs are designed to meet the needs of adults and seniors of all genders. If you or someone close to you requires tailored and thorough treatment, this facility creates a nurturing and effective setting for the recovery journey.

Chesapeake Integrated Behavioral Hlth

Chesapeake Integrated Behavioral Hlth in Chesapeake, VA provides distinct programs for individuals of all ages facing substance use and co-occurring mental health conditions. Their approach emphasizes intensive outpatient care, general outpatient services, and medication-assisted treatment options including methadone, buprenorphine, or naltrexone. Employing proven methods like 12-step facilitation, anger management, and brief interventions, the center customizes care to meet diverse patient requirements. Specialized tracks are available for adolescents, adult men, and women. Catering to a wide demographic, from adults to seniors of any gender, Chesapeake Integrated Behavioral Hlth is dedicated to fostering high-quality, comprehensive recovery and overall wellness.

Chesterfield Community Services Board

Chesterfield Community Services Board, located in Chesterfield, VA, provides a variety of outpatient services for substance use disorders, including support for adults with co-existing substance issues and serious mental health disorders, as well as emotional challenges in children. The center employs proven methods like cognitive behavioral therapy and motivational incentives to enhance recovery efforts. With tailored programs designed for teenagers, adult males, and females, this facility addresses the needs of diverse groups. It offers a welcoming atmosphere for adults and seniors of all genders who are pursuing effective addiction recovery solutions in the Chesterfield region.

Chestnut Health Systems Inc

Chestnut Health Systems Inc, situated in Belleville, IL, provides various treatment options for adults facing substance use challenges alongside significant mental health disorders. The facility offers multiple levels of care, including intensive outpatient, outpatient, and standard outpatient programs, effectively utilizing proven methods such as cognitive behavioral therapy and motivational interviewing. There are also specialized programs designed for adolescents, as well as adult men and women. Emphasizing personalized care, this center ensures that services are tailored to meet the specific needs of adults and seniors of all genders. Chestnut Health Systems Inc is recognized for its thorough treatment solutions and distinct programs catering to diverse age groups and genders.

Chestnut Ridge Center
Morgantown, WV

Nestled in Morgantown, WV, Chestnut Ridge Center is dedicated to providing extensive treatment options for addiction affecting both adults and youth. This facility offers inpatient detox services as well as treatment targeting substance use disorders, with a particular emphasis on addressing co-occurring mental health issues. The center implements a range of programs including 12-step support, anger management strategies, and concise interventions, all designed to cater to the unique requirements of each patient. Specialized programs for men, women, and those with dual diagnoses ensure that the care provided is tailored to various needs. Chestnut Ridge Center is committed to delivering compassionate and effective support, guiding individuals toward sustainable recovery.

Child and Family Addiction Center

Situated in Ellenville, NY, the Child and Family Addiction Center provides a wide range of substance abuse treatment services for both adults and children. This center specializes in intensive outpatient programs, outpatient care, and targeted treatment for those facing both substance use issues and significant mental health disorders. Emphasizing 12-step support, anger management techniques, and brief intervention strategies, the facility serves adolescents and adult clients, including men and women. Individuals of every age and gender can find customized programs designed to assist them in their recovery journey. The Child and Family Addiction Center is committed to offering exceptional, personalized care to support individuals in achieving enduring sobriety and improved mental health.

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Cherokee Health Systems, located in Seymour, TN, specializes in outpatient treatment programs designed for adults facing substance use issues and concurrent severe mental health disorders, as well as for children dealing with emotional challenges. The center emphasizes personalized care through various strategies, including anger management, brief intervention, and cognitive behavioral therapy. With an emphasis on customized treatment plans, it serves adults and elderly individuals across all gender identities. Cherokee Health Systems is distinguished by its outpatient options for methadone/buprenorphine or naltrexone treatment, showcasing its dedication to providing exceptional care within a nurturing setting.

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Situated in Highland, NY, the Child and Family Guidance Center delivers extensive treatment for substance use disorders along with specialized support for individuals facing simultaneous substance use and significant mental health challenges. Emphasizing intensive outpatient programs, outpatient services, and medication-assisted options, this facility designs custom programs catering to adolescents, adult males, and females. Employing techniques such as 12-step facilitation, anger management, and brief intervention, the center serves individuals of all ages and genders, including adults, children, and seniors. Dedicated to providing exceptional care, the center fosters a nurturing atmosphere for individuals on their journey to recovery and overall wellness.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated May 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

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