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Medically Reviewed Content
Updated: October 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Central Ozarks Medical Center

Central Ozarks Medical Center in Richland, MO, provides a comprehensive outpatient program addressing substance use disorders and dual diagnoses in adults, alongside emotional health concerns for children. Their therapeutic offerings encompass 12-step facilitation, anger management, and short-term counseling. They also feature distinct programs designed for active military members, young people, and adult men. Catering to a broad demographic of adults and older adults across all genders, the center offers various outpatient care options, including medication-assisted treatment with methadone or buprenorphine. Dedicated to delivering high-quality, individualized care, this institution guides individuals toward lasting recovery.

Central Texas VA Healthcare

Central Texas VA Healthcare, located in Austin, TX, delivers extensive rehabilitation programs designed for adults and young adults confronting substance abuse and co-occurring mental health challenges. Their services include intensive outpatient care, outpatient detox, and an array of proven therapeutic methods like 12-step facilitation and anger management. They also offer specialized support for those who have undergone trauma, intimate partner violence, sexual abuse, or domestic violence. Prioritizing high-quality, personalized care, this center serves male and female individuals pursuing healing and assistance within a secure and welcoming setting.

Central Texas VA Healthcare System

Central Texas VA Healthcare System in Waco, TX, delivers extensive support for individuals battling substance use disorders, including specialized care for those with co-occurring mental health conditions in adults and emotional challenges in children. The facility offers round-the-clock hospital inpatient services and intensive outpatient treatment. Utilizing therapeutic methods such as anger management, brief intervention, and cognitive behavioral therapy, the center supports adult men and women, along with active duty military members. Catering to adults and young adults, it provides distinct programs for males and females. Central Texas VA Healthcare System in Waco is recognized for providing excellent, individualized care, establishing itself as a leading option for comprehensive rehabilitation.

Central Valley Clinic

Nestled in San Jose, CA, Central Valley Clinic delivers a full spectrum of substance abuse recovery services via personalized outpatient plans. They offer medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside standard outpatient care. Their approach incorporates scientifically proven methods such as anger management, cognitive behavioral therapy, and motivational interviewing. The clinic is adept at serving adult men and women, including those affected by intimate partner or domestic violence. Central Valley Clinic is dedicated to providing effective rehabilitation and compassionate support to adults and young adults of all genders.

Central Wyoming Counseling Center

Central Wyoming Counseling Center in Casper, WY, provides extensive support for individuals struggling with substance abuse and offers tailored services for children and adults facing concurrent mental health challenges. The center delivers various treatment modalities, including intensive outpatient, extended residential stays, and flexible outpatient options, all adapted to each person's unique requirements. Employing proven therapeutic methods such as cognitive behavioral therapy and anger management, Central Wyoming Counseling Center also features distinct programs for active military personnel, teenagers, and adult men. The facility is dedicated to serving adults and seniors across all gender identities, prioritizing excellent care aimed at fostering lasting recovery and overall wellness.

Chalmers P Wylie VA ACC

Chalmers P Wylie VA ACC located in Columbus, OH, provides an extensive variety of rehabilitation services aimed at adults and young adults who are struggling with substance abuse along with co-existing mental health issues. Their offerings encompass detoxification, intensive outpatient therapy, and targeted assistance for those affected by intimate partner violence. Emphasizing techniques such as 12-step facilitation, anger management, and brief interventions, this facility delivers customized support for both genders. The center's dedication to high-quality care and a range of treatment modalities position it as an essential asset for individuals in need of effective and compassionate support in overcoming addiction.

Changed Lives Mental Health and

Situated in Lexington, KY, Changed Lives Mental Health and Rehabilitation Center provides extensive treatment options for adults dealing with substance use issues alongside major mental health challenges. The facility offers a range of programs including intensive outpatient, outpatient, and standard outpatient services, employing methodologies such as 12-step facilitation, anger management techniques, and brief interventions. Tailored programs are available for adult men and women, as well as children and adolescents, including services for those affected by domestic or intimate partner violence. With a focus on delivering effective care to both genders, this center is committed to supporting individuals on their journey toward sustained recovery and enhanced mental health.

Changed Lives Substance

Changed Lives Substance in Lexington, KY provides tailored programs for individuals of all ages struggling with addiction and accompanying mental health conditions. The center utilizes proven therapies, including 12-step facilitation, cognitive behavioral therapy, and motivational interviewing, within intensive outpatient and standard outpatient settings. Services are available for adult men and women, as well as those affected by domestic or intimate partner violence. Changed Lives Substance is dedicated to personalized care for adults, children, and adolescents, assisting both males and females on their journey to recovery and enhanced mental well-being.

Central Nassau Guidance Srvs

Central Nassau Guidance Srvs, located in Hicksville, NY, provides extensive outpatient services for detox, addiction treatment, and co-occurring mental health conditions for all ages. Their expertise includes anger management, brief interventions, and cognitive behavioral therapy, with specialized support for active military, men, and women. The center offers outpatient detox and medication-assisted treatment (methadone/buprenorphine) to adult men, women, and young people. Central Nassau Guidance Srvs is dedicated to offering excellent, personalized support to foster long-term healing and mental well-being.

Central Peninsula General Hospital

Situated in Soldotna, AK, Central Peninsula General Hospital presents an array of thorough rehabilitation services aimed at individuals recovering from substance use disorders. This center features detox programs, intensive outpatient care, and extended residential treatment options for both adults and young adults. It includes specialized services for active military personnel, as well as tailored programs for adult men and women, employing methods like 12-step facilitation and anger management. The facility also offers transitional housing and outpatient services, focusing on personalized care for male and female clients alike. Central Peninsula General Hospital is distinguished by its high-quality care and dedication to supporting individuals in achieving long-term sobriety.

ChangePoint Integrated Health

ChangePoint Integrated Health, located in Show Low, AZ, provides a wide range of services for individuals dealing with substance use disorders and co-existing serious mental health challenges in adults, as well as emotional disturbances in children. The facility offers various treatment options, including intensive outpatient programs, outpatient services, and medications such as methadone, buprenorphine, or naltrexone. Utilizing techniques such as anger management, brief interventions, and cognitive behavioral therapy, the center supports adolescents, men, and women. ChangePoint Integrated Health is dedicated to delivering high-quality care to adults and seniors of all genders, focusing on personalized treatment strategies and evidence-based methods to facilitate enduring recovery.

Central Minnesota Mental Health Center

The Central Minnesota Mental Health Center, situated in Saint Cloud, MN, delivers extensive support for overcoming addiction. Their expertise encompasses detoxification and addressing substance use, offering inpatient detox and continuous care for those pursuing sobriety. Employing methods like 12-step integration, brief counseling, and cognitive behavioral therapy, the center crafts personalized recovery plans. Recognizing diverse needs, their individualized programs serve children, teenagers, and adult men and women. For superior care within a nurturing setting, the Central Minnesota Mental Health Center is distinguished by its tailored services and dedication to fostering enduring recovery.

Champlain Valley Family Center

Situated in Plattsburgh, NY, Champlain Valley Family Center delivers a wide array of outpatient programs for substance use treatment. This center is dedicated to addressing co-occurring substance use disorders alongside significant mental health challenges in adults, in addition to supporting children with emotional issues. Emphasizing approaches such as cognitive behavioral therapy, anger management, and short-term interventions, the center offers personalized treatment plans for adult men and women, teenagers, and older adults. By focusing on outpatient therapies involving methadone, buprenorphine, or naltrexone, this facility prioritizes providing effective care for those on the road to recovery. It welcomes a diverse clientele, fostering a nurturing atmosphere for everyone in need of rehabilitation assistance.

Champlain Valley Family Center

Champlain Valley Family Center, situated in Schuyler Falls, NY, delivers thorough support for addiction recovery. This facility offers extended residential stays, detox services, and round-the-clock assistance for adults and young adults. Their approach integrates 12-step principles, anger management techniques, and brief intervention strategies, serving both men and women. Dedicated programs are designed for active military members, adult males, and adult females. Champlain Valley Family Center is committed to delivering excellent care and tailored treatment paths to guide individuals toward overcoming substance use challenges.

ChangePoint Integrated Health

ChangePoint Integrated Health, located in Winslow, AZ, specializes in holistic treatment for adults facing substance use issues alongside mental health disorders. The facility offers both intensive outpatient and standard outpatient services, featuring treatment alternatives such as methadone, buprenorphine, and naltrexone. Emphasizing techniques like anger management, brief interventions, and cognitive behavioral therapy, ChangePoint devises customized treatment strategies to meet the unique needs of each individual. The center also has specialized programs designed for adolescents and distinct groups, including adult men and women. By welcoming adults and seniors of all genders, ChangePoint Integrated Health is committed to delivering excellent care and support to those on their journey to recovery from addiction and mental health struggles.

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Central Park Recovery LLC, located in Yonkers, NY, delivers thorough substance abuse treatment via intensive outpatient, outpatient, and day program options. The center is particularly adept at addressing issues such as anger management, short-term intervention, and cognitive behavioral therapy, offering customized support for teenagers as well as adult men and women. Catering to adults and seniors of any gender, this facility adapts its services to the specific requirements of each client. Committed to providing high-quality care through research-backed methods, Central Park Recovery LLC stands out as a reputable choice for individuals seeking tailored addiction recovery solutions in the Yonkers community.

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Central Park Recovery LLC, located in Yonkers, NY, delivers a full spectrum of care for adults and youngsters facing addiction and simultaneous mental health challenges. Their offerings include intensive outpatient, outpatient, and day treatment services, grounded in proven therapeutic methods like cognitive behavioral therapy and anger management. The center features distinct programs for those who have endured trauma and individuals with co-occurring disorders. Catering to both men and women, Central Park Recovery LLC prioritizes personalized treatment plans for every individual. Their commitment to excellence and bespoke care is central to helping clients achieve sustained recovery and enhanced emotional health.

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Saint Louis, MO

Centrec Care, located in Saint Louis, MO, delivers a wide range of addiction treatment services for both adults and young adults. The center specializes in detoxification, addressing substance use issues, and providing targeted support for individuals dealing with co-occurring disorders, including serious mental health challenges for adults and emotional issues for children. With a variety of treatment formats such as intensive outpatient, outpatient, and day programs, patients have access to resources like 12-step facilitation, anger management sessions, and brief intervention strategies. Centrec Care serves adult men, women, and active duty military members, offering tailored care aimed at fostering recovery, making it a top option for those in need of effective and empathetic addiction support.

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ChangePoint Integrated Health in Snowflake, AZ, provides a wide array of services aimed at treating substance use disorders for both adults and children facing concurrent mental health challenges. Their offerings encompass intensive outpatient programs, standard outpatient treatment, as well as specific options for methadone, buprenorphine, or naltrexone therapies. Emphasizing techniques such as anger management, brief intervention strategies, and cognitive behavioral therapy, this center delivers customized assistance for youths, adult males, and adult females. ChangePoint Integrated Health is committed to delivering exceptional care for individuals of all genders, including seniors, as they navigate their recovery journey.

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ChangePoint Integrated Health in Holbrook, AZ, is a premier facility dedicated to adults facing substance use disorders, particularly those with concurrent serious mental health conditions or emotional challenges in youth. They offer robust intensive outpatient and standard outpatient services, which include pharmacotherapy options like methadone and buprenorphine. Their therapeutic approach incorporates proven methods such as anger management, brief interventions, and cognitive behavioral therapy. ChangePoint Integrated Health serves a diverse population, including adolescents, adult men, adult women, and seniors, ensuring gender-inclusive and age-appropriate care. This center is committed to providing exceptional, all-encompassing rehabilitation programs focused on achieving sustained recovery and overall well-being.

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ChangePoint Psychiatric Hospital, located in Lakeside, AZ, provides a wide range of rehabilitation services aimed at adults and young adults struggling with addiction and concurrent mental health challenges. The center features targeted programs designed for adult males, adult females, and those who have faced experiences of intimate partner violence. Various treatment methods are utilized, including anger management, brief interventions, and cognitive behavioral therapy. Committed to delivering high-quality care, the facility offers inpatient detoxification along with treatment services, ensuring around-the-clock support. ChangePoint Psychiatric Hospital is dedicated to serving both men and women, offering personalized care plans for each individual on their path to recovery.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated October 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)