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Medically Reviewed Content
Updated: October 2026
Sources: SAMHSA, NIDA

Naltrexone and Vivitrol Treatment Centers

Naltrexone is an FDA-approved opioid antagonist medication used to treat both alcohol dependence and opioid use disorder. Available as a daily oral tablet (Revia) or a monthly Vivitrol injection, naltrexone works by blocking opioid receptors in the brain to reduce cravings and prevent relapse. Use our directory to find treatment centers that offer naltrexone-based medication-assisted treatment near you.

Found 6,655 treatment centers offering naltrexone (vivitrol) across the United States.

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Eagle Healthworks
Thornville, OH

Eagle Healthworks, situated in Thornville, OH, delivers focused treatment options for substance use disorders tailored to both adults and young adults. The facility offers a range of services, including intensive outpatient programs, general outpatient support, as well as outpatient treatments using methadone, buprenorphine, or naltrexone. Emphasizing techniques such as anger management, brief interventions, and cognitive behavioral therapy, the center customizes its approach to meet the unique needs of each individual. Catering to both men and women, Eagle Healthworks adopts a thorough and personalized methodology for recovery. For those in search of exceptional care within a nurturing atmosphere, this center’s dedication to tailored treatment makes it an essential option for individuals on their recovery journey.

Eagle Healthworks
Byesville, OH

Eagle Healthworks, situated in Byesville, OH, presents an array of thorough treatment options for substance use disorders. The facility offers a range of services including intensive outpatient programs, general outpatient care, and outpatient treatments using methadone, buprenorphine, or naltrexone. Employing techniques such as anger management, brief interventions, and cognitive behavioral therapy, Eagle Healthworks customizes its treatment to meet the unique needs of each client. The center is committed to an individualized treatment philosophy, catering to adults and young adults of all genders. With a strong emphasis on high-quality care, this facility strives to assist individuals in overcoming their addiction and reaching sustainable recovery.

East Amherst Family Recovery Center

The East Amherst Family Recovery Center, situated in East Amherst, NY, offers premier substance abuse care for adults experiencing dual diagnoses of severe mental health conditions and for children facing significant emotional challenges. They provide outpatient services including methadone, buprenorphine, or naltrexone therapy, and their areas of expertise include facilitating 12-step programs, anger management techniques, and short-term therapeutic interventions. The center welcomes active military members, teenagers, and adult men, striving to offer complete support. Their adaptable programs are designed for adults and young people of all genders, aiming to deliver impactful and individualized recovery support to guide individuals toward healing.

East Coast Recovery

East Coast Recovery, situated in Cohasset, MA, delivers targeted addiction recovery services for adults and adolescents confronting combined mental health challenges. The center features intensive outpatient, outpatient, and day treatment options, integrating methodologies such as 12-step support, emotional regulation techniques, and concise therapeutic interventions. What distinguishes East Coast Recovery is its personalized approach for individuals with dual diagnoses. Dedicated to high standards and customized care, this facility accommodates both male and female patients in pursuit of complete recovery within a nurturing setting.

East Indiana Comprehensive Trt Ctr

East Indiana Comprehensive Trt Ctr, situated in Lawrenceburg, IN, delivers extensive care for adults and young adults struggling with substance use. The center features outpatient services, including medication-assisted treatment with methadone, buprenorphine, or naltrexone, alongside standard outpatient programming. They emphasize 12-step facilitation, anger management, and cognitive behavioral therapy, customizing approaches to meet personal recovery goals. Specific support is offered for adult men, adult women, and those who are pregnant or postpartum. Serving a diverse clientele of both genders, the facility is dedicated to providing high-quality recovery support for everyone.

Eastern Colorado Healthcare System

Situated in Aurora, CO, the Eastern Colorado Healthcare System delivers a wide range of rehabilitation services for both adults and young adults facing challenges related to substance use and mental health disorders. This center features hospital-based detoxification, around-the-clock inpatient support, and intensive outpatient programs. It includes specialized services designed for those who have undergone trauma, domestic violence, sexual abuse, or intimate partner violence, creating a nurturing atmosphere for all clients, regardless of gender. Employing techniques like 12-step support, anger management, and short-term intervention, the center aims to provide exceptional care customized to meet the unique needs of each individual.

Eastern Oklahoma VA Healthcare System

The Eastern Oklahoma VA Healthcare System located in Muskogee, OK, provides a wide range of addiction recovery services for both adults and young adults. This center offers inpatient detoxification, treatment for substance use disorders, and targeted programs designed for those who have faced trauma, domestic violence, intimate partner violence, or sexual abuse. Various therapeutic techniques are employed, such as 12-step programs, anger management, and brief intervention strategies. Committed to delivering high-quality, personalized care, the facility is open to all clients, regardless of gender, who are looking to overcome their substance use challenges.

Easter Seals Michigan

Easter Seals Michigan in Pontiac, MI, delivers a full spectrum of care for those struggling with addiction. Their services encompass medical detox, treatment for substance dependence, and tailored support for individuals facing both addiction and significant mental health challenges. They offer various levels of care, including residential treatment, partial hospitalization, and outpatient services, ensuring flexibility for different recovery journeys. The center employs evidence-based practices like 12-step support, emotional regulation training, and brief counseling strategies. Specific programs are developed for active military personnel, teenagers, and adult males. Serving a broad demographic of adults and older adults across all genders, Easter Seals Michigan is committed to delivering exceptional, personalized recovery support.

Easter Seals Michigan
Auburn Hills, MI

At its Auburn Hills, MI location, Easter Seals Michigan delivers a full spectrum of support for individuals battling addiction and those dealing with intertwined mental health disorders. This establishment features hospital inpatient, intensive outpatient, and outpatient programs designed for adults and children experiencing emotional difficulties. Emphasizing a holistic methodology, Easter Seals Michigan accommodates adolescents, survivors of sexual abuse, and individuals impacted by trauma. Catering to adults, seniors, and young adults of all gender identities, this center is dedicated to providing excellent care that is customized to meet the specific requirements of each person.

Each 1 Teach 1 Community Health LLC

Situated in Baltimore, MD, Each 1 Teach 1 Community Health LLC delivers exceptional rehabilitation services aimed at adult males facing substance abuse challenges along with significant mental health disorders. The center offers extended residential care that integrates cognitive behavioral therapy, anger management techniques, and short intervention methods. With a focus on trauma-informed practices, this facility serves adults, seniors, and young adults within a supportive, gender-specific setting. The program includes transitional housing and sober living arrangements, emphasizing the empowerment of clients on their journey to sustainable recovery and overall well-being. Opt for this center for empathetic support and proven treatment methodologies.

East Central MO Behavioral Health

East Central MO Behavioral Health, situated in Mexico, MO, stands as a premier institution dedicated to outpatient treatment for substance use disorders affecting both adults and youth. The facility is particularly adept at addressing co-occurring mental health conditions, offering distinct programs for adolescents and those with dual diagnoses. Their therapeutic interventions encompass a range of approaches, including support for the 12-step model, anger management training, and concise therapeutic interventions. Catering to a diverse clientele, East Central MO Behavioral Health provides gender-specific services, fostering a holistic recovery journey. They offer customized outpatient options using methadone, buprenorphine, or naltrexone, alongside standard outpatient care. Serving a broad age spectrum from adults to seniors, the center is committed to delivering high-quality care and developing personalized treatment strategies for each individual.

East Alabama Mental Health Center

Situated in Opelika, AL, the East Alabama Mental Health Center provides expert care for individuals facing addiction and co-occurring mental health challenges, serving both young and adult populations. Their outpatient services encompass medication-assisted treatment (methadone/buprenorphine) and address crucial areas like anger management, cognitive behavioral therapy, and motivational interviewing. The center is committed to delivering personalized support to adults and young adults of all backgrounds, crafting unique treatment strategies for each individual's recovery path. For those in search of empathetic and scientifically-backed assistance, the East Alabama Mental Health Center stands ready to offer high-quality services to guide you toward wellness.

East Kentucky Rehabilitation Center

East Kentucky Rehabilitation Center, situated in Prestonsburg, KY, delivers a full spectrum of addiction recovery services for adults and adolescents. Their offerings include intensive outpatient programs, general outpatient care, and medication-assisted treatment options such as methadone, buprenorphine, or naltrexone. Employing strategies like brief intervention, the Matrix Model, and relapse prevention, the center ensures a personalized treatment plan for every client. This facility is equipped to support both male and female individuals through a highly individualized recovery process. Patients are assured of receiving excellent care and custom-designed programs to aid them in achieving lasting sobriety.

Eagleville Hospital
Norristown, PA

Eagleville Hospital, situated in Norristown, PA, delivers thorough addiction recovery programs for adults and adolescents. The center excels in aiding individuals through detoxification, addressing substance dependency, and supporting those with intertwined mental health conditions. Their approach emphasizes 12-step integration, emotional regulation techniques, and cognitive behavioral strategies, ensuring personalized support tailored to individual requirements. Eagleville Hospital also offers specialized tracks for individuals with a history of trauma, dual diagnoses, and challenges related to pain and substance use. Dedicated to superior treatment, the hospital provides residential services within a nurturing setting for both male and female patients.

Easter Seals
Southfield, MI

Easter Seals, situated in Southfield, MI, provides a wide range of addiction treatment options for both adults and children who are dealing with simultaneous mental health issues. The center offers various programs, including hospital inpatient, intensive outpatient, and regular outpatient services. Emphasizing 12-step support, anger management, and brief intervention techniques, Easter Seals customizes its treatment plans to address the unique needs of each client. Additionally, specialized programs for active military personnel, young people, and adult men further enhance the center's approach to individualized care. Catering to adults, seniors, and young adults of all genders, Easter Seals in Southfield, MI, is committed to delivering high-quality, evidence-based rehabilitation solutions for individuals striving to overcome substance use challenges.

Easter Seals Michigan
Walled Lake, MI

Easter Seals Michigan, located in Walled Lake, MI, provides an extensive array of addiction treatment options for both adults and children facing dual diagnoses of mental health concerns. The center features a range of services, including inpatient care, intensive outpatient programs, and standard outpatient options that employ research-backed methods like 12-step support, strategies for anger control, and brief therapeutic interventions. Catering to various demographics, the facility has distinct programs designed for active military personnel, young people, and adult males. Easter Seals Michigan is committed to delivering exceptional care for adults and seniors of every gender, fostering a nurturing atmosphere that supports sustainable recovery.

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The East Alabama Mental Health Center located in Phenix City, AL, specializes in treating adults with substance use disorders alongside serious mental health issues, as well as addressing significant emotional disturbances in children. This center provides outpatient options that include treatments such as methadone/buprenorphine or naltrexone, conventional outpatient therapy, and customized programs targeting anger management, cognitive behavioral therapy, and motivational interviewing. By focusing on personalized care, the center serves individuals of all genders, both adults and young adults. Its holistic approach and dedication to high-quality care position it as an essential option for anyone in need of effective and individualized rehabilitation services.

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East Hampton Outpatient Services, situated in East Hampton, NY, delivers targeted therapeutic interventions for adults grappling with co-occurring serious mental health conditions or emotional distress in youth. The center offers outpatient services including methadone, buprenorphine, and naltrexone, alongside a holistic approach incorporating 12-step facilitation, anger management strategies, and brief intervention techniques. Specific programming is available for adult men, adult women, and individuals with a history of trauma, facilitating personalized care plans. Catering to a diverse clientele encompassing adults and children/adolescents of all genders, the facility is dedicated to providing high-quality, scientifically-backed treatment to foster successful recovery.

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Center Line, MI

Easter Seals Michigan in Center Line, MI, delivers extensive addiction treatment. Services encompass detox, general substance use treatment, and dedicated support for those with dual diagnoses of substance use and significant mental health conditions. Offering hospital inpatient, intensive outpatient, and outpatient programs, this center serves adults and seniors across all genders. Special programs are also provided for active duty military, teenagers, and adult men. The center's recovery strategies feature 12-step facilitation, anger management techniques, and brief intervention methods, all designed to provide individualized support for everyone on their journey to recovery.

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The Eastern Shore Behavioral Health Care Center located in Parksley, VA, specializes in outpatient treatment for adults dealing with substance use disorders alongside mental health challenges, as well as for children facing serious emotional issues. This facility offers unique programs specifically designed for adult men and women, as well as individuals with dual diagnoses. Treatment methods used include 12-step programs, brief interventions, and cognitive behavioral therapy. The center caters to both men and women, providing outpatient services that include methadone, buprenorphine, or naltrexone treatments alongside standard outpatient care. Experience high-quality, individualized treatment at the Eastern Shore Behavioral Health Care Center.

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Eastern Shore Community Services Board in Parksley, VA provides comprehensive outpatient substance use disorder services for adults and older adults. The center is equipped to address dual diagnoses, including co-occurring mental health conditions in adults and significant emotional challenges in children. Emphasizing excellence in care, they offer tailored programs for adult men, adult women, and individuals with combined mental health and substance use issues. Their therapeutic methods encompass 12-step facilitation, brief intervention, and cognitive behavioral therapy. Additionally, they offer outpatient treatment with methadone, buprenorphine, or naltrexone for both male and female individuals pursuing sobriety.

Frequently Asked Questions

What is naltrexone and how does it work?
Naltrexone is an opioid antagonist medication approved by the FDA to treat both alcohol use disorder and opioid dependence. It works by binding to opioid receptors in the brain, blocking the euphoric and sedative effects of opioids and reducing alcohol cravings. Naltrexone is available as an oral tablet (brand name Revia) and as a monthly injection (brand name Vivitrol).
What are the most common naltrexone side effects?
The most common naltrexone side effects include nausea, headache, dizziness, fatigue, insomnia, and anxiety. Some patients also experience joint or muscle pain, decreased appetite, and stomach cramps. Most side effects are mild and tend to diminish within the first few weeks of treatment. Serious but rare side effects include liver damage, so physicians typically monitor liver function during treatment.
What is Vivitrol and how is the injection administered?
Vivitrol is the brand name for extended-release naltrexone, delivered as a once-monthly intramuscular injection. The Vivitrol injection is administered by a healthcare provider into the gluteal muscle and slowly releases naltrexone over approximately 30 days. This eliminates the need for daily pill compliance, making it a preferred option for many patients in recovery from alcohol or opioid dependence.
What is the difference between naltrexone and naloxone?
Although their names sound similar, naltrexone and naloxone serve different purposes. Naloxone (brand name Narcan) is a short-acting opioid antagonist used as an emergency rescue medication to reverse opioid overdoses, while naltrexone is a long-acting antagonist taken on a scheduled basis to prevent relapse. Naloxone works within minutes but wears off quickly, whereas naltrexone provides sustained receptor blockade over hours or weeks depending on the formulation.
How does naltrexone compare to Suboxone?
Naltrexone and Suboxone take fundamentally different approaches to treating opioid dependence. Suboxone contains buprenorphine (a partial opioid agonist) and reduces withdrawal symptoms by mildly activating opioid receptors, while naltrexone fully blocks those receptors without any opioid effect. Patients must be fully detoxed from opioids before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. The best choice depends on individual treatment history and clinical needs.
What is the standard naltrexone dosage?
The standard oral naltrexone dosage for both alcohol and opioid dependence is 50 mg taken once daily. Some providers use an initial dose of 25 mg for the first day to minimize side effects. For Vivitrol, the dosage is 380 mg delivered as a single intramuscular injection once every four weeks. Dosage should not be adjusted without medical supervision.
How much does naltrexone cost and does insurance cover it?
Generic oral naltrexone tablets typically range from $30 to $80 per month without insurance. Vivitrol injections are considerably more expensive, often costing $1,000 to $1,800 per injection without coverage. Most private insurance plans, Medicaid, and Medicare cover naltrexone in both forms, and manufacturer assistance programs are available for eligible patients.
What is low dose naltrexone (LDN)?
Low dose naltrexone (LDN) refers to naltrexone taken at very small doses, typically between 1 mg and 5 mg, far below the standard 50 mg addiction treatment dose. LDN is used off-label for conditions such as chronic pain, fibromyalgia, and certain autoimmune disorders, and it is not an approved treatment for addiction. Patients should not confuse LDN with standard naltrexone therapy for substance use disorders.

About Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist, meaning it binds to the mu-opioid receptors in the brain without activating them. By occupying these receptors, naltrexone effectively blocks the rewarding effects of opioids and reduces the neurochemical reinforcement that drives alcohol cravings. Unlike medications such as methadone or buprenorphine, naltrexone has no potential for abuse or physical dependence because it produces no opioid effect whatsoever.

How Naltrexone Works

When a person taking naltrexone consumes alcohol, the pleasurable dopamine surge that normally reinforces drinking behavior is significantly blunted. For individuals with opioid dependence, naltrexone prevents any ingested opioid from reaching the receptors, rendering opioid use ineffective. This pharmacological mechanism makes naltrexone a cornerstone of medication-assisted treatment (MAT) programs across the country. Naltrexone was first approved by the FDA in 1984 for opioid dependence and received additional approval for alcohol dependence in 1994.

Naltrexone Side Effects

Common side effects include:

  • Nausea, especially during the first few days
  • Headache and dizziness
  • Fatigue and insomnia
  • Joint and muscle pain
  • Decreased appetite and anxiety

Serious side effects are less common but include signs of liver injury such as yellowing of the skin or eyes, dark urine, and persistent abdominal pain. Severe injection site reactions from Vivitrol, including tissue necrosis, have been reported in rare cases. Importantly, naltrexone lowers opioid tolerance over time — if a person discontinues naltrexone and attempts to use opioids at previously tolerated doses, the risk of fatal overdose increases significantly.

Naltrexone for Alcohol Dependence

Naltrexone is one of only three FDA-approved medications for alcohol use disorder, alongside disulfiram (Antabuse) and acamprosate (Campral). For individuals struggling with alcohol dependence, naltrexone reduces heavy drinking days and increases the percentage of days abstinent. The oral formulation, sold under the brand name Revia, is typically prescribed at 50 mg daily and is most effective when combined with behavioral therapy and support groups.

Naltrexone for Opioid Dependence

For opioid dependence, naltrexone serves as a relapse-prevention tool rather than a detox medication. Patients must complete a full opioid detoxification and remain opioid-free for a minimum of 7 to 14 days before beginning naltrexone therapy. Starting naltrexone while opioids are still present can trigger sudden and severe precipitated withdrawal. Once initiated, naltrexone provides a pharmacological safety net — if a patient relapses, naltrexone blocks the drug from producing its usual effects.

Vivitrol: Injectable Naltrexone

Vivitrol is the brand name for naltrexone extended-release injectable suspension, delivering 380 mg in a single intramuscular dose once per month. A healthcare provider injects Vivitrol into the gluteal muscle using a special needle included in the product kit, alternating sides each month. The Vivitrol shot has become increasingly popular because it solves one of the biggest challenges in addiction treatment: medication adherence. Studies show that patients receiving monthly Vivitrol injections are significantly more likely to remain in treatment compared to those prescribed daily oral naltrexone.

Vivitrol Side Effects

Vivitrol shares many side effects with oral naltrexone but carries additional risks related to the injection site. These range from mild tenderness, redness, and swelling to severe complications including induration and in rare cases tissue necrosis requiring surgical intervention. As with oral naltrexone, Vivitrol can affect liver function, and depressed mood and suicidal thoughts have also been reported.

Revia: Oral Naltrexone Brand

Revia is the primary brand name for oral naltrexone hydrochloride tablets in a 50 mg strength. Today, most prescriptions are filled with generic naltrexone, which is bioequivalent and significantly less expensive. The main advantage of oral naltrexone over injectable Vivitrol is lower cost and greater dosing flexibility, but it requires daily compliance, which patients in early recovery frequently struggle with.

Low Dose Naltrexone (LDN)

Low dose naltrexone (LDN) refers to naltrexone prescribed at doses ranging from 0.5 mg to 5 mg — a fraction of the standard 50 mg addiction treatment dose. LDN is used off-label and is not FDA-approved for any condition at these low doses. It is not a treatment for addiction and operates through a fundamentally different mechanism. The theory proposes that a brief, transient blockade of opioid receptors causes a rebound effect that increases the body's natural endorphin production. LDN has been investigated for conditions including fibromyalgia, multiple sclerosis, and Crohn's disease, but large-scale clinical trials are still needed.

Naltrexone Cost and Insurance

Generic oral naltrexone typically costs $30 to $80 per month without insurance. With insurance or discount programs, out-of-pocket cost can fall below $15. Vivitrol injections cost $1,000 to $1,800 without insurance, but most private plans, Medicaid, and Medicare cover it. Alkermes offers the Vivitrol Co-Pay Savings Program for insured patients and a Patient Assistance Program for those without insurance.

Naltrexone Dosage

The standard oral dose is 50 mg once daily, with some providers starting at 25 mg for the first day to minimize side effects. For Vivitrol, the dose is 380 mg as a single intramuscular injection every four weeks. Patients must be opioid-free for a minimum of 7 to 14 days before initiating either formulation.

Naltrexone vs Naloxone: What's the Difference?

Both are opioid antagonists, but they differ in duration and use. Naloxone (Narcan) is a short-acting emergency overdose reversal agent that takes effect within minutes and wears off in 30 to 90 minutes. Naltrexone is a long-acting antagonist for ongoing relapse prevention, providing blockade for 24 hours (oral) or 30 days (Vivitrol). Naloxone is also a component of Suboxone, where it deters injection misuse.

Naltrexone vs Suboxone

Suboxone contains buprenorphine (a partial opioid agonist) that mildly stimulates opioid receptors, reducing cravings and withdrawal. Naltrexone fully blocks receptors with zero agonist activity. Patients must be fully detoxed before starting naltrexone, whereas Suboxone can be initiated during early withdrawal. A landmark 2017 clinical trial (X:BOT) found that among patients who successfully started treatment, relapse rates were similar between Vivitrol and Suboxone.

Naltrexone and Weight Loss

Naltrexone is one of two active ingredients in Contrave (naltrexone/bupropion), an FDA-approved weight management medication. However, naltrexone alone is not approved for weight loss. Some patients undergoing addiction treatment report modest weight changes related to reduced alcohol calories or appetite-suppressing side effects, but naltrexone should not be selected as an addiction medication primarily for weight effects.

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Medically Reviewed Updated October 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)