Medication-Assisted Treatment (MAT) Centers in Mississippi
Medically reviewed by Sarah Mitchell, LCSWLast reviewed: April 2026
Our directory lists 56 MAT programs across Mississippi, with the largest concentrations in Jackson (6), Oxford (3) and Hattiesburg (3).
Medication-Assisted Treatment (MAT) combines FDA-approved medications — methadone, buprenorphine, and naltrexone — with counseling and behavioral therapies for comprehensive addiction care. MAT is the evidence-based gold standard for opioid and alcohol use disorders.
Treatment landscape in Mississippi:
- Mississippi Medicaid covers substance abuse services
- Faith-based recovery community
- Affordable treatment options throughout the state
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MAT programs in Mississippi
Jackson · 6 centers

Jackson Comprehensive Treatment Center
Jackson, MS
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Hinds Behavioral Health Services
Jackson, MS
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Jackson VAMC GV Sonny Montgomery
Jackson, MS
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Pathway Healthcare
Jackson, MS
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Corinth · 3 centers

Region IV MHS
Corinth, MS
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Region IV MHS
Corinth, MS
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Region IV MHS
Corinth, MS
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Hattiesburg · 3 centers

Pine Grove BH and Addiction Servs
Hattiesburg, MS
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PBMHR Region XII
Hattiesburg, MS
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PBMHR Region XII
Hattiesburg, MS
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Meridian · 3 centers

HamiltonDavis Treatment Services
Meridian, MS
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Weems Community MH Center
Meridian, MS
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Oxford · 3 centers

Oxford Outpatient Treatment Center
Oxford, MS
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Communicare
Oxford, MS
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Communicare
Oxford, MS
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Biloxi · 2 centers

Mississippi Drug and Alcohol
Biloxi, MS
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Brandon · 2 centers

Defining Wellness Centers
Brandon, MS
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Region 8 Mental Health Services
Brandon, MS
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Byram · 2 centers

Harbor Houses of Jackson Inc
Byram, MS
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Harbor Houses of Jackson Inc
Byram, MS
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Columbus · 2 centers

Recovery House
Columbus, MS
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Pines and Cady Hill
Columbus, MS
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Ridgeland · 2 centers

Essential Touchstones
Ridgeland, MS
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Innovative Behavioral Services Inc
Ridgeland, MS
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Vicksburg · 2 centers

Belmont Gardens Recovery Center
Vicksburg, MS
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Brookhaven · 1 center

Region 8 Mental Health Services
Brookhaven, MS
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Canton · 1 center

Region 8 Mental Health Services
Canton, MS
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Carthage · 1 center

Weems Community MH Center
Carthage, MS
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Decatur · 1 center

Weems Community MH Center
Decatur, MS
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Etta · 1 center
Forest · 1 center

Weems Community MH Center
Forest, MS
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Greenwood · 1 center

Denton House CDC
Greenwood, MS
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Hazlehurst · 1 center

Region 8 Mental Health Services
Hazlehurst, MS
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Hernando · 1 center

Region 4 Desoto
Hernando, MS
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Holly Springs · 1 center

Communicare
Holly Springs, MS
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Laurel · 1 center

Pathway Healthcare Laurel
Laurel, MS
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Moselle · 1 center

PBMHR Region XII
Moselle, MS
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Pascagoula · 1 center

Region XIV Singing River Services
Pascagoula, MS
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Philadelphia · 1 center

Weems Community MH Center
Philadelphia, MS
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Pittsboro · 1 center

Communicare
Pittsboro, MS
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Purvis · 1 center

PBMHR Region XII
Purvis, MS
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Quitman · 1 center

Weems Community MH Center
Quitman, MS
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Raleigh · 1 center

Weems Community MH Center
Raleigh, MS
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Sardis · 1 center

Communicare
Sardis, MS
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Senatobia · 1 center

Communicare
Senatobia, MS
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Summit · 1 center

PBMHR Region XII
Summit, MS
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Tupelo · 1 center

Region III Chem Dependency
Tupelo, MS
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Tutwiler · 1 center

Life Help/Region 6 CMC
Tutwiler, MS
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Walls · 1 center

Desoto County Treatment Center
Walls, MS
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Water Valley · 1 center

Communicare
Water Valley, MS
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Whitfield · 1 center

Mississippi State Hospital
Whitfield, MS
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Mississippi Medicaid
Mississippi Medicaid covers buprenorphine and naltrexone for opioid use disorder; the state does not currently reimburse methadone for OUD through Medicaid.
State regulations
Mississippi has a limited OTP network; the state Department of Mental Health oversees OTP licensing in addition to SAMHSA certification.
- Cash or self-payment55
- Federal, or any government funding for substance use treatment programs43
- Private health insurance38
- SAMHSA funding/block grants38
- Medicaid37
- Federal military insurance (e.g., TRICARE)32
- Outpatient45
- Regular outpatient treatment44
- Outpatient methadone/buprenorphine or naltrexone treatment24
- Intensive outpatient treatment23
- Residential/24-hour residential20
Frequently Asked Questions About MAT in Mississippi
Do I need a formal OUD diagnosis before starting mat?
Yes. Providers in Mississippi must document a current OUD diagnosis to prescribe mat as part of medication-assisted treatment. The intake assessment typically takes 60–90 minutes and includes a physical exam, drug screen, and psychiatric history — results are used to confirm eligibility.
How much does Vivitrol (naltrexone injection) cost without insurance?
Vivitrol monthly cost without insurance typically falls between $1,100 and $1,500 per injection in Mississippi. The manufacturer Alkermes offers a patient-assistance co-pay savings card; state-funded programs also cover Vivitrol for uninsured patients in many counties.
What is the Mississippi Medicaid copay for mat visits?
Mississippi Medicaid copays for MAT visits are typically $0–$3, and are often waived for patients with behavioral-health conditions. Pharmacy copays for buprenorphine or naltrexone prescriptions follow the same schedule.
What happens if my Mississippi provider bills insurance out-of-network?
You may owe the full charge minus any out-of-network benefit. Ask MAT programs whether they will file an insurance claim, charge you up-front, or negotiate a single-case agreement with your insurer. No Surprises Act protections may apply — request a Good Faith Estimate.
Is mat covered under Mississippi’s Good Samaritan law?
Mississippi’s Good Samaritan law provides immunity from low-level drug-possession prosecution when someone seeks help for an overdose. MAT enrollment is not penalized; Mississippi specifically prohibits probation or family court from forcing patients to stop mat.
How long does mat treatment typically last in Mississippi?
Many Mississippi patients stay on mat for a year or more, and some stay indefinitely. Duration depends on individual stability, quality of life, and risk of relapse. Research consistently shows that longer MAT duration is associated with lower overdose mortality.
How do I find a mat provider near me in Mississippi?
Use the SAMHSA treatment locator at findtreatment.gov, filter by Mississippi, and search for medications offered. You can also browse our directory of MAT programs filtered to Mississippi, or call 988 for live referrals from a trained counselor.
What happens if my drug screen is positive at the first visit?
A positive urine drug screen is expected for most patients entering MAT — it confirms the diagnosis. Positive screens are not used to deny admission at any Mississippi SAMHSA-certified OTP. Your clinician interprets results and builds an individualized plan from there.
Can I drink alcohol on mat?
Combining alcohol with methadone or buprenorphine increases sedation and respiratory-depression risk; avoidance is strongly recommended. Naltrexone treats alcohol use disorder directly and is not impaired by occasional drinking, but heavy drinking can still cause liver harm. Be honest about use with your Mississippi clinician.
Can I start mat while already pregnant?
Yes. Starting MAT during pregnancy is strongly recommended for patients with OUD. Mississippi perinatal-addiction programs offer priority same-day access; OB-MAT coordinated care improves maternal and infant outcomes dramatically compared to untreated OUD.
Can my counselor prescribe mat?
No — counselors with master’s-level licensure (LCSW, LPC, LMFT) provide therapy but do not prescribe medication. A nurse practitioner, physician assistant, or physician on the Mississippi MAT team handles the prescription. Counselor and prescriber collaborate on your care plan.
What rights do I have if my records are disclosed improperly?
Improper disclosure of your records under 42 CFR Part 2 can be grounds for federal complaint and civil damages. File complaints with SAMHSA, the HHS Office of Civil Rights, and Mississippi’s behavioral-health licensing agency. An attorney can advise on civil remedies.
Other Treatment Options in Mississippi
Medication-Assisted Treatment in Other States
Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)



