Medication-Assisted Treatment (MAT) Centers in Missouri
Medically reviewed by Sarah Mitchell, LCSWLast reviewed: April 2026
Our directory lists 172 MAT programs across Missouri, with the largest concentrations in Saint Louis (20), Kansas City (11) and Cape Girardeau (7).
Medication-Assisted Treatment (MAT) combines FDA-approved medications — methadone, buprenorphine, and naltrexone — with counseling and behavioral therapies for comprehensive addiction care. MAT is the evidence-based gold standard for opioid and alcohol use disorders.
Treatment landscape in Missouri:
- MO HealthNet covers addiction treatment
- Major treatment hubs in St. Louis and Kansas City
- Diverse treatment philosophies and approaches
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MAT programs in Missouri
Saint Louis · 20 centers

Care STL Health
Saint Louis, MO
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Carestl Health Pope
Saint Louis, MO
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Carestl Health Riverview
Saint Louis, MO
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Carestlhealth
Saint Louis, MO
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INSynergy Treatment Program
Saint Louis, MO
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Places for People
Saint Louis, MO
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Places for People
Saint Louis, MO
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St Louis Metro Treatment Center
Saint Louis, MO
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Saint Louis Veterans Affairs Med Ctr
Saint Louis, MO
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Queen of Peace Center
Saint Louis, MO
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Amanda Luckett Murphy Hopewell Center
Saint Louis, MO
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Aviary Recovery Center
Saint Louis, MO
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BJC Behavioral Health
Saint Louis, MO
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Gateway Foundation Inc
Saint Louis, MO
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BASIC
Saint Louis, MO
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Centrec Care
Saint Louis, MO
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Preferred Family Healthcare Inc
Saint Louis, MO
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Preferred Family Healthcare Inc
Saint Louis, MO
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Preferred Family Healthcare Inc
Saint Louis, MO
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Kansas City · 11 centers
Beacon Mental Health
Kansas City, MO
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Beacon Mental Health
Kansas City, MO
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Swope Health Services
Kansas City, MO
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ReDiscover
Kansas City, MO
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Heartland Center for Behavioral Change
Kansas City, MO
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Preferred Family Healthcare Inc
Kansas City, MO
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ReDiscover
Kansas City, MO
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Sana Lake Behavioral Wellness Center
Kansas City, MO
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Cape Girardeau · 7 centers

Cape Girardeau Metro Treatment Ctr
Cape Girardeau, MO
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Vision House of Cape Girardeau
Cape Girardeau, MO
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Gibson Recovery Center Inc
Cape Girardeau, MO
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Gibson Recovery Center Inc
Cape Girardeau, MO
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Community Counseling Center
Cape Girardeau, MO
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Community Counseling Center
Cape Girardeau, MO
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Gibson Center for Behavioral Change
Cape Girardeau, MO
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Columbia · 5 centers

Harry S Truman Memorial
Columbia, MO
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Compass Health
Columbia, MO
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Compass Health
Columbia, MO
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Compass Health
Columbia, MO
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Joplin · 5 centers

BHG Joplin Treatment Center
Joplin, MO
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Ozark Center
Joplin, MO
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Ozark Center
Joplin, MO
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Ozark Center/New Directions
Joplin, MO
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Springfield · 5 centers

Synergy Counseling Center
Springfield, MO
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Center for Addictions
Springfield, MO
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Communities of Recovery Inc
Springfield, MO
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Poplar Bluff · 4 centers

BHG Poplar Bluff Treatment Center
Poplar Bluff, MO
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Southeast Missouri Behavioral Health
Poplar Bluff, MO
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Southeast Missouri Behavioral Health
Poplar Bluff, MO
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FCC Behavioral Health
Poplar Bluff, MO
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Farmington · 3 centers

BJC Behavioral Health
Farmington, MO
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Southeast Missouri Behavioral Health
Farmington, MO
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Southeast Missouri Behavioral Health
Farmington, MO
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Fredericktown · 3 centers

Community Counseling Center
Fredericktown, MO
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Community Counseling Center
Fredericktown, MO
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Community Counseling Center
Fredericktown, MO
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Hannibal · 3 centers

Mark Twain Behavioral Health
Hannibal, MO
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Mark Twain Behavioral Health
Hannibal, MO
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Preferred Family Healthcare Inc
Hannibal, MO
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Saint Charles · 3 centers

New Season St Charles Trt Center
Saint Charles, MO
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Preferred Family Healthcare Inc
Saint Charles, MO
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Preferred Family Healthcare Inc
Saint Charles, MO
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Saint Joseph · 3 centers

Northwest Health Services
Saint Joseph, MO
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Family Guidance Center
Saint Joseph, MO
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St Kolbe Puckett Center for Healing
Saint Joseph, MO
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West Plains · 3 centers

BHG West Plains Treatment Center
West Plains, MO
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FCC Behavioral Health
West Plains, MO
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FCC Behavioral Health
West Plains, MO
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Boonville · 2 centers

Compass Health
Boonville, MO
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Valley Hope of Boonville
Boonville, MO
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Brookfield · 2 centers

North Central MO Mental Health Center
Brookfield, MO
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Preferred Family Healthcare Inc
Brookfield, MO
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Clinton · 2 centers

Compass Health
Clinton, MO
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Compass Health
Clinton, MO
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Florissant · 2 centers

BJC Behavioral Health
Florissant, MO
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Preferred Family Healthcare Inc
Florissant, MO
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Fulton · 2 centers

Compass Health
Fulton, MO
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Harrisonville · 2 centers

Comm Mental Health Consultants Inc
Harrisonville, MO
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Compass Health
Harrisonville, MO
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Jefferson City · 2 centers

Preferred Family Healthcare Inc
Jefferson City, MO
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Compass Health
Jefferson City, MO
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Kirksville · 2 centers

Mark Twain Behavioral Health
Kirksville, MO
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Preferred Family Healthcare Inc
Kirksville, MO
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Marble Hill · 2 centers

Gibson Recovery Center Inc
Marble Hill, MO
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Community Counseling Center
Marble Hill, MO
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Moberly · 2 centers

Mark Twain Behavioral Health
Moberly, MO
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Preferred Family Healthcare Inc
Moberly, MO
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Neosho · 2 centers

Ozark Center/New Directions
Neosho, MO
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Nevada · 2 centers

Compass Health
Nevada, MO
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Comm Mental Health Consultants Inc
Nevada, MO
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Perryville · 2 centers

Community Counseling Center
Perryville, MO
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Gibson Recovery Center Inc
Perryville, MO
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Piedmont · 2 centers

FCC Behavioral Health
Piedmont, MO
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Southeast Missouri Behavioral Health
Piedmont, MO
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Raymore · 2 centers

Compass Health
Raymore, MO
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Compass Health
Raymore, MO
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Salem · 2 centers

Southeast Missouri Behavioral Health
Salem, MO
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Compass Health
Salem, MO
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Sikeston · 2 centers

Bootheel Counseling Services
Sikeston, MO
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Gibson Recovery Center Inc
Sikeston, MO
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Sullivan · 2 centers

Compass Health
Sullivan, MO
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Union · 2 centers

Freedom Recovery Center
Union, MO
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Preferred Family Healthcare Inc
Union, MO
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Warrensburg · 2 centers

Compass Health
Warrensburg, MO
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Compass Health
Warrensburg, MO
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Wentzville · 2 centers

Compass Health
Wentzville, MO
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SSM Health Treatment and Recovery
Wentzville, MO
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Ava · 1 center

Family Counseling Center Inc
Ava, MO
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Ballwin · 1 center
Bowling Green · 1 center

Mark Twain Behavioral Health
Bowling Green, MO
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Branson · 1 center

Communities of Recovery Inc
Branson, MO
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Butler · 1 center

Compass Health
Butler, MO
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Cadet · 1 center

Southeast Missouri Behavioral Health
Cadet, MO
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Cameron · 1 center

Family Guidance Center/Cameron
Cameron, MO
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Canton · 1 center

Preferred Family Healthcare Inc
Canton, MO
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Caruthersville · 1 center

FCC Behavioral Health
Caruthersville, MO
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Cassville · 1 center

Clark Community Mental Health Center
Cassville, MO
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Charleston · 1 center

FCC Behavioral Health
Charleston, MO
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Chillicothe · 1 center

North Central MO Mental Health Center
Chillicothe, MO
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Dittmer · 1 center

Sana Lake Recovery
Dittmer, MO
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Doniphan · 1 center

FCC Behavioral Health
Doniphan, MO
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El Dorado Springs · 1 center

Compass Health
El Dorado Springs, MO
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Eldon · 1 center

Compass Health
Eldon, MO
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Ellington · 1 center

FCC Behavioral Health
Ellington, MO
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Eolia · 1 center

Aviary Recovery Center
Eolia, MO
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Greenfield · 1 center

Clark Community Mental Health Center
Greenfield, MO
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Greenville · 1 center

Family Counseling Center Inc
Greenville, MO
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Hayti · 1 center

Family Counseling Center Inc
Hayti, MO
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Higginsville · 1 center

Compass Health
Higginsville, MO
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Houston · 1 center

Southeast Missouri Behavioral Health
Houston, MO
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Kahoka · 1 center

Preferred Family Healthcare Inc
Kahoka, MO
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Kennett · 1 center

FCC Behavioral Health
Kennett, MO
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Lamar · 1 center

Ozark Center
Lamar, MO
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Lebanon · 1 center
Lees Summit · 1 center

ReDiscover
Lees Summit, MO
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Liberty · 1 center

Heartland Center for Behavioral Change
Liberty, MO
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Linn Creek · 1 center

Compass Health
Linn Creek, MO
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Macon · 1 center

Preferred Family Healthcare Inc
Macon, MO
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Maryland Heights · 1 center

Sana Lake Behavioral Wellness
Maryland Heights, MO
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Maryville · 1 center

Family Guidance Center
Maryville, MO
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Mexico · 1 center

East Central MO Behavioral Health
Mexico, MO
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Monett · 1 center

Clark Community Mental Health Center
Monett, MO
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Montgomery City · 1 center

Arthur Center Community Health
Montgomery City, MO
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Mountain Grove · 1 center

Family Counseling Center Inc
Mountain Grove, MO
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Odessa · 1 center

Compass Health
Odessa, MO
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Osage Beach · 1 center

Compass Health
Osage Beach, MO
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Osceola · 1 center

Compass Health
Osceola, MO
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Owensville · 1 center

Compass Health
Owensville, MO
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Ozark · 1 center

Synergy Executive
Ozark, MO
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Richland · 1 center

Central Ozarks Medical Center
Richland, MO
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Richmond · 1 center

Tri County Mental Health Services
Richmond, MO
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Rogersville · 1 center

Synergy Recovery Center
Rogersville, MO
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Rolla · 1 center

Southeast Missouri Behavioral Health
Rolla, MO
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Saint Peters · 1 center

Preferred Family Healthcare Inc
Saint Peters, MO
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Sainte Genevieve · 1 center

Community Counseling Center
Sainte Genevieve, MO
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Sedalia · 1 center

Compass Health Network Inc
Sedalia, MO
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Steelville · 1 center

Southeast Missouri Behavioral Health
Steelville, MO
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Trenton · 1 center

Preferred Family Healthcare Inc
Trenton, MO
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Troy · 1 center

Preferred Family Healthcare Inc
Troy, MO
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Van Buren · 1 center

FCC Behavioral Health
Van Buren, MO
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Warrenton · 1 center

Preferred Family Healthcare
Warrenton, MO
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Warsaw · 1 center

Compass Health
Warsaw, MO
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MO HealthNet
MO HealthNet covers MAT medications and funds MAT induction in jails and emergency departments through state general-fund grants.
State regulations
Missouri Department of Mental Health (DMH) licenses OTPs under 9 CSR 30-3 and funds a Medication First program giving same-day buprenorphine.
- Cash or self-payment164
- Private health insurance158
- Medicaid154
- Federal military insurance (e.g., TRICARE)135
- Medicare128
- Federal, or any government funding for substance use treatment programs120
- Outpatient159
- Regular outpatient treatment154
- Outpatient methadone/buprenorphine or naltrexone treatment130
- Intensive outpatient treatment83
- Outpatient day treatment or partial hospitalization41
Frequently Asked Questions About MAT in Missouri
Do I need to provide a criminal-history check to enroll in MAT programs in Missouri?
No. Missouri MAT providers do not require criminal-history disclosure to enroll. Federal law (42 CFR Part 2) protects substance-use treatment records; a criminal record will not block admission to a mat program.
Do I have to pay for counseling separately from the medication?
It depends on the program. Bundled MAT programs include counseling in a single weekly or monthly fee. Others bill counseling separately ($40–$150 per session). MO HealthNet and most commercial plans cover both components when delivered by a licensed provider.
Does MO HealthNet cover both the medication and the counseling for mat?
Yes. MO HealthNet covers the medication (methadone, buprenorphine, or naltrexone), counseling sessions, group therapy, drug screening, and care coordination as an integrated MAT benefit. Peer-recovery support is also reimbursable in Missouri under the state plan.
Does my commercial plan cover long-acting buprenorphine (Sublocade) in Missouri?
Yes. Missouri commercial plans cover Sublocade under the medical benefit (administered in clinic) with prior authorization documenting adherence to sublingual buprenorphine. The mat provider’s office handles the PA paperwork.
Is mat treatment legal and regulated in Missouri?
Yes. mat is a federally approved medication used legally across Missouri. Methadone is dispensed only at SAMHSA-certified Opioid Treatment Programs (OTPs); buprenorphine is prescribed by licensed clinicians; naltrexone has no prescriber waiver requirement. State licensing agencies oversee all MAT programs.
What happens when I taper off mat?
Tapering happens under medical supervision over weeks to months — usually slower for methadone, faster for buprenorphine. Your Missouri provider will monitor withdrawal symptoms and cravings, and resume MAT immediately if cravings return. Never taper without clinical oversight.
Can I start mat through telehealth in Missouri?
Yes. Buprenorphine induction and follow-up are routinely delivered by telehealth in Missouri under permanent federal rules. Naltrexone can be prescribed via telehealth too. Methadone induction requires an in-person OTP visit for the first dose.
What questions will the clinician ask at my first mat visit?
Expect questions about your substance use history, overdose history, medical and mental-health conditions, current medications, pregnancy risk, social support, housing, legal status, and treatment goals. Answers help tailor the plan — honesty produces better clinical care, and answers are protected under 42 CFR Part 2.
Will mat make me tired or affect my ability to work in Missouri?
During induction (first 1–2 weeks), mild drowsiness is common. Once stabilized, most patients fully resume work, including safety-sensitive jobs such as CDL driving, subject to any employer drug-testing policies. Missouri clinicians can issue letters documenting stability.
Is naltrexone recommended during pregnancy in Missouri?
Naltrexone is typically not started during pregnancy due to limited safety data — methadone or buprenorphine are preferred. Patients already stable on naltrexone who become pregnant discuss continuing versus switching with their Missouri MAT provider and obstetrician.
What types of counseling are available with mat in Missouri?
Common options include cognitive-behavioral therapy, motivational interviewing, contingency management, group counseling, and trauma-focused therapy. Many Missouri programs also offer peer-recovery support. The clinical team matches you with the modality most aligned to your goals.
Are my mat records confidential in Missouri?
Yes. Your records are protected by federal law 42 CFR Part 2, which is stricter than HIPAA. Disclosure requires your signed consent or a specific court order; even law enforcement cannot access records without one of these.
Other Treatment Options in Missouri
Medication-Assisted Treatment in Other States
Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)






