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Medically Reviewed Content
Updated: May 2026
Sources: SAMHSA, NIDA

Medication-Assisted Treatment (MAT) Centers

Medication-Assisted Treatment (MAT) combines FDA-approved medications with counseling and behavioral therapies for comprehensive addiction care. MAT is the gold standard for opioid and alcohol use disorders, significantly reducing overdose deaths and improving treatment outcomes.

Found 300 treatment centers offering medication-assisted treatment (mat) across the United States.

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Situated in Henderson, NC, the Addiction Recovery Center for Men delivers extensive substance abuse treatment within a nurturing setting designed specifically for adult males. This center features long-term residential care with round-the-clock support, employing proven methods like 12-step programs, brief interventions, and motivational interviewing. Dedicated to aiding adult men in their recovery journey, the center also provides transitional housing solutions. Prioritizing high-quality care and personalized treatment strategies, this facility serves adults, seniors, and younger individuals aiming for a sober living space that fosters sustained recovery.

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Situated in Concordia, KS, Addiction Recovery Center LLC specializes in extensive treatment for substance use disorders targeting both adults and seniors. The facility emphasizes various treatment options, including intensive outpatient, outpatient, and standard outpatient programs. It incorporates methods such as 12-step facilitation, anger management, and brief intervention strategies. Additionally, customized programs are designed specifically for adolescents, adult males, and adult females. Focused on providing gender-responsive care, this center serves the unique needs of both women and men. Commitment to offering effective, quality rehabilitation services is at the core of Addiction Recovery Center LLC's mission to assist individuals on their path to recovery.

Addiction Recovery Centers (ARC)

Addiction Recovery Centers (ARC) in Ashland, KY provides tailored substance use disorder therapy for women of all ages and young adults. Their offerings include intensive outpatient, extended residential, and outpatient services, all designed to meet individual requirements. ARC employs strategies such as 12-step program support, anger management, and brief intervention. The center is distinguished by its commitment to personalized care and custom treatment strategies, making it a premier option for effective and thorough addiction recovery.

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Situated in Rapid City, SD, the Addiction Recovery Centers of the provides an extensive array of substance abuse treatment services tailored for both adults and young adults. The center offers various treatment formats, including intensive outpatient therapy, outpatient care, and standard outpatient programs. By employing research-supported methodologies like 12-step approaches, cognitive behavioral therapy, and motivational incentives, this facility serves both men and women, including those with trauma backgrounds. With tailored programs catering to distinct genders and age categories, the center guarantees individualized attention and assistance for those aiming to conquer addiction.

Addiction Recovery Centers of the

Addiction Recovery Centers of the in Hot Springs, SD delivers an all-encompassing approach to substance use treatment, offering options such as intensive outpatient, outpatient, and regular outpatient programs. The facility focuses on techniques such as 12-step support, cognitive behavioral therapy, and motivational incentives. Catering to a wide array of clients, it includes specific programs designed for adult men, adult women, and those who have faced trauma. The center serves both adults and youth, providing specialized care for males and females. With a knowledgeable team dedicated to high-quality care, the center prioritizes personalized treatment plans, making it an excellent option for individuals seeking effective addiction rehabilitation solutions.

Addiction Recovery Consultants

Addiction Recovery Consultants, situated in Berlin, NJ, provides a variety of scientifically-supported treatment options for those struggling with substance use issues and related mental health challenges. This center offers intensive outpatient services, long-term residential stays, and regular outpatient care, accommodating both adults and young adults of all genders. With a focus on methods such as 12-step facilitation, anger management, and brief intervention strategies, the center also extends its services to individuals dealing with trauma or sexual abuse histories. Clients can anticipate personalized care designed to meet their specific needs, fostering an encouraging atmosphere for healing and recovery.

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At the Addiction Recovery Institute in Warwick, RI, we provide comprehensive outpatient services designed to guide individuals through detoxification and the journey of substance use recovery. Our programs cater to adults and young adults, utilizing evidence-based strategies such as 12-step facilitation, cognitive behavioral therapy, and motivational interviewing. We are dedicated to personalized treatment plans, with specialized tracks for adult men, adult women, and individuals managing co-occurring mental health and substance use challenges, fostering a nurturing setting for all who aim to achieve lasting sobriety.

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Situated in Pawtucket, RI, the Addiction Recovery Institute provides an extensive array of outpatient services aimed at substance use rehabilitation. This center focuses on detox programs, outpatient detox, and treatments involving methadone, buprenorphine, or naltrexone. Utilizing proven methods such as 12-step facilitation, cognitive behavioral therapy, and motivational interviewing, the program prioritizes personalized care. The facility serves adult men and women, including those grappling with both mental health and substance use challenges. Catering to the needs of adults and young adults of varying genders, the Addiction Recovery Institute ensures high-quality support that is customized to the specific requirements of each individual.

Addiction Recovery Medical Services

Addiction Recovery Medical Services located in Statesville, NC, delivers extensive addiction treatment tailored for both adults and young adults. This facility offers detox services along with substance abuse programs, including intensive outpatient, outpatient, and outpatient detox options. Emphasizing a variety of therapeutic methodologies such as 12-step facilitation, brief interventions, and cognitive behavioral therapy, the center customizes its approaches to meet the unique requirements of each individual. Specialized programs are available for adult men, adult women, and individuals who have faced intimate partner or domestic violence. With a commitment to gender-specific care, the center fosters a nurturing atmosphere conducive to recovery. If you're seeking effective addiction treatment within a supportive environment, Addiction Recovery Medical Services is an excellent choice.

Addiction Recovery Medical Services

Addiction Recovery Medical Services in Taylorsville, NC, provides comprehensive outpatient services, including substance use disorder treatment and medication-assisted treatment utilizing methadone, buprenorphine, or naltrexone. The facility emphasizes therapeutic interventions such as 12-step program integration, motivational interviewing, and cognitive behavioral therapy. Catering to adult men and women, including those affected by domestic or intimate partner violence, they offer personalized care for adult and young adult clients of all genders. Their commitment to a supportive, evidence-informed approach ensures high-quality treatment aimed at fostering lasting recovery.

Addiction Recovery Services

Situated in Cleveland, Ohio, Addiction Recovery Services provides a wide range of addiction treatment options, including detoxification and services for substance use disorders. The center features intensive outpatient programs, standard outpatient care, and partial hospitalization or day treatment programs. Emphasizing 12-step facilitation, brief interventions, and cognitive behavioral therapy, this facility serves a diverse clientele, including adults, seniors, and young adults across all genders. Additionally, specialized programs are designed for those dealing with both pain and substance use issues. Addiction Recovery Services is committed to delivering high-quality care to aid individuals in their recovery process.

Addiction Recovery Systems
Cape May Court House, NJ

Addiction Recovery Systems, situated in Cape May Court House, NJ, provides a wide array of treatment options for substance use disorders. The center features intensive outpatient programs, standard outpatient services, and medication-assisted treatments with methadone, buprenorphine, or naltrexone. It focuses on methods such as anger management, brief interventions, and cognitive behavioral therapy. Catering to a varied population that includes adult males, adult females, and clients involved with the criminal justice system, Addiction Recovery Systems is dedicated to delivering tailored care for adults and young adults of all genders, aiming to support effective recovery from addiction.

Addiction Recovery Systems LLC

Addiction Recovery Systems LLC in Charlottesville, VA, delivers thorough substance abuse treatment for adults and adolescents. Their offerings encompass various levels of care, such as detox, intensive outpatient programs, and outpatient detox. Employing proven therapeutic methods including cognitive behavioral therapy, motivational interviewing, and contingency management, the facility customizes plans to suit each person's unique requirements. They also feature specialized support for expectant and new mothers. Committed to high-standard care, Addiction Recovery Systems LLC welcomes both men and women. For individualized and successful addiction recovery services in Charlottesville, explore what Addiction Recovery Systems LLC provides.

Addiction Research and Treatment

Addiction Research and Treatment in Oakland, CA, delivers thorough outpatient care for individuals pursuing sobriety from substance use disorders. This establishment features distinct programs tailored for active service members, adult males, and adult females. Employing scientifically supported methods like 12-step integration, emotional regulation skills, and concise intervention strategies, the facility supports adults and younger adults of all genders. Patients have access to outpatient services involving methadone, buprenorphine, or naltrexone, alongside standard outpatient care. The center's dedication to high-standard treatment and personalized plans establishes it as a crucial support system for those in need of effective addiction recovery solutions.

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Situated in San Francisco, CA, Addiction Research and Treatment Inc delivers focused programs for substance use rehabilitation. This center offers a range of outpatient options, which include choices such as methadone/buprenorphine or naltrexone treatments alongside standard outpatient care. Employing research-backed techniques like brief interventions, motivational interviewing, and contingency management/motivational incentives, the facility serves a diverse clientele, including young people, and both adult men and women. Committed to quality and individualized treatment, Addiction Research and Treatment Inc is devoted to assisting individuals as they navigate their recovery journeys.

Addiction Research and Treatment Inc

Addiction Research and Treatment Inc, situated in Los Angeles, CA, provides comprehensive outpatient services including medical detoxification, comprehensive substance use disorder therapy, and medication-assisted treatment with methadone, buprenorphine, or naltrexone. This facility is dedicated to serving adults and young adults, employing therapeutic modalities such as cognitive behavioral therapy, the Matrix Model, and motivational interviewing. Recognizing the unique needs of women, particularly those who are pregnant or postpartum, Addiction Research and Treatment Inc offers tailored, gender-specific programs for both men and women. Their commitment lies in delivering effective, scientifically-backed care to guide individuals toward lasting recovery.

Addiction Research and Treatment Inc

Addiction Research and Treatment Inc, located in Concord, CA, provides comprehensive outpatient services for individuals struggling with substance use disorders. Their treatment modalities encompass anger management techniques, cognitive behavioral therapy (CBT), and contingency management strategies, also known as motivational incentives. The center serves a diverse clientele, including adult men and women, and extends its services to active duty military members. Addiction Research and Treatment Inc offers specialized recovery programs designed for both adults and young adults. They are committed to delivering high-quality care, featuring outpatient treatment options that may include methadone, buprenorphine, or naltrexone, alongside standard outpatient services. Furthermore, the facility recognizes the importance of tailored support through its gender-specific programs for men and women navigating their journey toward sobriety.

Addiction Research and Treatment Inc

Addiction Research and Treatment Inc, situated in Antioch, CA, delivers targeted programs for adults and young adults overcoming substance use disorders. Their offerings include outpatient care, featuring medication-assisted treatment with methadone, buprenorphine, or naltrexone. The center emphasizes 12-step integration, individual counseling for addiction, and remote therapy options. Specialized support is provided for active military members, adult men, and adult women, catering to diverse client populations. Addiction Research and Treatment Inc ensures comprehensive and personalized care to aid clients in their recovery journey.

Addiction Research and Treatment Inc

Addiction Research and Treatment Inc, situated in La Puente, CA, provides extensive support for individuals facing addiction. This center is dedicated to outpatient detoxification, addressing substance use disorders, and offering medication-assisted treatment with methadone, buprenorphine, or naltrexone on an outpatient basis. They employ proven therapeutic methods such as cognitive behavioral therapy, the Matrix Model, and motivational interviewing to deliver personalized care plans for adults and young adults. Addiction Research and Treatment Inc places a special emphasis on supporting pregnant and postpartum women, ensuring that every client receives unique assistance. Catering to both male and female patients, the facility is committed to delivering high-quality services that facilitate recovery.

Addiction Research and Treatment Inc

Addiction Research and Treatment Inc in Los Angeles, CA, provides extensive outpatient care for withdrawal management and recovery from substance dependence. They have distinct programs for active service members, adult males, and adult females, addressing varied requirements. Employing methods such as guided 12-step work, emotional regulation training, and concise counseling techniques, this establishment delivers customized support for adults and young adults across all gender identities. Their outpatient detox and medication-assisted treatment options, including methadone, buprenorphine, or naltrexone, offer adaptable and successful pathways to healing. Prioritizing excellent service and personal attention, Addiction Research and Treatment Inc is a dependable option for individuals pursuing freedom from addiction.

Addiction Research and Treatment Inc

Addiction Research and Treatment Inc, situated in Porterville, CA, provides extensive outpatient support for those pursuing freedom from addiction. The facility excels in offering detoxification, substance abuse therapy, and care for dual-diagnosis mental health issues, catering to both adults and younger individuals. Through approaches like cognitive behavioral therapy, motivational interviewing, and strategies for avoiding relapse, they craft personalized care paths aimed at sustained sobriety. Specialized offerings exist for active military members, adult men, and women. Addressing adults and young adults across all gender identities, this center delivers exceptional care and encouragement to those embarking on their healing path.

Frequently Asked Questions

What is Medication-Assisted Treatment (MAT)?
MAT combines FDA-approved medications with counseling and behavioral therapies for comprehensive addiction treatment. Medications normalize brain chemistry, block euphoric effects of substances, relieve physiological cravings, and normalize body functions without negative effects of substance use. MAT is the gold standard for opioid and alcohol use disorders.
What medications are used in MAT?
For opioid use disorder: methadone, buprenorphine (Suboxone, Sublocade), and naltrexone (Vivitrol). For alcohol use disorder: naltrexone, acamprosate, and disulfiram. Each medication has unique benefits and considerations. A physician experienced in addiction medicine determines the most appropriate option based on individual circumstances, substance used, and treatment goals.
Is MAT just replacing one addiction with another?
No, this is a common misconception. MAT medications are prescribed at stable, therapeutic doses and don't produce euphoria when taken as directed. They're medicine, not substitution. MAT allows normal functioning, eliminates cravings, prevents withdrawal, dramatically reduces overdose risk, and enables engagement in therapy and rebuilding life. Research consistently shows MAT saves lives and improves outcomes.
How long does MAT last?
MAT duration varies by individual needs. Some people benefit from months of treatment, others years or indefinitely. There's no predetermined timeline. Research shows longer MAT duration improves outcomes and reduces overdose risk. Decisions about duration should be made collaboratively with healthcare providers based on stability, quality of life, and recovery goals, not arbitrary timelines.
Does insurance cover MAT?
Most health insurance plans cover MAT under mental health and substance use benefits. The Affordable Care Act and Mental Health Parity Act require coverage for addiction treatment including MAT. Coverage includes medications, office visits, counseling, and therapy. Contact your insurance provider or treatment center admissions to verify specific coverage and costs.

About Medication-Assisted Treatment (MAT)

Medication-Assisted Treatment (MAT) represents the gold standard for treating opioid and alcohol use disorders. By combining FDA-approved medications with counseling and behavioral therapies, MAT addresses both the biological and psychological aspects of addiction. Research consistently demonstrates that MAT reduces overdose deaths by more than 50%, improves treatment retention, and supports long-term recovery.

MAT Medications for Opioid Use Disorder

Three FDA-approved medications treat opioid addiction:

  • Methadone: Full opioid agonist eliminating withdrawal and cravings; administered daily at certified opioid treatment programs (OTPs). Longest track record with extensive research supporting effectiveness.
  • Buprenorphine (Suboxone, Sublocade): Partial opioid agonist with ceiling effect, reducing abuse potential; prescribed by certified physicians in office settings or as monthly injection. Offers greater flexibility and privacy.
  • Naltrexone (Vivitrol): Opioid antagonist blocking opioid effects; requires complete detox before starting; available as daily pill or monthly injection. Best for motivated individuals after detox completion.

MAT for Alcohol Use Disorder

FDA-approved medications for alcohol addiction:

  • Naltrexone: Reduces cravings and blocks rewarding effects of alcohol; available as daily pill or monthly injection
  • Acamprosate (Campral): Helps restore brain chemistry balance; reduces cravings and supports abstinence
  • Disulfiram (Antabuse): Causes unpleasant reaction if alcohol consumed; provides deterrent for impulsive drinking

Comprehensive Treatment Approach

MAT is never medication alone. Quality programs integrate counseling, behavioral therapies, case management, recovery support services, treatment for co-occurring conditions, and peer support. The medication component allows individuals to engage fully in therapy and recovery activities by eliminating withdrawal, cravings, and physiological barriers to recovery.

Addressing Stigma and Misconceptions

MAT faces unfortunate stigma, with some viewing it as "replacing one drug with another." This is false. MAT medications are prescribed at stable therapeutic doses, don't produce euphoria, allow normal functioning, and are medicine treating a medical condition. Research overwhelming supports MAT as most effective treatment for opioid use disorder. Organizations like SAMHSA, NIDA, and medical professional societies strongly endorse MAT.

Finding MAT Treatment

Look for programs offering multiple MAT medication options, addiction medicine physicians, comprehensive counseling services, individualized treatment planning, support for long-term medication management, and evidence-based behavioral therapies. Our directory helps locate opioid treatment centers and programs offering MAT.

Harm Reduction and Medication-Assisted Treatment

Harm reduction is a public health philosophy that meets people where they are in their relationship with substance use. Rather than demanding abstinence as a precondition for support, harm reduction focuses on reducing the negative health, social, and economic consequences of drug use while keeping individuals alive, safe, and connected to care. This pragmatic approach recognizes that not everyone is ready or able to stop using substances immediately, and that incremental steps toward health are meaningful and worth supporting.

Harm reduction programs take many forms in communities across the country. Needle exchange and syringe service programs reduce the spread of HIV and hepatitis C among people who inject drugs. Naloxone (Narcan) distribution puts lifesaving overdose reversal medication directly into the hands of people who use drugs and their loved ones. Drug checking services, including fentanyl test strips, help people identify dangerous adulterants in their supply. Supervised consumption sites, operating in several countries and piloted in the United States, provide sterile environments with medical staff on hand to prevent fatal overdoses. Low-threshold MAT programs remove barriers to treatment by offering same-day starts, flexible scheduling, and minimal requirements for enrollment.

Harm reduction and abstinence are not competing philosophies — they are complementary approaches along a continuum of care. Many people who initially engage with harm reduction services eventually choose to pursue abstinence-based recovery. Research consistently shows that harm reduction programs serve as a critical bridge, connecting individuals to treatment they might never have accessed otherwise. Forcing a choice between the two creates a false dichotomy that costs lives.

MAT is itself a cornerstone harm reduction strategy. Buprenorphine and methadone maintenance programs dramatically reduce overdose deaths — studies show a 50% or greater reduction in all-cause mortality among patients receiving opioid agonist therapy. Beyond preventing fatal overdoses, MAT reduces HIV and hepatitis C transmission by decreasing injection drug use, lowers criminal activity and incarceration rates, and improves overall quality of life, housing stability, and employment outcomes. These benefits occur even when patients are not fully abstinent from all substances. By stabilizing brain chemistry and eliminating the desperate cycle of withdrawal and compulsive use, MAT gives people the stability they need to rebuild their lives. Facilities offering MAT as part of a harm reduction framework can be found through our opioid rehab directory.

FDA-Approved Medications: Detailed Guides

The U.S. Food and Drug Administration has approved several medications for the treatment of opioid and alcohol use disorders. Each works through a different mechanism and is suited to different clinical situations. Understanding the distinctions can help patients and families make informed decisions alongside their treatment providers. Explore our in-depth guides below.

Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist that completely blocks the euphoric and sedative effects of opioids, removing the incentive to use. It is available as a daily oral pill or as a monthly extended-release injection marketed as Vivitrol. Because naltrexone requires a full detox period before initiation — typically 7 to 14 days opioid-free — it is best suited for patients who have already completed withdrawal management. Naltrexone is also FDA-approved for alcohol use disorder, where it reduces cravings and heavy drinking days.

Learn more about Naltrexone →

Buprenorphine (Suboxone)

Buprenorphine is a partial opioid agonist with a built-in ceiling effect, meaning its opioid effects plateau at moderate doses — significantly lowering the risk of respiratory depression and overdose. It is available as a sublingual film or tablet (commonly known by the brand name Suboxone, which also contains naloxone to deter misuse) and as a monthly subcutaneous injection (Sublocade). Buprenorphine can be prescribed in office-based settings by qualified providers, making it one of the most accessible MAT options. It effectively reduces cravings and withdrawal symptoms while carrying lower abuse potential than full agonists.

Learn more about Buprenorphine →

Methadone

Methadone is a full opioid agonist with more than 60 years of clinical evidence supporting its effectiveness. Administered daily at certified Opioid Treatment Programs (OTPs), methadone eliminates withdrawal symptoms, suppresses cravings, and blocks the effects of other opioids when dosed correctly. It is considered the most effective option for individuals with severe opioid use disorder, particularly those who have not responded to other medications. The structured program participation required — including regular clinic visits, counseling, and drug screening — provides an additional layer of accountability and support.

Learn more about Methadone →

Naloxone (Narcan)

Naloxone is an opioid antagonist used to rapidly reverse opioid overdoses. Available as a nasal spray (Narcan) and in injectable formulations, naloxone can restore normal breathing within minutes in a person experiencing respiratory depression from opioids. In 2023, Narcan nasal spray became available over the counter without a prescription, making it more accessible than ever. Every person who uses opioids, is prescribed high-dose opioid pain medication, or has a loved one at risk should keep naloxone on hand — it is safe, effective, and saves lives.

Learn more about Naloxone →

MAT resources and information:

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Browse medication-assisted treatment (mat) programs in states with the most treatment options.

Explore Related Options

Related conditions, treatment approaches, and levels of care.

Medically Reviewed Updated May 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)