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Medically Reviewed Content
Updated: May 2026
Sources: SAMHSA, NIDA

Medication-Assisted Treatment (MAT) Centers

Medication-Assisted Treatment (MAT) combines FDA-approved medications with counseling and behavioral therapies for comprehensive addiction care. MAT is the gold standard for opioid and alcohol use disorders, significantly reducing overdose deaths and improving treatment outcomes.

Found 300 treatment centers offering medication-assisted treatment (mat) across the United States.

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Situated in Lisbon, ND, the Abuse Resource Network and Therapy center delivers outpatient services focused on substance abuse and complex mental health issues in adults, along with emotional challenges in children. Employing techniques such as brief intervention, cognitive behavioral therapy, and the Matrix Model, this center aims to provide personalized support for adults and young adults of all genders. By emphasizing customized treatment plans, the facility is committed to meeting the distinct needs of each client. If you are in search of expert care tailored to your individual circumstances, this center's holistic strategy may align well with your recovery goals.

Acadia Hospital
Bangor, ME

Acadia Hospital, located in Bangor, ME, specializes in rehabilitation services aimed at addressing substance abuse and concurrent mental health disorders. The facility offers both intensive outpatient and standard outpatient programs designed for adults facing significant emotional challenges or mental health conditions. Treatment options encompass techniques such as anger management, cognitive behavioral therapy, and the Matrix Model. They also feature tailored programs for adult men, women, and those who have faced trauma. Focusing on the needs of adults and young adults, Acadia Hospital provides gender-specific treatment for both sexes. The center is dedicated to delivering high-quality care and creating individualized treatment strategies to assist individuals in their recovery journey.

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Portland, OR

Acadia Northwest, situated in Portland, OR, delivers extensive treatment programs for substance use aimed at both adults and teenagers. The center features a variety of options including intensive outpatient, outpatient, and standard outpatient therapies. By employing research-backed methods such as cognitive behavioral therapy, motivational interviewing, and strategies for preventing relapse, the facility customizes treatment plans according to individual requirements. With focused programs catering to adult men, adult women, and clients involved in legal issues, Acadia Northwest prioritizes personalized support for all demographics. Renowned for its high standard of care and dedication to recovery, this center is a reliable option for individuals looking for effective addiction support in the Portland community.

Acadia Northwest
Oregon City, OR

Acadia Northwest, situated in Oregon City, OR, provides thorough addiction care for adult men, adult women, and individuals within the criminal justice system. Their recovery services encompass intensive outpatient, standard outpatient, and less intensive outpatient plans. Employing proven therapeutic methods like cognitive behavioral therapy, motivational interviewing, and relapse prevention strategies, this center delivers tailored support for adults and young people of all genders. Acadia Northwest is dedicated to offering superior, focused treatment to aid individuals in achieving lasting sobriety.

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Lafayette, LA

Acadiana CARES, located in Lafayette, Louisiana, delivers a wide array of services focused on substance use rehabilitation. It includes transitional housing and specialized treatment for adults grappling with both substance use issues and significant mental health disorders, as well as support for children facing emotional challenges. The center offers several treatment modalities, such as intensive outpatient programs, long-term residential options, and general outpatient services, employing techniques like 12-step support, anger management, and cognitive behavioral therapy. Designed to meet the distinct needs of adult men, adult women, and clients affected by HIV or AIDS, Acadiana CARES ensures that care is both high-quality and highly personalized, tailoring treatment plans to foster effective recovery for individuals across all genders.

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Acadiana Recovery Center, situated in Lafayette, LA, delivers comprehensive substance use disorder treatment for adults and young adults. Services include inpatient hospital care around the clock and intensive outpatient programs. The center utilizes methodologies like 12-step facilitation, anger management, and brief intervention, serving both male and female individuals, including survivors of intimate partner violence. Tailored treatment is available for adult men and women, ensuring individualized support. Acadiana Recovery Center stands as a dedicated provider of extensive addiction recovery services.

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Dearborn, MI

Situated in Dearborn, MI, ACC Dearborn specializes in outpatient treatment for individuals dealing with substance use issues, including both adults and children facing significant mental health challenges. The center offers tailored programs that address the needs of adolescents and adult men and women, fostering a nurturing environment to support their recovery journeys. Employing techniques like anger management, brief intervention, and cognitive behavioral therapy, ACC Dearborn emphasizes personalized care to encourage long-term sobriety. With a devoted team of experts, the center is focused on providing exceptional treatment for clients of all genders who are aiming to conquer addiction and enhance their mental health.

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Queensbury, NY

Situated in Queensbury, NY, ACCA Quaker Road stands out as a premier rehabilitation facility dedicated to substance use recovery for adult males. The center offers both long-term and 24-hour residential care, creating a nurturing atmosphere for those on the path to recovery. By employing evidence-based methods like anger management, cognitive behavioral therapy, and motivational incentives, ACCA Quaker Road personalizes its treatment plans to suit the distinct requirements of each individual. Catering to adult men, seniors, and younger adult males, the center is committed to providing exceptional care and support during the recovery process.

Acceptance Counseling

Acceptance Counseling in Westmont, IL, offers outpatient services for individuals of all ages grappling with substance use disorders, particularly when accompanied by significant mental health conditions or emotional difficulties. Their treatment approach incorporates evidence-based methods such as 12-step facilitation, anger management techniques, and brief intervention strategies. The center provides ongoing outpatient programs designed with a strong emphasis on personalized treatment plans. Catering to both male and female patients, Acceptance Counseling adapts its offerings to suit the distinct needs of various age demographics, thereby ensuring focused and impactful therapeutic interventions. Dedicated to delivering high-quality care and featuring a distinctive focus on tailored therapy, Acceptance Counseling distinguishes itself as a supportive and all-encompassing provider for those pursuing recovery from addiction and mental health concerns.

Acceptance Recovery Counseling

Acceptance Recovery Counseling in Coralville, IA, provides outpatient care for substance abuse and concurrent challenges involving mental health disorders in adults or emotional distress in young people. Their treatment utilizes proven methods including 12-step support, brief counseling, and cognitive behavioral strategies. Serving adolescents, adult men, and women, this facility accommodates individuals across all age groups and genders, including seniors. They deliver consistent outpatient services, ensuring treatment is personalized and of high quality. Acceptance Recovery Counseling is a dependable choice for anyone looking for complete recovery support in a welcoming setting.

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Access Ashland Family Health Ctr offers expert care for substance abuse recovery.

Access Austin Family Health Ctr

Access Austin Family Health Center, located in Chicago, IL, provides an extensive range of outpatient services for individuals battling substance use issues and concurrent mental health conditions, applicable to both adults and children. The facility offers focused support for adults experiencing significant emotional challenges. By employing evidence-backed methods such as cognitive behavioral therapy and motivational incentives, Access Austin Family Health Center delivers customized treatment strategies for men and women, including those living with HIV/AIDS. The center also offers outpatient options for methadone, buprenorphine, and naltrexone, accommodating adult and young adult clients of all genders. Prioritizing high-quality care and personalized assistance, Access Austin Family Health Center is committed to helping clients navigate their journey to recovery from substance use disorders.

Access Behavioral Associates LLC

Access Behavioral Associates LLC, located in Plymouth, MI, specializes in outpatient services for adults dealing with substance use disorders along with mental health challenges, as well as emotional issues in children. Their treatment methods are grounded in research, featuring techniques such as anger management, brief intervention strategies, and cognitive behavioral therapy. The center creates customized programs that address the unique needs of each client, supporting adults as well as children and adolescents of all backgrounds. Committed to providing high-quality care and individualized support, Access Behavioral Associates LLC aims to assist clients in their recovery journey through empathetic and skilled guidance.

Access Behavioral Health Services

Access Behavioral Health Services in Boise, ID, delivers extensive substance abuse recovery options for individuals of all ages. Their offerings encompass intensive outpatient services, standard outpatient care, and targeted treatments utilizing methadone, buprenorphine, or naltrexone. The center employs scientifically validated therapeutic methods including anger management, cognitive behavioral therapy, and the Matrix Model. Designed to accommodate the unique requirements of adolescents, adult men, and adult women, the facility provides specialized pathways to recovery. This center, serving both genders, is dedicated to providing superior support for those addressing substance use disorders and co-occurring mental health challenges.

Access Behavioral Health Services

Access Behavioral Health Services in Nampa, ID, delivers targeted interventions for addiction and simultaneous mental health conditions. They offer robust intensive outpatient and standard outpatient programs, along with medication-assisted treatments like methadone, buprenorphine, or naltrexone. Employing techniques such as anger management, cognitive behavioral therapy, and the Matrix Model, the center customizes care to each person's unique situation. Specific programs are designed for young people, adult males, and adult females. Serving a broad age range from children to adults and accommodating all genders, Access Behavioral Health Services provides complete support for individuals navigating recovery from substance abuse and mental health struggles.

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Access Behavioral Services Inc in Chicago, IL, provides outpatient addiction treatment for adults. Their approach centers on evidence-based methods, including 12-step facilitation, motivational interviewing, and counseling for substance use disorders. The center serves both adults and young adults, offering personalized treatment plans. With distinct programs designed for men and women, Access Behavioral Services Inc fosters a nurturing setting for recovery. Their dedication to gender-specific care and individual needs underscores their mission to deliver excellent addiction treatment services in the Chicago region.

Access Blue Island Family Health Ctr

Access Blue Island Family Health Ctr, located in Blue Island, IL, specializes in outpatient care for adults and adolescents struggling with substance misuse and co-occurring severe mental health conditions. The facility offers distinct programs designed for adult men, adult women, and individuals diagnosed with HIV or AIDS, emphasizing personalized treatment pathways. Their therapeutic methods encompass brief counseling, substance use disorder therapy, and outpatient medication-assisted treatment involving methadone, buprenorphine, or naltrexone. This center is dedicated to providing high-quality, supportive services to both male and female patients seeking comprehensive recovery solutions in a supportive setting.

ACCESS Blue Island Medical Center

ACCESS Blue Island Medical Center, located in Blue Island, IL, provides outpatient treatment for adults dealing with substance use disorders, particularly those with concurrent severe mental health challenges or emotional issues in children. The facility employs various therapeutic approaches, including cognitive behavioral therapy and the Matrix Model, to deliver holistic support. Tailored programs are available for both men and women, alongside services designed for clients living with HIV or AIDS. Focusing on young adults as well, this center fosters a nurturing atmosphere conducive to recovery. By offering outpatient treatments with methadone, buprenorphine, or naltrexone, ACCESS Blue Island Medical Center emphasizes personalized care for all clients.

Access Booker Family Health Ctr

Access Booker Family Health Center, located in Chicago, IL, provides tailored outpatient treatment for adults facing substance use challenges, especially those dealing with concurrent severe mental health conditions or emotional issues in children. The center boasts specialized programs designed for both adult males and females, as well as clients living with HIV or AIDS. Various treatment methods are utilized, including brief intervention, cognitive behavioral therapy, and the Matrix Model. Catering to adults and young adults of any gender, the center also offers outpatient methadone/buprenorphine and naltrexone therapies alongside standard outpatient services. Access Booker Family Health Center is dedicated to delivering high-quality care and support to individuals pursuing comprehensive rehabilitation in the Chicago region.

Access Brandon Family Health Ctr

Brandon Family Health Center, located in Chicago, IL, provides outpatient treatment for substance use disorders in adults who are facing serious mental health challenges, along with emotional issues in children. This center offers outpatient options for methadone, buprenorphine, or naltrexone, combined with ongoing outpatient services. Emphasizing brief interventions, cognitive behavioral therapy, and the Matrix Model, clients benefit from personalized treatment plans. There are dedicated programs available for adult men and women, along with specialized services for individuals living with HIV or AIDS. This facility supports adults and young adults across all genders, focusing on high-quality, evidence-based care to assist each individual in their recovery journey.

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Access Counseling Services LLC, located in Middletown, OH, specializes in addressing substance use issues and co-existing mental health disorders in both adults and children. The center offers various outpatient treatment options, including intensive day programs, personalized to meet each individual's needs through proven methods such as cognitive behavioral therapy and anger management. Programs designed for clients facing dual diagnoses are also provided. Committed to delivering high-quality care, this facility serves adults and young adults across all gender identities, focusing on guiding individuals toward a successful recovery. If you are looking for effective and compassionate support for substance use and mental health challenges, Access Counseling Services LLC is ready to assist you.

Frequently Asked Questions

What is Medication-Assisted Treatment (MAT)?
MAT combines FDA-approved medications with counseling and behavioral therapies for comprehensive addiction treatment. Medications normalize brain chemistry, block euphoric effects of substances, relieve physiological cravings, and normalize body functions without negative effects of substance use. MAT is the gold standard for opioid and alcohol use disorders.
What medications are used in MAT?
For opioid use disorder: methadone, buprenorphine (Suboxone, Sublocade), and naltrexone (Vivitrol). For alcohol use disorder: naltrexone, acamprosate, and disulfiram. Each medication has unique benefits and considerations. A physician experienced in addiction medicine determines the most appropriate option based on individual circumstances, substance used, and treatment goals.
Is MAT just replacing one addiction with another?
No, this is a common misconception. MAT medications are prescribed at stable, therapeutic doses and don't produce euphoria when taken as directed. They're medicine, not substitution. MAT allows normal functioning, eliminates cravings, prevents withdrawal, dramatically reduces overdose risk, and enables engagement in therapy and rebuilding life. Research consistently shows MAT saves lives and improves outcomes.
How long does MAT last?
MAT duration varies by individual needs. Some people benefit from months of treatment, others years or indefinitely. There's no predetermined timeline. Research shows longer MAT duration improves outcomes and reduces overdose risk. Decisions about duration should be made collaboratively with healthcare providers based on stability, quality of life, and recovery goals, not arbitrary timelines.
Does insurance cover MAT?
Most health insurance plans cover MAT under mental health and substance use benefits. The Affordable Care Act and Mental Health Parity Act require coverage for addiction treatment including MAT. Coverage includes medications, office visits, counseling, and therapy. Contact your insurance provider or treatment center admissions to verify specific coverage and costs.

About Medication-Assisted Treatment (MAT)

Medication-Assisted Treatment (MAT) represents the gold standard for treating opioid and alcohol use disorders. By combining FDA-approved medications with counseling and behavioral therapies, MAT addresses both the biological and psychological aspects of addiction. Research consistently demonstrates that MAT reduces overdose deaths by more than 50%, improves treatment retention, and supports long-term recovery.

MAT Medications for Opioid Use Disorder

Three FDA-approved medications treat opioid addiction:

  • Methadone: Full opioid agonist eliminating withdrawal and cravings; administered daily at certified opioid treatment programs (OTPs). Longest track record with extensive research supporting effectiveness.
  • Buprenorphine (Suboxone, Sublocade): Partial opioid agonist with ceiling effect, reducing abuse potential; prescribed by certified physicians in office settings or as monthly injection. Offers greater flexibility and privacy.
  • Naltrexone (Vivitrol): Opioid antagonist blocking opioid effects; requires complete detox before starting; available as daily pill or monthly injection. Best for motivated individuals after detox completion.

MAT for Alcohol Use Disorder

FDA-approved medications for alcohol addiction:

  • Naltrexone: Reduces cravings and blocks rewarding effects of alcohol; available as daily pill or monthly injection
  • Acamprosate (Campral): Helps restore brain chemistry balance; reduces cravings and supports abstinence
  • Disulfiram (Antabuse): Causes unpleasant reaction if alcohol consumed; provides deterrent for impulsive drinking

Comprehensive Treatment Approach

MAT is never medication alone. Quality programs integrate counseling, behavioral therapies, case management, recovery support services, treatment for co-occurring conditions, and peer support. The medication component allows individuals to engage fully in therapy and recovery activities by eliminating withdrawal, cravings, and physiological barriers to recovery.

Addressing Stigma and Misconceptions

MAT faces unfortunate stigma, with some viewing it as "replacing one drug with another." This is false. MAT medications are prescribed at stable therapeutic doses, don't produce euphoria, allow normal functioning, and are medicine treating a medical condition. Research overwhelming supports MAT as most effective treatment for opioid use disorder. Organizations like SAMHSA, NIDA, and medical professional societies strongly endorse MAT.

Finding MAT Treatment

Look for programs offering multiple MAT medication options, addiction medicine physicians, comprehensive counseling services, individualized treatment planning, support for long-term medication management, and evidence-based behavioral therapies. Our directory helps locate opioid treatment centers and programs offering MAT.

Harm Reduction and Medication-Assisted Treatment

Harm reduction is a public health philosophy that meets people where they are in their relationship with substance use. Rather than demanding abstinence as a precondition for support, harm reduction focuses on reducing the negative health, social, and economic consequences of drug use while keeping individuals alive, safe, and connected to care. This pragmatic approach recognizes that not everyone is ready or able to stop using substances immediately, and that incremental steps toward health are meaningful and worth supporting.

Harm reduction programs take many forms in communities across the country. Needle exchange and syringe service programs reduce the spread of HIV and hepatitis C among people who inject drugs. Naloxone (Narcan) distribution puts lifesaving overdose reversal medication directly into the hands of people who use drugs and their loved ones. Drug checking services, including fentanyl test strips, help people identify dangerous adulterants in their supply. Supervised consumption sites, operating in several countries and piloted in the United States, provide sterile environments with medical staff on hand to prevent fatal overdoses. Low-threshold MAT programs remove barriers to treatment by offering same-day starts, flexible scheduling, and minimal requirements for enrollment.

Harm reduction and abstinence are not competing philosophies — they are complementary approaches along a continuum of care. Many people who initially engage with harm reduction services eventually choose to pursue abstinence-based recovery. Research consistently shows that harm reduction programs serve as a critical bridge, connecting individuals to treatment they might never have accessed otherwise. Forcing a choice between the two creates a false dichotomy that costs lives.

MAT is itself a cornerstone harm reduction strategy. Buprenorphine and methadone maintenance programs dramatically reduce overdose deaths — studies show a 50% or greater reduction in all-cause mortality among patients receiving opioid agonist therapy. Beyond preventing fatal overdoses, MAT reduces HIV and hepatitis C transmission by decreasing injection drug use, lowers criminal activity and incarceration rates, and improves overall quality of life, housing stability, and employment outcomes. These benefits occur even when patients are not fully abstinent from all substances. By stabilizing brain chemistry and eliminating the desperate cycle of withdrawal and compulsive use, MAT gives people the stability they need to rebuild their lives. Facilities offering MAT as part of a harm reduction framework can be found through our opioid rehab directory.

FDA-Approved Medications: Detailed Guides

The U.S. Food and Drug Administration has approved several medications for the treatment of opioid and alcohol use disorders. Each works through a different mechanism and is suited to different clinical situations. Understanding the distinctions can help patients and families make informed decisions alongside their treatment providers. Explore our in-depth guides below.

Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist that completely blocks the euphoric and sedative effects of opioids, removing the incentive to use. It is available as a daily oral pill or as a monthly extended-release injection marketed as Vivitrol. Because naltrexone requires a full detox period before initiation — typically 7 to 14 days opioid-free — it is best suited for patients who have already completed withdrawal management. Naltrexone is also FDA-approved for alcohol use disorder, where it reduces cravings and heavy drinking days.

Learn more about Naltrexone →

Buprenorphine (Suboxone)

Buprenorphine is a partial opioid agonist with a built-in ceiling effect, meaning its opioid effects plateau at moderate doses — significantly lowering the risk of respiratory depression and overdose. It is available as a sublingual film or tablet (commonly known by the brand name Suboxone, which also contains naloxone to deter misuse) and as a monthly subcutaneous injection (Sublocade). Buprenorphine can be prescribed in office-based settings by qualified providers, making it one of the most accessible MAT options. It effectively reduces cravings and withdrawal symptoms while carrying lower abuse potential than full agonists.

Learn more about Buprenorphine →

Methadone

Methadone is a full opioid agonist with more than 60 years of clinical evidence supporting its effectiveness. Administered daily at certified Opioid Treatment Programs (OTPs), methadone eliminates withdrawal symptoms, suppresses cravings, and blocks the effects of other opioids when dosed correctly. It is considered the most effective option for individuals with severe opioid use disorder, particularly those who have not responded to other medications. The structured program participation required — including regular clinic visits, counseling, and drug screening — provides an additional layer of accountability and support.

Learn more about Methadone →

Naloxone (Narcan)

Naloxone is an opioid antagonist used to rapidly reverse opioid overdoses. Available as a nasal spray (Narcan) and in injectable formulations, naloxone can restore normal breathing within minutes in a person experiencing respiratory depression from opioids. In 2023, Narcan nasal spray became available over the counter without a prescription, making it more accessible than ever. Every person who uses opioids, is prescribed high-dose opioid pain medication, or has a loved one at risk should keep naloxone on hand — it is safe, effective, and saves lives.

Learn more about Naloxone →

MAT resources and information:

Find Medication-Assisted Treatment (MAT) by State

Browse medication-assisted treatment (mat) programs in states with the most treatment options.

Explore Related Options

Related conditions, treatment approaches, and levels of care.

Medically Reviewed Updated May 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)