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Medically Reviewed Content
Updated: September 2026
Sources: SAMHSA, NIDA

Medication-Assisted Treatment (MAT) Centers

Medication-Assisted Treatment (MAT) combines FDA-approved medications with counseling and behavioral therapies for comprehensive addiction care. MAT is the gold standard for opioid and alcohol use disorders, significantly reducing overdose deaths and improving treatment outcomes.

Found 300 treatment centers offering medication-assisted treatment (mat) across the United States.

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AMS of Wisconsin LLC
Janesville, WI

AMS of Wisconsin LLC in Janesville, WI, provides outpatient services for detox and substance use disorder treatment. Their approach incorporates techniques like anger management, brief intervention, and cognitive behavioral therapy to foster recovery. The center offers distinct programs for active military, adult men, and adult women, addressing a wide range of individuals. Serving adults and seniors of all genders, AMS of Wisconsin LLC delivers personalized, high-quality care. Clients can anticipate thorough assistance and proven methods for detoxification and substance use recovery at this esteemed facility.

AMS of Wisconsin LLC

AMS of Wisconsin LLC, located in Oshkosh, WI, provides community-based withdrawal management and addiction rehabilitation services. Employing techniques such as dialectical behavior therapy, motivational interviewing, and trauma-informed care, this establishment serves adult men and women, older adults, and individuals affected by intimate partner or domestic violence. Through tailored interventions for various demographics, AMS of Wisconsin LLC delivers personalized support to address unique requirements. For those requiring outpatient methadone, buprenorphine, or naltrexone therapies, or standard outpatient care, clients can anticipate effective, scientifically supported treatment at this facility.

ANEW Chemical Health Services

ANEW Chemical Health Services in Saint Paul, MN provides extensive support for individuals battling substance use, along with targeted assistance for those facing co-occurring severe mental health challenges. This center delivers robust outpatient, extended residential, and standard outpatient options designed for adults and young adults. By incorporating principles of 12-step recovery, anger management techniques, and cognitive behavioral therapy, ANEW Chemical Health Services presents a distinct recovery model. They also feature specialized services for adult women, individuals who have experienced intimate partner violence, domestic abuse, and sexual trauma. The center's dedication to gender-specific treatment for women fosters a nurturing and secure atmosphere conducive to healing. Patients can anticipate receiving superior, personalized care to aid them in their path to wellness and lasting sobriety.

APS Clinics of Puerto Rico

APS Clinics of Puerto Rico, located in Mayaguez, provides outpatient treatment for substance use disorders aimed at both adults and young adults. This facility specializes in managing co-occurring substance use issues in conjunction with significant mental health conditions for adults and emotional challenges in children. The center employs various treatment methods, including anger management, short-term interventions, and cognitive behavioral therapy. With an emphasis on personalized care, the center offers outpatient services that include methadone, buprenorphine, or naltrexone treatments. Catering to both males and females, APS Clinics of Puerto Rico prioritizes high-quality care that addresses the unique requirements of each patient.

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APS Clinics of Puerto Rico, located in Aguadilla, delivers extensive addiction recovery services for adults facing simultaneous mental health challenges and for children dealing with significant emotional issues. The center offers a range of services including intensive outpatient programs, day treatment options, and partial hospitalization. Treatment plans incorporate specialized methods such as anger management, brief interventions, and strategies for preventing relapse. Programs are designed specifically for adolescents as well as adult men and women. APS Clinics serves individuals of all genders, including seniors, and is committed to personalized care and the use of evidence-based methods, ensuring top-notch rehabilitation services for those seeking support.

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Spanish Fork, UT

APS Spanish Fork, situated in Spanish Fork, UT, delivers complete care for individuals of all ages facing addiction and co-occurring mental health concerns. The facility offers various treatment levels, including intensive outpatient, outpatient, and day treatment, all grounded in proven methods like cognitive behavioral therapy and anger management. Tailored programs are available for active military personnel, teenagers, and adult men, ensuring that APS Spanish Fork meets diverse needs. The center is dedicated to providing excellent support and treatment for adults and seniors, regardless of gender, on their journey toward recovery from substance abuse and mental health issues.

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New Haven, CT

Situated in New Haven, CT, APT Foundation Inc delivers extensive treatment for substance use disorders, catering to both adults and children/adolescents facing significant mental health challenges or emotional issues. The center offers a range of treatment modalities, including intensive outpatient, outpatient, and options featuring methadone/buprenorphine/naltrexone. With dedicated programs aimed at active military personnel, adult men, and women, APT Foundation Inc customizes its services to meet the distinct needs of each individual. By employing techniques such as 12-step facilitation, anger management, and brief therapeutic interventions, the facility promotes a well-rounded approach to recovery. Committed to high-quality care, APT Foundation Inc serves as a reputable option for individuals in pursuit of impactful rehabilitation solutions.

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New Haven, CT

APT Foundation Inc in New Haven, CT, delivers targeted substance use care for adults managing co-occurring mental health issues, as well as for children with emotional disturbances. The center offers diverse residential recovery options, including extended, round-the-clock, and brief placements. Their therapeutic methods incorporate 12-step engagement, emotional regulation skills, and concise counseling. Specialized services are available for active military personnel, adult women, and survivors of domestic abuse. APT Foundation Inc supports adults, older adults, and younger adults, with a particular emphasis on women. Dedicated to high-quality support, this establishment offers a holistic and nurturing setting for individuals pursuing healing from addiction and mental health concerns.

APT Foundation Inc
New Haven, CT

APT Foundation Inc. located in New Haven, CT, provides comprehensive treatment grounded in scientific research for individuals grappling with addiction and accompanying mental health concerns, serving both adolescents and adults. The facility delivers various levels of care, from intensive outpatient services to standard outpatient programs, which include medication-assisted treatment like methadone and buprenorphine. Their approach emphasizes personalized support, incorporating therapeutic methods such as 12-step engagement, strategies for managing anger, and short-term counseling techniques. Specialized services are available for active military members, as well as adult men and women. APT Foundation Inc. is dedicated to offering high-quality assistance to all genders within adult and young adult populations who are pursuing wellness from substance dependence and coexisting psychological conditions.

APT Foundation Inc
North Haven, CT

APT Foundation Inc. in North Haven, CT, delivers thorough care for individuals struggling with substance use, including specialized support for those facing co-occurring mental health conditions in adults or emotional challenges in children. The facility presents a range of treatment levels, such as intensive outpatient, outpatient, and medication-assisted options like methadone, buprenorphine, or naltrexone. Treatment modalities include 12-step program support, anger management techniques, and brief intervention strategies. Distinctive programs are offered for active military personnel, adult men, and adult women. Catering to adults and young adults regardless of gender, APT Foundation Inc. is committed to delivering exceptional, individualized rehabilitation services.

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New Haven, CT

The APT Foundation Inc, situated in New Haven, CT, provides extensive substance abuse treatment options for adults and young adults. They are particularly skilled in addressing dual diagnoses of substance use disorders and significant mental health conditions. The facility offers various levels of care, including extended stays, shorter programs, and 24-hour residential services. Their therapeutic approaches include 12-step facilitation, anger management training, and brief intervention strategies. The APT Foundation Inc serves adult men, women, and active duty military members. By developing personalized treatment strategies and tailored programs for diverse age groups and genders, they deliver superior recovery and rehabilitation support to everyone in their care.

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West Haven, CT

Situated in West Haven, CT, the APT Foundation Inc delivers extensive care for substance abuse for both adults and adolescents. This organization excels in addressing dual diagnoses, managing addiction alongside significant mental health conditions in adults or severe emotional challenges in youth. Their treatment modalities encompass intensive outpatient services, general outpatient support, and medication-assisted treatment (methadone/buprenorphine or naltrexone), ensuring personalized recovery plans. Employing therapeutic strategies like 12-step integration, anger management techniques, and brief counseling, the facility accommodates various client needs and philosophies. The APT Foundation Inc also provides distinct programs for active military personnel, adult men, and adult women, affirming their commitment to specialized support tailored to specific demographics.

ARC
Ashland, KY

ARC, situated in Ashland, KY, delivers targeted substance abuse therapy for adults and emerging adults, utilizing intensive outpatient, outpatient, and day treatment services. Emphasizing personalized attention, the facility incorporates 12-step facilitation, anger management, and brief intervention techniques to cater to diverse requirements. ARC distinguishes itself through its customized programs crafted for both male and female individuals, fostering a nurturing atmosphere. The center's dedication to high-caliber care and bespoke treatment strategies positions it as a premier option for those pursuing impactful and thorough recovery assistance.

ARC Addiction Recovery Care
Saint Catharine, KY

Situated in Saint Catharine, KY, ARC Addiction Recovery Care specializes in extensive treatment for substance use disorders specifically designed for adult and senior males. This center offers a range of programs including intensive outpatient, long-term residential, and outpatient options that are customized to meet the unique needs of each individual. ARC employs various methodologies such as 12-step facilitation, anger management techniques, and brief intervention strategies to aid in the recovery process. By emphasizing tailored care, this facility guarantees a personalized experience for its clients. ARC Addiction Recovery Care is recognized for its dedication to high-quality treatment and targeted programs aimed at assisting male adults and seniors facing addiction challenges.

ARC Addiction Recovery Care
Saint Catharine, KY

ARC Addiction Recovery Care in Saint Catharine, KY, provides complete substance abuse recovery for adult and senior men. They offer various treatment plans like intensive outpatient, extended residential stays, and standard outpatient services. Using methods such as 12-step facilitation, anger management, and brief intervention, ARC ensures each person receives personalized support. The center excels in crafting customized plans for every client, making it a perfect place for those needing focused help in a caring setting. ARC Addiction Recovery Care is committed to delivering excellent recovery support for sustained sobriety for you or someone you care about.

ARC Addiction Recovery Care
Saint Catharine, KY

Nestled in Saint Catharine, KY, ARC Addiction Recovery Care provides specialized substance abuse treatment for adult and elderly men. Emphasizing personalized support, the center offers intensive outpatient, extended residential stays, and outpatient services. They employ methods like 12-step integration, emotional regulation techniques, and brief therapeutic interventions to deliver a complete recovery journey. What makes ARC Addiction Recovery Care distinctive is their commitment to custom-fit care, addressing the unique circumstances of every individual. This facility is an excellent choice for younger men looking for effective addiction rehabilitation, as ARC Addiction Recovery Care is devoted to guiding them toward a life free from addiction.

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Situated in Madison, WI, ARC Community Services Inc provides a range of treatment options, including intensive outpatient programs, standard outpatient care, and day treatment for those dealing with substance use disorders. The facility implements techniques such as anger management, cognitive behavioral therapy, and motivational incentives to assist adult women who have experienced intimate partner violence, domestic violence, and sexual abuse. Catering to adults, seniors, and young adults, the center is dedicated to addressing the unique needs of female clients on their road to recovery. ARC Community Services Inc emphasizes high-quality care and relies on evidence-based methods to help individuals achieve sobriety and emotional healing.

ARC Counseling Centers

ARC Counseling Centers, situated in Louisa, KY, provides dedicated substance use rehabilitation services tailored for adults and young adults within a nurturing atmosphere. The center features various treatment options, including intensive outpatient, long-term residential, and outpatient programs, all designed to meet the specific needs of each client. Employing methodologies such as 12-step facilitation, anger management, and brief interventions, ARC Counseling Centers promotes a well-rounded recovery experience. Their commitment to personalized care and attention to gender-specific requirements differentiates them from other facilities. Serving both male and female individuals, this center emphasizes high-quality, customized support for those on their path to overcoming addiction.

ARC Counseling Centers

Situated in Louisa, KY, ARC Counseling Centers specializes in substance use rehabilitation for women of all ages, including adults, seniors, and young adults. The center offers a range of programs, including intensive outpatient services, long-term residential options, and outpatient care, all customized to meet the specific needs of each client. Incorporating techniques such as 12-step programs, anger management, and brief interventions, ARC Counseling Centers provides thorough and effective treatment. This facility is recognized for its dedication to crafting personalized recovery plans, ensuring that each individual receives the tailored support they require. If you are in search of exceptional addiction treatment that prioritizes individualized attention, ARC Counseling Centers is a great option for your recovery path.

ARC Counseling Centers

ARC Counseling Centers, situated in Tyner, Kentucky, is dedicated to providing targeted substance abuse rehabilitation for adult women, seniors, and young women. They offer a range of services, including intensive outpatient, extended residential stays, and outpatient care, all adapted to each person's specific requirements. The facility employs strategies such as 12-step support, emotional regulation training, and brief counseling techniques to foster a thorough and successful path to recovery. A distinguishing feature of ARC Counseling Centers is their personalized care model, which prioritizes individualized attention and treatment plans. For individuals in search of effective addiction treatment within a nurturing setting, this establishment is committed to fostering enduring sobriety and overall well-being.

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Kingston Springs, TN

Situated in Kingston Springs, TN, ARCH Academy delivers extensive treatment for substance use disorders specifically designed for adult men in a nurturing atmosphere. The center offers a variety of programs including intensive outpatient, long-term residential, and outpatient services, incorporating methods such as 12-step support, anger management, and brief interventions. While ARCH Academy primarily focuses on adolescent care, it also serves children, seniors, and adults. Prioritizing high-quality care and personalized treatment strategies, this center is committed to assisting clients in achieving sustainable recovery. For those seeking specialized addiction treatment in a male-only environment, ARCH Academy is an excellent choice for a customized rehabilitation journey.

Frequently Asked Questions

What is Medication-Assisted Treatment (MAT)?
MAT combines FDA-approved medications with counseling and behavioral therapies for comprehensive addiction treatment. Medications normalize brain chemistry, block euphoric effects of substances, relieve physiological cravings, and normalize body functions without negative effects of substance use. MAT is the gold standard for opioid and alcohol use disorders.
What medications are used in MAT?
For opioid use disorder: methadone, buprenorphine (Suboxone, Sublocade), and naltrexone (Vivitrol). For alcohol use disorder: naltrexone, acamprosate, and disulfiram. Each medication has unique benefits and considerations. A physician experienced in addiction medicine determines the most appropriate option based on individual circumstances, substance used, and treatment goals.
Is MAT just replacing one addiction with another?
No, this is a common misconception. MAT medications are prescribed at stable, therapeutic doses and don't produce euphoria when taken as directed. They're medicine, not substitution. MAT allows normal functioning, eliminates cravings, prevents withdrawal, dramatically reduces overdose risk, and enables engagement in therapy and rebuilding life. Research consistently shows MAT saves lives and improves outcomes.
How long does MAT last?
MAT duration varies by individual needs. Some people benefit from months of treatment, others years or indefinitely. There's no predetermined timeline. Research shows longer MAT duration improves outcomes and reduces overdose risk. Decisions about duration should be made collaboratively with healthcare providers based on stability, quality of life, and recovery goals, not arbitrary timelines.
Does insurance cover MAT?
Most health insurance plans cover MAT under mental health and substance use benefits. The Affordable Care Act and Mental Health Parity Act require coverage for addiction treatment including MAT. Coverage includes medications, office visits, counseling, and therapy. Contact your insurance provider or treatment center admissions to verify specific coverage and costs.

About Medication-Assisted Treatment (MAT)

Medication-Assisted Treatment (MAT) represents the gold standard for treating opioid and alcohol use disorders. By combining FDA-approved medications with counseling and behavioral therapies, MAT addresses both the biological and psychological aspects of addiction. Research consistently demonstrates that MAT reduces overdose deaths by more than 50%, improves treatment retention, and supports long-term recovery.

MAT Medications for Opioid Use Disorder

Three FDA-approved medications treat opioid addiction:

  • Methadone: Full opioid agonist eliminating withdrawal and cravings; administered daily at certified opioid treatment programs (OTPs). Longest track record with extensive research supporting effectiveness.
  • Buprenorphine (Suboxone, Sublocade): Partial opioid agonist with ceiling effect, reducing abuse potential; prescribed by certified physicians in office settings or as monthly injection. Offers greater flexibility and privacy.
  • Naltrexone (Vivitrol): Opioid antagonist blocking opioid effects; requires complete detox before starting; available as daily pill or monthly injection. Best for motivated individuals after detox completion.

MAT for Alcohol Use Disorder

FDA-approved medications for alcohol addiction:

  • Naltrexone: Reduces cravings and blocks rewarding effects of alcohol; available as daily pill or monthly injection
  • Acamprosate (Campral): Helps restore brain chemistry balance; reduces cravings and supports abstinence
  • Disulfiram (Antabuse): Causes unpleasant reaction if alcohol consumed; provides deterrent for impulsive drinking

Comprehensive Treatment Approach

MAT is never medication alone. Quality programs integrate counseling, behavioral therapies, case management, recovery support services, treatment for co-occurring conditions, and peer support. The medication component allows individuals to engage fully in therapy and recovery activities by eliminating withdrawal, cravings, and physiological barriers to recovery.

Addressing Stigma and Misconceptions

MAT faces unfortunate stigma, with some viewing it as "replacing one drug with another." This is false. MAT medications are prescribed at stable therapeutic doses, don't produce euphoria, allow normal functioning, and are medicine treating a medical condition. Research overwhelming supports MAT as most effective treatment for opioid use disorder. Organizations like SAMHSA, NIDA, and medical professional societies strongly endorse MAT.

Finding MAT Treatment

Look for programs offering multiple MAT medication options, addiction medicine physicians, comprehensive counseling services, individualized treatment planning, support for long-term medication management, and evidence-based behavioral therapies. Our directory helps locate opioid treatment centers and programs offering MAT.

Harm Reduction and Medication-Assisted Treatment

Harm reduction is a public health philosophy that meets people where they are in their relationship with substance use. Rather than demanding abstinence as a precondition for support, harm reduction focuses on reducing the negative health, social, and economic consequences of drug use while keeping individuals alive, safe, and connected to care. This pragmatic approach recognizes that not everyone is ready or able to stop using substances immediately, and that incremental steps toward health are meaningful and worth supporting.

Harm reduction programs take many forms in communities across the country. Needle exchange and syringe service programs reduce the spread of HIV and hepatitis C among people who inject drugs. Naloxone (Narcan) distribution puts lifesaving overdose reversal medication directly into the hands of people who use drugs and their loved ones. Drug checking services, including fentanyl test strips, help people identify dangerous adulterants in their supply. Supervised consumption sites, operating in several countries and piloted in the United States, provide sterile environments with medical staff on hand to prevent fatal overdoses. Low-threshold MAT programs remove barriers to treatment by offering same-day starts, flexible scheduling, and minimal requirements for enrollment.

Harm reduction and abstinence are not competing philosophies — they are complementary approaches along a continuum of care. Many people who initially engage with harm reduction services eventually choose to pursue abstinence-based recovery. Research consistently shows that harm reduction programs serve as a critical bridge, connecting individuals to treatment they might never have accessed otherwise. Forcing a choice between the two creates a false dichotomy that costs lives.

MAT is itself a cornerstone harm reduction strategy. Buprenorphine and methadone maintenance programs dramatically reduce overdose deaths — studies show a 50% or greater reduction in all-cause mortality among patients receiving opioid agonist therapy. Beyond preventing fatal overdoses, MAT reduces HIV and hepatitis C transmission by decreasing injection drug use, lowers criminal activity and incarceration rates, and improves overall quality of life, housing stability, and employment outcomes. These benefits occur even when patients are not fully abstinent from all substances. By stabilizing brain chemistry and eliminating the desperate cycle of withdrawal and compulsive use, MAT gives people the stability they need to rebuild their lives. Facilities offering MAT as part of a harm reduction framework can be found through our opioid rehab directory.

FDA-Approved Medications: Detailed Guides

The U.S. Food and Drug Administration has approved several medications for the treatment of opioid and alcohol use disorders. Each works through a different mechanism and is suited to different clinical situations. Understanding the distinctions can help patients and families make informed decisions alongside their treatment providers. Explore our in-depth guides below.

Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist that completely blocks the euphoric and sedative effects of opioids, removing the incentive to use. It is available as a daily oral pill or as a monthly extended-release injection marketed as Vivitrol. Because naltrexone requires a full detox period before initiation — typically 7 to 14 days opioid-free — it is best suited for patients who have already completed withdrawal management. Naltrexone is also FDA-approved for alcohol use disorder, where it reduces cravings and heavy drinking days.

Learn more about Naltrexone →

Buprenorphine (Suboxone)

Buprenorphine is a partial opioid agonist with a built-in ceiling effect, meaning its opioid effects plateau at moderate doses — significantly lowering the risk of respiratory depression and overdose. It is available as a sublingual film or tablet (commonly known by the brand name Suboxone, which also contains naloxone to deter misuse) and as a monthly subcutaneous injection (Sublocade). Buprenorphine can be prescribed in office-based settings by qualified providers, making it one of the most accessible MAT options. It effectively reduces cravings and withdrawal symptoms while carrying lower abuse potential than full agonists.

Learn more about Buprenorphine →

Methadone

Methadone is a full opioid agonist with more than 60 years of clinical evidence supporting its effectiveness. Administered daily at certified Opioid Treatment Programs (OTPs), methadone eliminates withdrawal symptoms, suppresses cravings, and blocks the effects of other opioids when dosed correctly. It is considered the most effective option for individuals with severe opioid use disorder, particularly those who have not responded to other medications. The structured program participation required — including regular clinic visits, counseling, and drug screening — provides an additional layer of accountability and support.

Learn more about Methadone →

Naloxone (Narcan)

Naloxone is an opioid antagonist used to rapidly reverse opioid overdoses. Available as a nasal spray (Narcan) and in injectable formulations, naloxone can restore normal breathing within minutes in a person experiencing respiratory depression from opioids. In 2023, Narcan nasal spray became available over the counter without a prescription, making it more accessible than ever. Every person who uses opioids, is prescribed high-dose opioid pain medication, or has a loved one at risk should keep naloxone on hand — it is safe, effective, and saves lives.

Learn more about Naloxone →

MAT resources and information:

Find Medication-Assisted Treatment (MAT) by State

Browse medication-assisted treatment (mat) programs in states with the most treatment options.

Explore Related Options

Related conditions, treatment approaches, and levels of care.

Medically Reviewed Updated September 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)