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Medically Reviewed Content
Updated: September 2026
Sources: SAMHSA, NIDA

Medication-Assisted Treatment (MAT) Centers

Medication-Assisted Treatment (MAT) combines FDA-approved medications with counseling and behavioral therapies for comprehensive addiction care. MAT is the gold standard for opioid and alcohol use disorders, significantly reducing overdose deaths and improving treatment outcomes.

Found 300 treatment centers offering medication-assisted treatment (mat) across the United States.

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ARCH Detox
Aurora, CO

ARCH Detox, situated in Aurora, CO, provides outpatient services for individuals of all ages grappling with substance use and mental health challenges. Their expertise lies in addressing dual diagnoses, encompassing co-occurring substance use disorders and severe mental health conditions in adults, and serious emotional disturbances in children. Utilizing evidence-based approaches like cognitive behavioral therapy, anger management, and brief intervention, ARCH Detox delivers personalized treatment plans. They also offer dedicated programs for active duty military, adult men, and adult women, welcoming both male and female clients on their journey to recovery and improved well-being.

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Omaha, NE

Situated in Omaha, Nebraska, ARCH Inc provides focused rehabilitation solutions for adult males struggling with substance use issues. This center specializes in long-term residential treatment, along with transitional and sober living facilities, emphasizing 12-step methods, cognitive behavioral therapy, and motivational interviewing techniques. Designed exclusively for adult men, ARCH Inc accommodates seniors, young adults, and men in a gender-specific setting. The center is dedicated to delivering high-quality care and prioritizes personalized treatment, making it an essential resource for individuals pursuing a thorough recovery journey.

ARCH Inc
Omaha, NE

ARCH Inc, situated in Omaha, NE, delivers targeted interventions for individuals struggling with substance use, alongside transitional living accommodations designed for adult males. This establishment is dedicated to extended residential recovery, employing methodologies such as 12-step support, cognitive behavioral therapy, and motivational interviewing. ARCH Inc's program is exclusively for adult men committed to their recovery journey, fostering a nurturing atmosphere for individuals of all adult age groups. As a gender-specific facility, ARCH Inc guarantees personalized treatment and focused support for its male clientele. Through a holistic rehabilitation strategy, encompassing halfway house and sober living options, this center champions high-quality care and enduring sobriety for those seeking help with addiction.

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Wichita, KS

ARROW, situated in Wichita, KS, is a premier treatment facility dedicated to helping individuals of all ages overcome substance use disorders. Their comprehensive outpatient programs are built upon proven methodologies, including 12-step integration, cognitive behavioral techniques, and strategies for maintaining sobriety. What distinguishes ARROW is its dedication to crafting unique treatment plans that cater to the specific needs of every individual. They are committed to delivering exceptional, customized care for both men and women, fostering a nurturing atmosphere conducive to long-term recovery from addiction. Opt for ARROW for reliable, research-supported interventions in a comfortable environment.

ARS New Castle
New Castle, DE

ARS New Castle, located in New Castle, DE, specializes in a wide range of substance use treatment and provides particular attention to adults facing both substance use disorders and significant mental health challenges, as well as addressing emotional issues in children. The center offers various treatment formats, including intensive outpatient care, outpatient programs, and options involving methadone, buprenorphine, or naltrexone. Utilizing research-backed methods like cognitive behavioral therapy and contingency management, ARS New Castle tailors its services to meet the unique needs of active duty military members and both men and women. With a focus on delivering exceptional care, the facility is recognized for its array of treatment options and personalized recovery paths.

ARS Of Lancaster LP
Lancaster, PA

ARS Of Lancaster LP, located in Lancaster, PA, provides a wide range of addiction rehabilitation services for both adults and young adults. The center focuses on detoxification and treatment for substance use, offering intensive outpatient and standard outpatient programs, inclusive of outpatient detox services. ARS Of Lancaster LP employs evidence-based methods like cognitive behavioral therapy and contingency management, customizing treatment plans to meet the unique needs of each individual. With specialized programs available for active duty military personnel, adult men, and adult women, the center is committed to delivering tailored care. Serving clients of all genders, ARS Of Lancaster LP is dedicated to facilitating recovery journeys with high-quality support.

ARS Treatment Centers of New Jersey

Situated in Rio Grande, NJ, ARS Treatment Centers of New Jersey specializes in outpatient treatment for substance use disorders, emphasizing high-quality care tailored to individual needs. The center provides treatments that include methadone, buprenorphine, and naltrexone, along with counseling services for those dealing with substance use issues. For added accessibility, telehealth options are also offered. The facility has unique programs designed for pregnant and postpartum women, and it serves adults and young adults of all genders. With a strong focus on personalized treatment and specialized programs, ARS Treatment Centers of New Jersey is committed to aiding individuals in their recovery journey from substance use challenges.

ARS Treatment Centers of New Jersey

ARS Treatment Centers of New Jersey, located in Stanhope, NJ, offers outpatient services for individuals grappling with substance use challenges. Their programs include options for methadone, buprenorphine, and naltrexone treatment. The center provides counseling for substance use disorders, along with telehealth therapy services. Targeting the unique needs of pregnant and postpartum women, ARS Treatment Centers of New Jersey serves adults and young adults across all gender identities. With a commitment to personalized care, the center strives to deliver effective support for those in pursuit of recovery from addiction. For individuals seeking well-rounded substance use treatment in a nurturing setting, this center provides tailored programs designed to address diverse requirements.

ARS Treatment Centers of New Jersey

ARS Treatment Centers of New Jersey, located in Absecon, NJ, provides outpatient programs for substance use treatment, which include methadone, buprenorphine, and naltrexone options. The center also offers counseling for substance use disorders alongside telemedicine and telehealth services. With a specialization in supporting pregnant and postpartum women, the facility serves both adults and young adults of all genders. Emphasizing high-quality care and individualized treatment strategies, ARS Treatment Centers of New Jersey creates a nurturing setting for those on their path to recovery from addiction. Their holistic methodology focuses on addressing the specific needs of each individual, fostering lasting healing and enduring sobriety.

ARS Treatment Centers of New Jersey

ARS Treatment Centers of New Jersey, situated in Hamburg, NJ, delivers outpatient addiction rehabilitation services for adults and young adults. They feature distinct programs for expectant and new mothers, employing thorough substance use disorder counseling via methods such as telemedicine and remote therapy. Personalized outpatient plans incorporating methadone, buprenorphine, or naltrexone are offered. This facility serves both male and female individuals, prioritizing bespoke support for everyone pursuing sobriety. Their dedication to high-quality treatment and a variety of therapeutic options establishes them as a crucial support system for individuals in recovery.

ARS Treatment Centers of New Jersey

In Lanoka Harbor, NJ, ARS Treatment Centers of New Jersey provides comprehensive outpatient care for substance use disorders, serving adults and young adults. The center features unique programs designed for women who are pregnant or have recently given birth. Their approach includes specialized counseling for addiction, alongside the convenience of telemedicine and telehealth services. Clients can receive individualized outpatient treatment plans incorporating methadone, buprenorphine, or naltrexone, available to both men and women. ARS Treatment Centers of New Jersey is committed to delivering effective support and high-quality recovery services, establishing itself as a key provider of detailed and gender-sensitive treatment options within the region.

ARS of Aberdeen
Aberdeen, MD

Situated in Aberdeen, MD, ARS of Aberdeen specializes in extensive treatment for substance use disorders targeting both adults and young adults. The center provides various levels of care including intensive outpatient programs, regular outpatient services, and treatments that utilize methadone/buprenorphine or naltrexone. Implementing research-backed methods such as cognitive behavioral therapy, motivational incentives, and the Matrix Model, ARS of Aberdeen serves both men and women, as well as individuals facing co-occurring mental health and substance use challenges. With tailored programs designed for diverse populations and a commitment to high-quality treatment, ARS of Aberdeen is focused on aiding individuals in their recovery journey.

ARS of Aberdeen LLC

ARS of Aberdeen LLC in Aberdeen, MD, provides a full spectrum of substance abuse treatment, including intensive outpatient, standard outpatient, and medication-assisted treatment options with methadone, buprenorphine, or naltrexone. Their therapeutic approach integrates cognitive behavioral therapy, motivational interviewing, and relapse prevention strategies, all delivered within a personalized framework designed to meet individual needs. The center welcomes adults and young adults of all genders, offering tailored support for a wide range of recovery journeys. ARS of Aberdeen LLC is dedicated to delivering high-quality, evidence-based care in a nurturing setting for individuals pursuing recovery. Discover individualized support and proven rehabilitation strategies at this location.

ARS of Ephrata
Ephrata, PA

Situated in Ephrata, Pennsylvania, ARS of Ephrata delivers extensive treatment for substance use through outpatient services and medication-assisted options such as methadone, buprenorphine, or naltrexone. The center focuses on remedies for anger management, provides brief interventions, and employs cognitive behavioral therapy. It offers distinct programs designed for those affected by trauma, members of the LGBTQ community, as well as expectant and new mothers. Catering to adults and young adults of all identities, ARS of Ephrata ensures high-quality support in a nurturing atmosphere. If you or someone you care about is in need of substance use assistance featuring specialized programs and proven methodologies, this center is well-prepared to aid in the recovery process.

ARS of Virginia LLC
Winchester, VA

ARS of Virginia LLC in Winchester, VA, provides thorough addiction recovery services, employing diverse treatment modalities such as intensive outpatient care and standard outpatient medication-assisted treatment with methadone, buprenorphine, or naltrexone. The facility employs scientifically validated methods like motivational interviewing, cognitive behavioral therapy, and reward-based motivation strategies to foster lasting sobriety. Tailored support is available through specific programs designed for adult men, adult women, and individuals with trauma histories. Catering to a broad demographic of adult and young adult clients, ARS of Virginia LLC delivers high-caliber, individualized treatment. For those in search of effective addiction treatment focused on bespoke care and specialized interventions, ARS of Virginia LLC stands ready to assist.

ARTS Potomac Street Center

Nestled in Aurora, Colorado, the ARTS Potomac Street Center delivers complete care for individuals struggling with substance use disorders, serving both adults and younger adults. Their offerings include intensive outpatient, standard outpatient, and medication-assisted treatment options using methadone, buprenorphine, or naltrexone. Addressing key areas such as anger management, brief interventions, and cognitive behavioral therapy, the center is equipped to support adult men and women, as well as those who have faced trauma. Tailored programs are a hallmark, ensuring each person receives personalized support. The ARTS Potomac Street Center is committed to high standards and proven methods, guiding individuals toward lasting recovery.

ASAP Cincinnati
Cincinnati, OH

ASAP Cincinnati, located in Cincinnati, OH, delivers thorough care for individuals struggling with addiction, addressing both adult co-occurring mental health conditions and childhood emotional challenges. Their treatment options include intensive outpatient, outpatient, and standard outpatient programs, all grounded in proven methods like 12-step facilitation, cognitive behavioral therapy, and contingency management. They also feature distinct programs designed specifically for teenagers and young adults, providing tailored support. Catering to all genders, ASAP Cincinnati is dedicated to high-quality, personalized treatment strategies aimed at fostering recovery and enhancing client welfare.

ASAP at Wilson Place
Bowling Green, KY

ASAP at Wilson Place, located in Bowling Green, KY, provides outpatient treatment for substance use disorders and specialized support for adults facing dual challenges of substance abuse and severe mental health conditions, as well as children dealing with significant emotional disturbances. The center employs various intervention methods, including anger management, brief interventions, and cognitive behavioral therapy, focusing on personalized care for adults and seniors across all genders. ASAP at Wilson Place is distinguished by its customized treatment plans and dedication to offering exceptional, holistic rehabilitation services for individuals pursuing recovery from addiction and co-occurring disorders.

ASCEND Csl and Recovery Services

ASCEND Csl and Recovery Services located in Portsmouth, OH, provides comprehensive treatment for individuals dealing with substance abuse and concurrent mental health issues, catering to both adults and children. The center offers a variety of services including intensive outpatient programs, outpatient care, and day treatment, employing tailored strategies such as 12-step facilitation, anger management, and cognitive behavioral therapy. Distinct programs are available for adult men, adult women, and those who have faced trauma. This facility is dedicated to serving individuals of all genders, including seniors, and emphasizes personalized care to facilitate clients' journeys toward recovery.

ASIC Recovery Services

ASIC Recovery Services in Fort Worth, TX, provides extensive addiction treatment for individuals of all ages, from children to adults. Their structured programs, including intensive, regular outpatient, and standard outpatient options, integrate effective therapeutic modalities such as 12-step facilitation, anger management techniques, and brief intervention strategies. A key feature of ASIC Recovery Services is their commitment to crafting bespoke treatment plans designed to meet the specific requirements of each person. Catering to both male and female clients, the center fosters a welcoming and encouraging atmosphere. For those in search of exceptional, personalized addiction care, ASIC Recovery Services is devoted to supporting your journey toward healing.

ASun Star Consulting Inc
East Rutherford, NJ

ASun Star Consulting Inc, situated in East Rutherford, New Jersey, delivers comprehensive, scientifically validated treatment options for individuals of all ages struggling with substance abuse and co-occurring mental health issues. Their services encompass intensive outpatient, outpatient, and standard outpatient levels of care, employing therapeutic modalities like anger management, brief intervention, and cognitive behavioral therapy. The center also caters to specific populations through dedicated programs for active military personnel, teenagers, and adult men. ASun Star Consulting Inc prioritizes personalized care within a nurturing setting for adult and senior clients of all genders.

Frequently Asked Questions

What is Medication-Assisted Treatment (MAT)?
MAT combines FDA-approved medications with counseling and behavioral therapies for comprehensive addiction treatment. Medications normalize brain chemistry, block euphoric effects of substances, relieve physiological cravings, and normalize body functions without negative effects of substance use. MAT is the gold standard for opioid and alcohol use disorders.
What medications are used in MAT?
For opioid use disorder: methadone, buprenorphine (Suboxone, Sublocade), and naltrexone (Vivitrol). For alcohol use disorder: naltrexone, acamprosate, and disulfiram. Each medication has unique benefits and considerations. A physician experienced in addiction medicine determines the most appropriate option based on individual circumstances, substance used, and treatment goals.
Is MAT just replacing one addiction with another?
No, this is a common misconception. MAT medications are prescribed at stable, therapeutic doses and don't produce euphoria when taken as directed. They're medicine, not substitution. MAT allows normal functioning, eliminates cravings, prevents withdrawal, dramatically reduces overdose risk, and enables engagement in therapy and rebuilding life. Research consistently shows MAT saves lives and improves outcomes.
How long does MAT last?
MAT duration varies by individual needs. Some people benefit from months of treatment, others years or indefinitely. There's no predetermined timeline. Research shows longer MAT duration improves outcomes and reduces overdose risk. Decisions about duration should be made collaboratively with healthcare providers based on stability, quality of life, and recovery goals, not arbitrary timelines.
Does insurance cover MAT?
Most health insurance plans cover MAT under mental health and substance use benefits. The Affordable Care Act and Mental Health Parity Act require coverage for addiction treatment including MAT. Coverage includes medications, office visits, counseling, and therapy. Contact your insurance provider or treatment center admissions to verify specific coverage and costs.

About Medication-Assisted Treatment (MAT)

Medication-Assisted Treatment (MAT) represents the gold standard for treating opioid and alcohol use disorders. By combining FDA-approved medications with counseling and behavioral therapies, MAT addresses both the biological and psychological aspects of addiction. Research consistently demonstrates that MAT reduces overdose deaths by more than 50%, improves treatment retention, and supports long-term recovery.

MAT Medications for Opioid Use Disorder

Three FDA-approved medications treat opioid addiction:

  • Methadone: Full opioid agonist eliminating withdrawal and cravings; administered daily at certified opioid treatment programs (OTPs). Longest track record with extensive research supporting effectiveness.
  • Buprenorphine (Suboxone, Sublocade): Partial opioid agonist with ceiling effect, reducing abuse potential; prescribed by certified physicians in office settings or as monthly injection. Offers greater flexibility and privacy.
  • Naltrexone (Vivitrol): Opioid antagonist blocking opioid effects; requires complete detox before starting; available as daily pill or monthly injection. Best for motivated individuals after detox completion.

MAT for Alcohol Use Disorder

FDA-approved medications for alcohol addiction:

  • Naltrexone: Reduces cravings and blocks rewarding effects of alcohol; available as daily pill or monthly injection
  • Acamprosate (Campral): Helps restore brain chemistry balance; reduces cravings and supports abstinence
  • Disulfiram (Antabuse): Causes unpleasant reaction if alcohol consumed; provides deterrent for impulsive drinking

Comprehensive Treatment Approach

MAT is never medication alone. Quality programs integrate counseling, behavioral therapies, case management, recovery support services, treatment for co-occurring conditions, and peer support. The medication component allows individuals to engage fully in therapy and recovery activities by eliminating withdrawal, cravings, and physiological barriers to recovery.

Addressing Stigma and Misconceptions

MAT faces unfortunate stigma, with some viewing it as "replacing one drug with another." This is false. MAT medications are prescribed at stable therapeutic doses, don't produce euphoria, allow normal functioning, and are medicine treating a medical condition. Research overwhelming supports MAT as most effective treatment for opioid use disorder. Organizations like SAMHSA, NIDA, and medical professional societies strongly endorse MAT.

Finding MAT Treatment

Look for programs offering multiple MAT medication options, addiction medicine physicians, comprehensive counseling services, individualized treatment planning, support for long-term medication management, and evidence-based behavioral therapies. Our directory helps locate opioid treatment centers and programs offering MAT.

Harm Reduction and Medication-Assisted Treatment

Harm reduction is a public health philosophy that meets people where they are in their relationship with substance use. Rather than demanding abstinence as a precondition for support, harm reduction focuses on reducing the negative health, social, and economic consequences of drug use while keeping individuals alive, safe, and connected to care. This pragmatic approach recognizes that not everyone is ready or able to stop using substances immediately, and that incremental steps toward health are meaningful and worth supporting.

Harm reduction programs take many forms in communities across the country. Needle exchange and syringe service programs reduce the spread of HIV and hepatitis C among people who inject drugs. Naloxone (Narcan) distribution puts lifesaving overdose reversal medication directly into the hands of people who use drugs and their loved ones. Drug checking services, including fentanyl test strips, help people identify dangerous adulterants in their supply. Supervised consumption sites, operating in several countries and piloted in the United States, provide sterile environments with medical staff on hand to prevent fatal overdoses. Low-threshold MAT programs remove barriers to treatment by offering same-day starts, flexible scheduling, and minimal requirements for enrollment.

Harm reduction and abstinence are not competing philosophies — they are complementary approaches along a continuum of care. Many people who initially engage with harm reduction services eventually choose to pursue abstinence-based recovery. Research consistently shows that harm reduction programs serve as a critical bridge, connecting individuals to treatment they might never have accessed otherwise. Forcing a choice between the two creates a false dichotomy that costs lives.

MAT is itself a cornerstone harm reduction strategy. Buprenorphine and methadone maintenance programs dramatically reduce overdose deaths — studies show a 50% or greater reduction in all-cause mortality among patients receiving opioid agonist therapy. Beyond preventing fatal overdoses, MAT reduces HIV and hepatitis C transmission by decreasing injection drug use, lowers criminal activity and incarceration rates, and improves overall quality of life, housing stability, and employment outcomes. These benefits occur even when patients are not fully abstinent from all substances. By stabilizing brain chemistry and eliminating the desperate cycle of withdrawal and compulsive use, MAT gives people the stability they need to rebuild their lives. Facilities offering MAT as part of a harm reduction framework can be found through our opioid rehab directory.

FDA-Approved Medications: Detailed Guides

The U.S. Food and Drug Administration has approved several medications for the treatment of opioid and alcohol use disorders. Each works through a different mechanism and is suited to different clinical situations. Understanding the distinctions can help patients and families make informed decisions alongside their treatment providers. Explore our in-depth guides below.

Naltrexone (Vivitrol)

Naltrexone is an opioid antagonist that completely blocks the euphoric and sedative effects of opioids, removing the incentive to use. It is available as a daily oral pill or as a monthly extended-release injection marketed as Vivitrol. Because naltrexone requires a full detox period before initiation — typically 7 to 14 days opioid-free — it is best suited for patients who have already completed withdrawal management. Naltrexone is also FDA-approved for alcohol use disorder, where it reduces cravings and heavy drinking days.

Learn more about Naltrexone →

Buprenorphine (Suboxone)

Buprenorphine is a partial opioid agonist with a built-in ceiling effect, meaning its opioid effects plateau at moderate doses — significantly lowering the risk of respiratory depression and overdose. It is available as a sublingual film or tablet (commonly known by the brand name Suboxone, which also contains naloxone to deter misuse) and as a monthly subcutaneous injection (Sublocade). Buprenorphine can be prescribed in office-based settings by qualified providers, making it one of the most accessible MAT options. It effectively reduces cravings and withdrawal symptoms while carrying lower abuse potential than full agonists.

Learn more about Buprenorphine →

Methadone

Methadone is a full opioid agonist with more than 60 years of clinical evidence supporting its effectiveness. Administered daily at certified Opioid Treatment Programs (OTPs), methadone eliminates withdrawal symptoms, suppresses cravings, and blocks the effects of other opioids when dosed correctly. It is considered the most effective option for individuals with severe opioid use disorder, particularly those who have not responded to other medications. The structured program participation required — including regular clinic visits, counseling, and drug screening — provides an additional layer of accountability and support.

Learn more about Methadone →

Naloxone (Narcan)

Naloxone is an opioid antagonist used to rapidly reverse opioid overdoses. Available as a nasal spray (Narcan) and in injectable formulations, naloxone can restore normal breathing within minutes in a person experiencing respiratory depression from opioids. In 2023, Narcan nasal spray became available over the counter without a prescription, making it more accessible than ever. Every person who uses opioids, is prescribed high-dose opioid pain medication, or has a loved one at risk should keep naloxone on hand — it is safe, effective, and saves lives.

Learn more about Naloxone →

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Find Medication-Assisted Treatment (MAT) by State

Browse medication-assisted treatment (mat) programs in states with the most treatment options.

Explore Related Options

Related conditions, treatment approaches, and levels of care.

Medically Reviewed Updated September 2026

Reviewed by licensed addiction specialists. Information reflects current clinical guidance.

Sources:SAMHSA·NIDA·CDC

Need immediate help? Call SAMHSA: 1-800-662-4357 (24/7, free)